Application of paramagnetic graphene quantum dots as a platform for simultaneous dual-modality bioimaging and tumor-targeted drug delivery

2015 ◽  
Vol 3 (4) ◽  
pp. 651-664 ◽  
Author(s):  
Chun-Lin Huang ◽  
Chih-Ching Huang ◽  
Fu-Der Mai ◽  
Chia-Liang Yen ◽  
Shin-Hwa Tzing ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Mr Imaging ◽  
Cancer Treatment ◽  
Targeted Drug Delivery ◽  
Graphene Quantum Dots ◽  
Dual Modality ◽  
Targeted Drug

This paper reports the development of a multifunctional nanocarrier platform consisting of paramagnetic graphene quantum dots, folate, and doxorubicin for simultaneous fluorescence and MR imaging, and cancer treatment.

Graphene quantum dots for cancer targeted drug delivery

2017 ◽  
Vol 518 (1-2) ◽  
pp. 185-192 ◽  
Author(s):  
Daniela Iannazzo ◽  
Alessandro Pistone ◽  
Marina Salamò ◽  
Signorino Galvagno ◽  
Roberto Romeo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Targeted Drug Delivery ◽  
Graphene Quantum Dots ◽  
Targeted Drug

Application of graphene quantum dots for simultaneous fluorescence imaging and tumor-targeted drug delivery

2018 ◽  
Vol 256 ◽  
pp. 616-623 ◽  
Author(s):  
Jian Dong ◽  
Kaiqi Wang ◽  
Liping Sun ◽  
Baoliang Sun ◽  
Mingfeng Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Fluorescence Imaging ◽  
Targeted Drug Delivery ◽  
Graphene Quantum Dots ◽  
Targeted Drug

Graphene quantum dots conjugated albumin nanoparticles for targeted drug delivery and imaging of pancreatic cancer

2014 ◽  
Vol 2 (21) ◽  
pp. 3190-3195 ◽  
Author(s):  
Preeti Nigam ◽  
Shobha Waghmode ◽  
Michelle Louis ◽  
Shishanka Wangnoo ◽  
Pooja Chavan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Quantum Dots ◽  
Targeted Drug Delivery ◽  
Poor Prognosis ◽  
Graphene Quantum Dots ◽  
Albumin Nanoparticles ◽  
Targeted Drug

Pancreatic cancer is considered to be the deadliest of all cancers due to its poor prognosis and resistance to conventional therapies.

Matrix Metalloproteinases (MMPs) in Targeted Drug Delivery: Synthesis of a Potent and Highly Selective Inhibitor against Matrix Metalloproteinase- 7

2020 ◽  
Vol 20 (27) ◽  
pp. 2459-2471
Author(s):  
Ling-Li Wang ◽  
Bing Zhang ◽  
Ming-Hua Zheng ◽  
Yu-Zhong Xie ◽  
Chang-Jiang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Matrix Metalloproteinases ◽  
Cancer Treatment ◽  
Targeted Drug Delivery ◽  
Selective Inhibitor ◽  
Migration And Invasion ◽  
Side Chains ◽  
Mesenchymal Transition ◽  
Targeted Drug

Background: Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that play a key role in both physiological and pathological tissue degradation. MMPs have reportedly shown great potentials in the degradation of the Extracellular Matrix (ECM), have shown great potentials in targeting bioactive and imaging agents in cancer treatment. MMPs could provoke Epithelial to Mesenchymal Transition (EMT) of cancer cells and manipulate their signaling, adhesion, migration and invasion to promote cancer cell aggressiveness. Therefore, targeting and particularly inhibiting MMPs within the tumor microenvironment is an effective strategy for cancer treatment. Based on this idea, different MMP inhibitors (MMPIs) have been developed to manipulate the tumor microenvironment towards conditions appropriate for the actions of antitumor agents. Studies are ongoing to improve the selectivity and specificity of MMPIs. Structural optimization has facilitated the discovery of selective inhibitors of the MMPs. However, so far no selective inhibitor for MMP-7 has been proposed. Aims: This study aims to comprehensively review the potentials and advances in applications of MMPs particularly MMP-7 in targeted cancer treatment approaches with the main focus on targeted drug delivery. Different targeting strategies for manipulating and inhibiting MMPs for the treatment of cancer are discussed. MMPs are upregulated at all stages of expression in cancers. Different MMP subtypes have shown significant targeting applicability at the genetic, protein, and activity levels in both physiological and pathophysiological conditions in a variety of cancers. The expression of MMPs significantly increases at advanced cancer stages, which can be used for controlled release in cancers in advance stages. Methods: Moreover, this study presents the synthesis and characteristics of a new and highly selective inhibitor against MMP-7 and discusses its applications in targeted drug delivery systems for therapeutics and diagnostics modalities. Results: Our findings showed that the structure of the inhibitor P3’ side chains play the crucial role in developing an optimized MMP-7 inhibitor with high selectivity and significant degradation activities against ECM. Conclusion: Optimized NDC can serve as a highly potent and selective inhibitor against MMP-7 following screening and optimization of the P3’ side chains, with a Ki of 38.6 nM and an inhibitory selectivity of 575 of MMP-7 over MMP-1.

