Silver-based wound dressings: current issues and future developments for treating bacterial infections

The Lister Symposium was held primarily to review the latest concepts of the mechanisms of bacterial infections, and to highlight the research being carried out currently in Toronto and in Canada. The inclusion of several speakers from outside of Toronto added a strong foundation for the meeting.A wide range of topics were addressed and these demonstrated the many areas of research being pursued to better understand the pathogenesis of microbial infections. By drawing together physicians, scientists, and students from a variety of disciplines, it was hoped that the Lister Symposium would contribute, not only to our knowledge of medicine and science in this field, but also to the continued local and national cooperation required for first-class investigative research.This meeting was the first of its kind held under the auspices of the Department of Surgery at the University of Toronto, demonstrating its commitment to research and interdepartmental collaboration. We are most grateful to Professor Bernard Langer, Chairman of the Department of Surgery, for his support in this regard. The assistance of our sponsors and the Continuing Medical Education Office facilitated a wide outreach and enabled recognition of the course and accreditation for Canadian and American Medical participants. It is hoped that this material will provide a useful reference for future developments in the field.

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Stimuli-Responsive Nanoplatform-Assisted Photodynamic Therapy Against Bacterial Infections

Frontiers in Medicine ◽

10.3389/fmed.2021.729300 ◽

2021 ◽

Vol 8 ◽

Author(s):

You Zhou ◽

Wenmin Deng ◽

Mulan Mo ◽

Dexu Luo ◽

Houhe Liu ◽

...

Keyword(s):

Photodynamic Therapy ◽

Bacterial Infections ◽

High Efficiency ◽

Clinical Settings ◽

Oxygen Species ◽

Human Beings ◽

Stimuli Responsive ◽

Therapeutic Technique ◽

Future Developments ◽

Effective Delivery

Bacterial infections are common diseases causing tremendous deaths in clinical settings. It has been a big challenge to human beings because of the antibiotics abuse and the newly emerging microbes. Photodynamic therapy (PDT) is a reactive oxygen species-based therapeutic technique through light-activated photosensitizer (PS). Recent studies have highlighted the potential of PDT as an alternative method of antibacterial treatment for its broad applicability and high efficiency. However, there are some shortcomings due to the low selectivity and specificity of PS. Growing evidence has shown that drug delivery nanoplatforms have unique advantages in enhancing therapeutic efficacy of drugs. Particularly, stimuli-responsive nanoplatforms, as a promising delivery system, provide great opportunities for the effective delivery of PS. In the present mini-review, we briefly introduced the unique microenvironment in bacterial infection tissues and the application of PDT on bacterial infections. Then we review the stimuli-responsive nanoplatforms (including pH-, enzymes-, redox-, magnetic-, and electric-) used in PDT against bacterial infections. Lastly, some perspectives have also been proposed to further promote the future developments of antibacterial PDT.

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Electrospun antibacterial nanofibers for wound dressings and tissue medicinal fields: A Review

Journal of Innovative Optical Health Sciences ◽

10.1142/s1793545820300128 ◽

2020 ◽

Vol 13 (05) ◽

pp. 2030012 ◽

Cited By ~ 1

Author(s):

Zhimei Wei ◽

Liqun Wang ◽

Shouyu Zhang ◽

Tonghai Chen ◽

Jie Yang ◽

...

Keyword(s):

Wound Healing ◽

Biomedical Applications ◽

Bacterial Infections ◽

Antibacterial Agents ◽

Antimicrobial Agents ◽

Electrospinning Process ◽

Wound Dressings ◽

Electrospun Fibers ◽

Chronic Infections ◽

Antibacterial Material

Bacterial infections are a major cause of chronic infections. Thus, antibacterial material is an urgent need in clinics. Antibacterial nanofibers, with expansive surface area, enable efficient incorporation of antibacterial agents. Meanwhile, structure similar to the extracellular matrix can accelerate cell growth. Electrospinning, the most widely used technique to fabricate nanofiber, is often used in many biomedical applications including drug delivery, regenerative medicine, wound healing and so on. Thus, this review provides an overview of all recently published studies on the development of electrospun antibacterial nanofibers in wound dressings and tissue medicinal fields. This reviewer begins with a brief introduction of electrospinning process and then discusses electrospun fibers by incorporating various types of antimicrobial agents used as in wound dressings and tissue. Finally, we finish with conclusions and further perspectives on electrospun antibacterial nanofibers as 2D biomedicine materials.

