scholarly journals Sintesis Hidrogel Pektin – Gelatin dengan Penambahan Ekstrak Kulit Buah Naga Sebagai Kandidat Pembalut Luka Bakar

2020 ◽  
Vol 4 (1) ◽  
pp. 53
Author(s):  
Fadhil Muhammad Tarmidzi ◽  
Inggit Kresna Maharsih ◽  
Tina Raihatul Jannah ◽  
Cici Sari Wahyuni
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Citric Acid ◽  
Wound Dressing ◽  
Wound Care ◽  
Crosslinking Agent ◽  
Wound Dressings ◽  
Esterification Reaction ◽  
Natural Polymers ◽  
Fruit Peel

Teknik pembalutan luka saat ini menerapkan metode perawatan luka modern dengan cara mempertahankan isolasi lingkungan luka dalam keadaan tertutup dan lembab. Ada beberapa jenis pembalut luka yang telah dikembangkan, salah satunya hidrogel. Hidrogel merupakan pembalut luka berbentuk lembaran yang memiliki kemampuan menyerap cairan luka dan memiliki stabilitas yang baik pada pH asam sehingga dapat digunakan untuk pengobatan luka bakar. Dalam penelitian ini, hidrogel dibuat menggunakan polimer alami seperti pektin dan gelatin. Kedua bahan tersebut dikombinasikan menggunakan metode ikatan silang dengan penambahan asam sitrat sebagai agen pengikat silang. Penambahan asam sitrat memberikan pengaruh terhadap karakteristik material hidrogel yang dihasilkan, sehingga diperlukan jumlah yang tepat agar didapatkan hidrogel dengan properti material yang baik. Hidrogel juga ditambahkan zat aktif berupa flavonoid pada ekstrak kulit buah naga agar dapat digunakan sebagai pembalut luka untuk menyembuhkan luka bakar. Dari hasil penelitian, hidrogel dengan konsentrasi asam sitrat 4% (Hidrogel CA 4%) menghasilkan nilai swelling, tensile strength, dan elongation tertinggi sebesar 890%, 0,05 Mpa, dan 200%. Hasil properti mekanik dari Hidrogel CA 4% ini dibuktikan dengan uji FTIR yang telah dilakukan, yaitu munculnya gugus karbonil C=O sebagai hasil reaksi esterifikasi yang terjadi antara polimer dengan asam sitrat di daerah serapan 1733,9 cm-1.Wound dressing technique currently applies modern wound care methods by maintaining the environmental isolation of the wound in a closed and moist state. There are several types of wound dressing that have been developed, one of them is hydrogel. Hydrogel is sheet-shaped wound dressings which have the ability to absorb exudate and have good stability acidic pH that can be used for the treatment of burns. In this study, hydrogel were made using natural polymers such as pectin and gelatin. The two polymers were combined using crosslinking method with the addition of citric acid as a crosslinking agent. The addition of citric acid has affect on the characteristics of the hydrogel material produced, therefore the right amount is needed to obtain a hydrogel with good mechanical properties. Hydrogel also added by an active substance in the form of flavonoids from dragon fruit peel extract that can be used as a wound dressing to cure burns. This study resulting hydrogel with a concentration of 4% citric acid (Hydrogel CA 4%) produced highest value of swelling, tensile strength, and elongation are 890%, 0.05 Mpa, and 200%, repectively. The mechanical properties of Hydrogel CA 4% was proved by FTIR test that had been carried out, namely the presence of C=O carbonyl group as a result of the esterification reaction that occurred between the polymers and citric acid in the absorption area of 1733.9 cm-1.

scholarly journals Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2104
Author(s):  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Cellular Adhesion ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
High Porosity ◽  
Hybrid Nanofibers

The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

scholarly journals Thermal, Physical and Mechanical Properties of Poly(Butylene Succinate)/Kenaf Core Fibers Composites Reinforced with Esterified Lignin

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2359
Author(s):  
Harmaen Ahmad Saffian ◽  
Masayuki Yamaguchi ◽  
Hidayah Ariffin ◽  
Khalina Abdan ◽  
Nur Kartinee Kassim ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Loss Modulus ◽  
Physical And Mechanical Properties ◽  
Weight Percent Gain ◽  
Weight Percent ◽  
Esterification Reaction ◽  
Butylene Succinate ◽  
Kenaf Core ◽  
Modified Lignin

