BSA-coated magnetic nanoparticles for improved therapeutic properties

2015 ◽  
Vol 3 (30) ◽  
pp. 6239-6247 ◽  
Author(s):  
Antonio Aires ◽  
Sandra M. Ocampo ◽  
David Cabrera ◽  
Leonor de la Cueva ◽  
Gorka Salas ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Cellular Uptake ◽  
Physiological Conditions ◽  
Therapeutic Properties ◽  
The Stability

Albumin coating improves the stability of magnetic nanoparticles under physiological conditions, favoring their magnetic properties, cellular uptake, and chemotherapeutic effects.

scholarly journals Synthesis, Characterization and Stabilization Analysis of Ferrofluid Based on Amazon Vegetable Copaifera O. L. Oil

2021 ◽  
Vol 9 (7) ◽  
pp. 208-213
Author(s):  
Laffert Gomes Ferreira da Silva ◽  
Tiago Aparício Salgado Beleza ◽  
Judes Gonçalves dos Santos ◽  
Luciene Batista da Silveira
Keyword(s):  
Magnetic Properties ◽  
Magnetic Susceptibility ◽  
Magnetic Nanoparticles ◽  
Physical Properties ◽  
Alkaline Solution ◽  
Fe3o4 Nanoparticles ◽  
Temporal Analysis ◽  
Magnetic Separations ◽  
Natural Components ◽  
The Stability

The Nanoscience and Nanobiotechnology develops several researches using nanostructures with magnetic properties. These nanostructures can have different physical properties depending on their composition and therefore can be used in various applications such as: drug markers and carriers, microelectronics, magnetic separations and environmental applications. Furthermore, the use of natural components in the synthesis of these nanostructures may come to complement these nanomaterials due to their underexplored properties and their renewable origin. This research will aim to carry out a pre-study to analyze the stability of magnetic fluids based on Fe3O4 nanoparticles functionalized with vegetable oil from the Copaifera SPP plant, known as Copaiba. Therefore, the Fe3O4 nanoparticles will be synthesized by the coprecipitation method by hydrolysis in an alkaline solution. Ferrofluid will be prepared by dispersing magnetic nanoparticles, at different concentrations, in the “in natura” oil. For the samples characterization measurements were taken of: UV-vis, FTIR, NIR spectrophotometry, XRD and Magnetic Susceptibility, the temporal analysis was recorded periodically, observing the possible stability of the samples. This work reports that the ferrofluid showed good stability and the magnetic properties associated with the nanoparticles the properties of the Amazon oil used.

Using FRET to Measure the Time it Takes for a Cell to Destroy a Virus

2019 ◽  
Author(s):  
Candace E. Benjamin ◽  
Zhuo Chen ◽  
Olivia Brohlin ◽  
Hamilton Lee ◽  
Stefanie Boyd ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Rhodamine B ◽  
Virus Like Particle ◽  
A Cell ◽  
Viral Nanoparticles ◽  
The Stability ◽  
Open Question ◽  
Viral Surface ◽  
Fret Pair

<div><div><div><p>The emergence of viral nanotechnology over the preceding two decades has created a number of intellectually captivating possible translational applications; however, the in vitro fate of the viral nanoparticles in cells remains an open question. Herein, we investigate the stability and lifetime of virus-like particle (VLP) Qβ - a representative and popular VLP for several applications - following cellular uptake. By exploiting the available functional handles on the viral surface, we have orthogonally installed the known FRET pair, FITC and Rhodamine B, to gain insight of the particle’s behavior in vitro. Based on these data, we believe VLPs undergo aggregation in addition to the anticipated proteolysis within a few hours of cellular uptake.</p></div></div></div>

Radix Pseudostellariae protein-curcumin nanocomplex: Improvement on the stability, cellular uptake and antioxidant activity of curcumin

2021 ◽  
Vol 151 ◽  
pp. 112110
Author(s):  
Xixi Cai ◽  
Qingxia Weng ◽  
Jiaming Lin ◽  
Guiqing Chen ◽  
Shaoyun Wang
Keyword(s):  
Antioxidant Activity ◽  
Cellular Uptake ◽  
The Stability

scholarly journals CLytA-DAAO Chimeric Enzyme Bound to Magnetic Nanoparticles. A New Therapeutical Approach for Cancer Patients?

