scholarly journals A metalloproteomic analysis of interactions between plasma proteins and zinc: elevated fatty acid levels affect zinc distribution

Metallomics ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1805-1819 ◽  
Author(s):  
James P. C. Coverdale ◽  
James P. Barnett ◽  
Adamu H. Adamu ◽  
Ellie J. Griffiths ◽  
Alan J. Stewart ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Serum Albumin ◽  
Plasma Proteins ◽  
Zinc Binding ◽  
Plasma Fatty Acid ◽  
Plasma Zinc ◽  
Binding Ability ◽  
Fatty Acid Binding ◽  
Zinc Speciation ◽  
Zinc Distribution

Serum albumin is the major zinc carrier in blood plasma. Fatty acid binding to albumin regulates its zinc-binding ability and alters plasma zinc speciation.

scholarly journals Albumin-mediated alteration of plasma zinc speciation by fatty acids modulates blood clotting in type-2 diabetes

2021 ◽  
Author(s):  
Amélie I. S. Sobczak ◽  
Kondwani G. H. Katundu ◽  
Fladia A. Phoenix ◽  
Siavash Khazaipoul ◽  
Ruitao Yu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Blood Clotting ◽  
Plasma Zinc ◽  
Zinc Speciation

Zn2+ is an essential regulator of coagulation. In plasma, Zn2+ availability is fine-tuned by human serum albumin (HSA). Here we show that elevated fatty acid levels contribute to altered coagulation in type-2 diabetes through Zn2+ mishandling by HSA.

Albumin as a zinc carrier: properties of its high-affinity zinc-binding site

2008 ◽  
Vol 36 (6) ◽  
pp. 1317-1321 ◽  
Author(s):  
Jin Lu ◽  
Alan J. Stewart ◽  
Peter J. Sadler ◽  
Teresa J.T. Pinheiro ◽  
Claudia A. Blindauer
Keyword(s):  
Fatty Acid ◽  
Serum Albumin ◽  
Molecular Mechanisms ◽  
Zinc Binding ◽  
Serum Albumins ◽  
Fatty Acid Binding ◽  
Zinc Binding Site ◽  
Essential Nutrient ◽  
The Subject ◽  
Zinc Site

Although details of the molecular mechanisms for the uptake of the essential nutrient zinc into the bloodstream and its subsequent delivery to zinc-requiring organs and cells are poorly understood, it is clear that in vertebrates the majority of plasma zinc (9–14 μM; approx. 75–85%) is bound to serum albumin, constituting part of the so-called exchangeable pool. The binding of metal ions to serum albumins has been the subject of decades of studies, employing a multitude of techniques, but only recently has the identity and putative structure of the major zinc site on albumin been reported. Intriguingly, this site is located at the interface between two domains, and involves two residues from each of domains I and II. Comparisons of X-ray crystal structures of free and fatty-acid bound human serum albumin suggest that zinc binding to this site and fatty acid binding to one of the five major sites may be interdependent. Interactive binding of zinc and long-chain fatty acids to albumin may therefore have physiological implications.

Kinetics of fatty acid binding ability of glycated human serum albumin

2005 ◽  
Vol 30 (4) ◽  
pp. 475-481 ◽  
Author(s):  
Eiji Yamazaki ◽  
Minoru Inagaki ◽  
Osamu Kurita ◽  
Tetsuji Inoue
Keyword(s):  
Fatty Acid ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Binding Ability ◽  
Fatty Acid Binding ◽  
Kinetics Of

scholarly journals Bariatric Surgery Is Accompanied by Changes in Extracellular Vesicle-Associated and Plasma Fatty Acid Binding Protein 4

2017 ◽  
Vol 28 (3) ◽  
pp. 767-774 ◽  
Author(s):  
Justyna K. Witczak ◽  
Thinzar Min ◽  
Sarah L. Prior ◽  
Jeffrey W. Stephens ◽  
Philip E. James ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Extracellular Vesicle ◽  
Plasma Fatty Acid ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Comparison of plasma fatty acid binding protein 4 concentration in venous and capillary blood

PLoS ONE ◽  
2019 ◽  
Vol 14 (12) ◽  
pp. e0226374
Author(s):  
Shigeharu Numao ◽  
Yoshinori Nagasawa ◽  
Naomi Goromaru ◽  
Shunichi Tamaki
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Capillary Blood ◽  
Plasma Fatty Acid ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals S-Nitrosylated Human Serum Albumin-mediated Cytoprotective Activity Is Enhanced by Fatty Acid Binding

2008 ◽  
Vol 283 (50) ◽  
pp. 34966-34975 ◽  
Author(s):  
Yu Ishima ◽  
Takaaki Akaike ◽  
Ulrich Kragh-Hansen ◽  
Shuichi Hiroyama ◽  
Tomohiro Sawa ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Fatty Acid Binding ◽  
Cytoprotective Activity

scholarly journals Plasma Fatty Acid-Binding Protein 4, Nonesterified Fatty Acids, and Incident Diabetes in Older Adults

Diabetes Care ◽  
2012 ◽  
Vol 35 (8) ◽  
pp. 1701-1707 ◽  
Author(s):  
L. Djousse ◽  
O. Khawaja ◽  
T. M. Bartz ◽  
M. L. Biggs ◽  
J. H. Ix ◽  
...  
Keyword(s):  
Older Adults ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Incident Diabetes ◽  
Plasma Fatty Acid ◽  
Fatty Acid Binding ◽  
Nonesterified Fatty Acids ◽  
Acid Binding Protein
Sign in / Sign up

Export Citation Format

Share Document