Dual-loaded, long-term sustained drug releasing and thixotropic hydrogel for localized chemotherapy of cancer

2019 ◽  
Vol 7 (7) ◽  
pp. 2975-2985 ◽  
Author(s):  
Han Cao ◽  
Yu Duan ◽  
Qinrui Lin ◽  
Yuhong Yang ◽  
Zuguang Gong ◽  
...  
Keyword(s):  
Side Effects ◽  
Drug Release ◽  
Silk Fibroin ◽  
Anticancer Therapy ◽  
Regenerated Silk Fibroin ◽  
Dual Drug

A thixotropic injectable regenerated silk fibroin/hydroxypropylcellulose (RSF/HPC) hydrogel for highly sustainable dual-drug release with improved anticancer therapy and alleviated side effects.

scholarly journals Dual-Drug-Loaded Silk Fibroin/PLGA Scaffolds for Potential Bone Regeneration Applications

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Jihang Yao ◽  
Yilong Wang ◽  
Wendi Ma ◽  
Wenying Dong ◽  
Mei Zhang ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Bone Regeneration ◽  
Silk Fibroin ◽  
Bone Morphogenetic Protein 2 ◽  
Burst Release ◽  
Nanofiber Membrane ◽  
Differentiation Potential ◽  
Dual Drug

Developing scaffold materials with excellent biocompatibility, mechanical properties, and controlled drug release properties is vital to tissue engineering. In this study, we fabricated silk fibroin (SF)/poly(lactide-co-glycolide) (PLGA) nanofiber scaffolds containing recombinant human bone morphogenetic protein 2 (rhBMP2) and dexamethasone (DXM) via coaxial electrospinning, which were used in in vitro bone formation with rat bone marrow mesenchymal stem cells (rBMSCs). An in vitro drug release study was adopted to evaluate the sustained release potential of the core-shell structured nanofibers. Furthermore, we detected the potential of the SF/PLGA nanofiber membrane in vitro. In vitro studies showed that rhBMP2 still remained active on the nanofiber membrane. In addition, the dual-drug-loaded nanofiber membrane showed an early burst release of DXM and late sustained release of rhBMP2. rhBMP2 and DXM exhibited strong osteogenic differentiation potential when they acted on rBMSCs. Therefore, the SF/PLGA nanofiber membrane loaded with rhBMP2 and DXM has great potential for the enhancement of bone regeneration.

scholarly journals Fabrication of aqueous-based dual drug loaded silk fibroin electrospun nanofibers embedded with curcumin-loaded RSF nanospheres for drugs controlled release

RSC Advances ◽  
2017 ◽  
Vol 7 (89) ◽  
pp. 56550-56558 ◽  
Author(s):  
Huijun Li ◽  
Jingxin Zhu ◽  
Song Chen ◽  
Lan Jia ◽  
Yanlong Ma
Keyword(s):  
Controlled Release ◽  
Silk Fibroin ◽  
Electrospun Nanofibers ◽  
Electrospinning Technique ◽  
Regenerated Silk Fibroin ◽  
Dual Drug

This paper presents a new nanofabrication method for dual drug loaded regenerated silk fibroin (RSF) nanofibers, based on a simple, colloid-electrospinning technique.

Silk fibroin-based vascular repairing sheet with angiogenic-promoting activity of SVVYGLR peptide regenerated the damaged vascular in rats

2020 ◽  
pp. 088532822092866
Author(s):  
Kazumi Shimada ◽  
Tadakatsu Honda ◽  
Kounosuke Kato ◽  
Ryosei Hori ◽  
Naoki Ujike ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Smooth Muscle ◽  
Side Effects ◽  
Silk Fibroin ◽  
Cell Layer ◽  
Histological Evaluation ◽  
Small Vessels ◽  
Fibrous Protein ◽  
Artificial Materials