2021 ◽  
Vol 22 (3) ◽  
pp. 1477
Author(s):  
María Fuentes-Baile ◽  
Elizabeth Pérez-Valenciano ◽  
Pilar García-Morales ◽  
Camino de Juan Romero ◽  
Daniel Bello-Gil ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Colorectal Carcinoma ◽  
Acid Oxidase ◽  
Oxygen Species ◽  
Cell Models ◽  
Amino Acid Oxidase ◽  
Direct Addition ◽  
Alginate Capsules ◽  
Anti Cancer ◽  
The Stability

D-amino acid oxidase (DAAO) is an enzyme that catalyzes the oxidation of D-amino acids generating H2O2. The enzymatic chimera formed by DAAO bound to the choline-binding domain of N-acetylmuramoyl-L-alanine amidase (CLytA) induces cytotoxicity in several pancreatic and colorectal carcinoma and glioblastoma cell models. In the current work, we determined whether the effect of CLytA-DAAO immobilized in magnetic nanoparticles, gold nanoparticles, and alginate capsules offered some advantages as compared to the free CLytA-DAAO. Results indicate that the immobilization of CLytA-DAAO in magnetic nanoparticles increases the stability of the enzyme, extending its time of action. Besides, we compared the effect induced by CLytA-DAAO with the direct addition of hydrogen peroxide, demonstrating that the progressive generation of reactive oxygen species by CLytA-DAAO is more effective in inducing cytotoxicity than the direct addition of H2O2. Furthermore, a pilot study has been initiated in biopsies obtained from pancreatic and colorectal carcinoma and glioblastoma patients to evaluate the expression of the main genes involved in resistance to CLytA-DAAO cytotoxicity. Based on our findings, we propose that CLytA-DAAO immobilized in magnetic nanoparticles could be effective in a high percentage of patients and, therefore, be used as an anti-cancer therapy for pancreatic and colorectal carcinoma and glioblastoma.

scholarly journals Effect of coverage on the magnetic properties of -COOH, -SH, and -NH2 ligand-protected cobalt nanoparticles

Nanoscale ◽  
2021 ◽  
Author(s):  
Barbara Farkas ◽  
Nora Henriette De Leeuw
Keyword(s):  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Cobalt Nanoparticles ◽  
Magnetic Behaviour

Implementation of magnetic nanoparticles in biomedicine requires their passivation, which often comes at a cost of diminished magnetic properties. For the design of nano-agents with targeted magnetic behaviour, it is...

Ropivacaine magnetic nanoparticles: An efficient local anesthetic nerve conduction blocker

2021 ◽  
Vol 11 (11) ◽  
pp. 1819-1825
Author(s):  
Junying Su ◽  
Xiaohu Chen ◽  
Huizhang Liu ◽  
Yuhui Luo
Keyword(s):  
Magnetic Nanoparticles ◽  
Postoperative Analgesia ◽  
Local Anesthetic ◽  
Temperature Response ◽  
Nociceptive Pain ◽  
Nerve Blocks ◽  
Anesthetic Effect ◽  
Field Of Vision ◽  
Clinical Anesthesia ◽  
The Stability

Ropivacaine (Rop) is one of the commonly used local nerve blocks in clinical anesthesia and postoperative analgesia and it inhibits the stimulation of peripheral nociceptive pain. However, Rop alone is not effective enough to exert a controllable anesthetic effect in patients with peripheral nociceptive pain. Therefore, there is an urgent need to improve the targeting of the local anesthetic effect of Rop and reduce its potential chronic or acute toxicity. In this study, a novel Rop nanocomposite hydrogel drug, N-isopropylacrylamide-methacrylic acid/ropivacaine magnetic nanoparticles (NIP-MAA/Rop MNPs), was constructed on magnetic iron oxide. The unique pH and temperature response of NIP-MAA can effectively retain magnetic properties, improve the stability and targeting controllability of magnetic nanoparticles, and avoid excessive drug diffusion. Therefore, the NIP-MAA/Rop MNPs is expected to open a new field of vision for the research of clinical anesthesia and postoperative analgesia.

