scholarly journals Importance of various antioxidant enzymes for cell stability. Confrontation between theoretical and experimental data

1992 ◽  
Vol 286 (1) ◽  
pp. 41-46 ◽  
Author(s):  
J Remacle ◽  
D Lambert ◽  
M Raes ◽  
E Pigeolet ◽  
C Michiels ◽  
...  
Keyword(s):  
Experimental Data ◽  
Antioxidant Enzymes ◽  
Steady State ◽  
Qualitative Description ◽  
Rate Equations ◽  
Stable Steady State ◽  
General View ◽  
Complex Situation ◽  
Cell Stability ◽  
The Stability

A theoretical model was developed taking into account the production and destruction of oxygen-derived free radicals. The steady state of the system was derived by using the rate equations of these reactions, and the stability of the system was tested. In the simplified model, only one stable steady state was found. However, we know that glutathione peroxidase can be inhibited by hydroperoxides, and, when incorporated into the model, this effect led to a complex situation with the presence of some stable and some unstable domains according to the concentration of either the enzyme or the hydroperoxide. This qualitative description of the system was compared with experimental data on the protection given by three antioxidant enzymes, and concordance of data was found which allows some quantification of the system. A general view of the efficiency of the three antioxidant enzymes and of the stability of the system according to their concentrations could be produced.

scholarly journals Suppression of marine ice sheet instability

2018 ◽  
Vol 857 ◽  
pp. 648-680 ◽  
Author(s):  
Samuel S. Pegler
Keyword(s):  
Steady State ◽  
Rapid Assessment ◽  
Ice Sheets ◽  
Ice Sheet ◽  
Stable Steady State ◽  
Ice Shelf ◽  
West Antarctic Ice Sheet ◽  
West Antarctic ◽  
Grounding Line ◽  
The Stability

A long-standing open question in glaciology concerns the propensity for ice sheets that lie predominantly submerged in the ocean (marine ice sheets) to destabilise under buoyancy. This paper addresses the processes by which a buoyancy-driven mechanism for the retreat and ultimate collapse of such ice sheets – the marine ice sheet instability – is suppressed by lateral stresses acting on its floating component (the ice shelf). The key results are to demonstrate the transition between a mode of stable (easily reversible) retreat along a stable steady-state branch created by ice-shelf buttressing to tipped (almost irreversible) retreat across a critical parametric threshold. The conditions for triggering tipped retreat can be controlled by the calving position and other properties of the ice-shelf profile and can be largely independent of basal stress, in contrast to principles established from studies of unbuttressed grounding-line dynamics. The stability and recovery conditions introduced by lateral stresses are analysed by developing a method of constructing grounding-line stability (bifurcation) diagrams, which provide a rapid assessment of the steady-state positions, their natures and the conditions for secondary grounding, giving clear visualisations of global stabilisation conditions. A further result is to reveal the possibility of a third structural component of a marine ice sheet that lies intermediate to the fully grounded and floating components. The region forms an extended grounding area in which the ice sheet lies very close to flotation, and there is no clearly distinguished grounding line. The formation of this region generates an upsurge in buttressing that provides the most feasible mechanism for reversal of a tipped grounding line. The results of this paper provide conceptual insight into the phenomena controlling the stability of the West Antarctic Ice Sheet, the collapse of which has the potential to dominate future contributions to global sea-level rise.

scholarly journals Experiments on an Ultrastable Gas Journal Bearing

1967 ◽  
Vol 89 (4) ◽  
pp. 433-438 ◽  
Author(s):  
S. B. Malanoski
Keyword(s):  
Experimental Data ◽  
Steady State ◽  
Journal Bearing ◽  
Journal Bearings ◽  
Design Data ◽  
Attitude Angle ◽  
Angle Data ◽  
The Stability ◽  
Data Design ◽  
Gas Journal Bearing

Shallow grooving in a herringbone pattern has been proposed to enhance the stability of both gas and liquid-lubricated journal bearings. It has been shown theoretically that this possibility is particularly advantageous for unloaded journal bearings. This paper describes corroborating experiments. The experiments included the running of an unloaded bearing up to speeds of 60,000 rpm and the collection of steady-state load-displacement, attitude angle data at intermediate speeds up to and including 60,000 rpm. No sign of bearing whirl instability was detected. There was good correlation between theoretical and experimental data. Design data for the partially grooved journal bearing is included for future designs.

