scholarly journals ZBTB20-mediated titanium particle-induced peri-implant osteolysis by promoting macrophage inflammatory responses

2020 ◽  
Vol 8 (11) ◽  
pp. 3147-3163
Author(s):  
Junxiong Qiu ◽  
Peng Peng ◽  
Min Xin ◽  
Zhenkang Wen ◽  
Zhong Chen ◽  
...  
Keyword(s):  
Aseptic Loosening ◽  
Inflammatory Responses ◽  
Wear Particles ◽  
Titanium Particle ◽  
Artificial Joints

Aseptic loosening (AL) caused by wear particles released from implant surfaces is one of the main causes for the failure of artificial joints, which is initiated by macrophage inflammatory responses.

scholarly journals Particle Disease: A Current Review of the Biological Mechanisms in Periprosthetic Osteolysis After Hip Arthroplasty

2016 ◽  
Vol 10 (1) ◽  
pp. 241-251 ◽  
Author(s):  
Erhan Sukur ◽  
Yunus Emre Akman ◽  
Yusuf Ozturkmen ◽  
Fatih Kucukdurmaz
Keyword(s):  
Aseptic Loosening ◽  
Hip Arthroplasty ◽  
Inflammatory Responses ◽  
Therapeutic Interventions ◽  
Wear Particles ◽  
Biological Mechanisms ◽  
Prosthesis Loosening ◽  
Periprosthetic Osteolysis ◽  
Aseptic Prosthesis Loosening

Background:Inflammatory responses to wear debris cause osteolysis that leads to aseptic prosthesis loosening and hip arthroplasty failure. Although osteolysis is usually associated with aseptic loosening, it is rarely seen around stable implants. Aseptic implant loosening is a simple radiologic phenomenon, but a complex immunological process. Particulate debris produced by implants most commonly causes osteolysis, and this is called particle-associated periprosthetic osteolysis (PPO).Objective:The objective of this review is to outline the features of particle-associated periprosthetic osteolysis to allow the physician to recognise this condition and commence early treatment, thereby optimizing patient outcome.Methods:A thorough literature search was performed using available databases, including Pubmed, to cover important research published covering particle-associated PPO.Results:Although osteolysis causes bone resorption, clinical, animal, andin vitrostudies of particle bioreactivity suggest that particle-associated PPO represents the culmination of several biological reactions of many cell types, rather than being caused solely by the osteoclasts. The biological activity is highly dependent on the characteristics and quantity of the wear particles.Conclusion:Despite advances in total hip arthroplasty (THA), particle-associated PPO and aseptic loosening continue to be major factors that affect prosthetic joint longevity. Biomarkers could be exploited as easy and objective diagnostic and prognostic targets that would enable testing for osteolysis after THA. Further research is needed to identify new biomarkers in PPO. A comprehensive understanding of the underlying biological mechanisms is crucial for developing new therapeutic interventions to reverse or suppress biological responses to wear particles.

scholarly journals Morphological residual convolutional neural network (M-RCNN) for intelligent recognition of wear particles from artificial joints

Friction ◽  
2021 ◽  
Author(s):  
Xiaobin Hu ◽  
Jian Song ◽  
Zhenhua Liao ◽  
Yuhong Liu ◽  
Jian Gao ◽  
...  
Keyword(s):  
Neural Network ◽  
Convolutional Neural Network ◽  
Data Augmentation ◽  
Support Vector ◽  
Wear Particles ◽  
Artificial Joints ◽  
Performance Deterioration ◽  
Overall Performance ◽  
Correct Category ◽  
Intelligent Recognition

AbstractFinding the correct category of wear particles is important to understand the tribological behavior. However, manual identification is tedious and time-consuming. We here propose an automatic morphological residual convolutional neural network (M-RCNN), exploiting the residual knowledge and morphological priors between various particle types. We also employ data augmentation to prevent performance deterioration caused by the extremely imbalanced problem of class distribution. Experimental results indicate that our morphological priors are distinguishable and beneficial to largely boosting overall performance. M-RCNN demonstrates a much higher accuracy (0.940) than the deep residual network (0.845) and support vector machine (0.821). This work provides an effective solution for automatically identifying wear particles and can be a powerful tool to further analyze the failure mechanisms of artificial joints.

Autophagy inhibitors 3-MA and LY294002 repress osteoclastogenesis and titanium particle-stimulated osteolysis

2021 ◽  
Author(s):  
Weishen Chen ◽  
Guoyan Xian ◽  
Minghui Gu ◽  
Baiqi Pan ◽  
Xiaoyu Wu ◽  
...  
Keyword(s):  
Aseptic Loosening ◽  
Joint Replacement ◽  
Revision Surgery ◽  
Wear Particle ◽  
Common Complication ◽  
Titanium Particle ◽  
Inflammation Response

Aseptic loosening caused by peri-implant osteolysis (PIO) is a common complication after joint replacement, and there is still no better treatment than revision surgery. The wear particle-induced inflammation response, especially...

