Tumor targeting profiling of hyaluronan-coated lipid based-nanoparticles

Nanoscale ◽  
2014 ◽  
Vol 6 (7) ◽  
pp. 3742-3752 ◽  
Author(s):  
Shoshy Mizrahy ◽  
Meir Goldsmith ◽  
Shani Leviatan-Ben-Arye ◽  
Einat Kisin-Finfer ◽  
Orit Redy ◽  
...  
Keyword(s):  
Cell Growth ◽  
Embryonic Development ◽  
Tumor Targeting ◽  
Tumor Development ◽  
Naturally Occurring ◽  
Healing Processes

Hyaluronan (HA), a naturally occurring high Mw (HMw) glycosaminoglycan, has been shown to play crucial roles in cell growth, embryonic development, healing processes, inflammation, and tumor development and progression.

Screening for naturally occurring oxyprenylated secondary metabolites as cancer cell growth inhibitory agents

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
F Epifano ◽  
S Genovese ◽  
P Lullo ◽  
S Fiorito ◽  
G Trivisonno ◽  
...  
Keyword(s):  
Cell Growth ◽  
Secondary Metabolites ◽  
Cancer Cell ◽  
Cancer Cell Growth ◽  
Naturally Occurring ◽  
Growth Inhibitory ◽  
Inhibitory Agents

Nanosizing Noncrystalline and Porous Silica Material—Naturally Occurring Opal Shale for Systemic Tumor Targeting Drug Delivery

2018 ◽  
Vol 10 (31) ◽  
pp. 25994-26004 ◽  
Author(s):  
Qian Guo ◽  
Zengyan Chang ◽  
Naveed Ullah Khan ◽  
Tongtong Miao ◽  
Xiufeng Ju ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Targeting ◽  
Porous Silica ◽  
Naturally Occurring ◽  
Silica Material

scholarly journals Microbial Synthesis of Non-Natural Anthraquinone Glucosides Displaying Superior Antiproliferative Properties

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2171 ◽  
Author(s):  
Trang Nguyen ◽  
Ramesh Pandey ◽  
Prakash Parajuli ◽  
Jang Han ◽  
Hye Jung ◽  
...  
Keyword(s):  
Cell Growth ◽  
Biological Activities ◽  
Uterine Cervical Cancer ◽  
Cell Growth Inhibition ◽  
Microbial Synthesis ◽  
E Coli ◽  
Anticancer Effects ◽  
Naturally Occurring ◽  
Spectroscopic Analyses ◽  
Proliferative Assay

Anthraquinones, naturally occurring bioactive compounds, have been reported to exhibit various biological activities, including anti-inflammatory, antiviral, antimicrobial, and anticancer effects. In this study, we biotransformed three selected anthraquinones into their novel O-glucoside derivatives, expressing a versatile glycosyltransferase (YjiC) from Bacillus licheniformis DSM 13 in Escherichia coli. Anthraflavic acid, alizarin, and 2-amino-3-hydroxyanthraquinone were exogenously fed to recombinant E. coli as substrate for biotransformation. The products anthraflavic acid-O-glucoside, alizarin 2-O-β-d-glucoside, and 2-amino-3-O-glucosyl anthraquinone produced in the culture broths were characterized by various chromatographic and spectroscopic analyses. The comparative anti-proliferative assay against various cancer cells (gastric cancer-AGS, uterine cervical cancer-HeLa, and liver cancer-HepG2) were remarkable, since the synthesized glucoside compounds showed more than 60% of cell growth inhibition at concentrations ranging from ~50 μM to 100 μM. Importantly, one of the synthesized glucoside derivatives, alizarin 2-O-glucoside inhibited more than 90% of cell growth in all the cancer cell lines tested.

scholarly journals Naturally occurring benzoic acid derivatives retard cancer cell growth by inhibiting histone deacetylases (HDAC)

2017 ◽  
Vol 18 (7) ◽  
pp. 492-504 ◽  
Author(s):  
Preethi G. Anantharaju ◽  
Bandi Deepa Reddy ◽  
Mahesh A. Padukudru ◽  
CH. M. Kumari Chitturi ◽  
Manjunath G. Vimalambike ◽  
...  
Keyword(s):  
Cell Growth ◽  
Benzoic Acid ◽  
Cancer Cell ◽  
Histone Deacetylases ◽  
Cancer Cell Growth ◽  
Benzoic Acid Derivatives ◽  
Naturally Occurring

scholarly journals PACT is a negative regulator of p53 and essential for cell growth and embryonic development

