Polyphenolic profiles and the in vivo antioxidant effect of nipa vinegar on paracetamol induced liver damage

Nipa vinegar, which is rich in gallic acid and protocatechuic acid, has reverted the paracetamol-induced liver damage in mice by reduction of inflammation and oxidative stress.

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In vivo antioxidant effect of aqueous root bark, stem bark and leaves extracts of Vitex doniana in CCl4 induced liver damage rats

Asian Pacific Journal of Tropical Biomedicine ◽

10.1016/s2221-1691(13)60083-0 ◽

2013 ◽

Vol 3 (5) ◽

pp. 395-400 ◽

Cited By ~ 9

Author(s):

Kadejo Olubukola Adetoro ◽

James Dorcas Bolanle ◽

Sallau Balarebe Abdullahi ◽

Ozigi Abdulrahaman Ahmed

Keyword(s):

Liver Damage ◽

Stem Bark ◽

Antioxidant Effect ◽

Root Bark ◽

Vitex Doniana ◽

In Vivo Antioxidant Effect

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Antioxidant and hepatoprotective effects of the food seasoning curry leaves Murraya koenigii (L.) Spreng. (Rutaceae)

RSC Advances ◽

10.1039/c5ra19154h ◽

2015 ◽

Vol 5 (122) ◽

pp. 100589-100597 ◽

Cited By ~ 3

Author(s):

Wan Yong Ho ◽

Boon Kee Beh ◽

Kian Lam Lim ◽

Nurul Elyani Mohamad ◽

Hamidah Mohd Yusof ◽

...

Keyword(s):

Oxidative Stress ◽

Gallic Acid ◽

Liver Damage ◽

Water Extract ◽

Leaf Water ◽

Murraya Koenigii ◽

Curry Leaves ◽

Hepatoprotective Effects ◽

And Oxidative Stress

The curry leaf water extract, which is rich in gallic acid, reversed paracetamol-induced liver damage in mice by reducing inflammation and oxidative stress.

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In vivo and in vitro evidence for the involvement of Nrf2-antioxidant response element signaling pathway in the inflammation and oxidative stress induced by particulate matter (PM10): the effective role of gallic acid

Free Radical Research ◽

10.1080/10715762.2018.1563689 ◽

2019 ◽

Vol 53 (2) ◽

pp. 210-225 ◽

Cited By ~ 10

Author(s):

Maryam Radan ◽

Mahin Dianat ◽

Mohammad Badavi ◽

Seyyed Ali Mard ◽

Vahid Bayati ◽

...

Keyword(s):

Oxidative Stress ◽

Particulate Matter ◽

Gallic Acid ◽

Antioxidant Response ◽

Antioxidant Response Element ◽

Effective Role ◽

And Oxidative Stress

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Nutritional Compositions and In-vivo Antioxidant Effect of Corchorus olitorius Ethanol Leaf Extract in CCl4-induced Oxidative Stress in Wistar Rats

European Journal of Nutrition & Food Safety ◽

10.9734/ejnfs/2021/v13i530421 ◽

2021 ◽

pp. 73-81

Author(s):

Josiah Ndukwe ◽

Antoinette N. C. Okaka ◽

Victor Henry Azubuike Enemor ◽

Uchechukwu Chibuzo Ogbodo ◽

Precious Uchenna Ezeobi

Keyword(s):

