scholarly journals Aromatic secondary amine-functionalized fluorescent NO probes: improved detection sensitivity for NO and potential applications in cancer immunotherapy studies

2019 ◽  
Vol 10 (1) ◽  
pp. 145-152 ◽  
Author(s):  
Yingying Huo ◽  
Junfeng Miao ◽  
Junru Fang ◽  
Hu Shi ◽  
Juanjuan Wang ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Secondary Amine ◽  
High Sensitivity ◽  
Detection Sensitivity ◽  
Tumor Associated Macrophages ◽  
Amine Functionalized ◽  
Potential Applications

Fluorescent NO probes reported herein display high sensitivity for NO by responding to both N2O3 and ONOO− and robust abilities for evaluating the repolarization of tumor-associated macrophages (TAMs).

scholarly journals High-sensitivity tunneling magneto-resistive micro-gyroscope with immunity to external magnetic interference

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Li Jin ◽  
Shi-Yang Qin ◽  
Rui Zhang ◽  
Meng-Wei Li
Keyword(s):  
Bridge Circuit ◽  
High Sensitivity ◽  
Micro Electro Mechanical System ◽  
Detection Sensitivity ◽  
Force Detection ◽  
Mems Gyroscope ◽  
Mems Gyroscopes ◽  
Potential Applications ◽  
Magneto Resistance ◽  
Total Sensitivity

Abstract Micro-electro-mechanical system (MEMS) gyroscopes have numerous potential applications including guidance, robotics, tactical-grade navigation, and automotive applications fields. The methods with ability of the weak Coriolis force detection are critical for MEMS gyroscopes. In this paper, we presented a design of MEMS gyroscope based on the tunneling magneto-resistance effect with higher detection sensitivity. Of all these designed parameters, the structural, magnetic field, and magneto-resistance sensitivity values reach to 21.6 nm/°/s, 0.0023 Oe/nm, and 29.5 mV/Oe, thus, with total sensitivity of 1.47 mV/°/s. Multi-bridge circuit method is employed to suppress external magnetic interference and avoid the integration error of the TMR devices effectively. The proposed tunneling magneto-resistive micro-gyroscope shows a possibility to make an inertial grade MEMS gyroscope in the future.

scholarly journals Functionalized Microstructured Optical Fibers: Materials, Methods, Applications

Materials ◽  
2020 ◽  
Vol 13 (4) ◽  
pp. 921 ◽  
Author(s):  
Timur Ermatov ◽  
Julia S. Skibina ◽  
Valery V. Tuchin ◽  
Dmitry A. Gorin
Keyword(s):  
Fiber Optics ◽  
Optical Fibers ◽  
Selective Adsorption ◽  
High Sensitivity ◽  
Detection Sensitivity ◽  
Guided Mode ◽  
Microstructured Optical Fiber ◽  
Potential Applications ◽  
Target Molecules ◽  
Biological Liquids

Microstructured optical fiber-based sensors (MOF) have been widely developed finding numerous applications in various fields of photonics, biotechnology, and medicine. High sensitivity to the refractive index variation, arising from the strong interaction between a guided mode and an analyte in the test, makes MOF-based sensors ideal candidates for chemical and biochemical analysis of solutions with small volume and low concentration. Here, we review the modern techniques used for the modification of the fiber’s structure, which leads to an enhanced detection sensitivity, as well as the surface functionalization processes used for selective adsorption of target molecules. Novel functionalized MOF-based devices possessing these unique properties, emphasize the potential applications for fiber optics in the field of modern biophotonics, such as remote sensing, thermography, refractometric measurements of biological liquids, detection of cancer proteins, and concentration analysis. In this work, we discuss the approaches used for the functionalization of MOFs, with a focus on potential applications of the produced structures.

scholarly journals Circulating Tumor Cells from Enumeration to Analysis: Current Challenges and Future Opportunities

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2723
Author(s):  
Yu-Ping Yang ◽  
Teresa M. Giret ◽  
Richard J. Cote
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Ex Vivo ◽  
Detection Sensitivity ◽  
Clinical Utilization ◽  
Diagnosis And Prognosis ◽  
Early Cancer Diagnosis ◽  
Potential Marker ◽  
Potential Applications ◽  
Downstream Analysis

Circulating tumor cells (CTCs) have been recognized as a major contributor to distant metastasis. Their unique role as metastatic seeds renders them a potential marker in the circulation for early cancer diagnosis and prognosis as well as monitoring of therapeutic response. In the past decade, researchers mainly focused on the development of isolation techniques for improving the recovery rate and purity of CTCs. These developed techniques have significantly increased the detection sensitivity and enumeration accuracy of CTCs. Currently, significant efforts have been made toward comprehensive molecular characterization, ex vivo expansion of CTCs, and understanding the interactions between CTCs and their associated cells (e.g., immune cells and stromal cells) in the circulation. In this review, we briefly summarize existing CTC isolation technologies and specifically focus on advances in downstream analysis of CTCs and their potential applications in precision medicine. We also discuss the current challenges and future opportunities in their clinical utilization.

scholarly journals High Sensitivity Continuous Monitoring of Chloroform Gas by Using Wavelength Modulation Photoacoustic Spectroscopy in the Near-Infrared Range

2021 ◽  
Vol 11 (15) ◽  
pp. 6992
Author(s):  
Tie Zhang ◽  
Yuxin Xing ◽  
Gaoxuan Wang ◽  
Sailing He
Keyword(s):  
Photoacoustic Spectroscopy ◽  
Continuous Monitoring ◽  
Near Infrared ◽  
Resonant Cavity ◽  
High Sensitivity ◽  
Industrial Applications ◽  
Detection Sensitivity ◽  
Infrared Range ◽  
Wavelength Modulation ◽  
Linear Coefficient

An optical system for gaseous chloroform (CHCl3) detection based on wavelength modulation photoacoustic spectroscopy (WMPAS) is proposed for the first time by using a distributed feedback (DFB) laser with a center wavelength of 1683 nm where chloroform has strong and complex absorption peaks. The WMPAS sensor developed possesses the advantages of having a simple structure, high-sensitivity, and direct measurement. A resonant cavity made of stainless steel with a resonant frequency of 6390 Hz was utilized, and eight microphones were located at the middle of the resonator at uniform intervals to collect the sound signal. All of the devices were integrated into an instrument box for practical applications. The performance of the WMPAS sensor was experimentally demonstrated with the measurement of different concentrations of chloroform from 63 to 625 ppm. A linear coefficient R2 of 0.999 and a detection sensitivity of 0.28 ppm with a time period of 20 s were achieved at room temperature (around 20 °C) and atmosphere pressure. Long-time continuous monitoring for a fixed concentration of chloroform gas was carried out to demonstrate the excellent stability of the system. The performance of the system shows great practical value for the detection of chloroform gas in industrial applications.

Targeted Delivery of Zoledronate to Tumor-Associated Macrophages for Cancer Immunotherapy

2019 ◽  
Vol 16 (5) ◽  
pp. 2249-2258 ◽  
Author(s):  
Xinlong Zang ◽  
Xiaoxu Zhang ◽  
Haiyang Hu ◽  
Mingxi Qiao ◽  
Xiuli Zhao ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Targeted Delivery ◽  
Tumor Associated Macrophages
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