pH-Sensitive ZnO Quantum Dots–Doxorubicin Nanoparticles for Lung Cancer Targeted Drug Delivery

2016 ◽  
Vol 8 (34) ◽  
pp. 22442-22450 ◽  
Author(s):  
Xiaoli Cai ◽  
Yanan Luo ◽  
Weiying Zhang ◽  
Dan Du ◽  
Yuehe Lin
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Quantum Dots ◽  
Targeted Drug Delivery ◽  
Ph Sensitive ◽  
Targeted Drug ◽  
Zno Quantum Dots

scholarly journals SW43-DOX ± loading onto drug-eluting bead, a potential new targeted drug delivery platform for systemic and locoregional cancer treatment - An in vitro evaluation

2016 ◽  
Vol 10 (7) ◽  
pp. 1133-1145 ◽  
Author(s):  
Johannes M. Ludwig ◽  
Yongkang Gai ◽  
Lingyi Sun ◽  
Guangya Xiang ◽  
Dexing Zeng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Targeted Drug Delivery ◽  
In Vitro Evaluation ◽  
Drug Eluting ◽  
Delivery Platform ◽  
Targeted Drug

scholarly journals Advanced and Innovative Nano-Systems for Anticancer Targeted Drug Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1151
Author(s):  
Lu Tang ◽  
Jing Li ◽  
Qingqing Zhao ◽  
Ting Pan ◽  
Hui Zhong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Small Molecule ◽  
Anticancer Agents ◽  
Targeted Drug Delivery ◽  
Treatment Modalities ◽  
Biological Macromolecules ◽  
Passive Targeting ◽  
Efficient Delivery ◽  
Targeted Drug

The encapsulation of therapeutic agents into nano-based drug delivery system for cancer treatment has received considerable attention in recent years. Advancements in nanotechnology provide an opportunity for efficient delivery of anticancer drugs. The unique properties of nanoparticles not only allow cancer-specific drug delivery by inherent passive targeting phenomena and adopting active targeting strategies, but also improve the pharmacokinetics and bioavailability of the loaded drugs, leading to enhanced therapeutic efficacy and safety compared to conventional treatment modalities. Small molecule drugs are the most widely used anticancer agents at present, while biological macromolecules, such as therapeutic antibodies, peptides and genes, have gained increasing attention. Therefore, this review focuses on the recent achievements of novel nano-encapsulation in targeted drug delivery. A comprehensive introduction of intelligent delivery strategies based on various nanocarriers to encapsulate small molecule chemotherapeutic drugs and biological macromolecule drugs in cancer treatment will also be highlighted.

Hybrid silica-coated Gd-Zn-Cu-In-S/ZnS bimodal quantum dots as an epithelial cell adhesion molecule targeted drug delivery and imaging system

2019 ◽  
Vol 570 ◽  
pp. 118645 ◽  
Author(s):  
Marzieh Akbarzadeh ◽  
Maryam Babaei ◽  
Khalil Abnous ◽  
Seyed Mohammad Taghdisi ◽  
Mohammad Taghi Peivandi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Cell Adhesion ◽  
Epithelial Cell ◽  
Targeted Drug Delivery ◽  
Cell Adhesion Molecule ◽  
Imaging System ◽  
Epithelial Cell Adhesion Molecule ◽  
Hybrid Silica ◽  
Targeted Drug
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