Oxidative Stress ◽

Free Radicals ◽

Wistar Rats ◽

Leaf Extract ◽

Defense Mechanism ◽

Antioxidant Effect ◽

Albino Rats ◽

Antioxidant Enzyme Activities ◽

In Vivo Antioxidant Effect

Background: Oxidative stress has been implicated in the pathophysiology of various disease conditions with concomitant toll on the body’s defense mechanism against free radicals. To continuously sustain and support the efficiency of the body’s antioxidant defense system, natural plant sources are required. Thus, the need for alternative options especially of plants that are neglected and under-utilized. Hence, this study aimed at investigating the proximate and phytochemical compositions and in-vivo antioxidant effect of ethanol leaf extract of C. olitorius on antioxidant enzyme activities in CCl4-induced oxidative stress in Wistar rats. Methods: Thirty albino rats of Wistar strain (120-150g) were divided into six groups (A – F) of five rats each. Groups A, B and C served as test groups and were administered 200 mg/kg, 400 mg/kg and 600 mg/kg doses of C. olitorius leaf extract respectively while Group D served as normal control. Groups E and F served as the positive and negative controls and were administered 50 mg/kg Silymarin and distilled water respectively. The administration lasted for 15 days after which blood was collected via cardiac puncture. Results: Findings showed that the leaf was rich in total phenol (21.47 ± 0.00 mgGAE/g) and tannin (23.34 ± 0.75 mgTAE/g) with little quantity of oxalate (0.48 ± 0.09 mg/g), cardiac glycosides (0.30 ± 0.07 %) and phytate (0.25 ± 0.01 %). The result of the proximate composition revealed that the leaf was rich in carbohydrate (44.16 ± 1.21 %), ash (20.31 ± 0.51 %) and protein (11.29 ± 2.06 %) with negligible quantity of lipid (0.46 ± 0.11 %). More so, the activities of superoxide dismutase, catalase and glutathione peroxidase were all increased in the extract treated group when compared to the controls. Conclusion: From the above findings, it can be concluded that the ethanol leaf extract of C. olitorius may possess exploitable nutritional components and potential antioxidant activity against the debilitating effects of free radicals.

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Canthin-6-one ameliorates TNBS-induced colitis in rats by modulating inflammation and oxidative stress. An in vivo and in silico approach

Biochemical Pharmacology ◽

10.1016/j.bcp.2021.114490 ◽

2021 ◽

Vol 186 ◽

pp. 114490

Author(s):

Karuppusamy Arunachalam ◽

Amilcar Sabino Damazo ◽

Antonio Macho ◽

Monica Steffi Matchado ◽

Eduarda Pavan ◽

...

Keyword(s):

Oxidative Stress ◽

In Silico ◽

And Oxidative Stress

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Impact of Polyphenolic-Food on Longevity: An Elixir of Life. An Overview

Antioxidants ◽

10.3390/antiox10040507 ◽

2021 ◽

Vol 10 (4) ◽

pp. 507

Author(s):

Rosaria Meccariello ◽

Stefania D’Angelo

Keyword(s):

Oxidative Stress ◽

Food Sources ◽

Preventive Action ◽

Nutritional Interventions ◽

Beneficial Effects ◽

Age Related ◽

Macromolecular Damage ◽

And Oxidative Stress

Aging and, particularly, the onset of age-related diseases are associated with tissue dysfunction and macromolecular damage, some of which can be attributed to accumulation of oxidative damage. Recently, growing interest has emerged on the beneficial effects of plant-based diets for the prevention of chronic diseases including obesity, diabetes, and cardiovascular disease. Several studies collectively suggests that the intake of polyphenols and their major food sources may exert beneficial effects on improving insulin resistance and related diabetes risk factors, such as inflammation and oxidative stress. They are the most abundant antioxidants in the diet, and their intake has been associated with a reduced aging in humans. Polyphenolic intake has been shown to be effective at ameliorating several age-related phenotypes, including oxidative stress, inflammation, impaired proteostasis, and cellular senescence, both in vitro and in vivo. In this paper, effects of these phytochemicals (either pure forms or polyphenolic-food) are reviewed and summarized according to affected cellular signaling pathways. Finally, the effectiveness of the anti-aging preventive action of nutritional interventions based on diets rich in polyphenolic food, such as the diets of the Blue zones, are discussed.

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Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis

Food & Function ◽

10.1039/d0fo02910f ◽

2021 ◽

Vol 12 (5) ◽

pp. 2323-2334

Author(s):

Shihong Zheng ◽

Peichang Cao ◽

Zequn Yin ◽

Xuerui Wang ◽

Yuanli Chen ◽

...

Keyword(s):

Oxidative Stress ◽

Lipid Metabolism ◽

Liver Fibrosis ◽

Liver Damage ◽

Liver Diseases ◽

Potential Drug ◽

Abnormal Lipid Metabolism ◽

And Oxidative Stress

Apigenin prevented the DDC-induced abnormal lipid metabolism, liver damage and liver fibrosis by reducing inflammation and oxidative stress. Apigenin might be a potential drug for the treatment of cholestatic liver diseases.

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