scholarly journals Polymorphism rs7214723 in CAMKK1: a new genetic variant associated with cardiovascular diseases

2021 ◽  
Author(s):  
Sofia Beghi ◽  
Francesca Cavaliere ◽  
Matteo Manfredini ◽  
Sandro Ferrarese ◽  
Claudio Corazzari ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Previous History ◽  
Kinase Domain ◽  
Cross Sectional Study ◽  
Calcium Signal ◽  
Cross Sectional ◽  
Gene Coding ◽  
History Of ◽  
Dependent Protein

Cardiovascular diseases (CVDs) are leading cause of death worldwide. CVDs have a complex etiology due to the several factors underlying its development including environment, lifestyle, and genetics. Given the role of calcium signal transduction in several CVDs, we investigated via PCR-RFLP the single nucleotide polymorphism (SNP) rs7214723 within the CAMKK1 gene coding for the Ca2 + / calmodulin dependent protein kinase kinase I. The variant rs7214723 causes a E375G substitution within the kinase domain of CAMKK1. A cross-sectional study was conducted on 300 cardiac patients. RFLP-PCR technique was applied, and statistical analysis was performed to evaluate genotypic and allelic frequencies and to identify an association between SNP and risk of developing specific CVD. Genotype and allele frequencies for rs7214723 were statistically different between cardiopathic and several European reference populations. A logistic regression analysis adjusted for gender, age, diabetes, hypertension, BMI and previous history of malignancy was applied on cardiopathic genotypic data and no association was found between rs7214723 polymorphism and a risk of developing specific CAD. These results suggest the potential role of rs7214723 in CVD susceptibility as a possible genetic biomarker.

Malaria among migrants in a university hospital in Colombia during 2018: A case series

2020 ◽  
pp. 004947552098130
Author(s):  
Fabián R Carreño-Almánzar ◽  
Adán Coronado-Galán ◽  
Sonia A Cala-Gómez ◽  
Agustín Vega-Vera
Keyword(s):  
Latin American ◽  
Previous History ◽  
Case Series ◽  
Cross Sectional Study ◽  
Imported Malaria ◽  
University Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
Clinical Profiles

Imported malaria has increased in Colombia since 2015 and has been attributed to migrants coming from Venezuela. We present a series of malaria cases, nested in a retrospective cross-sectional study between 2017 and 2018, aimed at calculating the prevalence of medical diseases among immigrants in a University Hospital in Colombia. Among 154 immigrants admitted for medical causes between 2017 and 2018, 8 were diagnosed with malaria, all due to Plasmodium vivax. Of these, seven had uncomplicated malaria, five had a previous history of malaria, one was critically ill, but none died. We highlight that, similar to other case series of imported malaria, Latin American migrants were young, with similar clinical profiles, having a low proportion of severe cases, and P. vivax was the most frequent cause.

scholarly journals Role of Psychosocial Factors In Vicarious Traumatization: A Comparative Study

2022 ◽  
Vol 9 (1) ◽  
pp. 53-57
Author(s):  
Nazia Mustafa ◽  
Hina Iqbal
Keyword(s):  
Psychosocial Factors ◽  
Health Care Professionals ◽  
Healthcare Professionals ◽  
Vicarious Traumatization ◽  
Cross Sectional Study ◽  
Personal History ◽  
Vulnerable Group ◽  
Cross Sectional ◽  
History Of

OBJECTIVES: The present study aimed at investigating the role of psychosocial factors such as, gender, marital status, profession, and personal history of trauma in vicarious traumatization (VT). METHODOLOGY: Cross sectional study was conducted at various hospitals in Rawalpindi and Islamabad over the period of 6 months from January 2018 to June 2018. A sample of 170 healthcare professionals (doctors=39, psychiatrists=27, psychologists=36, nurses=30 and others=38) (men=67, women=103) was taken from various hospitals in Rawalpindi and Islamabad. Data were collected by using the Secondary Traumatic Stress Scale. RESULTS: Results revealed significant differences have been found among various groups of healthcare professionals (doctors, psychiatrist, psychologists, nurses and others) in whom psychiatrists are the most vulnerable group for vicarious traumatization and psychologists are the least vulnerable group. Moreover, healthcare professionals who are married and have personal history of trauma are more vulnerable for vicarious traumatization as compared to those who are unmarried and without personal history of trauma. No significant gender differences have been found among health care professionals on vicarious traumatization. CONCLUSION: The findings of present research have emphasized that vicarious traumatization must be addressed and identified in a health setting.

