scholarly journals Research progress of EMT in Cancer Metastasis

2021 ◽  
Vol 245 ◽  
pp. 03049
Author(s):  
Ruoyun Du
Keyword(s):  
Cancer Treatment ◽  
Influencing Factors ◽  
High Mortality ◽  
Malignant Tumor ◽  
Cancer Metastasis ◽  
Research Progress ◽  
Signal Pathways ◽  
Tumor Patients ◽  
Deadly Disease ◽  
To Receive

Cancer is still a deadly disease that haunts people. Once there is a malignant tumor, patients need to receive a series of expensive, complex and painful treatments. Even so, cancer still causes high mortality, for its ability to easily metastasizing to other organs, without effective cures for any kind of cancer so far. Therefore, researchers have been trying to explore its mechanism and find ways to inhibit its development and discover new cure from various aspects. The latest research found that Epithelial-Mesenchymal Transitions (EMT) may be related to cancer, especially in the metastasis. It can be a breakthrough finding that render cancer a curable disease. In this paper, we systematically introduce the definition, classification, mechanism, influencing factors of EMT and its relationship with cancer metastasis and provide new angles and ideas for further exploring all levels of signal pathways and cancer treatment.

scholarly journals How the resource allocation and inpatient behavior affect the expenditures of terminal malignant tumor patients?

2019 ◽  
Author(s):  
Fen Li ◽  
Bifan Zhu ◽  
Peimin Sang ◽  
Chunlin JIN
Keyword(s):  
Resource Allocation ◽  
Influencing Factors ◽  
Malignant Tumor ◽  
Behavioral Model ◽  
Tumor Patients ◽  
Medical Resources ◽  
Terminal Stage ◽  
Inappropriate Use ◽  
Medical Institutions ◽  
Tertiary Hospitals

Abstract Background: The inappropriate use of medical resources and escalating health expenditures of severe diseases patients has been a great concern in China’s health system especially among terminal stage. This study aims to analyze how the resource allocation and hospitalization behavior affect the expenditures of terminal malignant tumor patients, and provide evidences on resource allocation and utilization. Methods: An analysis framework of influencing factors of medical expenses was built according to Andersen’s Behavioral Model. Hospitalization expenditures of malignant tumor patients who died in medical institutions were tracked in Shanghai in 2016. We use path analysis to analyze the influencing factors of hospitalization expenditures at terminal stage. Results: Results demonstrated that hospital services and expenditures during the terminal stage were primarily in tertiary hospitals. The top three influencing factors were length of stay, number of admissions and level of medical institutions. While the influence of demographic characteristics (age, gender, type of medical insurance, etc.) was relatively low. Conclusions: Data suggest that hospitalization expenditures and patients’ economic burden can be reduced through adjusting allocation of medical resources and service utilization, as well as reducing unnecessary hospitalization days.

scholarly journals Research Progress of Anti-breast Cancer Peptides

2019 ◽  
Vol 4 (08) ◽  
Author(s):  
Zhi-Gang Sun ◽  
Zhi-Na Li ◽  
Liang-Hui Zhao ◽  
Jin-Mai Zhang
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Cancer Treatment ◽  
Malignant Tumor ◽  
Breast Cancer Treatment ◽  
New Drugs ◽  
Research Progress ◽  
Epithelial Tissue ◽  
Anti Cancer

Breast cancer is a malignant tumor that occurs in the epithelial tissue of the breast, mostly in female. At present, drug resistance has emerged in the treatment of breast cancer. Therefore, the discovery of new drugs for breast cancer is particularly important. Some peptides have been found to have anti-cancer effects. This article reviews the recent discoveries of anti-breast cancer peptides, hoping to provide some help for the development of breast cancer treatment.

NOB1: A Potential Biomarker or Target in Cancer

2019 ◽  
Vol 20 (10) ◽  
pp. 1081-1089
Author(s):  
Weiwei Ke ◽  
Zaiming Lu ◽  
Xiangxuan Zhao
Keyword(s):  
Cancer Treatment ◽  
Molecular Mechanisms ◽  
Rna Binding ◽  
Binding Protein ◽  
Tumor Development ◽  
Anticancer Therapy ◽  
Research Progress ◽  
Normal Tissues ◽  
Potential Biomarker

