A non-invasive analysis method for on-chip spectrophotometric detection using liquid-core waveguiding within a 3D architecture

The Analyst ◽  
2003 ◽  
Vol 128 (11) ◽  
pp. 1336 ◽  
Author(s):  
Matthew P. Duggan ◽  
Tom McCreedy ◽  
Jonathan W. Aylott
Author(s):  
Preecha Yupapin ◽  
Amiri I. S. ◽  
Ali J. ◽  
Ponsuwancharoen N. ◽  
Youplao P.

The sequence of the human brain can be configured by the originated strongly coupling fields to a pair of the ionic substances(bio-cells) within the microtubules. From which the dipole oscillation begins and transports by the strong trapped force, which is known as a tweezer. The tweezers are the trapped polaritons, which are the electrical charges with information. They will be collected on the brain surface and transport via the liquid core guide wave, which is the mixture of blood content and water. The oscillation frequency is called the Rabi frequency, is formed by the two-level atom system. Our aim will manipulate the Rabi oscillation by an on-chip device, where the quantum outputs may help to form the realistic human brain function for humanoid robotic applications.


Sensors ◽  
2018 ◽  
Vol 18 (10) ◽  
pp. 3234
Author(s):  
Insun Shin ◽  
Kyoungmin Koo ◽  
Daeil Kwon

Electronic products and systems are widely used in industrial network systems, control devices, and data acquisition devices across many industry sectors. Failures of such electronic systems might lead to unexpected downtime, loss of productivity, additional work for repairs, and delay in product and service development. Thus, developing an appropriate sensing technique is necessary, because it is the first step in system fault diagnosis and prognosis. Many sensing techniques often require external and additional sensing devices, which might disturb system operation and consequently increase operating costs. In this study, we present an on-chip health sensing method for non-destructive and non-invasive interconnect degradation detection. Bit error rate (BER), which represents data integrity during digital signal transmission, was selected to sense interconnect health without connecting external sensing devices. To verify the health sensing performance, corrosion tests were conducted with in situ monitoring of the BER and direct current (DC) resistance. The eye size, extracted from the BER measurement, showed the highest separation between the intact and failed interconnect, as well as a gradual transition, compared with abrupt changes in the DC resistance, during interconnect degradation. These experimental results demonstrate the potential of the proposed sensing method for on-chip interconnect health monitoring applications without disturbing system operation.


Author(s):  
Ruiqing Ni

Animal models of Alzheimer’s disease amyloidosis that recapitulate cerebral amyloid-beta pathology have been widely used in preclinical research, and have greatly enabled the mechanistic understanding of Alzheimer’s disease and the development of therapeutics. Comprehensive deep phenotyping of the pathophysiological and biochemical features in these animal models are essential. Recent advances in positron emission tomography have allowed the non-invasive visualization of the alterations in the brain of animal models as well as in patients with Alzheimer’s disease, These tools have facilitated our understanding of disease mechanisms, and provided longitudinal monitoring of treatment effect in animal models of Alzheimer’s disease amyloidosis. In this review, we focus on recent positron emission tomography studies of cerebral amyloid-beta accumulation, hypoglucose metabolism, synaptic and neurotransmitter receptor deficits (cholinergic and glutamatergic system), blood-brain barrier impairment and neuroinflammation (microgliosis and astrocytosis) in animal models of Alzheimer’s disease amyloidosis. We further propose the emerging targets and tracers for reflecting the pathophysiological changes, and discuss outstanding challenges in disease animal models and future outlook in on-chip characterization of imaging biomarkers towards clinical translation.


2016 ◽  
Vol 8 (22) ◽  
pp. 4473-4481 ◽  
Author(s):  
Tingjin Zhou ◽  
Yongming Huang ◽  
Dongxing Yuan ◽  
Sichao Feng ◽  
Yong Zhu ◽  
...  

A flexible, flow injection analysis method for shipboard use was developed for the on-line determination of trace dissolved aluminum (dAl) in seawater.


2005 ◽  
Vol 3 (7) ◽  
pp. 333-343 ◽  
Author(s):  
Yulia Mourzina ◽  
Alfred Steffen ◽  
Dmitri Kaliaguine ◽  
Bernhard Wolfrum ◽  
Petra Schulte ◽  
...  

Functional coupling of reconstructed neuronal networks with microelectronic circuits has potential for the development of bioelectronic devices, pharmacological assays and medical engineering. Modulation of the signal processing properties of on-chip reconstructed neuronal networks is an important aspect in such applications. It may be achieved by controlling the biochemical environment, preferably with cellular resolution. In this work, we attempt to design cell–cell and cell–medium interactions in confined geometries with the aim to manipulate non-invasively the activity pattern of an individual neuron in neuronal networks for long-term modulation. Therefore, we have developed a biohybrid system in which neuronal networks are reconstructed on microstructured silicon chips and interfaced to a microfluidic system. A high degree of geometrical control over the network architecture and alignment of the network with the substrate features has been achieved by means of aligned microcontact printing. Localized non-invasive on-chip chemical stimulation of micropatterned rat cortical neurons within a network has been demonstrated with an excitatory neurotransmitter glutamate. Our system will be useful for the investigation of the influence of localized chemical gradients on network formation and long-term modulation.


Author(s):  
Federica Caselli ◽  
Nicola A. Nodargi ◽  
Paolo Bisegna

Cell mechanics is a discipline that bridges cell biology with mechanics. Emerging microscale technologies are opening new venues in the field, due to their costeffectiveness, relatively easy fabrication, and high throughput. Two examples of those technologies are discussed here: microfluidic impedance cytometry and erythrocyte electrodeformation. The former is a lab-on-chip technology offering a simple, non-invasive, label-free method for counting, identifying and monitoring cellular biophysical and mechanical function at the single-cell level. The latter is a useful complement to the former, enabling cell deformation under the influence of an applied electric field.


2014 ◽  
Vol 1030-1032 ◽  
pp. 1206-1209
Author(s):  
Vladimír Hönig ◽  
Štěpánka Horníčková ◽  
Matyáš Orsák

The process of running-in machines is a significant period of operation of the machine. This is not uniform in material but also in terms of time. The article describes a specific individual storylines that just in the context of the run-run. It also describes the composition of individual particles that arise during this period, describing their size, morphology and diversity against the regime after running-in machines. The experimental part deals with the particle analysis method ferrography as a non-invasive technique. For analyzes were 3 tractor machines, which have been collected and assessed primarily levels and intensity of wear of individual samples taken from 0 to 15 mh. Were subsequently analyzed the running-in modes of individual machines and designed tribological verdicts.


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