DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides
Keyword(s):
We have identified a novel 280 amino acid protein which contains a putative myristoylation site at its N-terminus followed by an Src homology (SH2) domain and a pleckstrin homology (PH) domain at its C-terminus. It has been termed dual adaptor for phosphotyrosine and 3-phosphoinositides (DAPP1). DAPP1 is widely expressed and exhibits high-affinity interactions with PtdIns(3,4,5)P3 and PtdIns(3,4)P2, but not with other phospholipids tested. These observations predict that DAPP1 will interact with both tyrosine phosphorylated proteins and 3-phosphoinositides and may therefore play a role in regulating the location and/or activity of such proteins(s) in response to agonists that elevate PtdIns(3,4,5)P3 and PtdIns(3,4)P2.
1995 ◽
Vol 15
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pp. 3227-3237
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2005 ◽
Vol 187
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pp. 5067-5074
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2017 ◽
Vol 4
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pp. 625-628
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1999 ◽
Vol 31
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pp. S91
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1998 ◽
Vol 64
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pp. 1650-1656
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2002 ◽
Vol 184
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pp. 2225-2234
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2001 ◽
Vol 276
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pp. 21250-21256
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