Polyphenol extract and essential oil of Amomum tsao-ko equally alleviate hypercholesterolemia and modulate gut microbiota

2021 ◽  
Author(s):  
Lijun Liu ◽  
Yimin Zhao ◽  
Jian Ming ◽  
Jia Chen ◽  
Guohua Zhao ◽  
...  
Keyword(s):  
Essential Oil ◽  
Gut Microbiota ◽  
Total Cholesterol ◽  
Plasma Total Cholesterol

This study explored the effects of polyphenol extract (TKP) and essential oil (TKO) from Amomum tsao-ko Crevost et Lemaire (tsao-ko) on plasma total cholesterol and gut microbiota. Four groups of...

COMBINATION OF POTASSIUM PERCHLORATE AND PROPYLTHIOURACIL IN THE TREATMENT OF THYROTOXICOSIS

1968 ◽  
Vol 57 (4) ◽  
pp. 565-577 ◽  
Author(s):  
K. E. Røkke ◽  
J. H. Vogt
Keyword(s):  
Drug Therapy ◽  
Side Effects ◽  
Metabolic Rate ◽  
Total Cholesterol ◽  
Basal Metabolic Rate ◽  
Combined Therapy ◽  
Combined Treatment ◽  
Control Measures ◽  
Potassium Perchlorate ◽  
Plasma Total Cholesterol

ABSTRACT A report is given on 95 thyrotoxic patients treated with a combination of 400 mg propylthiouracil and 400 mg of potassium perchlorate. Perchlorate was stopped when a marked remission of symptoms was obtained, on an average after less than 7 weeks. Euthyroidism was found on an average after 7.2 weeks. The basal metabolic rate, PBI, plasma total cholesterol and weight showed a fairly rapid normalization. Thirteen of the 95 patients were given radio-iodine therapy shortly before drug therapy was started. The remaining 82 cases were grouped together with the 23 cases previously reported. Of the total of 105 cases, 96 became euthyroid on combined therapy. For the frequency of side-effects, the thirteen cases mentioned above were included, giving a total of 118 cases. Eight cases showed an increase in goitre size and 15 cases had other side-effects, of which three were granulocytopenia due to propylthiouracil. The possibility of a higher frequency of mainly minor side-effects on combined therapy has to be balanced against the seemingly rapid and reliable therapeutic effect. Combined treatment, perhaps with even smaller doses than reported here, can be recommended in selected cases of thyrotoxicosis where a shortening of the thyrotoxic state seems of importance, or possibly where difficulties due to iodine exposure may be anticipated, provided adequate control measures are taken.

Influence of Dietary Supplementation with Fish on Plasma Total Cholesterol and Lipoprotein Cholesterol Fractions in Patients with Coronary Heart Disease

1992 ◽  
Vol 3 (2) ◽  
pp. 107-115
Author(s):  
Maria Jose Santos ◽  
María Lopez-Jurado ◽  
Juan Llopis ◽  
José Luis Marti ◽  
Gloria Urbano ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Total Cholesterol ◽  
Dietary Supplementation ◽  
Lipoprotein Cholesterol ◽  
Plasma Total Cholesterol

scholarly journals Assessment of Gut Microbiota and Selected Blood Parameters in Weaned Piglets Following Supplementation with a Probiotic and Vitamin C

2020 ◽  
Vol 20 (1) ◽  
pp. 179-189
Author(s):  
Leszek Tymczyna ◽  
Beata Trawińska ◽  
Marta Kowaleczko ◽  
Anna Chmielowiec-Korzeniowska ◽  
Jerzy Lechowski
Keyword(s):  
Vitamin C ◽  
Gut Microbiota ◽  
Total Cholesterol ◽  
Hdl Cholesterol ◽  
Blood Parameters ◽  
Control Group ◽  
Weaned Piglets ◽  
E Coli ◽  
Experimental Group ◽  
Control Group Group

