The Effect of Moderate Exercise on Blood Metabolites in Patients with Hypopituitarism

1971 ◽  
Vol 40 (2) ◽  
pp. 127-136 ◽  
Author(s):  
R. H. Johnson ◽  
M. J. Rennie ◽  
J. L. Walton ◽  
M. H. C. Webster
Keyword(s):  
Growth Hormone ◽  
Ketone Bodies ◽  
Venous Blood ◽  
Normal Subjects ◽  
Bicycle Ergometer ◽  
Blood Metabolites ◽  
Serum Growth Hormone ◽  
Post Exercise ◽  
Blood Samples ◽  
Fat Mobilization

1. Six patients with panhypopituitarism and eight controls were studied before, during and after 30 min of moderate, steady exercise on a bicycle ergometer. Venous blood samples were taken for estimation of growth hormone, pyruvate, lactate, glucose, FFA, glycerol and ketone bodies. 2. Exercise caused a rise in serum growth hormone levels in control subjects and these fell to pre-exercise levels within 90 min. There was no change in the levels in the patients. The patients showed changes in blood metabolites resembling those of the controls. FFA levels were considerably elevated and post-exercise ketosis developed, these changes being more marked in the patients. 3. The differences in FFA and ketone bodies between patients and controls may be due to the lower levels of fitness in the patients. A further explanation may be that growth hormone depresses FFA levels after initial mobilization during exercise in normal subjects, but no such action can occur in patients with hypopituitarism. 4. It is concluded that growth hormone does not necessarily have a major role in fat mobilization or in the production of post-exercise ketosis. Thus, the lower levels of ketosis observed in athletes are not due to their lower levels of growth hormone.

Changes in fat and Carbohydrate Metabolism Caused by Moderate Exercise in Patients with Acromegaly

1973 ◽  
Vol 44 (1) ◽  
pp. 63-71 ◽  
Author(s):  
R. H. Johnson ◽  
M. J. Rennie
Keyword(s):  
Carbohydrate Metabolism ◽  
Ketone Bodies ◽  
Gradual Increase ◽  
Venous Blood ◽  
Pituitary Tumour ◽  
Bicycle Ergometer ◽  
Immunoreactive Insulin ◽  
Post Exercise ◽  
Control Subjects ◽  
Exercise Period

1. Seven patients with acromegaly and nine controls were studied before, during and after 30 min of moderate steady exercise on a bicycle ergometer. Venous blood samples were taken for estimation of growth hormone (HGH), immunoreactive insulin (IRI), pyruvate, lactate, glucose, free fatty acids (FFA), glycerol and ketone bodies. 2. Exercise caused a rise in HGH concentrations in the acromegalic patients, despite their pituitary tumour, and also in control subjects. Concentrations of IRI fell during exercise in control subjects, but rose in the acromegalic patients. 3. Concentrations of glycerol, FFA and ketone bodies rose rapidly to a maximum during exercise in the acromegalics and appeared to be suppressed before the end of exercise: there was no increase in the concentration of ketone bodies after exercise. In control subjects there was a gradual increase in glycerol and FFA concentrations towards the end of exercise, but no change in ketone bodies occurred until the post-exercise period, when ketone-body concentrations rose. 4. We conclude that exercise causes remarkable differences in metabolite concentrations in the blood of acromegalic patients compared with controls, with the concentration of fat metabolites reaching a maximum, then decreasing during the period of constant exercise. There was also elevation, instead of the normal fall, of plasma IRI activity and it is suggested that the decreased concentration of fat metabolites occurred because of the change of insulin concentration. It is further suggested that in acromegaly insulin retains its effect on re-esterification of fat in spite of resistance to its effects on carbohydrate metabolism.

scholarly journals Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude

2021 ◽  
Vol 18 (8) ◽  
pp. 4233
Author(s):  
Cristina Benavente ◽  
Josefa León ◽  
Belén Feriche ◽  
Brad J. Schoenfeld ◽  
Juan Bonitch-Góngora ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Resistance Training ◽  
Inflammatory Responses ◽  
Venous Blood ◽  
Moderate Altitude ◽  
Post Exercise ◽  
Blood Samples ◽  
Exercise Period ◽  
Standardized Mean Difference

