Polypyrrole-stabilized gold nanorods with enhanced photothermal effect towards two-photon photothermal therapy

Magnetic properties of the sets of Fe3O4(core)/CoFe2O4(shell) composite nanoparticles with a core diameter of about 6.3 nm and various shell thicknesses (0, 1.0, and 2.5 nm), as well as the mixtures of Fe3O4 and CoFe2O4 nanoparticles taken in the ratios corresponding to the core/shell material contents in the former case, have been studied. The results of magnetic research showed that the coating of magnetic nanoparticles with a shell gives rise to the appearance of two simultaneous effects: the modification of the core/shell interface parameters and the parameter change in both the nanoparticle’s core and shell themselves. As a result, the core/shell particles acquire new characteristics that are inherent neither to Fe3O4 nor to CoFe2O4. The obtained results open the way to the optimization and adaptation of the parameters of the core/shell spinel-ferrite-based nanoparticles for their application in various technological and biomedical domains.

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A Novel Fast Photothermal Therapy Using Hot Spots of Gold Nanorods for Malignant Melanoma Cells

Nanomaterials ◽

10.3390/nano8110880 ◽

2018 ◽

Vol 8 (11) ◽

pp. 880 ◽

Cited By ~ 3

Author(s):

Yanhua Yao ◽

Nannan Zhang ◽

Xiao Liu ◽

Qiaofeng Dai ◽

Haiying Liu ◽

...

Keyword(s):

Cell Death ◽

Malignant Melanoma ◽

Gold Nanorods ◽

Plasmon Resonance ◽

Photothermal Therapy ◽

Treatment Time ◽

High Energy ◽

Melanoma Cells ◽

Photothermal Effect ◽

A375 Cells

In this paper, the plasmon resonance effects of gold nanorods was used to achieve rapid photothermal therapy for malignant melanoma cells (A375 cells). After incubation with A375 cells for 24 h, gold nanorods were taken up by the cells and gold nanorod clusters were formed naturally in the organelles of A375 cells. After analyzing the angle and space between the nanorods in clusters, a series of numerical simulations were performed and the results show that the plasmon resonance coupling between the gold nanorods can lead to a field enhancement of up to 60 times. Such high energy localization causes the temperature around the nanorods to rise rapidly and induce cell death. In this treatment, a laser as low as 9.3 mW was used to irradiate a single cell for 20 s and the cell died two h later. The cell death time can also be controlled by changing the power of laser which is focused on the cells. The advantage of this therapy is low laser treatment power, short treatment time, and small treatment range. As a result, the damage of the normal tissue by the photothermal effect can be greatly avoided.

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Plasmonic Photothermal Therapy with Gold Nanorods/Reduced Graphene Oxide Core/Shell Nanocomposites

Encyclopedia of Nanotechnology ◽

10.1007/978-94-017-9780-1_100988 ◽

2016 ◽

pp. 3287-3294

Author(s):

Kostiantyn Turcheniuk ◽

Charles-Henri Hage ◽

Jolanda Spadavecchia ◽

Laurent Heliot ◽

Rabah Boukherroub ◽

...

Keyword(s):

Graphene Oxide ◽

Reduced Graphene Oxide ◽

Gold Nanorods ◽

Photothermal Therapy ◽

Core Shell ◽

Reduced Graphene ◽

Plasmonic Photothermal Therapy

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Multiple gold nanorods@hierarchically porous silica nanospheres for efficient multi-drug delivery and photothermal therapy

Journal of Materials Chemistry B ◽

10.1039/c6tb03020c ◽

2017 ◽

Vol 5 (8) ◽

pp. 1642-1649 ◽

Cited By ~ 10

Author(s):

Nan Li ◽

Dechao Niu ◽

Xiaobo Jia ◽

Jianping He ◽

Yu Jiang ◽

...

Keyword(s):

Drug Delivery ◽

Gold Nanorods ◽

Photothermal Therapy ◽

Biomedical Applications ◽

Porous Silica ◽

Photothermal Effect ◽

Silica Nanospheres ◽

Hierarchically Porous ◽

Silica Nanocomposites ◽

Hierarchically Porous Structure

Gold-based silica nanocomposites with hierarchically porous structure, as well as excellent photothermal effect, have shown great potentials in biomedical applications.

