In vitro evaluation of biodegradable magnesium alloys containing micro-alloying additions of strontium, with and without zinc

2015 ◽  
Vol 3 (45) ◽  
pp. 8874-8883 ◽  
Author(s):  
Jun-Lan Wang ◽  
Shayanti Mukherjee ◽  
David R. Nisbet ◽  
Nick Birbilis ◽  
Xiao-Bo Chen
Keyword(s):  
Magnesium Alloys ◽  
Solid Solubility ◽  
Bone Growth ◽  
Cathodic Reaction ◽  
In Vitro Evaluation ◽  
Alloying Additions ◽  
Biodegradable Magnesium ◽  
Kinetics Of

(a) Alloying of microlevels of Sr do not promote thein vitrocathodic reaction, whilst it slightly moderates the anodic kinetics of Mg in MEM and (b) adopted microadditions of Sr around its solid solubility in a Mg implant favourable for bone growth.

scholarly journals Differential apoptotic response of MC3T3-E1 pre-osteoblasts to biodegradable magnesium alloys in an in vitro direct culture model

2017 ◽  
Vol 28 (10) ◽  
Author(s):  
Ehsan Bonyadi Rad ◽  
Sepideh Mostofi ◽  
Matthias Katschnig ◽  
Patrik Schmutz ◽  
Magdalena Pawelkiewicz ◽  
...  
Keyword(s):  
Magnesium Alloys ◽  
Apoptotic Response ◽  
Culture Model ◽  
Biodegradable Magnesium

Growth, in vitro biodegradation and cytocompatibility properties of nano-hydroxyapatite coatings on biodegradable magnesium alloys

2016 ◽  
Vol 672 ◽  
pp. 366-373 ◽  
Author(s):  
Huawei Yang ◽  
Kada Xia ◽  
Taolei Wang ◽  
Junchao Niu ◽  
Yiming Song ◽  
...  
Keyword(s):  
Magnesium Alloys ◽  
Hydroxyapatite Coatings ◽  
Biodegradable Magnesium

Biodegradable Magnesium Implant: In Vivo and In Vitro Convergence

2014 ◽  
Author(s):  
Yeoheung Yun ◽  
Yongseok Jang ◽  
Juan Wang ◽  
Zhongyun Dong ◽  
Vesselin Shanov ◽  
...  
Keyword(s):  
Magnesium Alloys ◽  
Product Formation ◽  
In Vitro Test ◽  
Biodegradable Implant ◽  
Plasma Electrolyte ◽  
Vitro Test ◽  
Plasma Electrolyte Oxidation ◽  
Biodegradable Magnesium

In recent years, magnesium alloys have emerged as possible biodegradable implant material. A fundamental understanding of the nature of magnesium corrosion and the ability to control this process in vivo is critical to advancing the case for clinical use of magnesium based biomaterials. The biodegradation of magnesium is fundamentally linked to studies of its corrosion, which is dependent on the interfacing dynamics between the material and its environment. Thus, it is required to confirm what variable differentiate the corrosion behavior between in vitro and in vivo before optimizing and standardizing of in vitro test. This study was conducted to understand the biodegradation behavior of commercial AZ31 and Mg-Zn-Ca alloys with plasma electrolyte oxidation (PEO) under various biological environments using in vivo and in vitro testing methods mimicking in vivo physiological environment. This study is focused on the effect of Zn element concentration and PEO coating for magnesium alloys, and the correlation between the in vivo and in vitro in terms of corrosion rate, types of corrosion and corrosion product formation.

scholarly journals Advances and Challenges of Biodegradable Implant Materials with a Focus on Magnesium-Alloys and Bacterial Infections

2018 ◽  
Author(s):  
Muhammad Imran Rahim ◽  
Sami Ullah ◽  
Peter P. Mueller
Keyword(s):  
Magnesium Alloys ◽  
Bacterial Infections ◽  
Bone Growth ◽  
Healing Process ◽  
Bacterial Biofilm ◽  
Surgical Removal ◽  
Biodegradable Implant ◽  
Vascular Stents ◽  
Implant Materials

Medical implants made of biodegradable materials could be of advantage for temporary applications such mechanical support during bone-healing or as vascular stents to keep blood vessels open. After completion of the healing process the implant would disappear, avoiding long-term side effects or the need for surgical removal. Various corrodible metal alloys based on magnesium, iron or zinc have been proposed as sturdier and potentially less inflammatory alternative to degradable organic polymers, in particular for load-bearing applications. Despite the recent introduction of magnesium-based screws the remaining hurdles to routine clinical applications are still challenging, such as limiting mechanical material characteristics or unsuitable corrosion characteristics. Here, salient features and clinical prospects of currently investigated biodegradable implant materials are summarized with a main focus on magnesium alloys. A mechanism of action for the stimulation of bone growth due to the exertion of mechanical force by magnesium corrosion products is discussed. To explain divergent in vitro and in vivo effects of magnesium a novel model for bacterial biofilm infections is proposed which predicts crucial consequences antibacterial implant strategies.

scholarly journals The Functional Properties of Mg–Zn–X Biodegradable Magnesium Alloys

Materials ◽  
2020 ◽  
Vol 13 (3) ◽  
pp. 544 ◽  
Author(s):  
Dmitry Merson ◽  
Alexander Brilevsky ◽  
Pavel Myagkikh ◽  
Alexandra Tarkova ◽  
Alexei Prokhorikhin ◽  
...  
Keyword(s):  
Corrosion Resistance ◽  
Magnesium Alloys ◽  
Functional Properties ◽  
Biomedical Applications ◽  
Mechanical Performance ◽  
Chemical Compositions ◽  
Premature Failure ◽  
Inflammatory Reactions ◽  
Biodegradable Magnesium

The implantation of metallic devices in orthopaedic surgical procedures and coronary angioplasty is associated with the risk of various adverse events: (i) mechanical (premature failure), (ii) chemo-mechanical (corrosion and corrosion-fatigue degradation) and (iii) biomedical (chronic local inflammatory reactions, tissue necrosis, etc.). In this regard, the development of biodegradable implants/stents, which provide the necessary mechanical support for the healing period of the bone or the vessel wall and then are completely resorbed, has bright prospects. Magnesium alloys are the most suitable candidates for that purpose due to their superior mechanical performance, bioresorbability and biocompatibility. This article presents the results of the comparative research on several wrought biodegradable alloys, assessing their potential for biomedical applications. The Mg–Zn–X alloys with different chemical compositions and microstructures were produced using severe plastic deformation techniques. Functional properties pivotal for biomedical applications—mechanical strength, in vitro corrosion resistance and cytotoxic activity—were included in the focus of the study. Excellent mechanical performance and low cytotoxic effects are documented for all alloys with a notable exception for one of two Mg–Zn–Zr alloys. The in vitro corrosion resistance is, however, below expectations due to critical impurities, and this property has yet to be drastically improved through the cleaner materials fabrication processing before they can be considered for biomedical applications.

Reliable and fast sensor for in vitro evaluation of solar protection factor based on the photobleaching kinetics of a nanocrystalline TiO2/dye UV-dosimeter

2011 ◽  
Vol 156 (1) ◽  
pp. 325-331 ◽  
Author(s):  
Leonardo R. de Paula ◽  
André L.A. Parussulo ◽  
Koiti Araki ◽  
Henrique E. Toma
Keyword(s):  
Protection Factor ◽  
Nanocrystalline Tio2 ◽  
In Vitro Evaluation ◽  
Kinetics Of
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