The Advancement of Neuroimaging Research Investigating Developmental Stuttering

2011 ◽  
Vol 21 (3) ◽  
pp. 88-95 ◽  
Author(s):  
Deryk S. Beal
Keyword(s):  
Speech Production ◽  
Fast Rate ◽  
Neural Correlates ◽  
Future Research ◽  
Current State ◽  
Developmental Stuttering ◽  
The Brain ◽  
State Of The Field

We are amassing information about the role of the brain in speech production and the potential neural limitations that coincide with developmental stuttering at a fast rate. As such, it is difficult for many clinician-scientists who are interested in the neural correlates of stuttering to stay informed of the current state of the field. In this paper, I aim to inspire clinician-scientists to tackle hypothesis-driven research that is grounded in neurobiological theory. To this end, I will review the neuroanatomical structures, and their functions, which are implicated in speech production and then describe the relevant differences identified in these structures in people who stutter relative to their fluently speaking peers. I will conclude the paper with suggestions on directions of future research to facilitate the evolution of the field of neuroimaging of stuttering.

scholarly journals Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions

2017 ◽  
Vol 372 (1715) ◽  
pp. 20160158 ◽  
Author(s):  
Tara Keck ◽  
Taro Toyoizumi ◽  
Lu Chen ◽  
Brent Doiron ◽  
Daniel E. Feldman ◽  
...  
Keyword(s):  
Royal Society ◽  
Homeostatic Plasticity ◽  
Future Research ◽  
Research Directions ◽  
Functional Changes ◽  
Current State ◽  
Subsequent Discussion ◽  
Future Research Directions ◽  
The Brain ◽  
State Of The Field

We summarize here the results presented and subsequent discussion from the meeting on Integrating Hebbian and Homeostatic Plasticity at the Royal Society in April 2016. We first outline the major themes and results presented at the meeting. We next provide a synopsis of the outstanding questions that emerged from the discussion at the end of the meeting and finally suggest potential directions of research that we believe are most promising to develop an understanding of how these two forms of plasticity interact to facilitate functional changes in the brain. This article is part of the themed issue ‘Integrating Hebbian and homeostatic plasticity’.

scholarly journals Role of Immunity in Pathogenesis of Psychosis

2021 ◽  
Author(s):  
Wafa Abdelghaffar ◽  
Oussama Sidhom ◽  
Lilia Laadhar ◽  
Rym Rafrafi
Keyword(s):  
Mental Health ◽  
Immune System ◽  
Psychiatric Symptoms ◽  
Scientific Evidence ◽  
Health Conditions ◽  
Future Research ◽  
Antineuronal Antibodies ◽  
System Components ◽  
The Brain

The involvement of immunity in the pathogenesis of schizophrenia and related psychoses was suspected a century ago but was shadowed by the dopaminergic hypothesis after the discovery of antipsychotics. We currently know that this latter theory has many limits and cannot account for the wide variety of psychotic conditions. The immune-inflammatory theory is now one of the most promising axes of research in terms of pathogenesis of several mental health conditions. Immunity and inflammation play a role at least in a subgroup of patients with psychosis. The immune system is complex with a variety of components and mediators that can all have effects on the brain and thus mediate psychiatric symptoms. In this chapter we will explore the scientific evidence of the role of immune system in pathophysiology of psychosis. The sections of this chapter will discuss the role of innate system components (cytokines, microglia, inflammation.), the role of adaptive system (lymphocytes and antibodies) with a section focusing on auto-immunity and particularly antineuronal antibodies. Finally we will discuss how this research can impact patients management and elaborate recommendations for future research.

scholarly journals Functional and Neuroanatomical Bases of Developmental Stuttering: Current Insights

2018 ◽  
Vol 25 (6) ◽  
pp. 566-582 ◽  
Author(s):  
Soo-Eun Chang ◽  
Emily O. Garnett ◽  
Andrew Etchell ◽  
Ho Ming Chow
Keyword(s):  
General Population ◽  
Speech Production ◽  
Neurodevelopmental Disorder ◽  
Future Research ◽  
Childhood Onset ◽  
Structural Neuroimaging ◽  
The Past ◽  
Adults Who Stutter ◽  
Developmental Stuttering ◽  
Preschool Aged Children

Affecting 5% of all preschool-aged children and 1% of the general population, developmental stuttering—also called childhood-onset fluency disorder—is a complex, multifactorial neurodevelopmental disorder characterized by frequent disruption of the fluent flow of speech. Over the past two decades, neuroimaging studies of both children and adults who stutter have begun to provide significant insights into the neurobiological bases of stuttering. This review highlights convergent findings from this body of literature with a focus on functional and structural neuroimaging results that are supported by theoretically driven neurocomputational models of speech production. Updated views on possible mechanisms of stuttering onset and persistence, and perspectives on promising areas for future research into the mechanisms of stuttering, are discussed.

