Multiple gold nanorods@hierarchically porous silica nanospheres for efficient multi-drug delivery and photothermal therapy

2017 ◽  
Vol 5 (8) ◽  
pp. 1642-1649 ◽  
Author(s):  
Nan Li ◽  
Dechao Niu ◽  
Xiaobo Jia ◽  
Jianping He ◽  
Yu Jiang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Porous Silica ◽  
Photothermal Effect ◽  
Silica Nanospheres ◽  
Hierarchically Porous ◽  
Silica Nanocomposites ◽  
Hierarchically Porous Structure

Gold-based silica nanocomposites with hierarchically porous structure, as well as excellent photothermal effect, have shown great potentials in biomedical applications.

Lanthanide-doped upconversion nanoparticles complexed with nano-oxide graphene used for upconversion fluorescence imaging and photothermal therapy

2018 ◽  
Vol 6 (4) ◽  
pp. 877-884 ◽  
Author(s):  
Po Li ◽  
Yue Yan ◽  
Binlong Chen ◽  
Pan Zhang ◽  
Siling Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Research Interest ◽  
Upconversion Nanoparticles ◽  
Multifunctional Nanoparticles ◽  
Nano Oxide

In recent years, multifunctional nanoparticles have attracted much research interest in various biomedical applications such as biosensors, diagnosis, and drug delivery systems.

scholarly journals A Novel Fast Photothermal Therapy Using Hot Spots of Gold Nanorods for Malignant Melanoma Cells

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 880 ◽  
Author(s):  
Yanhua Yao ◽  
Nannan Zhang ◽  
Xiao Liu ◽  
Qiaofeng Dai ◽  
Haiying Liu ◽  
...  
Keyword(s):  
Cell Death ◽  
Malignant Melanoma ◽  
Gold Nanorods ◽  
Plasmon Resonance ◽  
Photothermal Therapy ◽  
Treatment Time ◽  
High Energy ◽  
Melanoma Cells ◽  
Photothermal Effect ◽  
A375 Cells

In this paper, the plasmon resonance effects of gold nanorods was used to achieve rapid photothermal therapy for malignant melanoma cells (A375 cells). After incubation with A375 cells for 24 h, gold nanorods were taken up by the cells and gold nanorod clusters were formed naturally in the organelles of A375 cells. After analyzing the angle and space between the nanorods in clusters, a series of numerical simulations were performed and the results show that the plasmon resonance coupling between the gold nanorods can lead to a field enhancement of up to 60 times. Such high energy localization causes the temperature around the nanorods to rise rapidly and induce cell death. In this treatment, a laser as low as 9.3 mW was used to irradiate a single cell for 20 s and the cell died two h later. The cell death time can also be controlled by changing the power of laser which is focused on the cells. The advantage of this therapy is low laser treatment power, short treatment time, and small treatment range. As a result, the damage of the normal tissue by the photothermal effect can be greatly avoided.

Polypeptide-Engineered Hydrogel Coated Gold Nanorods for Targeted Drug Delivery and Chemo-photothermal Therapy

2017 ◽  
Vol 3 (10) ◽  
pp. 2391-2398 ◽  
Author(s):  
Jie Yang ◽  
Ming-Hao Yao ◽  
Rui-Mei Jin ◽  
Dong-Hui Zhao ◽  
Yuan-Di Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanorods ◽  
Targeted Drug Delivery ◽  
Photothermal Therapy ◽  
Targeted Drug

A multifunctional near-infrared laser-triggered drug delivery system using folic acid conjugated chitosan oligosaccharide encapsulated gold nanorods for targeted chemo-photothermal therapy

2019 ◽  
Vol 7 (24) ◽  
pp. 3811-3825 ◽  
Author(s):  
Panchanathan Manivasagan ◽  
Seung Won Jun ◽  
Van Tu Nguyen ◽  
Nguyen Thanh Phong Truong ◽  
Giang Hoang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Combination Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Laser ◽  
Chitosan Oligosaccharide

FA–COS–TGA–GNRs–DOX have been successfully designed as a drug delivery system for chemo-photothermal combination therapy.

scholarly journals Magnetic-Plasmonic Heterodimer Nanoparticles: Designing Contemporarily Features for Emerging Biomedical Diagnosis and Treatments

Nanomaterials ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 97 ◽  
Author(s):  
S. Shams ◽  
Mohammad Ghazanfari ◽  
Carolin Schmitz-Antoniak
Keyword(s):  
Drug Delivery ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Recent Progress ◽  
Magnetic Hyperthermia ◽  
Future Research ◽  
Critical Properties ◽  
Interfacial Morphology ◽  
Biomedical Diagnosis ◽  
And Performance

Magnetic-plasmonic heterodimer nanostructures synergistically present excellent magnetic and plasmonic characteristics in a unique platform as a multipurpose medium for recently invented biomedical applications, such as magnetic hyperthermia, photothermal therapy, drug delivery, bioimaging, and biosensing. In this review, we briefly outline the less-known aspects of heterodimers, including electronic composition, interfacial morphology, critical properties, and present concrete examples of recent progress in synthesis and applications. With a focus on emerging features and performance of heterodimers in biomedical applications, this review provides a comprehensive perspective of novel achievements and suggests a fruitful framework for future research.

scholarly journals Gold Nanorod Bioconjugates for Active Tumor Targeting and Photothermal Therapy

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Hadiyah N. Green ◽  
Dmitry V. Martyshkin ◽  
Cynthia M. Rodenburg ◽  
Eben L. Rosenthal ◽  
Sergey B. Mirov
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Malignant Tumors ◽  
Photothermal Effect ◽  
Specific Antibodies ◽  
Before And After ◽  
Egfr Antibody

The mastery of active tumor targeting is a great challenge in near infrared photothermal therapy (NIRPTT). To improve efficiency for targeted treatment of malignant tumors, we modify the technique of conjugating gold nanoparticles to tumor-specific antibodies. Polyethylene glycol-coated (PEGylated) gold nanorods (GNRs) were fabricated and conjugated to an anti-EGFR antibody. We characterized the conjugation efficiency of the GNRs by comparing the efficiency of antibody binding and the photothermal effect of the GNRs before and after conjugation. We demonstrate that the binding efficiency of the antibodies conjugated to the PEGylated GNRs is comparable to the binding efficiency of the unmodified antibodies and 33.9% greater than PEGylated antibody-GNR conjugates as reported by Liao and Hafner (2005). In addition, cell death by NIRPTT was sufficient to kill nearly 90% of tumor cells, which is comparable to NIRPTT with GNRs alone confirming that NIRPTT using GNRs is not compromised by conjugation of GNRs to antibodies.

Polypyrrole-stabilized gold nanorods with enhanced photothermal effect towards two-photon photothermal therapy

2015 ◽  
Vol 3 (22) ◽  
pp. 4539-4545 ◽  
Author(s):  
Cuiling Du ◽  
Anhe Wang ◽  
Jinbo Fei ◽  
Jie Zhao ◽  
Junbai Li
Keyword(s):  
Tumor Cells ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Photothermal Effect ◽  
Core Shell ◽  
Two Photon ◽  
The Core ◽  
Shell Composite

The core–shell composite of Au–polypyrrole nanorods with high two-photon photothermal effect and stability could efficiently kill tumor cells under irradiation.

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