New Online Tool Accelerates Hearing Research

2021 ◽  
Keyword(s):  
Online Tool ◽  
Hearing Research

Further studies on the ultrastructure of the cochlea

1990 ◽  
Vol 48 (3) ◽  
pp. 440-441
Author(s):  
Zhixian Wang ◽  
Pinjin Zhu ◽  
Jianhe Sun ◽  
Xuezheng Song
Keyword(s):  
Hair Cells ◽  
Military Medicine ◽  
Outer Hair Cells ◽  
Apical Surface ◽  
Epithelial Surface ◽  
Hearing Research ◽  
New Findings ◽  
Fine Structures ◽  
Temporal Bones ◽  
Accurate Observation

Hearing research is important not only for clinical, professional and military medicine, but also for toxicology, gerontology and genetics. Ultrastructure of the cochlea attracts much attention of electron microscopists, (1―3) but the research lags far behind that of the other parts of the organnism. On the basis of careful microdissection, technical improvment and accurate observation, we have got some new findings which have not been reported in the literature.We collected four cochleas from human corpses. Temporal bones dissected 1 h after death and cochleas perfused with fixatives 4 h after death were good enough in terms of preservation of fine structures. SEM:The apical surface of OHCs (Outer hair cells) and DTs (Deiters cells) is narrower than that of IPs (Inner pillar cells). The mosaic configuration of the reticular membrane is not typical. The stereocilia of IHCs (Inner hair cells) are not uniform and some kinocilia could be seen on the OHCs in adults. The epithelial surface of RM (Reissner’s membrane) is not smooth and no mesh could be seen on the mesothelial surface of RM. TEM.

Sentence-Based Experience Logging in New Hearing Aid Users

2020 ◽  
Vol 29 (3S) ◽  
pp. 631-637
Author(s):  
Katja Lund ◽  
Rodrigo Ordoñez ◽  
Jens Bo Nielsen ◽  
Dorte Hammershøi
Keyword(s):  
Hearing Aid ◽  
Patient Experiences ◽  
Online Tool ◽  
Rehabilitation Process ◽  
Hearing Rehabilitation ◽  
Clinical Observations ◽  
Hearing Aid Use ◽  
Wide Range ◽  
Insight Into ◽  
Shed Light

Purpose The aim of this study was to develop a tool to gain insight into the daily experiences of new hearing aid users and to shed light on aspects of aided performance that may not be unveiled through standard questionnaires. Method The tool is developed based on clinical observations, patient experiences, expert involvement, and existing validated hearing rehabilitation questionnaires. Results An online tool for collecting data related to hearing aid use was developed. The tool is based on 453 prefabricated sentences representing experiences within 13 categories related to hearing aid use. Conclusions The tool has the potential to reflect a wide range of individual experiences with hearing aid use, including auditory and nonauditory aspects. These experiences may hold important knowledge for both the patient and the professional in the hearing rehabilitation process.

Phosphino-Triazole Ligands for Palladium-Catalysed Cross-Coupling

2018 ◽  
Author(s):  
Yiming Zhao ◽  
Huy van Nguyen ◽  
Louise Male ◽  
Philip Craven ◽  
Benjamin R. Buckley ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Cross Coupling ◽  
Product Formation ◽  
Coupling Reactions ◽  
Volume Determination ◽  
Online Tool ◽  
Triazole Derivatives ◽  
Cross Coupling Reactions ◽  
Modelling Approaches

<div>Twelve 1,5-disubtituted and fourteen 5-substituted 1,2,3-triazole derivatives bearing diaryl or dialkyl phosphines at the 5-position were synthesised and used as ligands for palladium-catalysed Suzuki-Miyaura cross-coupling reactions. Bulky substrates were tested, and lead-like product formation was demonstrated. The online tool SambVca 2.0 was used to assess steric parameters of ligands and preliminary buried volume determination using XRD obtained data in a small number of cases proved to be informative. Two modelling approaches were compared for the determination of</div><div>the buried volume of ligands where XRD data was not available. An approach with imposed steric restrictions was found to be superior in leading to buried volume determinations that closely correlate with observed reaction conversions. The online tool LLAMA was used to determine lead-likeness of potential Suzuki-Miyaura cross-coupling products, from which ten of the most lead-like were successfully synthesised. Thus, confirming these readily accessible triazole-containing phosphines as highly suitable ligands for reaction screening and optimisation in drug discovery campaigns.</div>

scholarly journals Development of an Online Tool for Tracking Soil Nitrogen to Improve the Environmental Performance of Maize Production

2021 ◽  
Vol 13 (10) ◽  
pp. 5649
Author(s):  
Giovani Preza-Fontes ◽  
Junming Wang ◽  
Muhammad Umar ◽  
Meilan Qi ◽  
Kamaljit Banger ◽  
...  
Keyword(s):  
Real Time ◽  
N Uptake ◽  
Growing Season ◽  
Weather Data ◽  
N Availability ◽  
Soil N ◽  
N Losses ◽  
Online Tool ◽  
Support Tool ◽  
Soil N Availability