scholarly journals Hepatitis C in pregnancy: an observational study highlighting its association with maternal parameters

2019 ◽  
Vol 8 (1) ◽  
pp. 344
Author(s):  
Bushra . ◽  
Ambreen Ghori ◽  
Azra Ahmed ◽  
Najma Dalwani ◽  
Mushtaque Ali Shah ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Previous History ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Prior History ◽  
Singleton Pregnancy ◽  
Cross Sectional ◽  
History Of

Background: Pregnancy is a very crucial time in a woman’s life. In this period of time, not only multiple physiological alterations effect the usual health status but also makes women more vulnerable to contract infection and face negative sequalae. Hepatitis C, a blood borne viral infection serve the similar fate when encountered by pregnant ladies. This study is based on exploring the prevalence of the Hepatitis C virus seropositivity among pregnant population. Moreover, we also evaluated the major risk factors leading to the infection in these mothers. Besides this, infected mothers were studied for their pregnancy outcomes.Methods: In this study 114 pregnant females were observed for this cross-sectional study. It was conducted in Gynecology Unit- 1, Liaquat University Hospital Hyderabad, for the period of January 2017 to July 2017. Chi square test was applied for statistical analysis on SPSS version 16. The criteria for enrollment in the study was set to be a pregnant lady belonging to age group 20-35 years; having singleton pregnancy; was a booked case at the hospital with compliant to antenatal follow ups; admitted to the labor room for delivery. All the non-pregnant ladies, whom had co morbid conditions such as hypertension or diabetes or had infected with hepatitis B or D were excluded from the study. Furthermore, pregnant ladies with multiple gestion or those who were either diagnosed of hepatitis C prior to conceive or had a previous history of hepatitis C were also excluded.Results: Present study revealed that out of 114, 10(8.8%) pregnant ladies were found seropositive for Hepatitis C virus. Prior history for transfusion of blood was the Foremost risk factor discovered, with 60.5% women reported this. History of surgery was the 2nd commonest factor and 43.9% had this in their medical records. On the other hand, only 8.8% women gave the history for previous evacuation. While observing pregnancy outcomes, we found 48.2% neonates had low birth weight, 41.2% were born preterm and 21.1% had low APGAR score.Conclusions: In a nutshell hepatitis c is prevalent in the pregnant population of this region and showing its effects in the form of compromised pregnancies. History of blood transfusion and previous surgery were found to be chief risk factors in the study.

scholarly journals Cardiovascular Risk Factors in Patients with Acute MI in a Secondary Hospital in Bangladesh

2020 ◽  
Vol 12 (2) ◽  
pp. 96-101
Author(s):  
Mohammad Ullah ◽  
Suman Kumar Saha ◽  
Md Toufiqur Rahman ◽  
Md Abdul Karim ◽  
Rashid Ahmed
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Family History ◽  
Cardiovascular Diseases ◽  
General Population ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
Secondary Hospital

Background: Incidence of noncommunicable disease, specially cardiovascular diseases, is increasing in Bangladesh. Prevalence of risk factors in ischaemic heart disease (IHD) has been studied in different tertiary hospitals and institutes. This study was done in a secondary hospital with a patient population mainly of low socioeconomic condition and was compared with other patient groups of the country and Indian subcontinent. Methods: this cross sectional study was conducted in Manikganj Sadar Hospital from July 2019 to December 2019. All the patients admitted with the diagnosis of myocardial infarction (MI) were included. Cardiovascular risk factors, like smoking, diabetes mellitus (DM), hypertension (HTN), family history of premature cardiovascular diseases, dyslipidaemia and obesity, were evaluated among the patients. Results: This cross-sectional study showed most of the patients were in the age group of 50-59 years. 66% of the male patients and 2% of the female patients were smoker. 66% of the patients were hypertensive, 44% patients were diabetic, 28.5% patients were overweight, 60.4% patients had total cholesterol > 200mg/dl, 73.6% patients had LDL>130 mg/dl, 110 76.3% patients had HDL < 40 mg/ dl, 72.2% had triglyceride >150 mg/dl and 39% patients had family history of premature cardiovascular disease. Ninety (62.5%) patients had anterior MI, 50 (34.7%) patients had inferior MI and 4 (2.7%) patients had NSTEMI. 65 patients had no major risk factor and 57 % had three or more risk factors. Conclusion: The study population was more aged in comparison to other studies conducted in different parts of Bangladesh. Prevalence of smoking habit was lower but the prevalence of HTN, DM and dyslipidaemia were higher than the general population and other cohorts of MI patients. The prevalence of major risk factors was much higher than the general population of Bangladesh. Cardiovasc. j. 2020; 12(2): 96-101