AbstractThe aim of the study was to assess the gut microbiota and selected haematological and biochemical blood parameters of weaned piglets following dietary supplementation with a probiotic and vitamin C. the piglets were divided into a control group (group C) and an experimental group (group E), with 30 piglets in each group. All animals received the same feed ad libitum. The animals in the control group (group C) received feed with no added probiotic and vitamin C. the piglets in the experimental group (group E) were given a supplement containing a probiotic (Bacillus cereus 1×109 CFU/kg) in the amount of 1.5 g/piglet/day and vitamin c in the amount of 300 mg/piglet/day. The supplement was administered for 28 days. The total numbers of bacteria of the family Enterobacteriaceae and of the genus Lactobacillus were determined in faeces. The erythrocyte count, haemoglobin level, haematocrit, leukocyte count, and percentages of neutrophils and lymphocytes were determined in the blood. The biochemical analysis concerned the concentration of triacylglycerols, total cholesterol, and LDL and HDL cholesterol. In group E a significant decrease (P<0.01) in the total number of Enterobacteriaceae bacteria was observed in the faeces of the piglets, accompanied by an increase in the number of lactobacilli relative to group C. E. coli was found to predominate over other microorganisms. Salmonella choleraesuis bacteria were present in the faeces of both groups before administration of the supplement, but were not found after its use. The supplement with probiotic and vitamin C caused a significant increase in the erythrocyte, haemoglobin and haematocrit levels in the blood of the piglets and a significant decrease in the concentration of triacylglycerols, total cholesterol and LDL cholesterol.

Gender effects of tall oil versus soybean phytosterols as cholesterol-lowering agents in hamsters

1998 ◽  
Vol 76 (7-8) ◽  
pp. 780-787 ◽  
Author(s):  
Fady Y Ntanios ◽  
Diane E MacDougall ◽  
Peter JH Jones
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Cholesterol Metabolism ◽  
Total Cholesterol Level ◽  
Cholesterol Biosynthesis ◽  
Gender Effects ◽  
Plasma Total Cholesterol ◽  
Tall Oil ◽  
Cholesterol Lowering ◽  
Plasma Total Cholesterol Level

To examine the effect of gender on the mechanisms of action of phytosterols extracted from tall oil (TO) and soybean (SB) on cholesterol and phytosterol metabolism, male and female hamsters were fed cholesterol-enriched diets containing 0.5 or 1% (w/w) TO or SB phytosterols for 90 days. Plasma lipoprotein cholesterol profile and tissue phytosterol and cholesterol biosynthesis levels were determined. Mean plasma total-cholesterol level in females fed 1% (w/w) SB was reduced (p < 0.05) by 44%, while in males it was lowered (p < 0.05) by 25% compared with their respective controls. Moreover, mean plasma total-cholesterol level was reduced (p < 0.05) in male hamsters by -31% and female hamsters by -32% when fed 1% (w/w) TO. Cholesterol biosynthesis was higher (p < 0.05) by twofold in groups fed TO at 0.5 and 1% (w/w) concentrations, compared with SB. Hamsters fed TO at 0.5 and 1% (w/w) levels also had higher (p < 0.05) hepatic and enterocytic campesterol contents than SB-fed animals. These findings demonstrate gender differences in cholesterol metabolism in TO- and SB-fed hamsters. The results suggest that TO, conversely to SB phytosterol, is a more effective cholesterol-lowering agent in male, but not as much in female, hamsters, over a feeding period of 90 days.Key words: phytosterols, cholesterol, sitosterol, sitostanol, gender, hamster.

scholarly journals Elevated Plasma Total Cholesterol Level Is Associated with the Risk of Asymptomatic Intracranial Arterial Stenosis

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e101232 ◽  
Author(s):  
Yuan Shen ◽  
Jing Wang ◽  
Jianwei Wu ◽  
Weikai Qu ◽  
Chunxue Wang ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Arterial Stenosis ◽  
Elevated Plasma ◽  
Intracranial Arterial Stenosis ◽  
Plasma Total Cholesterol ◽  
Plasma Total Cholesterol Level

scholarly journals Dietary Cholesterol Contained in Whole Eggs Is Not Well Absorbed and Does Not Acutely Affect Plasma Total Cholesterol Concentration in Men and Women: Results from 2 Randomized Controlled Crossover Studies

