scholarly journals Functionalized Microstructured Optical Fibers: Materials, Methods, Applications

Materials ◽  
2020 ◽  
Vol 13 (4) ◽  
pp. 921 ◽  
Author(s):  
Timur Ermatov ◽  
Julia S. Skibina ◽  
Valery V. Tuchin ◽  
Dmitry A. Gorin
Keyword(s):  
Fiber Optics ◽  
Optical Fibers ◽  
Selective Adsorption ◽  
High Sensitivity ◽  
Detection Sensitivity ◽  
Guided Mode ◽  
Microstructured Optical Fiber ◽  
Potential Applications ◽  
Target Molecules ◽  
Biological Liquids

Microstructured optical fiber-based sensors (MOF) have been widely developed finding numerous applications in various fields of photonics, biotechnology, and medicine. High sensitivity to the refractive index variation, arising from the strong interaction between a guided mode and an analyte in the test, makes MOF-based sensors ideal candidates for chemical and biochemical analysis of solutions with small volume and low concentration. Here, we review the modern techniques used for the modification of the fiber’s structure, which leads to an enhanced detection sensitivity, as well as the surface functionalization processes used for selective adsorption of target molecules. Novel functionalized MOF-based devices possessing these unique properties, emphasize the potential applications for fiber optics in the field of modern biophotonics, such as remote sensing, thermography, refractometric measurements of biological liquids, detection of cancer proteins, and concentration analysis. In this work, we discuss the approaches used for the functionalization of MOFs, with a focus on potential applications of the produced structures.

scholarly journals High-sensitivity tunneling magneto-resistive micro-gyroscope with immunity to external magnetic interference

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Li Jin ◽  
Shi-Yang Qin ◽  
Rui Zhang ◽  
Meng-Wei Li
Keyword(s):  
Bridge Circuit ◽  
High Sensitivity ◽  
Micro Electro Mechanical System ◽  
Detection Sensitivity ◽  
Force Detection ◽  
Mems Gyroscope ◽  
Mems Gyroscopes ◽  
Potential Applications ◽  
Magneto Resistance ◽  
Total Sensitivity

Abstract Micro-electro-mechanical system (MEMS) gyroscopes have numerous potential applications including guidance, robotics, tactical-grade navigation, and automotive applications fields. The methods with ability of the weak Coriolis force detection are critical for MEMS gyroscopes. In this paper, we presented a design of MEMS gyroscope based on the tunneling magneto-resistance effect with higher detection sensitivity. Of all these designed parameters, the structural, magnetic field, and magneto-resistance sensitivity values reach to 21.6 nm/°/s, 0.0023 Oe/nm, and 29.5 mV/Oe, thus, with total sensitivity of 1.47 mV/°/s. Multi-bridge circuit method is employed to suppress external magnetic interference and avoid the integration error of the TMR devices effectively. The proposed tunneling magneto-resistive micro-gyroscope shows a possibility to make an inertial grade MEMS gyroscope in the future.

scholarly journals Sensitivity Enhancement of Heterocore Macrobend Fiber Optics by Adding a ZnO Film

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Noor Azie Azura Mohd Arif ◽  
Dilla Duryha Berhanuddin ◽  
Abang Annuar Ehsan
Keyword(s):  
Refractive Index ◽  
Fiber Optics ◽  
Optical Fibers ◽  
High Sensitivity ◽  
Comsol Multiphysics ◽  
Zno Films ◽  
Curvature Radius ◽  
Optimum Thickness ◽  
Zno Film ◽  
The Relationship

Optical fibers with high sensitivity are in demand due to their great potential in sensor application. Semiconductors, such as ZnO, are good materials. Using them as a second cladding offers opportunities in realizing next-generation multimaterial fiber optics. COMSOL Multiphysics is used to simulate heterocore macrobend fiber optics with the same curvature radius but different values of refractive index and thickness of ZnO films. The optimum thickness of ZnO films is identified by determining the loss of optical fibers. Macrobend heterocore fiber optics by adding ZnO thin film has been established by simulating and interpreting the relationship in terms of transmission and refractive index in the evanescent field. These results will provide a reliable fundamental to guide the performance in practice.

scholarly journals Application of Fiber Optics in Bio-Sensing

2021 ◽  
Author(s):  
Lokendra Singh ◽  
Niteshkumar Agarwal ◽  
Himnashu Barthwal ◽  
Bhupal Arya ◽  
Taresh Singh
Keyword(s):  
Optical Fiber ◽  
Fiber Optics ◽  
Optical Fibers ◽  
Industrial Process ◽  
High Sensitivity ◽  
Integrated Electronics ◽  
Biomedical Sensing ◽  
Optical Fiber Sensing ◽  
Number Of Publications ◽  
Micro Organisms

