Click and release: bioorthogonal approaches to “on-demand” activation of prodrugs

2019 ◽  
Vol 48 (4) ◽  
pp. 1077-1094 ◽  
Author(s):  
Xingyue Ji ◽  
Zhixiang Pan ◽  
Bingchen Yu ◽  
Ladie Kimberly De La Cruz ◽  
Yueqin Zheng ◽  
...  
Keyword(s):  
Small Molecule ◽  
Bioorthogonal Chemistry ◽  
On Demand ◽  
Recent Developments

This review summarizes recent developments in using bioorthogonal chemistry in prodrug design for the delivery of traditional small molecule- and gasotransmitter-based therapeutics.

Analysis of Various Security Issues and Challenges in Cloud Computing Environment

2016 ◽  
pp. 221-247 ◽  
Author(s):  
Zhaolong Gou ◽  
Shingo Yamaguchi ◽  
B. B. Gupta
Keyword(s):  
Cloud Computing ◽  
Comparative Analysis ◽  
Solution Space ◽  
Future Research ◽  
Security Threats ◽  
Computing Environment ◽  
Cloud Computing Environment ◽  
Security Issues ◽  
On Demand ◽  
Recent Developments

Cloud computing is a system, where the resources of a data center are shared using virtualization technology, such that it provides elastic, on demand and instant services to its customers and charges them based on the resources they use. In this chapter, we will discuss recent developments in cloud computing, various security issues and challenges associated with Cloud computing environment, various existing solutions provided for dealing with these security threats and will provide a comparative analysis these approaches. This will provide better understanding of the various security problems associated with the cloud, current solution space, and future research scope to deal with such attacks in better way.

scholarly journals Recent Advances in Flavin-Dependent Halogenase Biocatalysis: Sourcing, Engineering, and Application

Catalysts ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1030 ◽  
Author(s):  
Johannes Büchler ◽  
Athena Papadopoulou ◽  
Rebecca Buller
Keyword(s):  
Small Molecule ◽  
Halogen Atom ◽  
Reaction Engineering ◽  
Special Focus ◽  
Molecular Scaffolds ◽  
Reaction Conditions ◽  
Bioactive Substances ◽  
Application Range ◽  
Technological Value ◽  
Recent Developments

The introduction of a halogen atom into a small molecule can effectively modulate its properties, yielding bioactive substances of agrochemical and pharmaceutical interest. Consequently, the development of selective halogenation strategies is of high technological value. Besides chemical methodologies, enzymatic halogenations have received increased interest as they allow the selective installation of halogen atoms in molecular scaffolds of varying complexity under mild reaction conditions. Today, a comprehensive library of aromatic halogenases exists, and enzyme as well as reaction engineering approaches are being explored to broaden this enzyme family’s biocatalytic application range. In this review, we highlight recent developments in the sourcing, engineering, and application of flavin-dependent halogenases with a special focus on chemoenzymatic and coupled biosynthetic approaches.

π-Electron rich small molecule sensors for the recognition of nitroaromatics

2015 ◽  
Vol 51 (89) ◽  
pp. 16014-16032 ◽  
Author(s):  
Sankarasekaran Shanmugaraju ◽  
Partha Sarathi Mukherjee
Keyword(s):  
Small Molecule ◽  
Fluorescent Sensors ◽  
Review Article ◽  
Special Focus ◽  
Nitroaromatic Explosives ◽  
Recent Developments ◽  
Made In

In this review article we provide an overview of the recent developments made in small molecule-based turn-off fluorescent sensors for nitroaromatic explosives with special focus on organic and H-bonded supramolecular sensors.

scholarly journals Bioorthogonal chemistry-based RNA labeling technologies: evolution and current state

2020 ◽  
Vol 56 (82) ◽  
pp. 12307-12318
Author(s):  
Jerrin Thomas George ◽  
Seergazhi G. Srivatsan
Keyword(s):  
Bioorthogonal Chemistry ◽  
Feature Article ◽  
Current State ◽  
Rna Labeling ◽  
Recent Developments

Recent developments and applications of bioorthogonal chemistry to label RNA by transcription and posttranscription chemo-enzymatic approaches are described in this feature article.

scholarly journals Recent developments in bioorthogonal chemistry and the orthogonality within

2021 ◽  
Vol 60 ◽  
pp. 79-88 ◽  
Author(s):  
Mike L.W.J. Smeenk ◽  
Jordi Agramunt ◽  
Kimberly M. Bonger
Keyword(s):  
Bioorthogonal Chemistry ◽  
Recent Developments

The Development of New Small-Molecule Inhibitors Targeting Bacterial Metallo-β-lactamases

2018 ◽  
Vol 18 (10) ◽  
pp. 834-843 ◽  
Author(s):  
Ping Wang ◽  
Jing Cheng ◽  
Cong-Cong Liu ◽  
Kai Tang ◽  
Feng Xu ◽  
...  
Keyword(s):  
Small Molecule ◽  
Horizontal Transfer ◽  
Gram Negative Bacteria ◽  
Drug Resistant ◽  
Gram Negative ◽  
Major Threat ◽  
Extensively Drug Resistant ◽  
Genes Encoding ◽  
Recent Developments ◽  
Almost All

Metallo-β-lactamases (MBLs) are a family of Zn(II)-dependent enzymes that can hydrolyze almost all β-lactam antibiotics. Horizontal transfer of the genes encoding MBLs among Gram-negative bacteria pathogens has led to the emergence of extensively drug-resistant pathogens, which now represent a major threat to human health. As there is not to date yet a clinically available MBL inhibitor, the discovery of new MBL inhibitors has great urgency. This review highlights the recent developments in the discovery of small-molecule MBL inhibitors.

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