Photobioreactor Stability by Phase Plane Technique Applied to Spirulina Maxima Growth

2003 ◽  
Vol 1 (1) ◽  
Author(s):  
Khaled Belkacemi ◽  
Safia Hamoudi
Keyword(s):  
Steady State ◽  
Phase Plane ◽  
Biologically Active ◽  
Raw Material ◽  
System Stability ◽  
Stable Steady State ◽  
Monod Kinetics ◽  
Spirulina Maxima ◽  
Plane Technique ◽  
The Stability

Spirulina maxima is a worthy multicellular filamentous micro-algae used as a food supplement and raw material for fine chemicals and biologically active compounds production. Intensive approach consisting of cultivating pure strains of this photoautotroph microorganism in photobioreactors is more desirable than extensive ones, largely incontrollable with regard to production stability. Determining the best reaction conditions to reach a steady state in the runway events is often needed in biological systems. For a biochemical engineer, knowing the system stability for an optimal bioreactor configuration is crucial to estimate the rate at which dependent variables grow or decay with the time reaction. The stability analysis becomes important in recycle processes in which possibility that these systems influence themselves exists. The aim of this work deals with the 1) description of the growth kinetics by a logistic and unstructured model based on Monod kinetics taking into account the maintenance in life of viable cells; 2) establishment of a dynamic growth model for Spirulina maxima cultivated in continuous lamellar photobioreactors using industrial manures as macro-nutrients; 3) determination of optimal culture conditions sustaining a stable growth of S. maxima in a system of two bioreactors in series; and 4) investigation of the dynamic stability of this multivariable system with nonlinear dynamics using phase plane technique (PPT). Although good mixing of the culture is essential for ensuring adequate supply of nutrients and prevention of the accumulation of toxic metabolites. Excessive agitation causes mechanical damage to Spirulina cells. An air flow rate of 2.5 L/min for airlift agitation represented a balance between the need to provide good mixing and to avoid cell damage. A stable steady state was achieved corresponding to a productivity of 10.8 g. m2/day when the system was supplied with 0.2 g N/L of minerals, at a dilution rate of 0.1 1/day, temperature of 30 °C under light intensity of 18 Klux. PPT as a powerful procedure successfully predicts the stability of such a complex system very well.

scholarly journals Travelling Wave and Turing Patterns in Subdiffusive Autocatalytic Systems

2021 ◽  
Author(s):  
Uttam Kumar ◽  
Pushpavanam Subramanian
Keyword(s):  
Steady State ◽  
Stability Boundary ◽  
Mean Square Displacement ◽  
Travelling Wave ◽  
Turing Patterns ◽  
Logistic Growth ◽  
Stable Steady State ◽  
Phase Plane Analysis ◽  
Plane Analysis ◽  
The Stability

Abstract In this work, we analyse autocatalytic reactions in complex and disordered media which are governed by subdiffusion. The mean square displacement of molecules here scale as tγ where 0<γ<1. These systems are governed by fractional partial differential equations. Two systems are analysed i) in the first a logistic growth expression is used to represent the growth kinetics of bacteria. Here the system dynamics is governed by a single variable. ii) the second system is a two variable cubic autocatalytic system in a porous media. Here each reactant is involved in the autocatalytic generation of the other. These systems have multiple steady states. They exhibit traveling waves moving from an unstable steady state to a stable steady state. The minimum wave velocity has been obtained from phase plane analysis analytically for the first system. In addition, the two variable system also shows Turing patterns in selected regions of parameter space. The stability boundary for Turing patterns for subdiffusive system is found to be the same as that for regular diffusive systems obtained by Seshai et al. [1]. System behaviour as predicted by the stability analysis is verified using a robust implicit numerical method based on L1 scheme.