The unique properties of optical fibers such as small size, immunity to electromagnetic radiation, high sensitivity with simpler sensing systems have found their applications from structural monitoring to biomedical sensing. The inclusion of optical transducers, integrated electronics and new immobilization methods, the optical fibers have been used in industrial process, environmental monitoring, food processing and clinical applications. Further, the optical fiber sensing research has also been extended to the area of detection of micro-organisms such as bacteria, viruses, fungi and protozoa. The validation of optical fibers in bio-sensing applications can be observed from the growing number of publications. This chapter provides a brief picture of optical fiber biosensors, their geometries including the necessary procedure for their development. This chapter could be a milestone for the young researchers to establish their laboratory.

scholarly journals Aromatic secondary amine-functionalized fluorescent NO probes: improved detection sensitivity for NO and potential applications in cancer immunotherapy studies

2019 ◽  
Vol 10 (1) ◽  
pp. 145-152 ◽  
Author(s):  
Yingying Huo ◽  
Junfeng Miao ◽  
Junru Fang ◽  
Hu Shi ◽  
Juanjuan Wang ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Secondary Amine ◽  
High Sensitivity ◽  
Detection Sensitivity ◽  
Tumor Associated Macrophages ◽  
Amine Functionalized ◽  
Potential Applications

Fluorescent NO probes reported herein display high sensitivity for NO by responding to both N2O3 and ONOO− and robust abilities for evaluating the repolarization of tumor-associated macrophages (TAMs).

scholarly journals High-Sensitivity Raman Gas Probe for In Situ Multi-Component Gas Detection

Sensors ◽  
2021 ◽  
Vol 21 (10) ◽  
pp. 3539
Author(s):  
Jinjia Guo ◽  
Zhao Luo ◽  
Qingsheng Liu ◽  
Dewang Yang ◽  
Hui Dong ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Optical Fibers ◽  
Signal Transmission ◽  
High Sensitivity ◽  
Multiple Reflection ◽  
Detection Sensitivity ◽  
Gas Detection ◽  
In Situ Detection ◽  
Lower Background

Multiple reflection has been proven to be an effective method to enhance the gas detection sensitivity of Raman spectroscopy, while Raman gas probes based on the multiple reflection principle have been rarely reported on. In this paper, a multi-reflection, cavity enhanced Raman spectroscopy (CERS) probe was developed and used for in situ multi-component gas detection. Owing to signal transmission through optical fibers and the miniaturization of multi-reflection cavity, the CERS probe exhibited the advantages of in situ detection and higher detection sensitivity. Compared with the conventional, backscattering Raman layout, the CERS probe showed a better performance for the detection of weak signals with a relatively lower background. According to the 3σ criteria, the detection limits of this CERS probe for methane, hydrogen, carbon dioxide and water vapor are calculated to be 44.5 ppm, 192.9 ppm, 317.5 ppm and 0.67%, respectively. The results presented the development of this CERS probe as having great potential to provide a new method for industrial, multi-component online gas detection.

Remote, Long-Pathlength Cell for High-Sensitivity Raman Spectroscopy

1987 ◽  
Vol 41 (1) ◽  
pp. 126-130 ◽  
Author(s):  
Scott D. Schwab ◽  
Richard L. McCreery
Keyword(s):  
Fiber Optics ◽  
Laser Light ◽  
Capillary Tube ◽  
High Sensitivity ◽  
Sample Tube ◽  
Increased Sensitivity ◽  
Sampling Systems ◽  
Power Densities ◽  
Objective Being ◽  
Focused Beam

Fiber optics were used to interface a Raman spectrometer to a long (1 m) sample tube, with the objective being increased sensitivity. Internal reflection of the laser light and the Raman scatter within the sample tube permitted a long solution length to be sampled, increasing the Raman sensitivity by factors of 30–50 over conventional capillary tube sampling systems. In addition, the sample was subjected to much lower power densities than with systems employing a focused beam, thus minimizing radiation damage. Detection limits of 10−9 to 10−8 M were achieved for resonance Raman scatterers, and normal Raman scatterers could be detected at the 1 × 10−5 M level.

scholarly journals Topological guided-mode resonances at non-Hermitian nanophotonic interfaces

Nanophotonics ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ki Young Lee ◽  
Kwang Wook Yoo ◽  
Youngsun Choi ◽  
Gunpyo Kim ◽  
Sangmo Cheon ◽  
...  
Keyword(s):  
Fundamental Study ◽  
One Dimensional ◽  
Guided Mode ◽  
Wall Structures ◽  
Potential Applications ◽  
Photonic Microstructures ◽  
Guided Mode Resonance ◽  
The One ◽  
Photonic Band ◽  
Topological Correlations

Abstract The topological properties of photonic microstructures are of great interest because of their experimental feasibility for fundamental study and potential applications. Here, we show that robust guided-mode-resonance states exist in photonic domain-wall structures whenever the complex photonic band structures involve certain topological correlations in general. Using the non-Hermitian photonic analogy of the one-dimensional Dirac equation, we derive essential conditions for photonic Jackiw-Rebbi-state resonances taking advantage of unique spatial confinement and spot-like spectral features which are remarkably robust against random parametric errors. Therefore, the proposed resonance configuration potentially provides a powerful method to create compact and stable photonic resonators for various applications in practice.

