Ionic liquid enables the preparation of copper-loaded gel with transdermal delivery function for wound dressings

2022 ◽  
Author(s):  
Yi-Ru Gao ◽  
Wen-Xin Zhang ◽  
Ya-Nan Wei ◽  
You Li ◽  
teng fei ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Transdermal Delivery ◽  
Bacterial Infections ◽  
Copper Ions ◽  
Wound Dressings ◽  
Alternative Approaches ◽  
Direct Use

Antimicrobial resistant pathogens infections motivate the exploration of alternative approaches to treat bacterial infections. Copper ions (Cu2+) have been involved in sterilization, however, its direct use may cause high local...

scholarly journals Porous Curdlan-Based Hydrogels Modified with Copper Ions as Potential Dressings for Prevention and Management of Bacterial Wound Infection—An In Vitro Assessment

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1893
Author(s):  
Aleksandra Nurzynska ◽  
Katarzyna Klimek ◽  
Iga Swierzycka ◽  
Krzysztof Palka ◽  
Grazyna Ginalska
Keyword(s):  
Bacterial Infections ◽  
Chronic Wounds ◽  
Copper Ions ◽  
Bacterial Colonization ◽  
Antibacterial Properties ◽  
Biological Properties ◽  
Wound Dressings ◽  
Wound Fluid ◽  
Potential Safety

Bacterial infections at the wound site still remain a huge problem for current medicine, as they may lead to development of chronic wounds. In order to prevent such infections, there is a need to use wound dressings that possess ability to inhibit bacterial colonization. In this study, three new curdlan-based biomaterials modified with copper ions were fabricated via simple and inexpensive procedure, and their structural, physicochemical, and biological properties in vitro were evaluated. Received biomaterials possessed porous structure, had ability to absorb high amount of simulated wound fluid, and importantly, they exhibited satisfactory antibacterial properties. Nevertheless, taking into account all evaluated properties of new curdlan-based biomaterials, it seems that Cur_Cu_8% is the most promising biomaterial for management of wounds accompanied with bacterial infections. This biomaterial exhibited the best ability to reduce Escherichia coli and Staphylococcus aureus growth and moreover, it absorbed the highest amount of simulated wound fluid as well as enabled optimal water vapor transmission. Furthermore, Cur_Cu_8% biomaterial possessed the best values of selective indexes, which determine its potential safety in vitro. Thus, Cur_Cu_8% hydrogel may be considered as a promising candidate for management of infected wounds as well as it may constitute a good platform for further modifications.

scholarly journals The Use of Micro- and Nanocarriers for Resveratrol Delivery into and across the Skin in Different Skin Diseases—A Literature Review

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 451
Author(s):  
Beata Szulc-Musioł ◽  
Beata Sarecka-Hujar
Keyword(s):  
Transdermal Delivery ◽  
Bacterial Infections ◽  
Skin Diseases ◽  
Skin Surface ◽  
Non Invasive ◽  
Skin Abnormalities ◽  
Low Solubility ◽  
Active Substances ◽  
Poor Stability

In recent years, polyphenols have been extensively studied due to their antioxidant, anticancer, and anti-inflammatory properties. It has been shown that anthocyanins, flavonols, and flavan-3-ols play an important role in the prevention of bacterial infections, as well as vascular or skin diseases. Particularly, resveratrol, as a multi-potent agent, may prevent or mitigate the effects of oxidative stress. As the largest organ of the human body, skin is an extremely desirable target for the possible delivery of active substances. The transdermal route of administration of active compounds shows many advantages, including avoidance of gastrointestinal irritation and the first-pass effect. Moreover, it is non-invasive and can be self-administered. However, this delivery is limited, mainly due to the need to overpassing the stratum corneum, the possible decomposition of the substances in contact with the skin surface or in the deeper layers thereof. In addition, using resveratrol for topical and transdermal delivery faces the problems of its low solubility and poor stability. To overcome this, novel systems of delivery are being developed for the effective transport of resveratrol across the skin. Carriers in the micro and nano size were demonstrated to be more efficient for safe and faster topical and transdermal delivery of active substances. The present review aimed to discuss the role of resveratrol in the treatment of skin abnormalities with a special emphasis on technologies enhancing transdermal delivery of resveratrol.

