Comparative study of the laxative effects of konjac oligosaccharides and konjac glucomannan on loperamide-induced constipation in rats

2021 ◽  
Author(s):  
Mengmeng Hu ◽  
Changqian Fang ◽  
Youqian Liu ◽  
Meng Gao ◽  
Dongjian Zhang ◽  
...  
Keyword(s):  
Comparative Study ◽  
Dietary Fiber ◽  
Chronic Constipation ◽  
Konjac Glucomannan ◽  
Therapeutic Method ◽  
Laxative Effect ◽  
Laxative Effects

Dietary fiber is the basic therapeutic method to relieve the symptoms of chronic constipation. The aim of this study was to compare the laxative effect of Konjac Glucomannan (KGM) and...

Determination of the anal position in newborns and in children with chronic constipation: comparative study in two European healthcare centres

2011 ◽  
Vol 27 (10) ◽  
pp. 1111-1115 ◽  
Author(s):  
R. Núñez-Ramos ◽  
M. A. Fabbro ◽  
M. González-Velasco ◽  
R. Núñez Núñez ◽  
B. Romanato ◽  
...  
Keyword(s):  
Comparative Study ◽  
Chronic Constipation ◽  
European Healthcare

scholarly journals Psyllium: A Source of Dietary Fiber

2021 ◽  
Author(s):  
Ranu Agrawal
Keyword(s):  
Dietary Fiber ◽  
Mucous Membrane ◽  
Biodegradable Polymer ◽  
Chronic Constipation ◽  
Galacturonic Acid ◽  
Physiological Effect ◽  
Duodenal Ulcers ◽  
Stabilizing Agents ◽  
Daily Diet ◽  
Food Thickener

Dietary fiber is commonly known as roughage. Fibers are mostly present in vegetables, whole grain, nuts, legumes, and fruits. This is an indigestible part of the food obtained by plants. It includes polysaccharides such as cellulose, hemicellulose, pectic substances, mucilages, gums and lignin as well. Dietary fiber has beneficial physiological effect on health, so it is included in daily diet to decrease occurrence of several diseases. In this sequence, this chapter describes about the dietary fiber, psyllium commonly known as Isabgol which is prepared from the seed of the Plantago ovata Forsk (Psyllium ispaghula). Psyllium is hydrophilic mucilloid, has the capacity to absorb water and increases in volume while absorbing water. Psyllium consists of mixed viscous polysaccharide in which about 35% soluble and 65% insoluble polysaccharides (cellulose, hemicellulose, and lignin) are present. This can be used as gelling, food thickener, emulsifying and stabilizing agents in some food products. Psyllium is a natural biopolymer which has high quantity of hemicelluloses consist of xylan backbone connected with arabinose, galacturonic acid and rhamnose units. Since last many years it is being used as therapeutic agent in several diseases like chronic constipation, inflammation of mucous membrane of GIT tract, duodenal ulcers, piles or diarrohoea etc. It may be source of renewable and biodegradable polymer.

scholarly journals Antioxidant activity and laxative effects of tannin-enriched extract of Ecklonia cava in loperamide-induced constipation of SD rats

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246363
Author(s):  
Ji Eun Kim ◽  
Yun Ju Choi ◽  
Su Jin Lee ◽  
Jeong Eun Gong ◽  
Young Ju Lee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Transverse Colon ◽  
Chronic Constipation ◽  
Ecklonia Cava ◽  
Related Factor ◽  
Oxidative Balance ◽  
Sd Rats ◽  
Cholinergic Regulation ◽  
Laxative Effects ◽  
Muscarinic Cholinergic

To investigate the role of tannin-enriched extracts of Ecklonia cava (TEE) on the regulation of oxidative balance and laxative activity in chronic constipation, we investigated alterations after exposure to TEE, on constipation phenotypes, muscarinic cholinergic regulation, and oxidative stress responses in the transverse colons of SD rats with loperamide (Lop)-induced constipation. This extract contains high levels of total condensed tannin content (326.5 mg/g), and exhibited high inhibitory activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. TEE treatment induced significant improvements in reactive oxygen species (ROS) production, superoxide dismutase (SOD) expression and nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation in primary smooth muscles of rat intestine cells (pRISMCs) and transverse colon of constipation model. Also, Lop+TEE treated groups showed alleviated outcomes for the following: most stool parameters, gastrointestinal transit, and intestine length were remarkably recovered; a similar recovery pattern was observed in the histopathological structure, mucin secretion, water channel expression and gastrointestinal hormones secretion in the transverse colon; expressions of muscarinic acetylcholine receptors M2/M3 (mAChR M2/M3) and their mediators on muscarinic cholinergic regulation were significantly recovered. Taken together, these results provide the first evidence that TEE stimulates oxidative stress modulation and muscarinic cholinergic regulation when exerting its laxative effects in chronic constipation models.

Measurement of Low Dietary Fiber Intake As a Risk Factor for Chronic Constipation in Children

1999 ◽  
Vol 29 (2) ◽  
pp. 132-135 ◽  
Author(s):  
Mauro B. Morais ◽  
Márcia R. Vítolo ◽  
Andrea N. C. Aguirre ◽  
Ulysses Fagundes-Neto
Keyword(s):  
Risk Factor ◽  
Dietary Fiber ◽  
Chronic Constipation ◽  
Fiber Intake ◽  
Dietary Fiber Intake

scholarly journals The Manufacturing Process of Kiwifruit Fruit Powder with High Dietary Fiber and Its Laxative Effect

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 3813 ◽  
Author(s):  
Ziqi Zhuang ◽  
Min Chen ◽  
Jihan Niu ◽  
Na Qu ◽  
Bing Ji ◽  
...  
Keyword(s):  
Dietary Fiber ◽  
Retention Rate ◽  
Milling Process ◽  
Mice Model ◽  
Fecal Output ◽  
Laxative Effect ◽  
Swelling Capacity ◽  
Fruit Powder ◽  
Functional Components ◽  
Water Holding

Kiwifruit is rich in vitamins, minerals, dietary fiber and other functional components, and it has long been used as a functional food to treat intestinal ailments such as constipation. The current research made full use of the kiwifruit, the juice was prepared by microencapsulation, and the dietary fiber in kiwifruit pomace was modified by enzymatic hydrolysis and grinding, then, the two were mixed to obtain an ultra-micro kiwifruit powder (UKP). In addition, the laxative effect of the UKP was verified by a diphenoxylate induced constipated mice model. The results demonstrated that compared with the raw samples, the retention rate of vitamin C, lutein and catechin in UKP were 83.3%, 81.9% and 88.3%, respectively, thus effectively avoiding the loss of functional components during the processing of kiwifruit. Moreover, α-amylase, protease and the ball milling process effectively reduced the size of dietary fiber in kiwifruit pomace, and its water-holding capacity (WHC), oil-holding capacity (OHC) and swelling capacity (SWC) were enhanced by 1.26, 1.65 and 1.10 times, respectively. Furthermore, to analyze the laxative effect of the UKP, a constipation mice model was established by diphenoxylate treatment (5 mg·kg−1, i.g.) for the last week, with or without UKP supplementation (2.4 g·kg−1 B.W. per day) for 4 weeks. The results demonstrated that UKP significantly increased feces condition (fecal output and dejecta moisture content, gut transit (the intestinal propulsion rates) and substance P (SP) levels in portal vein plasma, and it decreased the whole gut transit time and mucinogen granules secreted by goblet cell in constipated mice.

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