scholarly journals Wet-spinning of magneto-responsive helical chitosan microfibers

2020 ◽  
Vol 11 ◽  
pp. 991-999
Author(s):  
Dorothea Brüggemann ◽  
Johanna Michel ◽  
Naiana Suter ◽  
Matheus Grande de Aguiar ◽  
Michael Maas
Keyword(s):  
Tissue Engineering ◽  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Mechanical Energy ◽  
Accessible Surface Area ◽  
Wet Spinning ◽  
Helical Structures ◽  
Structural Reinforcement ◽  
Electron Microscopy Analysis ◽  
Accessible Surface

Helical structures can be found in nature at various length scales ranging from the molecular level to the macroscale. Due to their ability to store mechanical energy and to optimize the accessible surface area, helical shapes contribute particularly to motion-driven processes and structural reinforcement. Due to these special features, helical fibers have become highly attractive for biotechnological and tissue engineering applications. However, there are only a few methods available for the production of biocompatible helical microfibers. Given that, we present here a simple technique for the fabrication of helical chitosan microfibers with embedded magnetic nanoparticles. Composite fibers were prepared by wet-spinning and coagulation in an ethanol bath. Thereby, no toxic components were introduced into the wet-spun chitosan fibers. After drying, the helical fibers had a diameter of approximately 130 µm. Scanning electron microscopy analysis of wet-spun helices revealed that the magnetic nanoparticles agglomerated into clusters inside the fiber matrix. The helical constructs exhibited a diameter of approximately 500 µm with one to two windings per millimeter. Due to their ferromagnetic properties they are easily attracted to a permanent magnet. The results from the tensile testing show that the helical chitosan microfibers exhibited an average Young’s modulus of 14 MPa. By taking advantage of the magnetic properties of the feedstock solution, the production of the helical fibers could be automated. The fabrication of the helical fibers was achieved by utilizing the magnetic properties of the feedstock solution and winding the emerging fiber around a rotating magnetic collector needle upon coagulation. In summary, our helical chitosan microfibers are very attractive for future use in magnetic tissue engineering or for the development of biocompatible actuator systems.

Effect of aluminum doped iron oxide nanoparticles on magnetic properties of the polyacrylonitrile nanofibers

2017 ◽  
Vol 37 (2) ◽  
pp. 135-141
Author(s):  
Armin Ourang ◽  
Soheil Pilehvar ◽  
Mehrzad Mortezaei ◽  
Roya Damircheli
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Negative Interaction ◽  
Magnetic Nanofibers

Abstract In this work, polyacrylonitrile (PAN) was electrospun with and without magnetic nanoparticles (aluminum doped iron oxide) and was turned into magnetic nanofibers. The results showed that nanofibers diameter decreased from 700 nm to 300 nm by adding nanoparticles. Furthermore, pure PAN nanofibers were indicated to have low magnetic ability due to polar bonds that exist in their acrylonitrile groups. Obviously by adding only 4 wt% of the nanoparticles to PAN nanofibers, magnetic ability soared by more than 10 times, but at a higher percentage, it was shown to change just a little due to negative interaction among nanoparticles. This event relates to antiferromagnetically coupling of nanoparticles due to incomplete dispersion at higher percentage.

Thermal Stability of Magnetic Properties in Dehydrogenated Triarylmethane Resins

1989 ◽  
Vol 173 ◽  
Author(s):  
Michiya Otani ◽  
Sugio Otani
Keyword(s):  
Thermal Stability ◽  
Magnetic Properties ◽  
Magnetic Property ◽  
Room Temperature ◽  
Permanent Magnets ◽  
Elevated Temperatures ◽  
Mechanical Response ◽  
The Stability ◽  
Thermal Stability Of

ABSTRACTThe stability of the magnetic properties of dehydrogenated triaryl-methane resins was investigated both at room temperature and at elevated temperatures. A magnetic property different from that reported in a previous paper was found in the course of studying the reproducibility of synthesis. This new property was examined through a mechanical response of the resins to a set of permanent magnets.

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