This study investigated the effect of a traditional hypertrophy-oriented resistance training (RT) session at acute terrestrial hypoxia on inflammatory, hormonal, and the expression of miR-378 responses associated with muscular gains. In a counterbalanced fashion, 13 resistance trained males completed a hypertrophic RT session at both moderate-altitude (H; 2320 m asl) and under normoxic conditions (N; <700 m asl). Venous blood samples were taken before and throughout the 30 min post-exercise period for determination of cytokines (IL6, IL10, TNFα), hormones (growth hormone [GH], cortisol [C], testosterone), and miR-378. Both exercise conditions stimulated GH and C release, while miR-378, testosterone, and inflammatory responses remained near basal conditions. At H, the RT session produced a moderate to large but nonsignificant increase in the absolute peak values of the studied cytokines. miR-378 revealed a moderate association with GH (r = 0.65; p = 0.026 and r = −0.59; p = 0.051 in N and H, respectively) and C (r = 0.61; p = 0.035 and r = 0.75; p = 0.005 in N and H, respectively). The results suggest that a RT session at H does not differentially affect the hormonal, inflammatory, and miR-378 responses compared to N. However, the standardized mean difference detected values in the cytokines suggest an intensification of the inflammatory response in H that should be further investigated.

Serum somatotropin concentrations in Holstein heifers administered growth hormone-releasing factor and somatostatin

1998 ◽  
Vol 66 (3) ◽  
pp. 551-556 ◽  
Author(s):  
G. W. Kazmer ◽  
S. A. Zinn
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Early Identification ◽  
Response Curve ◽  
Dairy Calves ◽  
Production Traits ◽  
Individual Animal ◽  
Milk Production Traits ◽  
Serum Growth Hormone ◽  
Blood Samples

AbstractDose-response experiments were designed to determine the dosage of somatostatin (SRIF) necessary to alter serum growth hormone (GH) response to administration of GH-releasing factor (1·44; GRF) in cattle. The objective of this experimentation was to develop a GRF/SRIF challenge model that might be useful in early identification of animals which are genetically superior for milk production traits. In experiment 1, calves received either 0, 5 or 10 /JLg GRF per 100 kg body weight (BW) or GRF 1·29 at 1 ug per 100 kg BW. Both the 5 and 10 ug GRF per 100 kg BW dosages increased GH concentrations (P < 0·05). In experiment 2, animals received 3 ug GRF per 100 kg BW concurrent with administration of 0, 0·5, 1 or 2 ug SRIF per 100 kg BW at 0 min, with second dosage of GRF at +120 min. Administration of SRIF in those dosages did not alter GH response to GRF. In experiment 3, animals received 5 ug SRIF per 100 kg BW at -2, -1, 0 or +1 min relative to 3 ug GRF per 100 kg BW, with a second GRF injection at +120 min. No differences (P < 0·05) were found in response due to timing of SRIF administration. In experiment 4, animals were administered 0, 5, 10 or 20 Xg SRIF per 100 kg BW concurrent with 3 ug GRF per 100 kg BW. SRIF delayed (P < 0·05) the occurrence of maximum GH concentrations but did not affect the maximum concentration nor the area under the GH response curve (AUC) following either the first or second GRF injection. Utilizing data from experiment 4, individual animal response to GRF was reasonably consistent, as repeatabilities of AUCs for 1 h following first and second GRF injections were 0·80 and 0·65, respectively. Furthermore, sufficient among-animal variation existed so that animals could be distinguished from each other. Thus we conclude the method described herein might be useful in identifying superior dairy calves but accuracy would potentially be enhanced by collecting blood samples more frequently during the 20 min immediately after GRF injection.