Freshwater nitrogen (N) pollution is a significant sustainability concern in agriculture. In the U.S. Midwest, large precipitation events during winter and spring are a major driver of N losses. Uncertainty about the fate of applied N early in the growing season can prompt farmers to make additional N applications, increasing the risk of environmental N losses. New tools are needed to provide real-time estimates of soil inorganic N status for corn (Zea mays L.) production, especially considering projected increases in precipitation and N losses due to climate change. In this study, we describe the initial stages of developing an online tool for tracking soil N, which included, (i) implementing a network of field trials to monitor changes in soil N concentration during the winter and early growing season, (ii) calibrating and validating a process-based model for soil and crop N cycling, and (iii) developing a user-friendly and publicly available online decision support tool that could potentially assist N fertilizer management. The online tool can estimate real-time soil N availability by simulating corn growth, crop N uptake, soil organic matter mineralization, and N losses from assimilated soil data (from USDA gSSURGO soil database), hourly weather data (from National Weather Service Real-Time Mesoscale Analysis), and user-entered crop management information that is readily available for farmers. The assimilated data have a resolution of 2.5 km. Given limitations in prediction accuracy, however, we acknowledge that further work is needed to improve model performance, which is also critical for enabling adoption by potential users, such as agricultural producers, fertilizer industry, and researchers. We discuss the strengths and limitations of attempting to provide rapid and cost-effective estimates of soil N availability to support in-season N management decisions, specifically related to the need for supplemental N application. If barriers to adoption are overcome to facilitate broader use by farmers, such tools could balance the need for ensuring sufficient soil N supply while decreasing the risk of N losses, and helping increase N use efficiency, reduce pollution, and increase profits.

scholarly journals AB0008 THE IMPACT OF STAT4 RS7574865, IL6 RS1800795, IL6R RS2228145 AND RS4845618 ON RHEUMATOID ARTHRITIS SUSCEPTIBILITY IN BELARUSIAN POPULATION

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1307.1-1308
Author(s):  
E. Siniauskaya ◽  
T. Kuzhir ◽  
V. Yagur ◽  
R. Goncharova
Keyword(s):  
Rheumatoid Arthritis ◽  
Blood Donors ◽  
Genetic Model ◽  
Online Tool ◽  
Genotype Frequencies ◽  
Systemic Disorder ◽  
Autoimmune Pathogenesis ◽  
The Impact ◽  
Arthritis Susceptibility

Background:Rheumatoid arthritis (RA) is a chronic systemic disorder of the connective tissue of still unknown aetiology and complex autoimmune pathogenesis that primarily affects small joints. HLA alleles provide for 11-37% of the RA heritability, suggesting the substantial role of the non-HLA loci in genetic predisposition to RA. Among non-HLA loci,IL6, IL6RandSTAT4genes attract attention, however, the data concerning their influence on RA risk are somewhat contradictory.Objectives:The aim of the study was to analyze the involvement of four SNPs (STAT4rs7574865,IL6rs1800795,IL6Rrs2228145 and rs4845618) in RA susceptibility.Methods:187 patients diagnosed with RA (mean age 58.2 ± 11.9), and 380 healthy blood donors (mean age 37.18 ± 10.69 years) were included into the study. DNA extraction from peripheral blood samples was performed using the phenol-chloroform method. SNPs were genotyped using the real-time PCR with fluorescent probes. The allele and genotype frequencies were compared using the χ2 test. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using the VassarStats online tool.Results:Utilizing recessive genetic model we found an association between TT genotype ofSTAT4rs7574865 (OR = 2.362; 95%CI [1.0378 – 5.376], p = 0.038) and RA. ForIL6rs1800795, it was found that CC genotype had significantly higher frequency among patients with rheumatoid arthritis as compared to that in controls (OR = 1.52; 95%CI [1.02 – 2.27], p = 0.0456). No associations ofIL6Rrs2228145 and rs4845618 SNPs with risk of RA were found in the total group of patients vs. controls. It was also shown thatIL6rs1800795 CC genotype frequency was significantly higher among the patients with RF-negative status (p = 0.0019).Conclusion:Thus, we provide evidence for association of theSTAT4rs7574865 andIL6rs1800795 variants with risk of RA in the Belarusian population, some features of interplay being revealed between gene polymorphisms analyzed and RA antibody status. Abovementioned SNPs may contribute to RA genetic susceptibility in the Belarusian population.Disclosure of Interests:None declared

scholarly journals Prospective prediction of PTSD and depressive symptoms during social unrest and COVID-19 using a brief online tool

2021 ◽  
Vol 298 ◽  
pp. 113773
Author(s):  
Stephanie MY Wong ◽  
Christy LM Hui ◽  
Corine SM Wong ◽  
YN Suen ◽  
Sherry KW Chan ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Online Tool ◽  
Social Unrest

scholarly journals Viral Host Range database, an online tool for recording, analyzing and disseminating virus-host interactions

2021 ◽  
Author(s):  
Quentin Lamy-Besnier ◽  
Bryan Brancotte ◽  
Hervé Ménager ◽  
Laurent Debarbieux
Keyword(s):  
Host Range ◽  
Source Code ◽  
Range Data ◽  
Web Based ◽  
Online Tool ◽  
Experimental Host ◽  
Living World ◽  
Host Interactions ◽  
Experimental Host Range ◽  
Viral Host Range

Abstract Motivation Viruses are ubiquitous in the living world, and their ability to infect more than one host defines their host range. However, information about which virus infects which host, and about which host is infected by which virus, is not readily available. Results We developed a web-based tool called the Viral Host Range database to record, analyze and disseminate experimental host range data for viruses infecting archaea, bacteria and eukaryotes. Availability The ViralHostRangeDB application is available from https://viralhostrangedb.pasteur.cloud. Its source code is freely available from the Gitlab hub of Institut Pasteur (https://gitlab.pasteur.fr/hub/viralhostrangedb).

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