Development of a reactive oxygen species (ROS)-responsive nanoplatform for targeted oral cancer therapy

2016 ◽  
Vol 4 (27) ◽  
pp. 4675-4682 ◽  
Author(s):  
Qing Li ◽  
Yong Wen ◽  
Xinru You ◽  
Fenghe Zhang ◽  
Vishva Shah ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Oral Cancer ◽  
Reactive Oxygen ◽  
Oxygen Species

A new targeted and ROS-triggered drug delivery nanoplatform was developed from the RGD–PEG–TK–PLGA polymer for effective oral cancer therapy.

A new biosafe reactive oxygen species (ROS)-responsive nanoplatform for drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (45) ◽  
pp. 38984-38989 ◽  
Author(s):  
Qing Li ◽  
Yong Wen ◽  
Jie Wen ◽  
Yun-Peng Zhang ◽  
Xiao-Ding Xu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Oral Cancer ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Rapid Release ◽  
Oral Cancer Cells

.A new ROS-responsive nanoplatform was deleveloped to load anticancer drug for oral cancer therapy. The ROS in cytoplasm can efficiently destroy the nanoplatform, leading to a rapid release of loaded drug and apoptosis of oral cancer cells.

scholarly journals Curcumin-coordinated nanoparticles with improved stability for reactive oxygen species-responsive drug delivery in lung cancer therapy

2017 ◽  
Vol Volume 12 ◽  
pp. 855-869 ◽  
Author(s):  
Cheng-Qiong Luo ◽  
Lei Xing ◽  
Peng-Fei Cui ◽  
Jian-Bin Qiao ◽  
Yu-Jing He ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Reactive Oxygen Species ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Improved Stability ◽  
Lung Cancer Therapy

PEGylated FePt–Fe3O4 composite nanoassemblies (CNAs): in vitro hyperthermia, drug delivery and generation of reactive oxygen species (ROS)

2015 ◽  
Vol 44 (19) ◽  
pp. 9103-9113 ◽  
Author(s):  
Niroj Kumar Sahu ◽  
Jagriti Gupta ◽  
Dhirendra Bahadur
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Schematic Representation

Schematic representation of in vitro cancer therapy using DOX loaded PEGylated FePt/Fe3O4 composite nanoassemblies (CNAs) in the presence of ACMF or H2O2.

A Novel Reactive Oxygen Species Triggered Polymeric Nanoplatform for Controlled Drug Delivery and Cancer Therapy

2017 ◽  
Vol 13 (5) ◽  
pp. 513-521 ◽  
Author(s):  
Qing Li ◽  
Jin Liang ◽  
Xinru You ◽  
Xiaojing Liu ◽  
Haitao Wu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Reactive Oxygen ◽  
Controlled Drug Delivery ◽  
Oxygen Species

scholarly journals Costunolide Induces Apoptosis via the Reactive Oxygen Species and Protein Kinase B Pathway in Oral Cancer Cells

2021 ◽  
Vol 22 (14) ◽  
pp. 7509
Author(s):  
Hai Huang ◽  
Jun-Koo Yi ◽  
Su-Geun Lim ◽  
Sijun Park ◽  
Haibo Zhang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Cycle ◽  
Flow Cytometry ◽  
Oral Cancer ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Migration And Invasion ◽  
Oxygen Species ◽  
Oral Cancer Cells

Oral cancer (OC) has been attracted research attention in recent years as result of its high morbidity and mortality. Costunolide (CTD) possesses potential anticancer and bioactive abilities that have been confirmed in several types of cancers. However, its effects on oral cancer remain unclear. This study investigated the potential anticancer ability and underlying mechanisms of CTD in OC in vivo and in vitro. Cell viability and anchorage-independent colony formation assays were performed to examine the antigrowth effects of CTD on OC cells; assessments for migration and invasion of OC cells were conducted by transwell; Cell cycle and apoptosis were investigated by flow cytometry and verified by immunoblotting. The results revealed that CTD suppressed the proliferation, migration and invasion of oral cancer cells effectively and induced cell cycle arrest and apoptosis; regarding the mechanism, CTD bound to AKT directly by binding assay and repressed AKT activities through kinase assay, which thereby downregulating the downstream of AKT. Furthermore, CTD remarkably promotes the generation of reactive oxygen species by flow cytometry assay, leading to cell apoptosis. Notably, CTD strongly suppresses cell-derived xenograft OC tumor growth in an in vivo mouse model. In conclusion, our results suggested that costunolide might prevent progression of OC and promise to be a novel AKT inhibitor.

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