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An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

Pharmaceutics ◽

10.3390/pharmaceutics12090840 ◽

2020 ◽

Vol 12 (9) ◽

pp. 840 ◽

Cited By ~ 3

Author(s):

Viorica Patrulea ◽

Gerrit Borchard ◽

Olivier Jordan

Keyword(s):

Antimicrobial Peptides ◽

Bacterial Infections ◽

Antimicrobial Agents ◽

New Technologies ◽

Multidrug Resistant ◽

Inorganic Nanoparticles ◽

Wound Dressings ◽

Wound Infections ◽

Clinical Phase ◽

Delivery Strategies

Bacterial infections occur when wound healing fails to reach the final stage of healing, which is usually hindered by the presence of different pathogens. Different topical antimicrobial agents are used to inhibit bacterial growth due to antibiotic failure in reaching the infected site, which is accompanied very often by increased drug resistance and other side effects. In this review, we focus on antimicrobial peptides (AMPs), especially those with a high potential of efficacy against multidrug-resistant and biofilm-forming bacteria and fungi present in wound infections. Currently, different AMPs undergo preclinical and clinical phase to combat infection-related diseases. AMP dendrimers (AMPDs) have been mentioned as potent microbial agents. Various AMP delivery strategies that are used to combat infection and modulate the healing rate—such as polymers, scaffolds, films and wound dressings, and organic and inorganic nanoparticles—have been discussed as well. New technologies such as Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated protein (CRISPR-Cas) are taken into consideration as potential future tools for AMP delivery in skin therapy.

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Organoselenium Coating on Cellulose Inhibits the Formation of Biofilms by Pseudomonas aeruginosa and Staphylococcus aureus

Applied and Environmental Microbiology ◽

10.1128/aem.02683-08 ◽

2009 ◽

Vol 75 (11) ◽

pp. 3586-3592 ◽

Cited By ~ 65

Author(s):

Phat L. Tran ◽

Adrienne A. Hammond ◽

Thomas Mosley ◽

Janette Cortez ◽

Tracy Gray ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Biofilm Formation ◽

Bacterial Infections ◽

Antimicrobial Agents ◽

Bacterial Attachment ◽

Wound Dressings ◽

Aqueous Environment ◽

Burn Victims ◽

Surgical Wounds

ABSTRACT Among the most difficult bacterial infections encountered in treating patients are wound infections, which may occur in burn victims, patients with traumatic wounds, necrotic lesions in people with diabetes, and patients with surgical wounds. Within a wound, infecting bacteria frequently develop biofilms. Many current wound dressings are impregnated with antimicrobial agents, such as silver or antibiotics. Diffusion of the agent(s) from the dressing may damage or destroy nearby healthy tissue as well as compromise the effectiveness of the dressing. In contrast, the antimicrobial agent selenium can be covalently attached to the surfaces of a dressing, prolonging its effectiveness. We examined the effectiveness of an organoselenium coating on cellulose discs in inhibiting Pseudomonas aeruginosa and Staphylococcus aureus biofilm formation. Colony biofilm assays revealed that cellulose discs coated with organoselenium completely inhibited P. aeruginosa and S. aureus biofilm formation. Scanning electron microscopy of the cellulose discs confirmed these results. Additionally, the coating on the cellulose discs was stable and effective after a week of incubation in phosphate-buffered saline. These results demonstrate that 0.2% selenium in a coating on cellulose discs effectively inhibits bacterial attachment and biofilm formation and that, unlike other antimicrobial agents, longer periods of exposure to an aqueous environment do not compromise the effectiveness of the coating.

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Ionic liquid enables the preparation of copper-loaded gel with transdermal delivery function for wound dressings

Biomaterials Science ◽

10.1039/d1bm01745d ◽

2022 ◽

Author(s):

Yi-Ru Gao ◽

Wen-Xin Zhang ◽

Ya-Nan Wei ◽

You Li ◽

teng fei ◽

...

Keyword(s):

Ionic Liquid ◽

Transdermal Delivery ◽

Bacterial Infections ◽

Copper Ions ◽

Wound Dressings ◽

Alternative Approaches ◽

Direct Use

Antimicrobial resistant pathogens infections motivate the exploration of alternative approaches to treat bacterial infections. Copper ions (Cu2+) have been involved in sterilization, however, its direct use may cause high local...

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Porous Curdlan-Based Hydrogels Modified with Copper Ions as Potential Dressings for Prevention and Management of Bacterial Wound Infection—An In Vitro Assessment

Polymers ◽

10.3390/polym12091893 ◽

2020 ◽

Vol 12 (9) ◽

pp. 1893

Author(s):

Aleksandra Nurzynska ◽

Katarzyna Klimek ◽

Iga Swierzycka ◽

Krzysztof Palka ◽

Grazyna Ginalska

Keyword(s):

Bacterial Infections ◽

Chronic Wounds ◽

Copper Ions ◽

Bacterial Colonization ◽

Antibacterial Properties ◽

Biological Properties ◽

Wound Dressings ◽

Wound Fluid ◽

Potential Safety

Bacterial infections at the wound site still remain a huge problem for current medicine, as they may lead to development of chronic wounds. In order to prevent such infections, there is a need to use wound dressings that possess ability to inhibit bacterial colonization. In this study, three new curdlan-based biomaterials modified with copper ions were fabricated via simple and inexpensive procedure, and their structural, physicochemical, and biological properties in vitro were evaluated. Received biomaterials possessed porous structure, had ability to absorb high amount of simulated wound fluid, and importantly, they exhibited satisfactory antibacterial properties. Nevertheless, taking into account all evaluated properties of new curdlan-based biomaterials, it seems that Cur_Cu_8% is the most promising biomaterial for management of wounds accompanied with bacterial infections. This biomaterial exhibited the best ability to reduce Escherichia coli and Staphylococcus aureus growth and moreover, it absorbed the highest amount of simulated wound fluid as well as enabled optimal water vapor transmission. Furthermore, Cur_Cu_8% biomaterial possessed the best values of selective indexes, which determine its potential safety in vitro. Thus, Cur_Cu_8% hydrogel may be considered as a promising candidate for management of infected wounds as well as it may constitute a good platform for further modifications.