Medical sheets are useful in surgically repair vascular disease. To avoid long-term side effects, they are to be replaced with regenerated tissue after implantation. Silk fibroin is a fibrous protein secreted by silkworm. The advantage of silk fibroin is its biocompatibility and has been used as regenerative artificial materials. The problem of its biodegradability is that the effect is time consuming. In this study, SVVYGLR peptide was used to expect promoting cell migration and accelerating the biodegradation of silk fibroin. Silk fibroin and polyurethane-based medical sheets with or without SVVYGLR peptide were implanted in rat abdominal aorta (silk fibroin/polyurethane/SVVYGLR peptide versus silk fibroin/polyurethane). The result of histological evaluation indicated that the new cell layer created under both sheets was composed of endothelial cells, smooth muscle, and fibroin in both sheets and similar to a native vessel. Both sheets did not show any excessive inflammation or calcification, and moderate biodegradability was observed. The decrease of silk fibroin indicated the biodegradability of all sheets. Silk fibroin/polyurethane/SVVYGLR peptide had many small vessels in the regenerated tissue than silk fibroin/polyurethane. This appearance indicated that SVVYGLR peptide promoted the angiogenesis in the regenerative tissue. This study suggested that SVVYGLR peptide could give the angiogenic-promoting activity to silk fibroin-based vascular repairing sheet.

Silk fibroin H-fibroin/poly(ε-caprolactone) core-shell nanofibers with enhanced mechanical property and long-term drug release

2021 ◽  
Vol 593 ◽  
pp. 142-151
Author(s):  
Zengkai Wang ◽  
Xiaolu Song ◽  
Yanhua Cui ◽  
Kai Cheng ◽  
Xiaohua Tian ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Drug Release ◽  
Silk Fibroin ◽  
Core Shell

scholarly journals Facile Fabrication of Composite Scaffolds for Long-Term Controlled Dual Drug Release

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Dawei Li ◽  
Chao Li ◽  
Xing Wang ◽  
Chunlin Li ◽  
Tunan Sun ◽  
...  
Keyword(s):  
Drug Release ◽  
Entrapment Efficiency ◽  
Water Soluble ◽  
Composite Scaffolds ◽  
Formidable Challenge ◽  
Facile Fabrication ◽  
Bone Tuberculosis ◽  
In Virtue Of ◽  
Dual Drug

Bone tuberculosis (TB) caused by mycobacterium tuberculosis continues to present a formidable challenge to humans. To effectively cure serious bone TB, a novel kind of composite scaffolds with long-term dual drug release behaviours were prepared to satisfy the needs of both bone regeneration and antituberculosis drug therapy. In virtue of an improved O/W emulsion technique, water-soluble isoniazid (INH)-loaded gelatin microparticles were obtained by tailoring the content of β-tricalcium phosphate (β-TCP), which played significant roles in INH entrapment efficiency and drug release behaviours. By mixing with the poly(ε-caprolactone)-block-poly (lactic-co-glycolic acid) (b-PLGC) solution containing oil-soluble rifampicin (RFP) via the particle leaching combined with phase separation technique, the dual drugs-loaded composite scaffolds were fabricated, which possessed interconnected porous structures and achieved the steady release of INH and RFP drugs for three months. Moreover, this dual drugs-loaded system could basically achieve their expectant roles of respective drugs without obvious influences with each other. This strategy on preparation of intelligent composite scaffolds with the multi-drugs loading capacity and controlled long-term release behaviour will be potential and promising substrates in clinical treatment of bone tuberculosis.

scholarly journals Silk Fibroin-Coated Liposomes as Biomimetic Nanocarrier for Long-Term Release Delivery System in Cancer Therapy

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4936
Author(s):  
Chanon Suyamud ◽  
Chanita Phetdee ◽  
Thanapak Jaimalai ◽  
Panchika Prangkio
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Anticancer Activity ◽  
Silk Fibroin ◽  
Delivery System ◽  
Drug Carrier ◽  
In Vitro Release ◽  
Potential Measurement ◽  
Wide Range

Despite much progress in cancer therapy, conventional chemotherapy can cause poor biodistribution and adverse side-effects on healthy cells. Currently, various strategies are being developed for an effective chemotherapy delivery system. Silk fibroin (SF) is a natural protein used in a wide range of biomedical applications including cancer therapy due to its biocompatibility, biodegradability, and unique mechanical properties. In this study, SF-coated liposomes (SF-LPs) were prepared as a biomimetic drug carrier. Physicochemical properties of SF-LPs were characterized by Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering, zeta potential measurement, and transmission electron microscopy (TEM). In vitro release of SF-LPs loaded with doxorubicin (DOX-SF-LPs) was evaluated over 21 days. Anticancer activity of DOX-SF-LPs was determined against MCF-7 and MDA-MB231 cells using the MTT assay. SF-LPs containing 1% SF exhibited favorable characteristics as a drug carrier. SF coating modified the kinetics of drug release and reduced the cytotoxic effect against L929 fibroblasts as compared to the uncoated liposomes containing cationic lipid. DOX-SF-LPs showed anticancer activity against breast cancer cells after 48 h or 72 h at 20 μM of DOX. This approach provides a potential platform of long-term release that combines biocompatible SF and phospholipids for cancer therapy, achieving efficient drug delivery and reducing side-effects.