Alternative approaches to treat bacterial infections: targeting quorum-sensing

2020 ◽  
Vol 18 (6) ◽  
pp. 499-510
Author(s):  
Pipat Piewngam ◽  
Janice Chiou ◽  
Priyanka Chatterjee ◽  
Michael Otto
Keyword(s):  
Quorum Sensing ◽  
Bacterial Infections ◽  
Alternative Approaches

Cellulose/Collagen Beads Prepared Using Ionic Liquid for Cu(II) Adsorption from Aqueous Solutions

2012 ◽  
Vol 535-537 ◽  
pp. 2365-2369 ◽  
Author(s):  
Ji Lei Wang ◽  
Ming Hui Li ◽  
Li Gang Wei ◽  
Ying Chong Ma ◽  
Kun Lan Li ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Aqueous Solutions ◽  
Adsorption Equilibrium ◽  
Copper Ions ◽  
Adsorption Time ◽  
Initial Concentration ◽  
Composite Beads ◽  
Adsorption Amount ◽  
Hcl Solution

Biodegradable cellulose/collagen beads were successfully prepared by coagulating a blend of cellulose and collagen using 1–butyl–3–methylimidazolium chloride ([C4mim]Cl). The copper ions (Cu(II)) adsorption from aqueous solutions using the prepared beads were investigated at 15 °C as a function of initial concentrations, adsorbents types and adsorption time. The results show that Cu(II) adsorption amount increases with increasing initial concentration. Cellulose/collagen beads can absorb more Cu(II) than cellulose beads and the adsorption equilibrium can be achieved at 30 min. The maxinum adsorption amount of the cellulose/collagen beads (1/1, wt/wt) is estimated to be 0.51 mmol/g. The 90% absorbed Cu(II) on the composite beads can be desorbed by treating with 1 mol/L HCl solution for 180 min.

scholarly journals Silver-based wound dressings: current issues and future developments for treating bacterial infections

2020 ◽  
Vol 28 (4) ◽  
Author(s):  
Hanif Haidari ◽  
Sanjay Garg ◽  
Krasimir Vasilev ◽  
Zlatko Kopecki ◽  
Allison Cowin
Keyword(s):  
Bacterial Infections ◽  
Wound Dressings ◽  
Future Developments

scholarly journals Current Challenges and Perspectives for the Use of Aqueous Plant Extracts in the Management of Bacterial Infections: The Case-Study of Salmonella enterica Serovars

2019 ◽  
Vol 20 (4) ◽  
pp. 940 ◽  
Author(s):  
Sónia Santos ◽  
Cátia Martins ◽  
Carla Pereira ◽  
Armando Silvestre ◽  
Sílvia Rocha
Keyword(s):  
Plant Extracts ◽  
Salmonella Enterica ◽  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Public Health Problem ◽  
Foodborne Diseases ◽  
Salmonella Infection ◽  
Antibiotics Use ◽  
Alternative Approaches

Worldwide, foodborne diseases are a growing public health problem. Among the infectious bacteria, non-typhoidal Salmonella enterica serovars (NTS) are the major cause of hospitalization and death, and the emergence and spread of their antibiotic-resistance is becoming a worldwide health issue. This, coupled with the restrictions of antibiotics use in agriculture and animal production, calls for alternative approaches to solve this problem. Plant-derived aqueous extracts compounds could provide novel straightforward approaches to control pathogenic bacteria. This review discusses the antimicrobial activity of aqueous plant extracts against Salmonella serovars, the possible mechanisms of action involved, which components/structures might be responsible for such activity, and the current challenges for the use of these extracts/components in Salmonella infection management and their application perspectives.

scholarly journals Electrospun antibacterial nanofibers for wound dressings and tissue medicinal fields: A Review

2020 ◽  
Vol 13 (05) ◽  
pp. 2030012 ◽  
Author(s):  
Zhimei Wei ◽  
Liqun Wang ◽  
Shouyu Zhang ◽  
Tonghai Chen ◽  
Jie Yang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Biomedical Applications ◽  
Bacterial Infections ◽  
Antibacterial Agents ◽  
Antimicrobial Agents ◽  
Electrospinning Process ◽  
Wound Dressings ◽  
Electrospun Fibers ◽  
Chronic Infections ◽  
Antibacterial Material

Bacterial infections are a major cause of chronic infections. Thus, antibacterial material is an urgent need in clinics. Antibacterial nanofibers, with expansive surface area, enable efficient incorporation of antibacterial agents. Meanwhile, structure similar to the extracellular matrix can accelerate cell growth. Electrospinning, the most widely used technique to fabricate nanofiber, is often used in many biomedical applications including drug delivery, regenerative medicine, wound healing and so on. Thus, this review provides an overview of all recently published studies on the development of electrospun antibacterial nanofibers in wound dressings and tissue medicinal fields. This reviewer begins with a brief introduction of electrospinning process and then discusses electrospun fibers by incorporating various types of antimicrobial agents used as in wound dressings and tissue. Finally, we finish with conclusions and further perspectives on electrospun antibacterial nanofibers as 2D biomedicine materials.

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