scholarly journals Cardiovascular Diseases’ Awareness Among Women in Northern Jordan

2019 ◽  
Vol 11 (3) ◽  
pp. 102
Author(s):  
Abdulhakeem M Okour ◽  
Rami A Saadeh ◽  
Neda Redwan ◽  
Muhammad Faizal Bin A. Ghani
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Cross Sectional Study ◽  
Demographic Information ◽  
Cross Sectional ◽  
Related Risk ◽  
History Of ◽  
Treatment Plans ◽  
The Mean ◽  
Health Objectives

BACKGROUND: Women&rsquo;s awareness of chronic diseases, including cardiovascular diseases, is the cornerstone in promoting women&rsquo;s health. Objectives: To examine the relationship of awareness levels about cardiovascular diseases and their related risk factors with demographic information of Jordanian women. METHODS: A cross-sectional study of 18 years and older women. Scores of awareness were computed for each individual and were divided into 4 quartiles. Logistic regression analysis was used to examine the association of demographic information of participants with mean scores of quartiles. ANOVA analysis was used to compare the mean scores of quartiles. RESULTS: A total of 514 women completed the questionnaire, with a mean age of 35.46 (&plusmn;12.53). Current smokers were 6.2%, and 34.6% had a family history of heart disease. The proportion of diabetes, hypertension, hypercholesterolemia, and overweight/obesity were 15.6%, 19.3%, 14.4%, &amp; 21.6% respectively. The mean score for awareness was 12.87 (+ 3.26). Women who had lower income and who were at younger age were more likely to score low in awareness. CONCLUSION: Women illustrated a fair level of awareness of CVD and its related risk factors. Increasing women awareness of CVD through educational programs, targeted toward women at risk, assists in disease prevention and help to improve treatment plans.

scholarly journals Alcohol use disorder and its determinant factors among patients with schizophrenia attending treatment at mental specialized hospital, Addis Ababa, Ethiopia: A cross-sectional study

2021 ◽  
Vol 9 ◽  
pp. 205031212110487
Author(s):  
Habtamu Tadesse ◽  
Yohannes Mirkana ◽  
Tadesse Misgana
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Addis Ababa ◽  
Previous History ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Duration Of Illness ◽  
Specialized Hospital ◽  
Audit Score ◽  
History Of

Background: Alcohol use disorder is one of the primary causes of avoidable death, illness, and injury in many societies throughout the world. Although alcohol use disorder can influence the natural history of a disease, disease recurrence, quality of life, and treatment adherence in psychiatric patients, the data on its magnitude is scarce. Objectives: This study was aimed to determine the magnitude of alcohol use disorder and its determinants among patients with schizophrenia attending a mental specialized hospital in Addis Ababa, Ethiopia. Methods: An institutional-based cross-sectional study was conducted from May 15 to June 15, 2018. An alcohol use disorder identification test was employed among a sample of 414 randomly selected patients with schizophrenia. Alcohol use disorder was categorized as hazardous drinking (Alcohol Use Disorders Identification Test (AUDIT) score of 8–15), harmful drinking (AUDIT score of 16–19), and alcohol dependence (AUDIT score of 20 or above). The data were entered into Epi-Data 3.1 and exported to SPSS 20 for analysis. Logistic regression was fitted to identify factors associated with alcohol use disorder. Results: The prevalence of alcohol use disorder was 38.4% (95% confidence interval (CI) 33.7, 42.9). Of this, 22.4% of the patients had hazardous drinking, 8.4% harmful drinking, and 7.6% alcohol dependence. Factors associated with alcohol use disorder were male sex (adjusted odds ratio (AOR) = 5.8, 95% CI 2.55, 13.19), being single (AOR = 3.0, 95% CI 1.63, 5.51), divorced (AOR = 4.3, 95% CI 1.95, 9.47) and widowed (AOR = 3.5, 95% CI 1.39, 8.81), having family history of alcoholism (AOR = 3.8, 95% CI 1.98, 7.19), longer duration of illness (AOR = 3.9, 95% CI 1.83, 8.36), previous history of psychiatric diagnosis (AOR = 2.2, 95% CI 1.1, 4.34), and concomitant use of non-alcoholic substances (AOR = 3.7, 95% CI 2.06, 6.74). Conclusions: Almost four in ten patients with schizophrenia had alcohol use disorder. Male sex, single, divorced, and widowed, family history of alcohol use, long duration of illness, previous history of psychiatric diagnosis, and concomitant use of non-alcoholic substances were significantly associated with alcohol use disorder. Continuous counseling of at risk populations about alcohol consumption should be strengthened.