scholarly journals Residual Fertility in Childhood Cancer Survivors

2007 ◽  
Vol 1 (2) ◽  
pp. 1-9
Author(s):  
Cesare Battaglia ◽  
Fulvia Mancini ◽  
Nicola Persico ◽  
Arianna Cianciosi ◽  
Paolo Busacchi ◽  
...  
Keyword(s):  
Side Effects ◽  
Hematological Malignancies ◽  
Young Patients ◽  
Childhood Cancer Survivors ◽  
Anticancer Therapy ◽  
Premature Menopause ◽  
The Past ◽  
Made In ◽  
Restoration Of Fertility

Abstract During the past three decades, major improvements have been made in the treatment and cure of certain hematological malignancies, as well as solid tumors in young patients. As a result of improved survival, attention has been turned to the long-term physical and psychological sequelae of treatment. The loss of fertility in males and premature menopause in females are important and common long-term side effects of curative radio- and chemotherapy. The frequency of fertility failure varies with the type, dose, duration of radio- and chemotherapy, and age of patient. Currently, there are no good estimates of the magnitude of the risk involved in relation to these factors. However, the combination of hormonal values, pubertal staging and the ultrasonography and Doppler analyses of the gonads may noninvasively study the subtle modification following anticancer therapies. This could help to find new insights on potential preventive acts before initiation of the anticancer therapy, and hopefully, the restoration of fertility after treatment.

Synergistic mediation of tumor signaling pathways in hepatocellular carcinoma therapy via dual-drug-loaded pH-responsive electrospun fibrous scaffolds

2015 ◽  
Vol 3 (17) ◽  
pp. 3436-3446 ◽  
Author(s):  
Ziming Yuan ◽  
Xin Zhao ◽  
Jingwen Zhao ◽  
Guoqing Pan ◽  
Wangwang Qiu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Release ◽  
Cancer Drug ◽  
Ph Responsive ◽  
Short Term ◽  
Fibrous Scaffold ◽  
Anti Cancer ◽  
Anti Inflammation ◽  
Dual Drug

A novel pH-sensitive electrospun composite PLLA fibrous scaffold was developed with long-term anti-cancer drug release and short-term anti-inflammation drug release for liver cancer therapy.

Cutaneous ulcers following hydroxyurea therapy

Phlebologie ◽  
2004 ◽  
Vol 33 (06) ◽  
pp. 202-205 ◽  
Author(s):  
K. Hartmann ◽  
S. Nagel ◽  
T. Erichsen ◽  
E. Rabe ◽  
K. H. Grips ◽  
...  
Keyword(s):  
Side Effects ◽  
Side Effect ◽  
Antineoplastic Agent ◽  
Limited Time ◽  
Myeloproliferative Diseases ◽  
Dermatological Side Effects ◽  
Chronic Myeloproliferative Diseases ◽  
Hydroxyurea Therapy

SummaryHydroxyurea (HU) is usually a well tolerated antineoplastic agent and is commonly used in the treatment of chronic myeloproliferative diseases. Dermatological side effects are frequently seen in patients receiving longterm HU therapy. Cutaneous ulcers have been reported occasionally.We report on four patients with cutaneous ulcers whilst on long-term hydroxyurea therapy for myeloproliferative diseases. In all patients we were able to reduce the dose, or stop HU altogether and their ulcers markedly improved. Our observations suggest that cutaneous ulcers should be considered as possible side effect of long-term HU therapy and healing of the ulcers can be achieved not only by cessation of the HU treatment, but also by reducing the dose of hydroxyurea for a limited time.

Long-term side effects following pneumonectomy: A case report and review of the literature

2019 ◽  
Author(s):  
BA Högerle ◽  
EL Bulut ◽  
L Klotz ◽  
F Eichhorn ◽  
M Eichhorn ◽  
...  
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Review Of The Literature
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