Growth hormone-releasing hormone in the diagnosis and treatment of growth hormone deficient children

1986 ◽  
Vol 113 (4_Suppl) ◽  
pp. S123-S129
Author(s):  
R.J.M. ROSS ◽  
A. GROSSMAN ◽  
G.M. BESSER ◽  
M.O. SAVAGE
Keyword(s):  
Growth Hormone ◽  
Linear Growth ◽  
Gh Deficiency ◽  
Venous Blood ◽  
Alternative Therapy ◽  
Normal Subjects ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Gh Secretion ◽  
Depot Preparations

ABSTRACT A growth hormone-releasing hormone (GHRH) has recently been extracted and synthesised, and appears to be identical to human hypothalamic GHRH. Immunoreactive GHRH is found in the venous blood of normal subjects and GH-deficient children, but is probably not hypothalamic in origin and therefore not important in GH regulation. GHRH is a potent specific stimulator of GH secretion in man, and provides a valuable diagnostic test in differentiating hypothalamic from pituitary causes of GH deficiency. Preliminary data suggests that GHRH may promote linear growth in some GH deficient children. GHRH may well prove an important alternative therapy for GH deficient children especially if depot preparations or intranasal administration prove effective.

THE EFFECT OF INTRAVENOUS L-DOPA ON GROWTH HORMONE AND LUTEINIZING HORMONE LEVELS IN MAN

1973 ◽  
Vol 73 (2) ◽  
pp. 259-265 ◽  
Author(s):  
Athanasius Souvatzoglou ◽  
Klaus von Werder ◽  
Peter Bottermann
Keyword(s):  
Growth Hormone ◽  
Luteinizing Hormone ◽  
Normal Subjects ◽  
Serum Levels ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Serum Growth Hormone ◽  
Provocative Test ◽  
Hormone Levels ◽  
Serum Lh

ABSTRACT The effect of various intravenous doses of L-dopa on growth hormone and LH-serum levels in 25 normal subjects was investigated. Growth hormone increased 30–40 minutes following the injection of 25 mg and 100 mg L-dopa whereas doses of less than 25 mg had no significant effect on the serum growth hormone levels. The serum LH-level was not significantly altered by the intravenous administration of various doses (1 to 100 mg) of L-dopa. These findings, which are in agreement with the results obtained with L-dopa given orally, suggest that the intravenous injection of 25 mg L-dopa may be useful as a short provocative test for growth hormone release in man.

A note on the effect of castration on the growth performance and concentrations of some blood metabolites and hormones in British Friesian male cattle

1978 ◽  
Vol 26 (3) ◽  
pp. 339-342 ◽  
Author(s):  
H. Galbraith ◽  
D. G. Dempster ◽  
T. B. Miller
Keyword(s):  
Fatty Acids ◽  
Growth Hormone ◽  
Weight Gain ◽  
Growth Performance ◽  
Blood Metabolites ◽  
Feed Conversion ◽  
Lean Tissue ◽  
Serum Total Protein ◽  
Serum Growth Hormone ◽  
Plasma Urea

AbstractEight British Friesian bulls and eight steers were compared in terms of performance and levels of metabolites and hormones in circulating blood. Under conditions of generous nutrition the bulls grew significantly more quickly, exhibited a superior feed conversion efficiency and had lower levels of serum albumin and plasma urea and higher levels of serum growth hormone and prolactin than the steers. Differences in levels of plasma glucose and free fatty acids and serum total protein and insulin were not significant. It is suggested that the superior growth performance of the bulls is due, at least partially, to hormonally mediated differences in nitrogen metabolism that result in a greater deposition of lean tissue and hence increased weight gain.

Nocturnal Secretion of Growth Hormone, Noradrenaline, Cortisol and Insulin in Cluster Headache Remission

Cephalalgia ◽  
2007 ◽  
Vol 27 (8) ◽  
pp. 912-919 ◽  
Author(s):  
EL Meyer ◽  
C Marcus ◽  
E Waldenlind
Keyword(s):  
Growth Hormone ◽  
Cluster Headache ◽  
Venous Blood ◽  
Healthy Controls ◽  
Blood Samples

We have previously shown decreased, nocturnal lipolysis in both phases of cluster headache (CH). Lipolysis is stimulated by noradrenaline (NA), growth hormone (GH) and cortisol, and inhibited by insulin, hormones which are directly or indirectly regulated by the hypothalamus. Our aim was to investigate the nocturnal secretion of NA, GH, cortisol and insulin in nine CH patients in remission and 10 healthy controls. Nocturnal venous blood samples were collected in hourly intervals for analysis of NA, cortisol and insulin and in 30-min intervals for GH. We found a reduced increase in GH between 24.00 h and 01.00 h (ANOVA, P < 0.05) in CH patients. Nocturnal secretion of NA, cortisol and insulin did not differ significantly between the groups. The altered nocturnal GH pattern that was seen in CH patients in remission might in part explain the altered nocturnal lipolysis previously found and further indicate a permanent hypothalamic disturbance in CH.

