scholarly journals Enhanced cytocompatibility and functional group content of poly(l-lysine) dendrimers by grafting with poly(oxazolines)

2016 ◽  
Vol 7 (28) ◽  
pp. 4609-4617 ◽  
Author(s):  
R. M. England ◽  
J. I. Hare ◽  
P. D. Kemmitt ◽  
K. E. Treacher ◽  
M. J. Waring ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Functional Group ◽  
Drug Loading ◽  
Group Content

We report the use of polyoxazolines as materials for modifying the surface of a generation 5 l-lysine dendrimer resulting in a significant improvement in the biocompatibility properties compared to the unmodified dendrimer. The polyoxazoline coatings represent interesting alternatives to polyethylene glycol and can also offer an opportunity for increasing drug loading.

Co-delivery of Doxorubicin and D-α-Tocopherol Polyethylene Glycol 1000 Succinate by Magnetic Nanoparticles

2018 ◽  
Vol 18 (8) ◽  
pp. 1138-1147 ◽  
Author(s):  
Esra Metin ◽  
Pelin Mutlu ◽  
Ufuk Gündüz
Keyword(s):  
Breast Cancer ◽  
Polyethylene Glycol ◽  
Magnetic Nanoparticles ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Drug Loading ◽  
Gravimetric Analysis ◽  
Polyethylene Glycol 1000 ◽  
Mcf 7

Background: Although conventional chemotherapy is the most common method for cancer treatment, it has several side effects such as neuropathy, alopecia and cardiotoxicity. Since the drugs are given to body systemically, normal cells are also affected, just like cancer cells. However, in recent years, targeted drug delivery has been developed to overcome these drawbacks. Objective: The aim of this study was targeted co-delivery of doxorubicin (Dox) which is an anticancer agent and D-α-Tocopherol polyethylene glycol 1000 succinate (vitamin E TPGS or simply TPGS) to breast cancer cells. For this purpose, Magnetic Nanoparticles (MNPs) were synthesized and coated with Oleic Acid (OA). Coated nanoparticles were encapsulated in Poly Lactic-co-Glycolic Acid (PLGA) and TPGS polymers and loaded with Dox. The Nanoparticles (NPs) were characterized by Fourier Transform Infrared (FTIR) spectroscopy, zetapotential analysis, Dynamic Light Scattering (DLS) analysis, Thermal Gravimetric Analysis (TGA) and Scanning Electron Microscope (SEM) analysis. Results: The results showed that NPs were spherical, superparamagnetic and in the desired range for use in drug targeting. The targetability of NPs was confirmed. Moreover, TPGS and Dox loading was shown by TGA and FTIR analyses. NPs were internalized by cells and the cytotoxic effect of drug loaded NPs on sensitive (MCF-7) and drug-resistant (MCF-7/Dox) cells were examined. It was seen that the presence of TPGS increased cytotoxicity significantly. TPGS also enhanced drug loading efficiency, release rate, cellular internalization. In MCF- 7/Dox cells, the drug resistance seems to be decreased when Dox is loaded onto TPGS containing NPs. Conclusion: This magnetic PLGA nanoparticle system is important for new generation targeted chemotherapy and could be used for breast cancer treatment after in vivo tests.

scholarly journals Silk fibroin/polyethylene glycol nanofibrous membranes loaded with curcumin

2017 ◽  
Vol 21 (4) ◽  
pp. 1587-1594 ◽  
Author(s):  
Qing Liu ◽  
Shufa Zhou ◽  
Zeyu Zhao ◽  
Ting Wu ◽  
Rong Wang ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Drug Release ◽  
Silk Fibroin ◽  
Drug Loading ◽  
Control Drug ◽  
Nanofiber Membranes ◽  
Utilization Ratio ◽  
The Stability ◽  
Control Drug Release

In order to improve the stability, utilization ratio and anti-tumor effect of curcumin drug, a set of curcumin-loaded nanofiber membranes with drug releasing property were fabricated using silk fibroin and polyethylene glycol. Various curcumin-loaded silk fibroin nanofiber membranes with different components and drug loading percentages were prepared using electrospinning technology. The morphology structure, mechanical properties, secondary structure, drug release property in vitro, and their interaction effects of the curcumin-loaded silk fibroin nanofiber membranes were examined. The result of in-vitro drug release experiment showed that the curcumin can be released stably up to 350 hours, the drug releasing speed increased with the decrease of the diameter of the fibers. The stability and utilization ratio of curcumin was improved after loading with curcumin-loaded silk fibroin nanofiber membranes. In conclusion, it can be used as a control drug release system alternately in the future.