Human NIN1/RPN12 binding protein 1 homolog (NOB1), an RNA binding protein, is expressed ubiquitously in normal tissues such as the lung, liver, and spleen. Its core physiological function is to regulate protease activities and participate in maintaining RNA metabolism and stability. NOB1 is overexpressed in a variety of cancers, including pancreatic cancer, non-small cell lung cancer, ovarian cancer, prostate carcinoma, osteosarcoma, papillary thyroid carcinoma, colorectal cancer, and glioma. Although existing data indicate that NOB1 overexpression is associated with cancer growth, invasion, and poor prognosis, the molecular mechanisms behind these effects and its exact roles remain unclear. Several studies have confirmed that NOB1 is clinically relevant in different cancers, and further research at the molecular level will help evaluate the role of NOB1 in tumors. NOB1 has become an attractive target in anticancer therapy because it is overexpressed in many cancers and mediates different stages of tumor development. Elucidating the role of NOB1 in different signaling pathways as a potential cancer treatment will provide new ideas for existing cancer treatment methods. This review summarizes the research progress made into NOB1 in cancer in the past decade; this information provides valuable clues and theoretical guidance for future anticancer therapy by targeting NOB1.

scholarly journals Nursing students' attitudes, knowledge, and willingness to receive the COVID-19 vaccine: A cross-sectional study

2021 ◽  
Author(s):  
Ning Jiang ◽  
Baojian Wei ◽  
Hua Lin ◽  
Youjuan Wang ◽  
Shouxia Chai ◽  
...  
Keyword(s):  
Nursing Students ◽  
Side Effects ◽  
Influencing Factors ◽  
Family Members ◽  
Cross Sectional Survey ◽  
School Students ◽  
Cross Sectional ◽  
Vaccine Acceptance ◽  
Academic Background ◽  
To Receive

Aim: To investigate nursing students' konwledge, attitudes and willingness to receive the COVID-19 vaccine, and the influencing factors. Background: Vaccination is one of the effective measures to prevent COVID-19, but the vaccination acceptance varies across countries and populations. As reserve nurses, nursing students have both the professionalism of medical personnel and the special characteristics of school students, their attitudes, knowledge, and willingness to receive the COVID-19 vaccine may greatly affect the vaccine acceptance of the population now and in the future. But little research has been done on vaccine acceptance among nursing students. Design: A cross-sectional survey of nursing students was conducted via online questionnaires in March 2021. Methods: Descriptive statistics, independent sample t tests/one-way ANOVA (normal distribution), Mann-Whitney U tests/Kruskal-Wallis H tests (skewness distribution) and multivariate linear regression were performed. Results: The score rate of attitude, knowledge and vaccination willingness were 70.07%, 80.70% and 84.38% respectively. Attitude was significantly influenced by family economic conditions and whether a family member had been vaccinated. The main factors influencing knowledge were gender, grade and academic background. In terms of willingness, gender, academic background, visits to risk areas, whether family members were vaccinated, and whether they had side effects were significant influencing factors. Conclusions: The vaccine acceptance of nursing students was fair. Greater focus needed to be placed on the males, those of younger age, with a science background, and having low grades, as well as on students whose family members had not received the COVID-19 vaccine or had side effects from the vaccine. Targeted intervention strategies were recommended to improve vaccination rates.

The influence of race on financial toxicity among cancer patients.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 1525-1525
Author(s):  
John Panzone ◽  
Christopher Welch ◽  
Ruben Pinkhasov ◽  
Joseph M Jacob ◽  
Oleg Shapiro ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Cancer Patients ◽  
Cross Sectional Study ◽  
Financial Toxicity ◽  
Cancer Awareness ◽  
Cross Sectional ◽  
History Of ◽  
Using Data ◽  
National Trends ◽  
To Receive

1525 Background: Studies show that cancer patients and survivors are likely to endure financial toxicity long after being diagnosed. Methods: To examine the influence of race on financial toxicity among individuals with a history of cancer, a US based cross sectional study was conducted using data on 1,328 cancer patients collected from the Health Information National Trends Survey. Multivariable logistic regression analyses were used to analyze the relationship between race and financial toxicity, adjusting for known confounders. Results: Blacks, Hispanics and other races were shown to have a lower rate of insurance compared to Whites. Whites were also more likely to receive cancer treatment than other races (6.1% received no treatment vs 15.0% of Blacks, 17.8% of Hispanics, and 9.7% of other races, p<0.001). Considerably more Whites underwent surgical treatment of their cancer (77%) vs. 60% of Blacks, 55% of Hispanics and 74.2% of other races, p<0.001. Blacks were found to be over 5 times more likely to be denied insurance (OR 5.003, 95% CI 2.451-10.213, p<0.001) and more than twice as likely to be hurt financially than Whites (OR 2.448, 95% CI 1.520-3.941, p<0.001). Other racial minorities were also more than twice as likely to be hurt financially than Whites (OR 2.421, 95% CI 1.248-4.698, p=0.009) (Table). Conclusions: These data suggest that race is significantly associated with increased rates of being hurt financially and being denied insurance due to cancer. Awareness of race inequality should be raised so that equal cancer treatment can be provided, irrespective of race, gender or socioeconomic status.[Table: see text]

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