In this study, Kraft lignin was esterified with phthalic anhydride and was served as reinforcing filler for poly(butylene succinate) (PBS). Composites with different ratios of PBS, lignin (L), modified lignin (ML) and kenaf core fibers (KCF) were fabricated using a compounding method. The fabricated PBS composites and its counterparts were tested for thermal, physical and mechanical properties. Weight percent gain of 4.5% after lignin modification and the FTIR spectra has confirmed the occurrence of an esterification reaction. Better thermo-mechanical properties were observed in the PBS composites reinforced with modified lignin and KCF, as higher storage modulus and loss modulus were recorded using dynamic mechanical analysis. The density of the composites fabricated ranged from 1.26 to 1.43 g/cm3. Water absorption of the composites with the addition of modified lignin is higher than that of composites with unmodified lignin. Pure PBS exhibited the highest tensile strength of 18.62 MPa. Incorporation of lignin and KCF into PBS resulted in different extents of reduction in tensile strength (15.78 to 18.60 MPa). However, PBS composite reinforced with modified lignin exhibited better tensile and flexural strength compared to its unmodified lignin counterpart. PBS composite reinforced with 30 wt% ML and 20 wt% KCF had the highest Izod impact, as fibers could diverge the cracking propagation of the matrix. The thermal conductivity value of the composites ranged from 0.0903 to 0.0983 W/mK, showing great potential as a heat insulator.

scholarly journals Established an eco-friendly cotton fabric treating process with enhancing anti-wrinkle performance

2021 ◽  
Vol 16 ◽  
pp. 155892502110034
Author(s):  
Xiongfang Luo ◽  
Pei Cheng ◽  
Wencong Wang ◽  
Jiajia Fu ◽  
Weidong Gao
Keyword(s):  
Tensile Strength ◽  
Citric Acid ◽  
Cotton Fabric ◽  
Crosslinking Agent ◽  
Cost Effective ◽  
Waterborne Polyurethane ◽  
Cotton Fabrics ◽  
Wrinkle Resistance ◽  
Before And After ◽  
Strength Retention

This study establishes an eco-friendly anti-wrinkle treating process for cotton fabric. Sodium hydroxide-liquid ammonia pretreatment followed by 6% (w/w) PU100 adding citric acid pad-cure-dry finishing. In this process, citric acid (CA) was used as the fundamental crosslinking agent during finishing because it is a non-formaldehyde based, cost-effective and well wrinkle resistance agent. Environmental-friendly waterborne polyurethane (WPU) was used as an additive to add to the CA finishing solution. Six commercial WPUs were systematically investigated. Fabric properties like wrinkle resistance, tensile strength retention, whiteness, durable press, softness, and wettability were well investigated. Fourier transform infrared spectra and X-ray diffraction spectra were also measured and discussed before and after adding waterborne polyurethane. Tentative mechanism of the interaction among the WPU, CA, and modified cotton fabrics is provided. The effect of cotton fabric pretreatment on fabric performance was also investigated. After the eco-process’s treatment, the fabric wrinkle resistant angle was upgraded to 271 ± 7°, tensile strength retention was maintained at 66.77% ± 3.50% and CIE whiteness was elevated to 52.13 ± 3.21, which are much better than the traditional CA anti-wrinkle finishing based on mercerized cotton fabrics. This study provides useful information for textile researchers and engineers.

A Review of Water-Resistant Cellulose-Based Materials in Pharmaceutical and Biomedical Application

2021 ◽  
Vol 28 ◽  
Author(s):  
Bei He ◽  
Xinxin Liu ◽  
Shi Qi ◽  
Run Zheng ◽  
Minmin Chang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Biomedical Application ◽  
Drug Loading ◽  
Cellulose Fibers ◽  
Dip Coating ◽  
Wound Dressings ◽  
Attractive Alternative ◽  
Natural Polymers ◽  
Insoluble Drugs ◽  
Good Biocompatibility