On the directly generated resonant standing waves in a rectangular tank

1990 ◽  
Vol 217 ◽  
pp. 143-165 ◽  
Author(s):  
Lev Shemer
Keyword(s):  
Experimental Data ◽  
Fixed Point ◽  
Steady State ◽  
Numerical Study ◽  
Standing Waves ◽  
Stationary Solutions ◽  
Damping Coefficients ◽  
Rectangular Tank ◽  
Starting Point ◽  
The Stability

A numerical study based on the nonlinear Schrödinger equation, as applied to nonlinear resonant standing waves excited directly by a wavemaker in a rectangular tank, is presented. The stationary solutions of the problem serve as a starting point of the investigation. Bifurcations from a single steady state to multiple stationary solutions are obtained for several values of damping coefficients along the tank and at the wavemaker. The stability of the latter solutions is tested. Limit-cycle or fixed-point solutions are obtained. The results of the numerical study are discussed in connection with experimental data. The necessity of incorporation of dissipation at the wavemaker in the theoretical model in order to obtain qualitative agreement with experiment is demonstrated.

scholarly journals THEORETICAL MODELING OF A TWO-PHASED THERMOSYPHON ASSUMING THE LIQUID RESERVATORY

2007 ◽  
Vol 6 (1) ◽  
pp. 74
Author(s):  
M. A. Zanardi ◽  
N. G. C. Leite
Keyword(s):  
Heat Transfer ◽  
Experimental Data ◽  
Steady State ◽  
Energy Conservation ◽  
Theoretical Modeling ◽  
General View ◽  
Two Phase ◽  
Conservation Equations ◽  
Stable Level ◽  
Steady State Operation

A theoretical modeling using the mass, momentum and energy conservation equations, about the intrinsic phenomena in the working of a cylindrical geometry two-phase thermosyphon operating on vertical was performed.  The conservation equations were solved in steady-state operation for all the phases of the thermosyphon. Then model also assumed the presence of a liquid reservatory whose valves of the coefficient of heat transfer that determine the operation of functioning in the reservatory, were obtained from the correlation published in literature.  The set of conservation equations was solved by using the method of finite volumes.  The results achieved were checked with experimental data from literature and also from specific experiments performed in laboratory. In a  general view, the theoric results matched reasonably well with those ones from the experiments, and the observed deviation were assumed by a inadequate prevision of the reservatory model used, besides keeping a stable level of the reservatory of liquid.

Local stability analysis of a low-dissipation cyclic refrigerator

2021 ◽  
Author(s):  
Kai Li ◽  
Jie Lin ◽  
Jian-Hui Wang
Keyword(s):  
Steady State ◽  
Local Stability ◽  
Figure Of Merit ◽  
Coefficient Of Performance ◽  
Stable Steady State ◽  
Local Stability Analysis ◽  
Low Dissipation ◽  
Internal Dissipation ◽  
The Stability

Abstract We study the local stability near the maximum figure of merit for the low-dissipation cyclic refrigerator, where the irreversible dissipation occurs not only in the thermal contacts but also the adiabatic strokes. We find that the bounds of the coefficient of performance at maximum figure of merit or maximum cooling rate in presence of internal dissipation are identical to corresponding those in absence of internal dissipation. Using two different scenarios, we prove the existence of a single stable steady state for the refrigerator, and clarify the role of internal dissipation on the stability of thermodynamic steady state, showing that the speed of system evolution to the steady state decreases due to internal dissipation.