Resveratrol Protects against Titanium Particle-Induced Aseptic Loosening Through Reduction of Oxidative Stress and Inactivation of NF-κB

Inflammation ◽  
2016 ◽  
Vol 39 (2) ◽  
pp. 775-785 ◽  
Author(s):  
Guotian Luo ◽  
Ziqing Li ◽  
Yu Wang ◽  
Haixing Wang ◽  
Ziji Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aseptic Loosening ◽  
Titanium Particle

Bionic Lubrication System of Artificial Joints: System Design and Mechanics Simulation

2005 ◽  
Author(s):  
S. H. Su ◽  
J. H. Zhang ◽  
D. H. Tao
Keyword(s):  
Three Dimensional ◽  
Joint Capsule ◽  
The Body ◽  
Artificial Joint ◽  
Lubrication System ◽  
Wear Particles ◽  
Element Analysis ◽  
Artificial Joints ◽  
Fea Model ◽  
Capsule Thickness

A new structure of artificial joints with bionic joint capsule was proposed and designed to overcome the feedback of current prostheses that omitted many functions of lubricant and joint capsule. The new structure was composed of three components: therapeutic lubricant, artificial joints and artificial joint capsule. The lubricant sealed by capsule not only can reduce the wear of artificial joints but also can prohibit the wear particles leaking to the body liquid. So the unwilling reactions between the wear particles and liquid may be avoided completely. Meanwhile, a three-dimensional (3-D) finite element analysis (FEA) model was created for the bionic artificial joints with joint capsule. The effects of capsule thickness and the flexion angels on the stress values and distributions were discussed in detail.

scholarly journals Micrometer-Sized Titanium Particles Induce Aseptic Loosening in Rabbit Knee

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Hao Xu ◽  
Cui-cui Guo ◽  
Zheng-yu Gao ◽  
Chang-yao Wang ◽  
Hai-ning Zhang ◽  
...  
Keyword(s):  
Aseptic Loosening ◽  
Bone Ingrowth ◽  
Osteoclast Differentiation ◽  
Rabbit Model ◽  
Medullary Cavity ◽  
Inflammatory Factors ◽  
Control Group ◽  
Titanium Particle ◽  
Effective Prevention ◽  
Rabbit Knee

Wear debris induced aseptic loosening is the leading cause of total knee arthroplasty (TKA) failure. The complex mechanism of aseptic loosening has been a major issue for introducing effective prevention and treatment methods, so a simplified yet efficient rabbit model was established to address this concern with the use of micrometer-sized titanium particles. 20 New Zealand white rabbits were selected and divided into two groups (control = 10, study = 10). A TKA surgery was then performed for each of them, with implantation of a titanium rod prosthesis which was coated evenly with micrometer-sized titanium in the study group and nothing in the control group, into right femoral medullary cavity. After 12 weeks, all the animals were euthanized and X-ray analyses, H&E staining, Goldner Masson trichrome staining, Von Kossa staining, PCR, and Western blotting of some specific mRNAs and proteins in the interface membrane tissues around the prosthesis were carried out. The implantation of a titanium rod prosthesis coated with 20 μm titanium particles into the femoral medullary cavity of rabbits caused continuous titanium particle stimulation around the prosthesis, effectively inducing osteolysis and aseptic loosening. Titanium particle-induced macrophages produce multiple inflammatory factors able to activate osteoclast differentiation through the OPG/RANKL/RANK signaling pathway, resulting in osteolysis while suppressing the function of osteoblasts and reducing bone ingrowth around the prosthesis. This model simulated the implantation and loosening process of an artificial prosthesis, which is an ideal etiological model to study the aseptic prosthetic loosening.

scholarly journals The USP14–NLRC5 pathway inhibits titanium particle–induced osteolysis in mice by suppressing NF-κB and PI3K/AKT activities

2020 ◽  
Vol 295 (20) ◽  
pp. 7018-7032 ◽  
Author(s):  
Guibin Fang ◽  
Yuan Fu ◽  
Shixun Li ◽  
Junxiong Qiu ◽  
Manyuan Kuang ◽  
...  
Keyword(s):  
Macrophage Polarization ◽  
Wear Particle ◽  
Wear Particles ◽  
Titanium Particle ◽  
Pathway Activation ◽  
M1 Macrophage ◽  
Phosphoinositide 3 Kinase ◽  
Factor Α