Background: Cellulose, huge reserves of natural polymers, have been widely applied in pharmaceutical and biomedicine fields due to its good biocompatibility, biodegradability, non-toxicity and excellent mechanical properties. At present, water-resistant metal-based and petroleum-based materials applied in medical field exists obvious problems of poor biocompatibility and high cost. Therefore, water-resistant cellulose-based materials with good biocompatibility and low price will become an attractive alternative. This review aims to summarize the preparation of water-resistant cellulose-based materials and their potential application in pharmaceutical and biomedical in recent years. Methods: Common hydrophobic treatments of cellulose fibers or paper were overviewed. The preparation, properties and applications of water-resistant cellulose-based materials in the pharmaceutical and biomedical fields were summarized. Results: Common hydrophobic treatments of cellulose fibers or paper were divided into chemical modification (graft polymerization, crosslinking, solution casting or dip-coating), physico-chemical surface modifications (plasma treatments, surface patterning, electrostatic spraying and electrowetting) and physical processing (electrostatic spinning, SAS process and 3D EHD printing). These hydrophobically processed cellulose fibers or paper could be prepared into various water-resistant cellulose-based materials and applied in pharmaceutical excipients, drug-loaded amphiphilic micelles, drug-loaded composite fibers, hydrophobic biocomposite film/coatings and paper-based detectors. They presented excellent water resistance and biocompatibility, low cytotoxicity and high drug loading ability, and stable drug release rate, etc., which could be used for water-insoluble drugs carriers, wound dressings, and medical testing equipment. Conclusion: Currently, water-resistant cellulose-based materials were mainly applied in water-insoluble drugs delivery carriers, wound dressing and medical diagnosis and presented great application prospects. However, the contradiction between hydrophobicity and mechanical properties of these reported water-resistant cellulose-based materials limited their wider application in biomedicine such as tissue engineering. In the future, attention will be focused on the higher hydrophobicity of water-resistant cellulose-based materials with excellent mechanical properties. In addition, clinical medical research of water-resistant cellulose-based materials should be strengthened.

Synthesis of Polyvinyl Formal Sponge for Wound Care Dressing Application

2010 ◽  
Vol 152-153 ◽  
pp. 1650-1659
Author(s):  
Qing Hao Yang ◽  
Guang Xu Cheng ◽  
Zhi Cheng Zhang
Keyword(s):  
Mechanical Properties ◽  
Mechanical Strength ◽  
Porous Structure ◽  
Pore Structure ◽  
Water Absorption ◽  
Wound Dressing ◽  
Wound Care ◽  
Acid Catalyst ◽  
The Other ◽  
Polyvinyl Formal

In an effort to seek poly(vinyl formal) (PVFM) foams based wound dressing pad material, a series of foamed PVFM materials have been synthesized under varied conditions. The influence of conditions on the properties of PVFM foam, such as mechanical properties, water absorption, pore structure and bulk density, is well discussed individually. It has been shown that both the reactant and acid catalyst affect the degree and speed of acetalization, therefore the mechanical properties, pores continuity and water absorption of the resultant sample. The addition of Na2CO3, surfactant and CMCNa are mainly influencing the porous structure as well as the mechanical properties and water absorption. One best sample with balanced properties is obtained. It possesses higher mechanical strength and water absorption while the other properties are similar, comparing with a commercial surgical PVFM sponge (YJ-1) currently used.

Improved mechanical, physical and biological properties of chitosan films using Aloe vera and electrospun PVA nanofibers for wound dressing applications

2019 ◽  
pp. 152808371986693 ◽  
Author(s):  
Shirin Rafieian ◽  
Hamid Mahdavi ◽  
Mir Esmaeil Masoumi
Keyword(s):  
Mechanical Properties ◽  
Wound Dressing ◽  
Aloe Vera ◽  
Composite Layer ◽  
Synthetic Polymers ◽  
Biological Properties ◽  
Vapor Permeability ◽  
Natural Polymers ◽  
Simple Method ◽  
Chitosan Films

