Emerging roles for centromere-associated proteins in DNA repair and genetic recombination
2013 ◽
Vol 41
(6)
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pp. 1726-1730
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Keyword(s):
Centromere proteins CENP-S and CENP-X are members of the constitutive centromere-associated network, which is a conserved group of proteins that are needed for the assembly and function of kinetochores at centromeres. Intriguingly CENP-S and CENP-X have alter egos going by the names of MHF1 (FANCM-associated histone-fold protein 1) and MHF2 respectively. In this guise they function with a DNA translocase called FANCM (Fanconi’s anemia complementation group M) to promote DNA repair and homologous recombination. In the present review we discuss current knowledge of the biological roles of CENP-S and CENP-X and how their dual existence may be a common feature of CCAN (constitutive centromere-associated network) proteins.
2019 ◽
Vol 116
(28)
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pp. 14174-14180
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2001 ◽
Vol 183
(19)
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pp. 5772-5777
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Keyword(s):
2006 ◽
Vol 86
(3)
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pp. 967-1008
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Keyword(s):
2018 ◽
Vol 52
(1)
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pp. 89-107
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Keyword(s):
Keyword(s):