scholarly journals Current concept of the pathogenesis of peri-implantitis and the role of bactéria.

2021 ◽  
Vol 3 (5) ◽  
pp. 09-30
Author(s):  
Anthony Davis ◽  
Mary Davis
Keyword(s):  
Previous History ◽  
Genetic Load ◽  
Current Concept ◽  
Risk Indicators ◽  
Cross Sectional ◽  
History Of ◽  
Periodontopathogenic Bacteria ◽  
Risk Situation ◽  
Edentulous Patients

Through an extensive review of the literature, our objective will be to clarify the current concept that exists about the pathogenesis of peri-implantitis, as well as the implications that bacteria may have on it. To date, different longitudinal and cross-sectional studies have identified some of the risk factors or risk indicators of peri-implantitis. Previous history of periodontal disease, diabetes, genetic load, poor oral hygiene, tobacco, alcohol consumption, absence of keratinized gingiva and the surface of the implants are some of the factors that have been analyzed in detail in the literature. The colonization of new surgically implanted surfaces represents a risk situation in partially edentulous patients, where periodontopathogenic bacteria from the residual bag play an important role.

scholarly journals MATERNAL OUTCOMES OF PREGNANCY-RELATED ACUTE KIDNEY INJURY

2021 ◽  
Vol 71 (6) ◽  
pp. 2057-60
Author(s):  
Irfan Khattak ◽  
Samina Naseem Khattak ◽  
Ayesha Imran ◽  
Khawar Kamal ◽  
Umairah Yaqoob
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Disease ◽  
Previous History ◽  
Kidney Injury ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
Maternal Outcomes ◽  
Recent Past ◽  
Cross Sectional ◽  
History Of

Objective: To determine the frequency of Pregnancy-related acute kidney injury in the Pakistani population and its effect on maternal health. Study Design: Cross-sectional study. Place and Duration of the Study: Department of Nephrology and Obstetrics and Gynecology, Combined Military Hospital Kharian, from Jan 2018 to Dec 2020. Methodology: All pregnant women with normal renal functions at the time of enrolment in the study and no previous history of any kidney disease or renal procedure in the recent past (at least 3 months) before conception were included in our study at Combined Military Hospital Kharian. All participants had serum creatinine tested at enrolment and were inquired specifically about any history of renal disease or any renal procedure in the recent past (at least 3 months old). Results: Mean maternal age in the study was 29 ± 7.67 years however it ranged from 16-41 years. Around a quarter of acute kidney injury cases occurred in the first and second trimesters combined, with 26 (12%) and 24 (11%) cases in the first and second trimesters, respectively. Thirty percent of acute kidney injury cases were diagnosed in the third trimester. A substantial number 58 (27%) of cases developed azotemia which persisted beyond three months and developed chronic kidney disease of various stages. Regarding maternal outcomes, 166 (77%) mothers recovered completely. However, 43 (20%) patients had some degree pf azotemia, a few cases required permanent renal replacement therapy. Conclusion: Acute kidney injury is a common problem in our community leading to suboptimal maternal outcomes..............

scholarly journals A Study of Posterior Segment Pathology in Cataractous Eyes Using B-scan Ultrasonography