scholarly journals Circulating Tumor Cells from Enumeration to Analysis: Current Challenges and Future Opportunities

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2723
Author(s):  
Yu-Ping Yang ◽  
Teresa M. Giret ◽  
Richard J. Cote
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Ex Vivo ◽  
Detection Sensitivity ◽  
Clinical Utilization ◽  
Diagnosis And Prognosis ◽  
Early Cancer Diagnosis ◽  
Potential Marker ◽  
Potential Applications ◽  
Downstream Analysis

Circulating tumor cells (CTCs) have been recognized as a major contributor to distant metastasis. Their unique role as metastatic seeds renders them a potential marker in the circulation for early cancer diagnosis and prognosis as well as monitoring of therapeutic response. In the past decade, researchers mainly focused on the development of isolation techniques for improving the recovery rate and purity of CTCs. These developed techniques have significantly increased the detection sensitivity and enumeration accuracy of CTCs. Currently, significant efforts have been made toward comprehensive molecular characterization, ex vivo expansion of CTCs, and understanding the interactions between CTCs and their associated cells (e.g., immune cells and stromal cells) in the circulation. In this review, we briefly summarize existing CTC isolation technologies and specifically focus on advances in downstream analysis of CTCs and their potential applications in precision medicine. We also discuss the current challenges and future opportunities in their clinical utilization.

scholarly journals High Sensitivity Continuous Monitoring of Chloroform Gas by Using Wavelength Modulation Photoacoustic Spectroscopy in the Near-Infrared Range

2021 ◽  
Vol 11 (15) ◽  
pp. 6992
Author(s):  
Tie Zhang ◽  
Yuxin Xing ◽  
Gaoxuan Wang ◽  
Sailing He
Keyword(s):  
Photoacoustic Spectroscopy ◽  
Continuous Monitoring ◽  
Near Infrared ◽  
Resonant Cavity ◽  
High Sensitivity ◽  
Industrial Applications ◽  
Detection Sensitivity ◽  
Infrared Range ◽  
Wavelength Modulation ◽  
Linear Coefficient

An optical system for gaseous chloroform (CHCl3) detection based on wavelength modulation photoacoustic spectroscopy (WMPAS) is proposed for the first time by using a distributed feedback (DFB) laser with a center wavelength of 1683 nm where chloroform has strong and complex absorption peaks. The WMPAS sensor developed possesses the advantages of having a simple structure, high-sensitivity, and direct measurement. A resonant cavity made of stainless steel with a resonant frequency of 6390 Hz was utilized, and eight microphones were located at the middle of the resonator at uniform intervals to collect the sound signal. All of the devices were integrated into an instrument box for practical applications. The performance of the WMPAS sensor was experimentally demonstrated with the measurement of different concentrations of chloroform from 63 to 625 ppm. A linear coefficient R2 of 0.999 and a detection sensitivity of 0.28 ppm with a time period of 20 s were achieved at room temperature (around 20 °C) and atmosphere pressure. Long-time continuous monitoring for a fixed concentration of chloroform gas was carried out to demonstrate the excellent stability of the system. The performance of the system shows great practical value for the detection of chloroform gas in industrial applications.

scholarly journals Monitoring of a Highly Flexible Aircraft Model Wing Using Time-Expanded Phase-Sensitive OTDR

Sensors ◽  
2021 ◽  
Vol 21 (11) ◽  
pp. 3766
Author(s):  
Miguel Soriano-Amat ◽  
David Fragas-Sánchez ◽  
Hugo F. Martins ◽  
David Vallespín-Fontcuberta ◽  
Javier Preciado-Garbayo ◽  
...  
Keyword(s):  
Optical Fibers ◽  
Fuel Efficiency ◽  
Optical Fiber Sensor ◽  
High Sensitivity ◽  
Time Domain Reflectometry ◽  
Structural Deformation ◽  
Flexible Wings ◽  
Sensing Technology ◽  
Distributed Optical Fiber Sensor ◽  
Phase Sensitive

In recent years, the use of highly flexible wings in aerial vehicles (e.g., aircraft or drones) has been attracting increasing interest, as they are lightweight, which can improve fuel-efficiency and distinct flight performances. Continuous wing monitoring can provide valuable information to prevent fatal failures and optimize aircraft control. In this paper, we demonstrate the capabilities of a distributed optical fiber sensor based on time-expanded phase-sensitive optical time-domain reflectometry (TE-ΦOTDR) technology for structural health monitoring of highly flexible wings, including static (i.e., bend and torsion), and dynamic (e.g., vibration) structural deformation. This distributed sensing technology provides a remarkable spatial resolution of 2 cm, with detection and processing bandwidths well under the MHz, arising as a novel, highly efficient monitoring methodology for this kind of structure. Conventional optical fibers were embedded in two highly flexible specimens that represented an aircraft wing, and different bending and twisting movements were detected and quantified with high sensitivity and minimal intrusiveness.

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