Scavenging of superoxide anions by lecithinized superoxide dismutase in HL-60 cells

2016 ◽  
Vol 12 (1) ◽  
pp. 274-282
Author(s):  
Tsutomu Ishihara ◽  
Misaki Shibui ◽  
Takaya Hoshi ◽  
Tohru Mizushima
Keyword(s):  
Superoxide Dismutase ◽  
Plasma Membrane ◽  
Therapeutic Effects ◽  
Superoxide Anions ◽  
Covalently Bound

Superoxide dismutase covalently bound to four lecithin molecules (PC-SOD) on plasma membrane has been found to have beneficial therapeutic effects.

scholarly journals The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis

2021 ◽  
Vol 394 (10) ◽  
pp. 1991-2002
Author(s):  
Junchao Luo ◽  
Yin Zhang ◽  
Senbo Zhu ◽  
Yu Tong ◽  
Lichen Ji ◽  
...  
Keyword(s):  
Metal Oxide ◽  
Metal Oxide Nanoparticles ◽  
Biological Response ◽  
Cell Uptake ◽  
Oxide Nanoparticles ◽  
Therapeutic Effects ◽  
Superoxide Anions ◽  
Metal Metal ◽  
Cartilage Wear

AbstractThe current understanding of osteoarthritis is developing from a mechanical disease caused by cartilage wear to a complex biological response involving inflammation, oxidative stress and other aspects. Nanoparticles are widely used in drug delivery due to its good stability in vivo and cell uptake efficiency. In addition to the above advantages, metal/metal oxide NPs, such as cerium oxide and manganese dioxide, can also simulate the activity of antioxidant enzymes and catalyze the degradation of superoxide anions and hydrogen peroxide. Degrading of metal/metal oxide nanoparticles releases metal ions, which may slow down the progression of osteoarthritis by inhibiting inflammation, promoting cartilage repair and inhibiting cartilage ossification. In present review, we focused on recent research works concerning osteoarthritis treating with metal/metal oxide nanoparticles, and introduced some potential nanoparticles that may have therapeutic effects.

Analysis of the content of zinc ions in the ejaculate of men with inflammatory diseases of the genitourinary system with indicators of sperm motility

2021 ◽  
pp. 28-32
Author(s):  
O.A. Gizinger
Keyword(s):  
Superoxide Dismutase ◽  
Plasma Membrane ◽  
Free Radical ◽  
Seminal Plasma ◽  
Inflammatory Diseases ◽  
Free Radical Oxidation ◽  
Zinc Ions ◽  
Radical Oxidation ◽  
Genitourinary System ◽  
Sperm Dna

The results of previous studies have shown that the content of zinc ions in the semen significantly correlated with the number of sperm and influenced the volume of ejaculate. After ejaculation, the zinc contained in the seminal plasma binds to the plasma membrane and stabilizes the sperm DNA. Due to its cyto- and immunoprotective properties: induction of zinc-dependent superoxide dismutase, protection of DNA and transcriptional proteins from free radical oxidation, inhibition of proteinases, zinc is an indispensable trace element in the processes of DNA synthesis and repair, embryogenesis and reproduction.

scholarly journals Spirulina maxima and its effect on antioxidant activity in fructose induced oxidative stress with histopathological observations

2015 ◽  
Vol 62 (2) ◽  
pp. 13-19
Author(s):  
Urmila Jarouliya ◽  
Anish Zacharia ◽  
Raj K. Keservani ◽  
Godavarthi B.K.S Prasad
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Superoxide Dismutase ◽  
Blood Glucose ◽  
Reduced Glutathione ◽  
Thiobarbituric Acid ◽  
Diabetic Rats ◽  
Therapeutic Effects ◽  
Thiobarbituric Acid Reactive Substances ◽  
Spirulina Maxima