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Electrospun Antibacterial Nanomaterials for Wound Dressings Applications

Membranes ◽

10.3390/membranes11120908 ◽

2021 ◽

Vol 11 (12) ◽

pp. 908

Author(s):

Aysegul Gul ◽

Izabela Gallus ◽

Akshat Tegginamath ◽

Jiri Maryska ◽

Fatma Yalcinkaya

Keyword(s):

Wound Healing ◽

Wound Dressing ◽

Bacterial Infections ◽

Antimicrobial Agents ◽

Chronic Wounds ◽

Antibacterial Properties ◽

Electrospun Nanofibers ◽

Electrospinning Process ◽

Wound Dressings ◽

Promising Solution

Chronic wounds are caused by bacterial infections and create major healthcare discomforts; to overcome this issue, wound dressings with antibacterial properties are to be utilized. The requirements of antibacterial wound dressings cannot be fulfilled by traditional wound dressing materials. Hence, to improve and accelerate the process of wound healing, an antibacterial wound dressing is to be designed. Electrospun nanofibers offer a promising solution to the management of wound healing, and numerous options are available to load antibacterial compounds onto the nanofiber webs. This review gives us an overview of some recent advances of electrospun antibacterial nanomaterials used in wound dressings. First, we provide a brief overview of the electrospinning process of nanofibers in wound healing and later discuss electrospun fibers that have incorporated various antimicrobial agents to be used in wound dressings. In addition, we highlight the latest research and patents related to electrospun nanofibers in wound dressing. This review also aims to concentrate on the importance of nanofibers for wound dressing applications and discuss functionalized antibacterial nanofibers in wound dressing.

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Chitosan and Cellulose-Based Hydrogels for Wound Management

International Journal of Molecular Sciences ◽

10.3390/ijms21249656 ◽

2020 ◽

Vol 21 (24) ◽

pp. 9656

Author(s):

Sibusiso Alven ◽

Blessing Atim Aderibigbe

Keyword(s):

Bacterial Infections ◽

Antibacterial Agents ◽

Chronic Wounds ◽

Wound Dressings ◽

Wound Management ◽

Bacterial Invasion ◽

High Moisture Content ◽

High Moisture ◽

Moist Environment ◽

Dressing Materials

Wound management remains a challenge worldwide, although there are several developed wound dressing materials for the management of acute and chronic wounds. The wound dressings that are currently used include hydrogels, films, wafers, nanofibers, foams, topical formulations, transdermal patches, sponges, and bandages. Hydrogels exhibit unique features which make them suitable wound dressings such as providing a moist environment for wound healing, exhibiting high moisture content, or creating a barrier against bacterial infections, and are suitable for the management of exuding and granulating wounds. Biopolymers have been utilized for their development due to their non-toxic, biodegradable, and biocompatible properties. Hydrogels have been prepared from biopolymers such as cellulose and chitosan by crosslinking with selected synthetic polymers resulting in improved mechanical, biological, and physicochemical properties. They were useful by accelerating wound re-epithelialization and also mimic skin structure, inducing skin regeneration. Loading antibacterial agents into them prevented bacterial invasion of wounds. This review article is focused on hydrogels formulated from two biopolymers—chitosan and cellulose—for improved wound management.

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Cellulose-Based Nanofibril Composite Materials as a New Approach to Fight Bacterial Infections

Frontiers in Bioengineering and Biotechnology ◽

10.3389/fbioe.2021.732461 ◽

2021 ◽

Vol 9 ◽

Author(s):

Somaye Rashki ◽

Neda Shakour ◽

Zahra Yousefi ◽

Marzieh Rezaei ◽

Mina Homayoonfal ◽

...

Keyword(s):

Antibacterial Activity ◽

Bacterial Infections ◽

Food Packaging ◽

Antimicrobial Agents ◽

Therapeutic Potential ◽

Low Cost ◽

Wound Dressings ◽

Antibiotic Resistant ◽

New Approach ◽

Global Challenge

Antibiotic resistant microorganisms have become an enormous global challenge, and are predicted to cause hundreds of millions of deaths. Therefore, the search for novel/alternative antimicrobial agents is a grand global challenge. Cellulose is an abundant biopolymer with the advantages of low cost, biodegradability, and biocompatibility. With the recent growth of nanotechnology and nanomedicine, numerous researchers have investigated nanofibril cellulose to try to develop an anti-bacterial biomaterial. However, nanofibril cellulose has no inherent antibacterial activity, and therefore cannot be used on its own. To empower cellulose with anti-bacterial properties, new efficient nanomaterials have been designed based on cellulose-based nanofibrils as potential wound dressings, food packaging, and for other antibacterial applications. In this review we summarize reports concerning the therapeutic potential of cellulose-based nanofibrils against various bacterial infections

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