A new triazine based π-conjugated mesoporous 2D covalent organic framework: itsin vitroanticancer activities

2018 ◽  
Vol 54 (81) ◽  
pp. 11475-11478 ◽  
Author(s):  
Sabuj Kanti Das ◽  
Snehasis Mishra ◽  
Krishnendu Manna ◽  
Utpal Kayal ◽  
Supratim Mahapatra ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Anticancer Activity ◽  
Cell Line ◽  
Covalent Organic Framework ◽  
Hct 116 ◽  
Line P ◽  
Organic Framework

A new 2D π-conjugated COF, TrzCOF has been synthesized and it showed excellent anticancer activity for the colorectal carcinoma HCT-116 cell line.

scholarly journals Cytotoxic Activity of Stem Bark Extracts from Canarium odontophyllum Miq (Dabai) against Human Colorectal Carcinoma HCT 116 Cell Line

2014 ◽  
Vol 05 (26) ◽  
pp. 3925-3933 ◽  
Author(s):  
Dayang Fredalina Basri ◽  
Muhammad Arifuddin Al Rasyid Mohd ◽  
Chan Kok Meng ◽  
Elda Surhaida Latif ◽  
Fahrul Zaman Huyop
Keyword(s):  
Colorectal Carcinoma ◽  
Cytotoxic Activity ◽  
Cell Line ◽  
Stem Bark ◽  
Hct 116 ◽  
Human Colorectal Carcinoma ◽  
Canarium Odontophyllum

The Identification of a Novel Unsymmetrical Azine as an Apoptosis Inducer in Colorectal Cancer

2020 ◽  
Vol 20 ◽  
Author(s):  
Fahad M. Almutairi ◽  
Ayat G. Ali ◽  
Abdou O. Abdelhamid ◽  
Adel I. Alalawy ◽  
Mai K. Bishr ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colorectal Carcinoma ◽  
Cell Line ◽  
Binding Affinity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Carcinoma Cell ◽  
Apoptosis Induction ◽  
Colorectal Carcinoma Cell Line ◽  
Hct 116

Background: Defects in the physiological mechanisms of apoptosis are one of the pivotal factors implicated in carcinogenesis. Thus, the development of novel compounds that target various apoptotic pathways has provided promising anticancer therapeutic opportunities. Objective: This study explores the cytotoxic effects of a novel unsymmetrical azine against specific cancer cell lines and investigates the mechanism of cytotoxicity. Methods: Molecular modeling was used to test the binding affinity of four new unsymmetrical azines to a model of an apoptosis inhibitor protein (XIAP). The compound with the highest binding affinity, C4, was further tested on different cell lines. Real-time polymerase chain reaction (PCR) and transmission electron microscope (TEM) were used to study apoptosis induction biochemically and morphologically. Results: In comparison to cisplatin as a control, the compound C4 exhibited notable cytotoxicity against all tested cancer cell lines, especially the human colorectal carcinoma cell line (HCT-116). Furthermore, C4-treated cells demonstrated marked overexpression of the pro-apoptotic proteins Bax and caspase-3 as well as the tumor suppressor p53. On the other hand, the expression of the anti-apoptotic protein Bcl-2 was inhibited. On TEM examination, C4-treated HCT-116 cells showed classical structural signs of apoptosis. Conclusion: This study identifies a novel azine (C4) which induces remarkable cytotoxicity against colorectal carcinoma cell line, mediated through apoptosis induction. These novel insights suggest C4 as a promising therapeutic agent in colorectal cancer.

In vitro antioxidant potential of Shemamruthaa (a herbal formulation) and its anticancer activity in the MCF-7 cell line

RSC Advances ◽  
2015 ◽  
Vol 5 (30) ◽  
pp. 23125-23133
Author(s):  
Nandhakumar Elumalai ◽  
Purushothaman Ayyakkannu ◽  
Shanthi Palanivelu ◽  
Sachdanandam Panchanadham
Keyword(s):  
Anticancer Activity ◽  
Cell Line ◽  
Ex Vivo ◽  
Radical Scavenging ◽  
Herbal Formulation ◽  
Hibiscus Rosa Sinensis ◽  
Line P ◽  
Mcf 7 ◽  
Free Radical Scavenging Activities

The current study investigates the free radical scavenging activities of methanolic and aqueous extracts of Shemamruthaa (Hibiscus rosa sinensis, Emblica officinalis and honey in definite ratio) and their anticancer activity in the breast cancer (MCF-7) cell line ex vivo.

Anticancer Activity of Nutrient Mixture in Malignant Leukemia Cell Line P-388 In Vitro

2005 ◽  
Vol 28 (6) ◽  
pp. 646-647
Author(s):  
M Waheed Roomi ◽  
Vadim Ivanov ◽  
Aleksandra Niedzwiecki ◽  
Matthias Rath
Keyword(s):  
Anticancer Activity ◽  
Cell Line ◽  
Leukemia Cell ◽  
Leukemia Cell Line ◽  
Line P

scholarly journals Synthesis of New Pt(II) Complex Bearing Organoselenium Ligands and Evaluation of Cytotoxic Activity of Some Structurally Related Pd(II) Complexes

2020 ◽  
Vol 39 (1) ◽  
pp. 59
Author(s):  
Ninko Radenković ◽  
Marina Kostić ◽  
Nataša Đorđević ◽  
Zana Doličanin ◽  
Tanja Soldatović ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Cytotoxic Activity ◽  
Cell Line ◽  
Mtt Assay ◽  
Carcinoma Cell ◽  
In Vitro Study ◽  
Colorectal Carcinoma Cell Line ◽  
Hct 116 ◽  
Healthy Lung

Herein we report the synthesis of new trans-bis(2-phenylselenylmethyl)oxolane)dichloroplatinum(II) complex Pt1. Newly synthetized complex, together with two, structurally related trans-Pd(II) complexes (trans-bis(2-(phenylselenylmethyl)oxolane)dichloropalladium(II) Pd1 and trans-bis(2-(phenylselenylmethyl)oxane)dichloropalladium(II)) Pd2, were screened for cytotoxic activity through in vitro study on the HCT-116 colorectal carcinoma cell line and on the MRC-5 healthy lung pleura cell line. Activity of complexes was assessed by comparing it to the cisplatin. The cells viability and proliferation were determined using MTT assay.

scholarly journals Anti-cancer, antiproliferative activity of active anionic H2O8 oxygen solution on HCT-116 cancer cell

2021 ◽  
Vol 12 (2) ◽  
pp. 179-184
Author(s):  
Apaydin Yildirim Betul
Keyword(s):  
Epithelial Cells ◽  
Colorectal Carcinoma ◽  
Cell Line ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Inflammatory Responses ◽  
Colorectal Cancer Cell Line ◽  
Hct 116 ◽  
Oxygen Solution ◽  
Human Colorectal Carcinoma

HCT116 cells are adherent epithelial cells derived from the human colorectal carcinoma cell line commonly used to study inflammatory responses in colonic epithelial cells. In this study, it was aimed to evaluate the effects of active anionic H2O8 oxygen solution, which is a very strong antiviral and antimicrobial agent, on HCT-116 human colorectal cancer cell line. Cell viability was determined by MTT analysis. Antiproliferative activity of the anionic H2O8 was investigated on HCT 116 (human colorectal carcinoma) cancer cells. Anionic H2O8 displayed the outstanding activities for MTT test, IC50= 9.44 for 24th hour was calculated as IC50= 11.73 for 48th hour on HCT 116 cell line. It is thought that it can serve as an agent with strong potential to be used in treatment.

Sign in / Sign up

Export Citation Format

Share Document