Water soluble multiarm-polyethylene glycol–betulinic acid prodrugs: design, synthesis, and in vivo effectiveness

2014 ◽  
Vol 5 (19) ◽  
pp. 5775-5783 ◽  
Author(s):  
Lin Dai ◽  
Dan Li ◽  
Jing Cheng ◽  
Jing Liu ◽  
Li-Hong Deng ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Betulinic Acid ◽  
Water Solubility ◽  
Drug Loading ◽  
Water Soluble ◽  
Loading Capacity ◽  
Design Synthesis ◽  
High Drug ◽  
High Drug Loading

Multiarm-polyethylene glycol–betulinic acid prodrugs were prepared by using multiarm-polyethylene glycol linkers and betulinic acid, which exhibited high drug loading capacity, good water solubility, and excellent anticancer activity.

A cascade strategy towards the direct synthesis of green polyesters with versatile functional groups

2021 ◽  
Author(s):  
Xueting Wan ◽  
Jian Jiang ◽  
Yanyan Tu ◽  
Siyuan Xu ◽  
Jing Li ◽  
...  
Keyword(s):  
Functional Groups ◽  
Functional Group ◽  
Direct Synthesis ◽  
Facile Synthesis ◽  
Biodegradable Polyesters ◽  
Group Content

The cascade coupling of ROP and CP enables the facile synthesis of high functional group content biodegradable polyesters.

Effect of Additives on Characteristics of Poly(3-Hydroxybutyrate) Microspheres

2010 ◽  
Vol 160-162 ◽  
pp. 54-59 ◽  
Author(s):  
Fan Li ◽  
Feng Tian ◽  
Chang Jun Liu
Keyword(s):  
Polyethylene Glycol ◽  
Glycolic Acid ◽  
Drug Loading ◽  
Double Emulsion ◽  
Average Diameter ◽  
Morphological Characters ◽  
Good Effect ◽  
Protein Loading ◽  
Effect Of Additives ◽  
Surface Morphologies

Poly(3-hydroxybutyrate) (PHB) based microspheres were prepared via double emulsion solvent evaporation using polyethylene glycol (PEG), poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV), polylactide (PLA), poly(dl-lactic-co-glycolic acid) (PLGA) or chitosan (CTS) as the additive of wall polymers. It was found that additives had distinct effect on the properties of microspheres, such as the yield, drug loading, average diameter, crystallization states microstructure and surface morphological characters. PHB based microspheres using PEG as the additive had the lowest yield, the smallest average diameter, and the highest drug loading which reached 12.2% thereinto. At the same time it had the lowest crystallinity of PHB, and the diameter of the crystal particles was only 11.44 nm. It was feasible to prepare PHB based microspheres using PEG and PHBV as additives, which had relatively high protein loading but different microstructures and surface morphologies, and they were anticipated to have a good effect of controlled release.

scholarly journals Formulation and development of fast dissolving oral film of a poorly soluble drug, frusemide with improved drug loading using mixed solvency concept and its evaluation

2018 ◽  
Vol 8 (6) ◽  
pp. 132-141 ◽  
Author(s):  
Garima Carpenter ◽  
R. K. Maheshwari
Keyword(s):  
Polyethylene Glycol ◽  
Sodium Benzoate ◽  
Sodium Citrate ◽  
Drug Loading ◽  
Research Work ◽  
Water Soluble ◽  
Polyethylene Glycol 200 ◽  
Poorly Soluble ◽  
Sodium Caprylate ◽  
Poorly Soluble Drug

The aim of the present research work is to explore the application of mixed solvency concept to formulate and develop a fast dissolving oral film of furosemide with improved drug loading. In the present study, poorly soluble drug, furosemide was tried to be solubilized by employing the combination of physiologically compatible water-soluble additives (solubilizers) to formulate its fast dissolving formulations. For the development of fast dissolving oral film, firstly, different film forming polymers were tested for their film properties. The second fast dissolving layer was also formed and optimized. Solubility studies were conducted to select water-soluble additives for formulation of fast dissolving drug layer. Keeping the total concentration less than 40 % w/v of mixed blends, different aqueous blends were prepared employing solubilizers from among sodium benzoate, sodium acetate, sodium citrate, urea, niacinamide, glycerin, propylene glycol, polyethylene glycol 200, polyethylene glycol 400, polyethylene glycol 600, and PVP K 30. Maximum solubility of furosemide was found in blends- F5 (10% sodium caprylate +2.5%sodium benzoate+ 2.5% niacinamide) and in blend F7 (10% sodium caprylate +2.5%sodium benzoate +2.5% sodium citrate + 2.5% niacinamide). Prepared films were evaluated for drug content, thickness, folding endurance, tensile strength and hydration ratio. Keywords: Furosemide, fast dissolving oral film, mixed solvency concept.

Sign in / Sign up

Export Citation Format

Share Document