The Stability of Steady-State Depth Distributions of Marine Phytoplankton

1974 ◽  
Vol 108 (963) ◽  
pp. 679-687 ◽  
Author(s):  
W. O. Criminale, ◽  
D. F. Winter
Keyword(s):  
Steady State ◽  
Marine Phytoplankton ◽  
The Stability ◽  
Depth Distributions

Kinetic analysis of mechanism of intestinal Na+-dependent sugar transport

1985 ◽  
Vol 248 (5) ◽  
pp. C498-C509 ◽  
Author(s):  
D. Restrepo ◽  
G. A. Kimmich
Keyword(s):  
Experimental Data ◽  
Steady State ◽  
Sugar Transport ◽  
Enzyme Kinetic ◽  
Steady State Distribution ◽  
State Distribution ◽  
Least Squares Fit ◽  
Coupling Stoichiometry ◽  
Rate Limiting ◽  
Kinetics Of

Zero-trans kinetics of Na+-sugar cotransport were investigated. Sugar influx was measured at various sodium and sugar concentrations in K+-loaded cells treated with rotenone and valinomycin. Sugar influx follows Michaelis-Menten kinetics as a function of sugar concentration but not as a function of Na+ concentration. Nine models with 1:1 or 2:1 sodium:sugar stoichiometry were considered. The flux equations for these models were solved assuming steady-state distribution of carrier forms and that translocation across the membrane is rate limiting. Classical enzyme kinetic methods and a least-squares fit of flux equations to the experimental data were used to assess the fit of the different models. Four models can be discarded on this basis. Of the remaining models, we discard two on the basis of the trans sodium dependence and the coupling stoichiometry [G. A. Kimmich and J. Randles, Am. J. Physiol. 247 (Cell Physiol. 16): C74-C82, 1984]. The remaining models are terter ordered mechanisms with sodium debinding first at the trans side. If transfer across the membrane is rate limiting, the binding order can be determined to be sodium:sugar:sodium.

scholarly journals Steady-state $$\dot{V}{\text{O}}_{2}$$ above MLSS: evidence that critical speed better represents maximal metabolic steady state in well-trained runners

2021 ◽  
Author(s):  
Rebekah J. Nixon ◽  
Sascha H. Kranen ◽  
Anni Vanhatalo ◽  
Andrew M. Jones
Keyword(s):  
Steady State ◽  
Critical Speed ◽  
Lactate Concentration ◽  
Practical Interest ◽  
Blood Lactate Concentration ◽  
Distance Runners ◽  
Severe Intensity ◽  
The Stability ◽  
Trained Runners ◽  
Over Time

AbstractThe metabolic boundary separating the heavy-intensity and severe-intensity exercise domains is of scientific and practical interest but there is controversy concerning whether the maximal lactate steady state (MLSS) or critical power (synonymous with critical speed, CS) better represents this boundary. We measured the running speeds at MLSS and CS and investigated their ability to discriminate speeds at which $$\dot{V}{\text{O}}_{2}$$ V ˙ O 2 was stable over time from speeds at which a steady-state $$\dot{V}{\text{O}}_{2}$$ V ˙ O 2 could not be established. Ten well-trained male distance runners completed 9–12 constant-speed treadmill tests, including 3–5 runs of up to 30-min duration for the assessment of MLSS and at least 4 runs performed to the limit of tolerance for assessment of CS. The running speeds at CS and MLSS were significantly different (16.4 ± 1.3 vs. 15.2 ± 0.9 km/h, respectively; P < 0.001). Blood lactate concentration was higher and increased with time at a speed 0.5 km/h higher than MLSS compared to MLSS (P < 0.01); however, pulmonary $$\dot{V}{\text{O}}_{2}$$ V ˙ O 2 did not change significantly between 10 and 30 min at either MLSS or MLSS + 0.5 km/h. In contrast, $$\dot{V}{\text{O}}_{2}$$ V ˙ O 2 increased significantly over time and reached $$\dot{V}{\text{O}}_{2\,\,\max }$$ V ˙ O 2 max at end-exercise at a speed ~ 0.4 km/h above CS (P < 0.05) but remained stable at a speed ~ 0.5 km/h below CS. The stability of $$\dot{V}{\text{O}}_{2}$$ V ˙ O 2 at a speed exceeding MLSS suggests that MLSS underestimates the maximal metabolic steady state. These results indicate that CS more closely represents the maximal metabolic steady state when the latter is appropriately defined according to the ability to stabilise pulmonary $$\dot{V}{\text{O}}_{2}$$ V ˙ O 2 .

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