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Synthesis of Core-Shell Composite of Conductive Polymeric Materials onto Silica Using Supercritical Carbon Dioxide

MRS Advances ◽

10.1557/adv.2020.201 ◽

2020 ◽

Vol 5 (40-41) ◽

pp. 2121-2127

Author(s):

Ssu-Hao Huang ◽

Pei-Hua Chen ◽

Yan-Ping Chen ◽

Muoi Tang

Keyword(s):

Carbon Dioxide ◽

Supercritical Carbon Dioxide ◽

Polymeric Materials ◽

Optimal Operation ◽

Molar Ratio ◽

Core Shell ◽

The Core ◽

Operation Conditions ◽

Shell Composite ◽

Supercritical Carbon

ABSTRACTThe polymerization of 3,4-ethylenedioxythiophene (EDOT) onto nanosilica (SiO2) was synthesized in this study by using supercritical carbon dioxide (SCCO2). With the addition of dopants of p-toluenesulfonic acid (p-TSA) or decylbenzene sulfonic acid (DBSA), the PEDOT/SiO2 composite became conductive. The product was characterized by FTIR spectroscopy and the core-shell structure was confirmed through the TEM images. The electrical properties were analyzed by UV-vis absorbance and four-point probe measurement. DBSA is shown as the better dopants with the molar ratio (DBSA/EDOT) of 0.2 at the reaction time of 48 hours. The maximum coating percentage is 63 wt% under the optimal operation conditions at 40oC and 280 bar. The conductivity is tuned up to 6.6×10-2 S/cm after the coating process.

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Synthesis Technology of Silica Aerogels/Polystyrene Core-Shell Composite Materials

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.168-170.1833 ◽

2010 ◽

Vol 168-170 ◽

pp. 1833-1836

Author(s):

Gang Qiang Geng ◽

Jing Tao Guo ◽

Jun Jun Zou ◽

Gong Xun Bian

Keyword(s):

Composite Materials ◽

Polymerization Process ◽

System Component ◽

Core Shell ◽

Ultrasound Technique ◽

The Core ◽

Optimum Reaction ◽

The Impact ◽

Shell Composite

In order to obtain super aerogels heat insulating composite materials with silane coupling agent on the in-situ surface treatment. The core-shell structure composite materials have been prepared by dispersion polymerization process of polystyrene grafted on the SiO2 particles. By TEM on these samples the impact of the system components initiator polymerization parameters and dispersion process was discussed. The results showed that the system component of the greatest impact on conversion rate is the ratio of aerogels /St ,the optimum reaction temperature is 75 °C.With organic initiator KPS as initiator after a unique ultrasound technique to obtain the core-shell composite materials structure which coating is 70%.

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Gold Nanorod Bioconjugates for Active Tumor Targeting and Photothermal Therapy

Journal of Nanotechnology ◽

10.1155/2011/631753 ◽

2011 ◽

Vol 2011 ◽

pp. 1-7 ◽

Cited By ~ 13

Author(s):

Hadiyah N. Green ◽

Dmitry V. Martyshkin ◽

Cynthia M. Rodenburg ◽

Eben L. Rosenthal ◽

Sergey B. Mirov

Keyword(s):

Gold Nanoparticles ◽

Gold Nanorods ◽

Photothermal Therapy ◽

Tumor Targeting ◽

Near Infrared ◽

Malignant Tumors ◽

Photothermal Effect ◽

Specific Antibodies ◽

Before And After ◽

Egfr Antibody

The mastery of active tumor targeting is a great challenge in near infrared photothermal therapy (NIRPTT). To improve efficiency for targeted treatment of malignant tumors, we modify the technique of conjugating gold nanoparticles to tumor-specific antibodies. Polyethylene glycol-coated (PEGylated) gold nanorods (GNRs) were fabricated and conjugated to an anti-EGFR antibody. We characterized the conjugation efficiency of the GNRs by comparing the efficiency of antibody binding and the photothermal effect of the GNRs before and after conjugation. We demonstrate that the binding efficiency of the antibodies conjugated to the PEGylated GNRs is comparable to the binding efficiency of the unmodified antibodies and 33.9% greater than PEGylated antibody-GNR conjugates as reported by Liao and Hafner (2005). In addition, cell death by NIRPTT was sufficient to kill nearly 90% of tumor cells, which is comparable to NIRPTT with GNRs alone confirming that NIRPTT using GNRs is not compromised by conjugation of GNRs to antibodies.

