Analysis of eicosanoids and related lipid mediators using mass spectrometry
2008 ◽
Vol 36
(5)
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pp. 1055-1059
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Keyword(s):
Eicosanoids are oxidized arachidonate-derived lipids products generated by lipoxygenase, cyclo-oxygenase and cytochrome P450. Their bioactivity is mediated via receptor-dependent mechanisms and they are involved in a diverse array of processes in both health and disease. For many years, GC–MS was the method of choice for eicosanoid analysis, but, more recently, the availability of high-sensitivity electrospray LC (liquid chromatography)–MS/MS (tandem MS) has provided a new approach for quantification, while minimizing sample preparation. The present review summarizes the various methods available for routine quantification of eicosanoids, focusing ultimately on their analysis using a hybrid Q-Trap mass spectrometer.
2012 ◽
Vol 23
(3)
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pp. 442-445
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2012 ◽
Vol 895-896
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pp. 56-64
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1985 ◽
Vol 323
(1)
◽
pp. 153-161
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2007 ◽
Vol 21
(20)
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pp. 3234-3244
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Keyword(s):
2005 ◽
Vol 817
(2)
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pp. 303-307
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2014 ◽
Vol 406
(18)
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pp. 4453-4464
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