Total hip arthroplasty (THA) is a widely-used surgical intervention for treating patients with end-stage degenerative and inflammatory osteoarthropathy. However, wear particles from the artificial titanium joint can induce osteolysis, limiting the long-term survivorship of THA. Monocyte/macrophage lineage cells are the key players in the response to wear particles, and the proinflammatory NF-κB and phosphoinositide 3-kinase (PI3K)–AKT Ser/Thr kinase (AKT)-signaling pathways have been shown to be the most important contributors to wear particle–induced osteolysis. In contrast, ubiquitin-specific protease 14 (USP14) specifically removes the polyubiquitin chains from the nucleotide-binding and oligomerization domain (NOD)-like receptor family Caspase recruitment domain (CARD)–containing 5 (NLRC5) and thereby enhances the NLRC5-mediated inhibition of NF-κB signaling. In this study, we aimed to clarify the role of the USP14–NLRC5 pathway in wear particle–induced osteolysis in vitro and in vivo. We found that NLRC5 or USP14 overexpression inhibits titanium particle–induced proinflammatory tumor necrosis factor α (TNFα) production and NF-κB pathway activation, and it also decreases M1 macrophage polarization and PI3K/AKT pathway activation. Of note, NLRC5 and USP14 overexpression attenuated titanium particle–induced cranial osteolysis in mice. In conclusion, the findings of our study indicate that the USP14–NLRC5 pathway inhibits titanium particle–induced osteolysis by suppressing the NF-κB and PI3K/AKT pathways both in vitro and in vivo.

scholarly journals Evaluation of Aerosol Electrospray Analysis of Metal-on-Metal Wear Particles from Simulated Total Joint Replacement

Sensors ◽  
2019 ◽  
Vol 19 (17) ◽  
pp. 3751 ◽  
Author(s):  
Gobert von Skrbensky ◽  
Karoline Mühlbacher ◽  
Emir Benca ◽  
Alexander Kolb ◽  
Reinhard Windhager ◽  
...  
Keyword(s):  
Joint Replacement ◽  
Wear Debris ◽  
Total Joint Replacement ◽  
Wear Particles ◽  
Particle Detection ◽  
Metal Debris ◽  
Artificial Joints ◽  
Hip Simulator ◽  
Metal On Metal ◽  
Metal Wear

Wear is a common cause for aseptic loosening in artificial joints. The purpose of this study was to develop an automated diagnostical method for identification of the number and size distribution of wear debris. For this purpose, metal debris samples were extracted from a hip simulator and then analyzed by the electrospray method combined with a differential mobility analyzer, allowing particle detection ranging from several nanometers up to 1 µm. Wear particles were identified with a characteristic peak at 15 nm. The electrospray setup was successfully used and validated for the first time to characterize wear debris from simulated total joint replacement. The advantages of this diagnostic method are its time- and financial efficiency and its suitability for testing of different materials.

scholarly journals The Role of TLR and Chemokine in Wear Particle-Induced Aseptic Loosening

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Qiaoli Gu ◽  
Qin Shi ◽  
Huilin Yang
Keyword(s):  
Inflammatory Response ◽  
Aseptic Loosening ◽  
Osteoclast Differentiation ◽  
Adaptor Protein ◽  
Wear Particle ◽  
Cellular Migration ◽  
Cellular Interaction ◽  
Wear Particles ◽  
Orthopaedic Implants ◽  
Inhibitory Protein

Wear particle-induced periprosthetic osteolysis remains the principal cause of aseptic loosening of orthopaedic implants. Monocytes/macrophages phagocytose wear particles and release cytokines that induce inflammatory response. This response promotes osteoclast differentiation and osteolysis. The precise mechanisms by which wear particles are recognized and induce the accumulation of inflammatory cells in the periprosthetic tissue have not been fully elucidated. Recent studies have shown that toll-like receptors (TLRs) contribute to the cellular interaction with wear particles. Wear particles are recognized by monocytes/macrophages through TLRs coupled with the adaptor protein MyD88. After the initial interaction, wear particles induce both local and systemic migration of monocytes/macrophages to the periprosthetic region. The cellular migration is mediated through chemokines including interleukin-8, macrophage chemotactic protein-1, and macrophage inhibitory protein-1 in the periprosthetic tissues. Interfering with chemokine-receptor axis can inhibit cellular migration and inflammatory response. This paper highlights recent advances in TLR, and chemokine participated in the pathogenesis of aseptic loosening. A comprehensive understanding of the recognition and migration mechanism is critical to the development of measures that prevent wear particle-induced aseptic loosening of orthopaedic implants.

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