Natural polymers such as chitosan and Aloe vera are widely used in novel wound dressings due to their biocompatibility and biodegradability. A problem associated with these polymers is their poor mechanical behavior. Efforts have been made to improve the mechanical properties by mixing synthetic polymers such as PVA, but the role of chitosan and Aloe vera in the final dressing is dimmed. The techniques are also time-consuming and costly and there is still a need for an acceptable and affordable wound dressing which can be made through easily accessible techniques. A new but very simple method is introduced in this work for incorporating PVA nanofibers with Aloe vera-containing chitosan films. Using this method the levels of Aloe vera and chitosan in the system can be optimized at higher scales while benefiting from PVA best mechanical properties as a composite layer. Higher amounts of Aloe vera and chitosan in the system lead to lower product costs and more biocompability. The biological properties of films were examined through cell cytotoxicity and antibacterial tests and compared with Atomic force microscopy results. Physical and mechanical properties of films containing PVA nanofibers were characterized by water vapor permeability, swelling ratio, and tensile tests. The morphology of fibers before and after applying on the films was also observed by scanning electron microscopy. According to the results, this combination of natural and synthetic polymers has led to an affordable, biocompatible, and flexible film for wound dressing applications.

In vitro biocompatibility evaluation of radiolytically synthesized silver/polyvinyl hydrogel nanocomposites for wound dressing applications

2020 ◽  
Vol 35 (4-5) ◽  
pp. 435-450
Author(s):  
Swaroop Kumaraswamy ◽  
Shrikant L Patil ◽  
Somashekarappa H Mallaiah
Keyword(s):  
Polyvinyl Alcohol ◽  
Gamma Irradiation ◽  
Wound Dressing ◽  
Wound Care ◽  
Crosslinking Agent ◽  
Homogeneous Distribution ◽  
Swelling Properties ◽  
In Vitro Biocompatibility ◽  
Hydrogel Nanocomposites

Nano silver/polyvinyl alcohol hydrogel nanocomposites have been prepared using gamma irradiation technique. Gamma irradiation serves as a crosslinking agent for the polyvinyl alcohol hydrogels and also acts as a reducing agent for reduction of Ag+ ions to zero valent Ag0 within the polyvinyl alcohol crosslinked network. The microstructural characteristics of the prepared composites were studied using powder X-ray diffraction, ultraviolet–visible spectroscopy, Fourier-transform infrared spectroscopy and field emission scanning electron microscopy analysis. The data obtained by these characterizations indicate the homogeneous distribution of silver nanoparticles on the polyvinyl alcohol network. The swelling properties and mechanical parameters of the silver/polyvinyl alcohol hydrogel nanocomposites tend to show improvements, making them a better material for wound care applications. The silver/polyvinyl alcohol hydrogel nanocomposites have shown good antibacterial potential against both Gram-positive and Gram-negative bacteria and shown nil or minimal cytotoxic effect on human melanoma (SK-MEL-2) and mouse melanoma (B16-F1) cell lines. Overall, it was concluded that under optimized condition, silver/polyvinyl alcohol hydrogel nanocomposites synthesized using gamma irradiation technique are excellent candidates for wound dressing application.

Influence of Multifunctional Monomers on Gamma Irradiated Polylactic Acid

2015 ◽  
Vol 804 ◽  
pp. 59-62 ◽  
Author(s):  
Kantima Chaochanchaikul ◽  
Wanlop Harnnarongchai
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Polylactic Acid ◽  
Irradiation Dose ◽  
Crosslinking Agent ◽  
Chain Scission ◽  
Chain Extension ◽  
Molecular Characteristics ◽  
High Irradiation Dose ◽  
Gamma Irradiated

The aim of this work was to compare and discuss the influence of multifunctional monomers as crosslinking agent (Triallyl Isocyanurate; TAIC) and chain extender (Joncryl ADR4368) on the gamma irradiated Polylactic acid (PLA). The modified PLA samples with varying amount of TAIC and Joncryl were characterized by observing the molecular characteristics and mechanical properties. The results showed that irradiated PLA had lower average molar mass and mechanical properties compared to non-irradiated PLA due to irradiation induced chain scission. Gel content was observed and increased with increasing irradiation dose for the TAIC modified sample, indicating that the further crosslink of irradiated PLA was occurring. Crosslinking and chain extension were responsible for the improved modulus and tensile strength of irradiated PLA, however the decrease in tensile strength at high irradiation dose was observed for crosslinked PLA.