Arterial Plasma Potassium Measured Continuously during Exercise in Man

1984 ◽  
Vol 67 (4) ◽  
pp. 427-431 ◽  
Author(s):  
R. A. F. Linton ◽  
M. Lim ◽  
C. B. Wolff ◽  
P. Wilmshurst ◽  
D. M. Band
Keyword(s):  
Transmembrane Potential ◽  
Venous Blood ◽  
Extracellular Fluid ◽  
Plasma Potassium ◽  
Normal Subjects ◽  
Receptor Sensitivity ◽  
Blood Samples ◽  
Hepatic Venous Blood ◽  
Arterial Plasma

1. Five continuous records of arterial plasma potassium were obtained from three normal subjects during brief periods (5–7 min) of exercise (100 W). 2. In two of these subjects hepatic venous blood samples were withdrawn at 0.5–1.0 min intervals and analysed in vitro for plasma potassium. 3. Arterial plasma potassium rose rapidly at the start of exercise from 3.8 ± 0.3 mmol/l (mean ± sd) to plateau levels of 5.4 ± 0.1 mmol/l. 4. One of the above subjects and a further subject were studied after β-blockade with propranolol. This resulted in an exaggerated rise in arterial plasma potassium during exercise. 5. Hepatic venous potassium measurements indicated that the liver probably had little effect on potassium changes during exercise. 6. The changes in arterial plasma potassium during exercise are rapid and substantial. If transmitted to the extracellular fluid these changes would alter cell transmembrane potential and might as a result alter receptor sensitivity.

Plasma metabolite and hormone concentrations in Friesian cows of differing genetic merit measured at two feeding levels

1984 ◽  
Vol 38 (3) ◽  
pp. 377-384 ◽  
Author(s):  
D. S. Flux ◽  
D. D. S. Mackenzie ◽  
G. F. Wilson
Keyword(s):  
Growth Hormone ◽  
Blood Metabolites ◽  
Blood Samples ◽  
Genetic Merit ◽  
The United Kingdom ◽  
Metabolite Concentrations ◽  
Plasma Metabolite ◽  
Milk Solids ◽  
Mean Concentration ◽  
Friesian Cows

ABSTRACTPhysiological differences between cows in hormone and metabolite concentrations were sought that may account for genetic differences in milk production.Two groups of New Zealand Friesian cows, differing in genetic merit for fat production (high breeding index (HBI) and low breeding index (LBI)) by approximately 23 breeding index units (20 kg fat on the United Kingdom improved contemporary comparison scale), were each divided into two further groups, one of which was given freshly cut pasture to appetite and in the other intake was restricted to 70% of appetite. Eighteen blood samples were collected over a 24-h period from each of 16 cows fitted with indwelling jugular catheters. Samples were analysed for growth hormone, insulin, free fatty acids and β-hydroxybutyrate. Mean concentration of insulin was significantly higher in the HBI underfed group than in any other group (P < 0·01). Glucose concentration was significantly lower in the LBI group (P < 0·05), whose intake was restricted. The concentration of (3-hydroxybutyrate was significantly higher in the cows whose intake was restricted (P < 0·01) and the concentration fell markedly after feeding. Growth hormone concentrations were higher in the cows on restricted intake (P < 0·05) and in HBI cows but the differences were not statistically significant.It was concluded that different patterns of blood metabolites and hormones are associated with cows that differ in genetic merit. Aspects of insulin and glucose metabolism, particularly at low planes of feeding, appear to offer most promise as indicators of high milk-solids production.

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