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Magnetoliposomes Based on Magnetic/Plasmonic Nanoparticles Loaded with Tricyclic Lactones for Combined Cancer Therapy

Pharmaceutics ◽

10.3390/pharmaceutics13111905 ◽

2021 ◽

Vol 13 (11) ◽

pp. 1905

Author(s):

Irina S. R. Rio ◽

Ana Rita O. Rodrigues ◽

Juliana M. Rodrigues ◽

Maria-João R. P. Queiroz ◽

R. C. Calhelha ◽

...

Keyword(s):

Cancer Therapy ◽

Tumor Cells ◽

Human Tumor ◽

Plasmonic Nanoparticles ◽

Core Shell ◽

Triggered Release ◽

Shell Nanoparticles ◽

Visible Absorption ◽

The Core ◽

Average Size

Liposome-like nanoarchitectures containing manganese ferrite nanoparticles covered or decorated with gold were developed for application in dual cancer therapy, combining chemotherapy and photothermia. The magnetic/plasmonic nanoparticles were characterized using XRD, UV/Visible absorption, HR-TEM, and SQUID, exhibiting superparamagnetic behavior at room temperature. The average size of the gold-decorated nanoparticles was 26.7 nm for MnFe2O4 with 5–7 nm gold nanospheres. The average size of the core/shell nanoparticles was 28.8 nm for the magnetic core and around 4 nm for the gold shell. Two new potential antitumor fluorescent drugs, tricyclic lactones derivatives of thienopyridine, were loaded in these nanosystems with very high encapsulation efficiencies (higher than 98%). Assays in human tumor cell lines demonstrate that the nanocarriers do not release the antitumor compounds in the absence of irradiation. Moreover, the nanosystems do not cause any effect on the growth of primary (non-tumor) cells (with or without irradiation). The drug-loaded systems containing the core/shell magnetic/plasmonic nanoparticles efficiently inhibit the growth of tumor cells when irradiated with red light, making them suitable for a triggered release promoted by irradiation.

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Controlled Synthesis of Core-Shell Structure SiO2 /NaGdF4:Eu3+ Magnetic and Optical Bifunctional Composite

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.936.359 ◽

2014 ◽

Vol 936 ◽

pp. 359-363

Author(s):

Yan Li Wu ◽

Min Liao ◽

Hai Xin Ding ◽

Ru Chun Yang ◽

Dan Dan Xiong ◽

...

Keyword(s):

Magnetic Properties ◽

Shell Structure ◽

Photo Luminescence ◽

Core Shell ◽

Controlled Synthesis ◽

X Ray Diffraction ◽

X Ray ◽

The Core ◽

Core Shell Structure ◽

Shell Composite

The SiO2/NaGdF4:Eu3+ core/shell composite was prepared by a template-mediated method, making monodispersed SiO2 as core and NaGdF4:Eu colloids as shell, the morphology and the core-shell structure of the resulting particles were analyzed by SEM,X-ray diffraction, and the photo-luminescence and magnetic properties of the microspheres were investigated too. The results shows the composite have great potential to be used as homogeneous magnetic/optical bifunctional material.

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The Organic/Inorganic Interface in Micro and Nano Composite Materials

MRS Proceedings ◽

10.1557/proc-796-v5.9 ◽

2003 ◽

Vol 796 ◽

Author(s):

Zhexiong Tang ◽

Hui Wan ◽

Robert Clark ◽

Sze C. Yang

Keyword(s):

Composite Particles ◽

Core Shell ◽

Electronic Interaction ◽

Material Synthesis ◽

Core Component ◽

Polymer Shell ◽

Nano Composite ◽

Inorganic Oxide ◽

The Core ◽

Shell Composite

ABSTRACTWe report the synthesis of new inorganic/organic composite particles with a core/shell structure. The core component is an inorganic oxide (e.g. TiO2, CeO2 or MoO3), and the shell component is a double-strand polyaniline. Three methods for material synthesis were examined. The electrochemical properties of one type of the composite particles show electronic interaction between the organic conducting polymer shell and its inorganic core. The double-strand polyaniline in the composite shows better pH stability of the conductive form than that of the corresponding single-strand polyaniline in a similar core/shell composite.

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