Tensile Strength of Electrospun Poly(ethylene-co-vinyl alcohol) Nanofibre Sheets

2013 ◽  
Vol 535-536 ◽  
pp. 215-218 ◽  
Author(s):  
Bin Wang ◽  
X. Chao ◽  
Y. Li ◽  
S.R. Reid
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Vinyl Alcohol ◽  
Wound Dressings ◽  
Thin Sheets ◽  
Random Orientation ◽  
Multiple Fractures ◽  
Hardening Behavior ◽  
Poly Ethylene ◽  
Potential Use

Electrospinning technology was used to obtain non-woven sheets made from fine fibres in a controllable diameter range from 50 nm to 3 µm. Poly(ethylene-co-vinyl alcohol), a large molecule polymer was chosen to make the fibres for its biodegradable and biocompatible properties. The thin sheets obtained were tested in uniaxial tension for their mechanical properties in view of the potential use as wound dressings. It is found that the sheets show a mild hardening behavior with extensive elongation and necking before failure in multiple fractures at random locations. Due to the random orientation of the continuous fibres in the sheet, detachment, shear, straightening and twinning. etc., occur amongst fibres to different extends at the same time. The Young’s modulus and the yield stress (at 0.4~0.5% proof strains) are predominately affected by fibre diameters, and are largely insensitive to strain rate over the range tested.

Alternative microwave curing approach for imparting ease and care characteristics and antimicrobial activity to viscose fabric

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Kh M. Mostafa ◽  
A. A. Elsanabary
Keyword(s):  
Tensile Strength ◽  
Antibacterial Activity ◽  
Citric Acid ◽  
Graft Copolymer ◽  
Crosslinking Agent ◽  
Sodium Hypophosphite ◽  
Content Type ◽  
Microwave Curing ◽  
Recovery Angle ◽  
The Impact

Purpose This study aims to use multi-functional viscose fabric that was facilely developed with with respect to ease and care characteristics, reinforcement effect and antibacterial activity by using novel echo friendly antibacterial finish based on citric acid/sodium hypophosphite and the authors’ previously tailor-made poly meth acrylic acid (MAA)-chitosan graft copolymer via alternative microwave curing approach instead of traditional high-temperature cure one. Design/methodology/approach Viscose fabric was paddled twice in the cross-linking formulations containing different concentrations of citric acid, poly (MAA)-chitosan graft copolymer and sodium hypophosphite to 90 % wet pick up and dried at 100°C for 3 min in an electric oven. Then, the treated fabrics were placed on the disk spinner of the microwave oven and cured at different power (100–800 Watt) for various durations (60–180 s). The fabric was then water-rinsed and dried at ambient condition before use. Findings Results revealed that the above echo friendly method for finished viscose fabrics was found to achieve relatively high dry wrinkle recovery angle and maintain the loss in tensile strength within the acceptable range, as well as antibacterial activity against Escherichia coli and Staphylococcus aureus as a gram-negative and gram-positive bacteria, respectively; in addition to durability up to ten washing cycles. Furthermore, scanning electron microscope images, nitrogen content and add on % of the finished fabric confirmed the penetration of grafted chitosan inside the fabric structure. The tentative mechanism for these reactions is advocated. Originality/value The novelty addressed here is undertaken with the advantages of using citric acid as a nonformaldehyde, safe and cheap poly carboxylic acid as a crosslinking agent and sodium hypophosphite as a potential catalyst, in addition to the authors’ noncitable multifunctional echo friendly tailor-made poly (MAA)-chitosan graft copolymer for imparting reinforcement and antibacterial characteristics to viscose fabric that uses the pad-dry/cure microwave fixation for progressively persuaded heat within the fabric during curing. Research limitations/implications This was done to see the impact of microwave as green and efficient tool with respect to reduction in organic solvents, chemicals and exposer time as well as fixation temperature on the finishing reaction in comparison with traditional pad-dry-cure method. Practical implications Poly (MAA)-chitosan graft copolymer as amphoteric biopolymer was expected to impart multifunctional properties to viscose fabrics especially with comparable dry wrinkle recovery angle and minimize the loss in tensile strength in addition to antibacterial properties in comparison with untreated one.

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