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1272 ◽  
Author(s):  
Jung Kim ◽  
Wayne Campbell
Keyword(s):  
Total Cholesterol ◽  
Plasma Cholesterol ◽  
Dietary Cholesterol ◽  
Cholesterol Absorption ◽  
Blood Cholesterol ◽  
Cholesterol Concentration ◽  
Total Cholesterol Concentration ◽  
Plasma Total Cholesterol ◽  
Crossover Studies ◽  
Whole Egg

Whole egg is a food source of dietary cholesterol and inconsistent research findings exist about the effect of dietary cholesterol from whole egg on blood cholesterol concentration. We assessed the effect of co-consuming cooked whole egg (CWE) on dietary cholesterol absorption from two randomized-crossover studies. For study 1, 16 men consumed raw vegetables with no egg, 75 g CWE, or 150 g CWE. For study 2, 17 women consumed cooked vegetables with no egg or 100 g CWE. Triacylglycerol-rich lipoprotein fractions (TRL) were isolated from collected blood. In study 1, total-cholesterol areas under the curve (AUC)0–10h in TRL were not different but triacylglycerol AUC0–10h in TRL was greater for 150 g CWE vs. 75 g CWE and no egg. Similarly, in study 2, total-cholesterol AUC0–10h in TRL was not different but triacylglycerol AUC0–10h in TRL was greater for 100 g CWE vs. no egg. In both studies, whole egg consumption did not affect plasma total-cholesterol AUC0–10h, while triacylglycerol AUC0–10h was increased. These results suggest that the dietary cholesterol in whole egg was not well absorbed, which may provide mechanistic insight for why it does not acutely influence plasma total-cholesterol concentration and is not associated with longer-term plasma cholesterol control.

scholarly journals Eggshell membrane powder lowers plasma triglyceride and liver total cholesterol by modulating gut microbiota and accelerating lipid metabolism in high‐fat diet‐fed mice

2020 ◽  
Vol 8 (5) ◽  
pp. 2512-2523 ◽  
Author(s):  
Nurul Shazini Ramli ◽  
Huijuan Jia ◽  
Ayumu Sekine ◽  
Weida Lyu ◽  
Kyohei Furukawa ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Gut Microbiota ◽  
Total Cholesterol ◽  
High Fat Diet ◽  
Plasma Triglyceride ◽  
Eggshell Membrane ◽  
High Fat

scholarly journals Plasma lipid modifications in elderly people after administration of two virgin olive oils of the same variety (Olea europaeavar.hojiblanca) with different triacylglycerol composition

2003 ◽  
Vol 89 (6) ◽  
pp. 819-826 ◽  
Author(s):  
Javier S. Perona ◽  
Julio Cañizares ◽  
Emilio Montero ◽  
José M. Sánchez-Domínguez ◽  
Valentina Ruiz-Gutierrez
Keyword(s):  
Blood Pressure ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Plasma Lipid ◽  
Cholesteryl Esters ◽  
Minor Components ◽  
Plasma Total Cholesterol ◽  
Virgin Olive Oils ◽  
Olive Oils ◽  
Triacylglycerol Molecular Species

In the present study we examined whether two virgin olive oils (VOO1 and VOO2), of the same variety (Olea europaeavar.hojiblanca) and with a similar composition of minor components but differing in the content of triacylglycerol molecular species, had different effects on blood pressure and plasma lipid levels in a healthy elderly population. Thirty-one participants, aged 84·9 (SD 6·4) years, were asked to participate in the study. No differences were found with regard to blood pressure after both experimental periods (VOO1 and VOO2). However, plasma total cholesterol and LDL-cholesterol were reduced only after VOO1 (P<0·01). The reduction of plasma cholesterol concentrations was related to the incorporation of oleic acid into plasma cholesteryl esters and phospholipids, which was higher after VOO1 (P<0·01). Indeed, the oleic acid concentration in cholesteryl esters and phospholipids strongly correlated with plasma total cholesterol and LDL-cholesterol levels in all experimental periods studied (r2>0·418,P<0·07), except for phospholipids in VOO1 (P=0·130 for total cholesterol andP=0·360 for LDL-cholesterol). These results have demonstrated that blood pressure and plasma lipids can be modified by the consumption of VOO in elderly people, but that the extent of such modification depends on the composition and amount of active minor components and triacylglycerol molecular species.

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