Abstract Diabetes mellitus is a metabolic disorder characterised by hyperglycemia and oxidative stress. The aim of the present study is to explore the antioxidant effect of Spirulina maxima in rat model along with the histopathological observations. Diabetes was induced by feeding 10% fructose solution orally to Wistar rats (n = 6) for 30 days, analysed for plasma blood glucose and the markers of the oxidative stress [catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH) and thiobarbituric acid reactive substances (TBARS)]. These biochemical studies were associated with histopathological examination of liver and kidney sections. The microalga Spirulina maxima being rich in proteins and other essential nutrients is widely used as a food supplement. S. maxima at a dose of 5 and 10% per kg and the metformin (500 mg/kg) as reference drug were given orally for 30 days to the diabetic rats. Diabetic rats showed significant (p < 0.001) elevations in plasma blood glucose, thiobarbituric acid-reactive substances and significant reduction in catalase, superoxide dismutase and reduced glutathione activity. Oral administration of 5 and 10% aqueous extract of S. maxima for 30 days restored not only of blood glucose levels but also markers of oxidative stress. Histopathological observations of tissues manifested that the S. maxima administration had the protective and therapeutic effects against fructose-induced abnormalities in diabetic rats. It is concluded that S. maxima is effective in reinstating the antioxidant activity in addition to its antidiabetic effect in type 2 diabetic rats.

scholarly journals Involvement of the superoxide anion in sulphoxidation (Short Communication)

1974 ◽  
Vol 137 (1) ◽  
pp. 119-121 ◽  
Author(s):  
K. Prema ◽  
K. P. Gopinathan
Keyword(s):  
Superoxide Dismutase ◽  
Superoxide Anion ◽  
Short Communication ◽  
Model System ◽  
Complete Inhibition ◽  
Superoxide Anions ◽  
Phenazine Methosulphate

Sulphoxidation of compounds capable of undergoing biological sulphoxidation has been demonstrated in a model system (NADH–phenazine methosulphate–O2), known to generate superoxide anions (O2-). Addition of superoxide dismutase to this system results in complete inhibition, suggesting the involvement of O2- in sulphoxidation.

Effect of antioxidants on the clinical outcome of patients with nasal polyposis

2011 ◽  
Vol 125 (8) ◽  
pp. 811-815 ◽  
Author(s):  
M Sagit ◽  
H Erdamar ◽  
C Saka ◽  
S Yalcin ◽  
I Akin
Keyword(s):  
Computed Tomography ◽  
Superoxide Dismutase ◽  
Nasal Polyposis ◽  
Serum Levels ◽  
Post Treatment ◽  
Rank Test ◽  
Therapeutic Effects ◽  
Tissue Levels ◽  
Positive Effects ◽  
Signed Rank Test

AbstractAim:To investigate the therapeutic effects of antioxidants on the clinical and biochemical outcome of patients with nasal polyposis.Methods:Thirty-four patients with nasal polyposis were divided into two groups receiving either intranasal steroid or intranasal steroid plus per-oral vitamins A, C and E and selenium. Paranasal sinus computed tomography, endoscopy, and polyp tissue and serum sampling were conducted pre- and post-therapy. Serum levels of malondialdehyde, superoxide dismutase, nitrite and myeloperoxidase and tissue levels of malondialdehyde and superoxide dismutase were measured. Group results were compared using the Mann–Whitney U test and Wilcoxon signed-rank test.Results:Both groups had significantly lower tissue parameters, computed tomography scores and serum malondialdehyde levels, comparing pre- versus post-treatment results. Post-treatment, the steroid plus antioxidant group had significantly lower tissue malondialdehyde levels and a greater fall in tissue and serum malondialdehyde, compared with the steroid group.Conclusion:Serum and tissue levels of malondialdehyde (an oxidative marker) were significantly decreased by adding antioxidants to standard therapy. This is the first report of the positive effects of adding antioxidants to steroid therapy for nasal polyposis.

Kinetic Investigations of the Autoxidation of Adrenalin

1978 ◽  
Vol 33 (11-12) ◽  
pp. 891-896 ◽  
Author(s):  
W. Bors ◽  
C. Michel ◽  
M. Saran ◽  
E. Lengfelder
Keyword(s):  
Superoxide Dismutase ◽  
Rate Constants ◽  
Alkaline Solutions ◽  
Superoxide Anions ◽  
Kinetic Investigations

Generation rates of superoxide anions (O2-) by autoxidizing adrenalin at pH 9.5 were deter­mined in solutions containing either superoxide dismutase (0.85 м-1 s-1) or hydroxylamine (0.0185 м-1 s-1) as competitive scavengers. The rate constants of O2- with adrenalin and hydroxyl­amine were calculated for neutral and alkaline solutions. The respective values were for adrenalin: 5.6 ×104 м-1 s-1, pH 7.8; 7.0 × 103 м-1 s-1, pH 9.5 - and for hydroxylamine 5.9 × 104 м-1 s-1, pH 7.8; 3.4 ×104 м-1 s-1, pH 9.5. The effects of various competitors and O2--sources on the rate constants were compared.

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