scholarly journals God Spots in the Brain: Nine Categories of Unasked, Unanswered Questions

Religions ◽  
2020 ◽  
Vol 11 (9) ◽  
pp. 468 ◽  
Author(s):  
W. R. Klemm
Keyword(s):  
Academic Discipline ◽  
Functional Anatomy ◽  
Future Research ◽  
Brain Scans ◽  
Brain Scan ◽  
Network Operations ◽  
Religious Thoughts ◽  
Self Learning ◽  
The Brain

Neurotheology is an emerging academic discipline that examines mind-brain relationships in terms of the inter-relatedness of neuroscience, spirituality, and religion. Neurotheology originated from brain-scan studies that revealed specific correlations between certain religious thoughts and localized activated brain areas known as “God Spots.” This relatively young scholarly discipline lacks clear consensus on its definition, ideology, purpose, or prospects for future research. Of special interest is the consideration of the next steps using brain scans to develop this field of research. This review proposes nine categories of future research that could build on the foundation laid by the prior discoveries of God Spots. Specifically, this analysis identifies some sparsely addressed issues that could be usefully explored with new kinds of brain-scan studies: neural network operations, the cognitive neuroscience of prayer, biology of belief, measures of religiosity, role of the self, learning and memory, religious and secular cognitive commonalities, static and functional anatomy, and recruitment of neural processing circuitry. God Spot research is poised to move beyond observation to robust hypothesis generation and testing.

The Nature and Treatment of Pain-Related Fear in Chronic Musculoskeletal Pain

2009 ◽  
Vol 23 (1) ◽  
pp. 85-103 ◽  
Author(s):  
Steven De Peuter ◽  
Jeroen de Jong ◽  
Geert Crombez ◽  
Johan W. S. Vlaeyen
Keyword(s):  
Musculoskeletal Pain ◽  
Patient Characteristics ◽  
Context Dependency ◽  
Future Research ◽  
Media Campaigns ◽  
Explicit Attitudes ◽  
Current State ◽  
Exposure In Vivo

Musculoskeletal pain is one of the most frequently reported complaints in primary care. The last decade’s research has evidenced the important role of pain-related fear in the maintenance and exacerbation of chronic pain problems. In this article we review the current state of the art regarding the nature, development, and consequences of pain-related fear. We also discuss the implications for therapy, including mass media campaigns, education, exercise therapy, and exposure in vivo. Finally, we propose directions for future research, including the need to tailor treatments to individual patient characteristics, the role of interoceptive conditioning, implications of the context dependency of learning, and the consideration of implicit versus explicit attitudes toward feared painful stimuli.

scholarly journals Critical assessment of the current state of scientific knowledge, terminology, and research needs concerning the role of organic aerosols in the atmosphere, climate, and global change

2006 ◽  
Vol 6 (7) ◽  
pp. 2017-2038 ◽  
Author(s):  
S. Fuzzi ◽  
M. O. Andreae ◽  
B. J. Huebert ◽  
M. Kulmala ◽  
T. C. Bond ◽  
...  
Keyword(s):  
Organic Aerosols ◽  
Chemical Properties ◽  
Research Priorities ◽  
Future Research ◽  
Current State ◽  
Basic Set ◽  
Physical And Chemical ◽  
Present Understanding ◽  
Key Questions

Abstract. In spite of impressive advances in recent years, our present understanding of organic aerosol (OA) composition, physical and chemical properties, sources and transformation characteristics is still rather limited, and their environmental effects remain highly uncertain. This paper discusses and prioritizes issues related to organic aerosols and their effects on atmospheric processes and climate, providing a basis for future activities in the field. Four main topical areas are addressed: i) sources of OA; ii) formation transformation and removal of OA; iii) physical, chemical and mixing state of OA; iv) atmospheric modelling of OA. Key questions and research priorities regarding these four areas are synthesized in this paper, and outstanding issues for future research are presented for each topical area. In addition, an effort is made to formulate a basic set of consistent and universally applicable terms and definitions for coherent description of atmospheric OA across different scales and disciplines.

scholarly journals The role of career shocks in contemporary career development: key challenges and ways forward

2021 ◽  
Vol 26 (4) ◽  
pp. 453-466
Author(s):  
Jos Akkermans ◽  
Ricardo Rodrigues ◽  
Stefan T. Mol ◽  
Scott E. Seibert ◽  
Svetlana N. Khapova
Keyword(s):  
Career Development ◽  
Lessons Learned ◽  
Future Research ◽  
Special Issue ◽  
Content Type ◽  
Future Research Agenda ◽  
Current State ◽  
Conceptual Clarity ◽  
The Impact

