Synthesis, molecular docking and in vitro antiproliferative activity of novel pyrano[3,2-c]carbazole derivatives

2016 ◽  
Vol 40 (10) ◽  
pp. 8305-8315 ◽  
Author(s):  
Pannala Padmaja ◽  
Basireddy V. Subba Reddy ◽  
Nishant Jain ◽  
Srinivasa Rao Mutheneni ◽  
Priyanka Bollepelli ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Carbazole Derivatives

A new series of polycyclic pyrano[3,2-c]carbazole derivatives were synthesized, of which three compounds displayed pronounced antiproliferative activity on cancer cells.

One new azido bridged dinuclear copper(ii) thiosemicarbazide complex: synthesis, DNA/protein binding, molecular docking study and cytotoxicity activity

2017 ◽  
Vol 41 (21) ◽  
pp. 12996-13011 ◽  
Author(s):  
Niladri Biswas ◽  
Sumit Khanra ◽  
Arnab Sarkar ◽  
Shamee Bhattacharjee ◽  
Deba Prasad Mandal ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Protein Binding ◽  
Cancer Cells ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Docking Study ◽  
Molecular Docking Study ◽  
Cytotoxicity Activity ◽  
Biological Potential

Biological potential of a copper(ii) complex found to exhibit in vitro antiproliferative activity towards two cell lines, AGS and A549 cancer cells.

Synthesis, Molecular Docking, in vitro Antiproliferative and Antioxidant Activity of Novel Pyrrolidinyl-Carbazole Derivatives

2018 ◽  
Vol 14 (8) ◽  
Author(s):  
Padmaja Pannala ◽  
Pedavenkatagari Narayana Reddy ◽  
Basireddy V. Subba Reddy ◽  
Sunil Misra ◽  
Koude Dhevendar ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Molecular Docking ◽  
Carbazole Derivatives

scholarly journals Antiproliferative Activity and Potential Mechanism of Marine-Sourced Streptoglutarimide H against Lung Cancer Cells

Marine Drugs ◽  
2021 ◽  
Vol 19 (2) ◽  
pp. 79
Author(s):  
Hengju Ge ◽  
Di Zhang ◽  
Muran Shi ◽  
Xiaoyuan Lian ◽  
Zhizhen Zhang
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Lung Cancer Cells ◽  
Potential Mechanism ◽  
Nucleotide Synthesis ◽  
Factor C ◽  
Antiglioma Activity

In 2019, streptoglutarimide H (SGH) was characterized as a new glutarimide from the secondary metabolites produced by a marine-derived actinomycete Streptomyces sp. ZZ741 and shown to have in vitro antiglioma activity. However, the antiproliferative activity and potential mechanism of SGH against lung cancer cells have not yet been characterized. This study demonstrated that SGH significantly inhibited the proliferation of different lung cancer cells. In terms of mechanism of action, SGH downregulated cell cycle- and nucleotide synthesis-related proteins to block cell cycle at G0/G1 phase, reduced the expression levels of glycolytic metabolic enzymes to inhibit glycolysis, and downregulated the important cancer transcription factor c-Myc and the therapeutic target deubiquitinase USP28. Potent anticancer activity and multiple mechanisms indicated SGH to be a novel antitumor compound against lung cancer cells.

scholarly journals Synthesis, Antiproliferative Activity and Molecular Docking Studies of Novel Doubly Modified Colchicine Amides and Sulfonamides as Anticancer Agents

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1789 ◽  
Author(s):  
Julia Krzywik ◽  
Witold Mozga ◽  
Maral Aminpour ◽  
Jan Janczak ◽  
Ewa Maj ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Cell Lines ◽  
Anticancer Agents ◽  
Antiproliferative Activity ◽  
Docking Studies ◽  
Binding Modes ◽  
Colchicine Binding Site ◽  
3T3 Cell Lines ◽  
Colchicine Derivatives

Colchicine is a well-known compound with strong antiproliferative activity that has had limited use in chemotherapy because of its toxicity. In order to create more potent anticancer agents, a series of novel colchicine derivatives have been obtained by simultaneous modification at C7 (amides and sulfonamides) and at C10 (methylamino group) positions and characterized by spectroscopic methods. All the synthesized compounds have been tested in vitro to evaluate their cytotoxicity toward A549, MCF-7, LoVo, LoVo/DX and BALB/3T3 cell lines. Additionally, the activity of the studied compounds was investigated using computational methods involving molecular docking of the colchicine derivatives to β-tubulin. The majority of the obtained derivatives exhibited higher cytotoxicity than colchicine, doxorubicin or cisplatin against tested cancer cell lines. Furthermore, molecular modeling studies of the obtained compounds revealed their possible binding modes into the colchicine binding site of tubulin.

Structural characterization of new zinc(ii) complexes with N2O2 chelating thiosemicarbazidato ligands; investigation of the relationship between their DNA interaction and in vitro antiproliferative activity towards human cancer cells

2020 ◽  
Vol 44 (22) ◽  
pp. 9313-9320
Author(s):  
Büşra Kaya ◽  
Zehra Kübra Yılmaz ◽  
Onur Şahin ◽  
Belma Aslim ◽  
Bahri Ülküseven
Keyword(s):  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Human Cancer ◽  
Dna Interaction ◽  
Antiproliferative Agents ◽  
Human Cancer Cells ◽  
Dna Targeting ◽  
The Relationship

New candidates to become DNA-targeting antiproliferative agents: Zinc(ii) complexes bearing N2O2-thiosemicarbazidato ligands.

Sign in / Sign up

Export Citation Format

Share Document