2021 ◽  
Vol 11 (1) ◽  
pp. 78-81
Author(s):  
Mohammed Shakour ◽  
Caroline Ayad ◽  
Samih Kajoak ◽  
Hamid Osman ◽  
E. Rahim
Keyword(s):  
Imaging Modality ◽  
Previous History ◽  
Cross Sectional Study ◽  
Posterior Segment ◽  
Ocular Surgery ◽  
Diagnostic Modality ◽  
Cross Sectional ◽  
History Of ◽  
And Gender ◽  
Cataract Patients

Background: Ultrasonography (US) is a valuable diagnostic modality for detecting posterior segment eye diseases (PSEDs) in patients with cataractous eyes. This imaging modality can better facilitate planning surgery and predicting prognosis. The purpose of this study was to determine the role of B-scan US in evaluating posterior segment abnormalities of eyes in cataract patients pre-operatively to limit complications and visual impairment. Methods and Results: A prospective, cross‑sectional study to assess cataracts by US, as well as to detect posterior segment abnormalities of eyes in cataract patients, was conducted in Sudan at Albasar International Foundation (Makah Eye Complex in Omdurman) between December 2018 and December 2019. All patients (n=380; 48% males and 52% females; a mean age of 63±12.57 years) with non-visualization of the fundus, regardless of age and gender, were involved and were assumed to have orbital pathologies. Patients with high-risk extrusion of intraocular contents and a previous history of ocular surgery were excluded from the present study. All patients with dense cataracts were evaluated using standard US machines (Echoscan US-4000; NIDEK CO., LTD.) equipped with a real-time high-frequency probe. The typical age of the patients complaining of cataracts was between 61 and 70 years, which constituted 35% of cases, followed by age >70 years, which constituted 24.2% of cases. About 47.63% patients had ocular pathology in the posterior segment of the eye (Table 3). The most common PSEDs were vitreous abnormalities (46.2%). Among vitreous abnormalities, most abnormal eyes had vitreous changes (36.1%), followed by VD (3.7%); 1.3% of patients had retinal detachment. Conclusion: Ocular US should be the first screening modality in the evaluation of posterior segment pathologies in cataractous eyes and should be performed in cataract patients pre-operatively for better surgical planning and predicting post-operative visual prognosis.

scholarly journals Echocardiographic and Electrocardiographic Findings in COVID-19 Patients; A Cross-Sectional Study

2022 ◽  
Author(s):  
Faeze Keihanian ◽  
Hoorak Poorzand ◽  
Amin Saeidinia ◽  
Ali Eshraghi
Keyword(s):  
Heart Disease ◽  
Previous History ◽  
Structural Heart Disease ◽  
Cross Sectional Study ◽  
Imaging Data ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
Electrocardiographic Findings ◽  
Polymerase Chain

Abstract Background: There are still many gaps in our knowledge regarding the direct cardiovascular injuries due to COVID-19 infection. In this study, we tried to find out the effect of SARS-CoV-2 infection on cardiac function in patients without any history of structural heart disease by electrocardiographic and echocardiographic evaluations.Methods: This was a cross-sectional study on patients with COVID-19 infection admitted to Imam Reza hospital, Mashhad, Iran between 14 April and 21 September 2020. COVID-19 infection was verified by a positive reverse-transcriptase polymerase chain reaction (PCR) assay for SARS-CoV-2 using nasopharyngeal/oropharyngeal samples. We enrolled all patients over 18 years old with definite diagnosis of COVID-19 infection. All patients underwent a comprehensive transthoracic echocardiography at the first week of admission. Clinical and imaging data were collected prospectively. Results: In total, 142 patients were enrolled in this study. The mean age of participants was 60.69± 15.70 years (range: 30-90 years). Most patients were male (82, 57.7%). Multivariate analysis showed that O2 saturation at admission was independently a predictor of re-hospitalization (P<0.001). RV size (P<0.001), dyslipidemia (P<0.001), ejection fraction (EF) (P<0.001), age (P=0.020), systolic blood pressure (P=0.001), O2 saturation (P=0.018) and diabetes (P=0.025) independently predicted 30-days mortality. Conclusion: Echocardiography can be used for risk assessment in patients with COVID-19, especially in those with previous history of diabetes and dyslipidemia. The infection could result in Ventricular dysfunction, even in those without previous history of structural heart disease.

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