PurposeThis article aims to introduce the special issue entitled “the role of career shocks in contemporary career development,” synthesize key contributions and formulate a future research agenda.Design/methodology/approachThe authors provide an introduction of the current state-of-the-art in career shocks research, offer an overview of the key lessons learned from the special issue and present several important avenues for future research.FindingsThe authors discuss how the special issue articles contribute to a better understanding of career shocks' role in contemporary career development, focusing on (1) conceptual clarity of the notion of career shocks, (2) career outcomes of career shocks, (3) mechanisms that can explain the impact of career shocks and (4) interdisciplinary connectivity.Originality/valueThis article offers a synthesis of the critical contributions made within this special issue, thereby formulating key ways to bring the field of career shocks research forward. It also provides new avenues for research.

scholarly journals Novel Insight Into the Development and Function of Hypopharyngeal Glands in Honey Bees

2021 ◽  
Vol 11 ◽  
Author(s):  
Saboor Ahmad ◽  
Shahmshad Ahmed Khan ◽  
Khalid Ali Khan ◽  
Jianke Li
Keyword(s):  
Honey Bees ◽  
Future Research ◽  
Factors Affecting ◽  
Hypopharyngeal Glands ◽  
And Function ◽  
First Time ◽  
The Brain ◽  
Insight Into ◽  
Made In

Hypopharyngeal glands (HGs) are the most important organ of hymenopterans which play critical roles for the insect physiology. In honey bees, HGs are paired structures located bilaterally in the head, in front of the brain between compound eyes. Each gland is composed of thousands of secretory units connecting to secretory duct in worker bees. To better understand the recent progress made in understanding the structure and function of these glands, we here review the ontogeny of HGs, and the factors affecting the morphology, physiology, and molecular basis of the functionality of the glands. We also review the morphogenesis of HGs in the pupal and adult stages, and the secretory role of the glands across the ages for the first time. Furthermore, recent transcriptome, proteome, and phosphoproteome analyses have elucidated the potential mechanisms driving the HGs development and functionality. This adds a comprehensive novel knowledge of the development and physiology of HGs in honey bees over time, which may be helpful for future research investigations.

scholarly journals Risk Prediction Using Polygenic Risk Scores for Prevention of Stroke and Other Cardiovascular Diseases

Stroke ◽  
2021 ◽  
Author(s):  
Gad Abraham ◽  
Loes Rutten-Jacobs ◽  
Michael Inouye
Keyword(s):  
Risk Prediction ◽  
Risk Scores ◽  
Future Research ◽  
Cvd Risk ◽  
Polygenic Risk ◽  
Monogenic Disorders ◽  
Current State ◽  
Common Genetic Variants ◽  
Artery Disease

Early prediction of risk of cardiovascular disease (CVD), including stroke, is a cornerstone of disease prevention. Clinical risk scores have been widely used for predicting CVD risk from known risk factors. Most CVDs have a substantial genetic component, which also has been confirmed for stroke in recent gene discovery efforts. However, the role of genetics in prediction of risk of CVD, including stroke, has been limited to testing for highly penetrant monogenic disorders. In contrast, the importance of polygenic variation, the aggregated effect of many common genetic variants across the genome with individually small effects, has become more apparent in the last 5 to 10 years, and powerful polygenic risk scores for CVD have been developed. Here we review the current state of the field of polygenic risk scores for CVD including stroke, and their potential to improve CVD risk prediction. We present findings and lessons from diseases such as coronary artery disease as these will likely be useful to inform future research in stroke polygenic risk prediction.

scholarly journals Bereavement in Times of COVID-19: A Review and Theoretical Framework

2020 ◽  
Vol 82 (3) ◽  
pp. 500-522
Author(s):  
Margaret Stroebe ◽  
Henk Schut
Keyword(s):  
Process Model ◽  
Theoretical Perspective ◽  
Theoretical Models ◽  
Dual Process ◽  
Future Research ◽  
Negative Consequences ◽  
Systematic Assessment ◽  
Current State ◽  
Expert Assessments

A review of the literature on adaptation to bereavement during the COVID-19 pandemic was conducted to assess the current state of knowledge. Scopus, Web of Science and Google Scholar databases were searched for studies published during the first 6 months of the COVID-19 outbreak. 44 articles were included in the review. Narrative synthesis showed that knowledge was largely based on expert assessments of prior bereavement research and professional experience; there is so far absence of empirical evidence linking features of COVID-19 bereavement situations to health outcomes. Severe negative consequences have been consistently predicted by authors. There is still relatively little consideration of positive or compensatory processes or the possibility that these could alleviate the effect of the shocking, traumatic circumstances. With two notable exceptions, there has been lack of attention to the role of theoretical models for guiding research and practice. A theoretical perspective (the Dual Process Model, DPM) was applied to the information derived from the available articles. Two features of the DPM framework illustrated its relevance: 1. It enables systematic assessment of the range of loss- and restoration-related challenges for the bereaved; 2. It speaks for extension of psychotherapeutic intervention to manage secondary, restoration- as well as primary, loss-oriented stressors; studies have demonstrated that this may increase the effectiveness of intervention. Directions for future research and DPM application are suggested.

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