2007 ◽  
Vol 104 (19) ◽  
pp. 7951-7956 ◽  
Author(s):  
L. Li ◽  
B. Deng ◽  
G. Xing ◽  
Y. Teng ◽  
C. Tian ◽  
...  
Keyword(s):  
Cell Growth ◽  
Embryonic Development ◽  
Negative Regulator

scholarly journals Inhibition of Osteoblast Proliferation and Migration by Exogenous and Endogenous Formaldehyde

2019 ◽  
Author(s):  
Xu Teng ◽  
Wei Huang ◽  
Hefeng Yu ◽  
Pei Wang ◽  
Weishi Li ◽  
...  
Keyword(s):  
Cell Growth ◽  
Potential Role ◽  
Expression Patterns ◽  
Cell Counting ◽  
Rna Seq ◽  
Cell Growth And Migration ◽  
Naturally Occurring ◽  
Significant Enrichment ◽  
And Migration ◽  
Proliferation And Migration

AbstractExogenous and endogenous formaldehyde (FA) plays an important role in cell growth and migration; however, its potential role in osteoblasts remains largely unclear. Cell counting kit-8 (CCK-8) and wound healing assays revealed that FA exposure at naturally occurring concentrations inhibited the proliferation and migration of mouse preosteoblast MC3T3-E1 cells. Moreover, RNA sequencing (RNA-seq) analysis revealed that FoxO1 signaling pathway components displayed distinct expression patterns upon FA exposure, reflected through significant enrichment of cell migration. In particular, FoxO1 Sirt1 and FA-induced related protein expression which were closely with cell proliferation and migration were confirmed by western blotting. The present results indicate that the FoxO1 pathway is involved in FA-induced inhibition of cell growth and migration.

scholarly journals Role of SOCS-1 Gene on Melanoma Cell Growth and Tumor Development

2011 ◽  
Vol 4 (2) ◽  
pp. 101-109 ◽  
Author(s):  
Jorge A. Borin Scutti ◽  
Alisson Leonardo Matsuo ◽  
Felipe Valença Pereira ◽  
Mariana Hiromi Massaoka ◽  
Carlos Rogério Figueiredo ◽  
...  
Keyword(s):  
Cell Growth ◽  
Melanoma Cell ◽  
Tumor Development

Synthesis and biological activity of nucleoside analogs involving modifications in the carbohydrate ring

1985 ◽  
Vol 63 (8) ◽  
pp. 2149-2161 ◽  
Author(s):  
Walter A. Szarek ◽  
B. Mario Pinto ◽  
Masaharu Iwakawa
Keyword(s):  
Biological Activity ◽  
Cell Growth ◽  
Antitumor Activity ◽  
Nucleoside Analogs ◽  
Hela Cell Line ◽  
Biological Screening ◽  
Naturally Occurring ◽  
Derivatives Of ◽  
Substituted 1

The synthesis of a variety of nucleoside analogs involving modifications in the carbohydrate ring is described. In particular, 6-substituted purin-9-yl derivatives of 1-oxa-4-thiacyclohexane and 1,4-dioxacyclohexane have been synthesized. A number of 6-chloropurin-9-yl derivatives of substituted 1-oxa-4-thiacyclohexane have also been derived from the parent compounds by way of a Pummerer rearrangement. A route to nucleoside analogs of 1-oxa-4-thiacyclohexane from naturally occurring nucleosides is illustrated for the case of inosine. A route to nucleoside analogs in which the carbohydrate moiety is replaced by an acyclic moiety bearing α,β-unsaturated esters is also illustrated for the case of uridine. The results of biological screening of these analogs and others previously synthesized in our program against leukemia L-1210 cells in vitro are presented; some of these compounds showed marginal antitumor activity. The screening results of selected compounds against the human HeLa cell line in vitro are also presented; none of the compounds that were tested showed significant inhibitory activity of cell growth.

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