Salivary diagnosis of oral cancers by salivary samples: a systematic literature review

The aim of this article is to carry out a systematic analysis of the literature concerning the diagnosis of oral cancers by salivary samples. Different biomarkers, produced by the tumor itself or by its environment, show significant variations in their concentration at the salivary level, correlated or not at the blood or tissue level. After studying 239 articles, we included 36 in this analysis. This allowed us to extract 46 potential molecules for salivary diagnostics. Only 26 demonstrated a good level of evidence. 8 clusters have also been proposed for better specificity and sensitivity. To date, the protocols of the studies carried out do not allow to affirm that one or more biomarkers are effective for a salivary diagnosis of oral cancers. Part of the results contradict or sometimes lack precision. In addition, the studies included here do not have a good methodological quality and do not always take into account other factors influencing the concentrations (systemic diseases, age, sex, tobacco, alcohol, etc.). Additional studies are still necessary, notably with larger groups of patients, representative of the general population and standardization of the protocols for the study and quantification of biomarkers.

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Assessment and Trends in the Methodological Quality of the Top 50 Most Cited Articles in Shoulder Instability

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967120967082 ◽

2020 ◽

Vol 8 (12) ◽

pp. 232596712096708

Author(s):

Avinesh Agarwalla ◽

Kaisen Yao ◽

Anirudh K. Gowd ◽

Nirav H. Amin ◽

J. Martin Leland ◽

...

Keyword(s):

Bone Loss ◽

Shoulder Instability ◽

Methodological Quality ◽

Surgical Techniques ◽

Case Series ◽

Cross Sectional Study ◽

Retrospective Case ◽

Level Of Evidence ◽

Cross Sectional ◽

Number Of Citations

Background: Citation counts have often been used as a surrogate for the scholarly impact of a particular study, but they do not necessarily correlate with higher-quality investigations. In recent decades, much of the literature regarding shoulder instability is focused on surgical techniques to correct bone loss and prevent recurrence. Purpose: To determine (1) the top 50 most cited articles in shoulder instability and (2) if there is a correlation between the number of citations and level of evidence or methodological quality. Study Design: Cross-sectional study. Methods: A literature search was performed on both the Scopus and the Web of Science databases to determine the top 50 most cited articles in shoulder instability between 1985 and 2019. The search terms used included “shoulder instability,” “humeral defect,” and “glenoid bone loss.” Methodological scores were calculated using the Modified Coleman Methodology Score (MCMS), Jadad scale, and Methodological Index for Non-Randomized Studies (MINORS) score. Results: The mean number of citations and mean citation density were 222.7 ± 123.5 (range, 124-881.5) and 16.0 ± 7.9 (range, 6.9-49.0), respectively. The most common type of study represented was the retrospective case series (evidence level, 4; n = 16; 32%) The overall mean MCMS, Jadad score, and MINORS score were 61.1 ± 10.1, 1.4 ± 0.9, and 16.0 ± 3.0, respectively. There were also no correlations found between mean citations or citation density versus each of the methodological quality scores. Conclusion: The list of top 50 most cited articles in shoulder instability comprised studies with low-level evidence and low methodological quality. Higher-quality study methodology does not appear to be a significant factor in whether studies are frequently cited in the literature.

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SALIVA AND SALIVAOMICS IN THE DIAGNOSIS OF ORAL AND SYSTEMIC DISEASES: A REVIEW

10.36106/paripex/8106360 ◽

2021 ◽

pp. 8-12

Author(s):

Sherly Ruth ◽

Koduri Sridevi ◽

Buduru Krishnaveni ◽

Nalli Prasanth Kumar ◽

Katru Sreekar ◽

...

Keyword(s):

Health Care ◽

Early Detection ◽

Patient Care ◽

Disease Diagnosis ◽

Response To Therapy ◽

Response To Treatment ◽

Systemic Diseases ◽

Early Disease ◽

Early Disease Detection ◽

Salivary Diagnostics

The quest for novel strategies in early disease detection and response to therapy is an essential ongoing process in health care setups.Along with other body fluids such as blood,mucus,urine,semen and vaginal fluids;saliva can also be considered for the detection of the disease.The Salivary diagnostics is a dynamic field that is being incorporated as part of disease diagnosis, clinical monitoring and for making important clinical decisions for patient care. This review presents the translational value of saliva as a credible clinical diagnostic biofluid in detection, early detection of the various diseases and response to treatment.

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Comparison of Local Load Influence on Crack Evolution of Coal and Briquette Coal Samples

Advances in Civil Engineering ◽

10.1155/2018/1790785 ◽

2018 ◽

Vol 2018 ◽

pp. 1-12 ◽

Cited By ~ 3

Author(s):

Hongbao Zhao ◽

Tao Wang ◽

Huan Zhang ◽

Ziqiang Wei

Keyword(s):

Crack Initiation ◽

Crack Growth ◽

Influencing Factor ◽

Local Load ◽

End Effect ◽

Crack Evolution ◽

Systematic Analysis ◽

Effect Factor ◽

Factors Influencing ◽

Major Factors

Taking raw coal and briquette coal samples with preset center holes as research objects, this paper makes a systematic analysis and research of crack evolution laws of the two different coal samples under the local load. The results show that the raw coal and briquette coal samples are different mainly in number, dimension, and complexity of the internal microstructures, so it is not right to replace raw coal with briquette coal when performing observational study of the crack evolution of microstructures; under the effect of local load, local property, randomness of crack initiation position, and crack initiation stress of raw coal samples are greater than those of briquette coal samples; law of instantaneous maximum effective cut-through rate of raw coal samples is more complex than that of briquette coals; under the effect of uniformly distributed load, end effect factor Fe, sample microstructure influencing factor Fs, and preset center hole factor Fh are the major factors influencing crack growth, among which the amplified end effect factor Fe and sample microstructure influencing factor Fs are dominant factors; under the effect of local load, local load influencing factor Fp, end effect factor Fe, sample microstructure influencing factor Fs, and preset center hole factor Fs are the major factors influencing crack growth, among which the local load influencing factor Fp, end effect factor Fe, and sample microstructure influencing factor Fs are dominant factors. Compared with briquette coal samples, raw coal samples are more sensitive to influencing factors, such as local load influencing factor Fp, end effect factor Fe, sample microstructure influencing factor Fs, and preset center hole factor Fh, and can aggravate the influence of these factors on the crack growth; the paper also puts forward a method for describing local load based on a coupling mechanical model of uniaxial compression and local shear.

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A Systematic Analysis on Factors Influencing Internet Word-of-Mouth Communication

2010 International Conference on E-Business and E-Government ◽

10.1109/icee.2010.506 ◽

2010 ◽

Cited By ~ 2

Author(s):

Gao Sidong

Keyword(s):

Word Of Mouth ◽

Systematic Analysis ◽

Factors Influencing ◽

Word Of Mouth Communication

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Surgery is no more effective than conservative treatment for Femoroacetabular impingement syndrome: Systematic review and meta-analysis of randomized controlled trials

Clinical Rehabilitation ◽

10.1177/0269215520966694 ◽

2020 ◽

pp. 026921552096669 ◽

Cited By ~ 2

Author(s):

Robson Massi Bastos ◽

Jorge Geraldo de Carvalho Júnior ◽

Suellen Aline Martinez da Silva ◽

Shirley Ferreira Campos ◽

Matheus Vieira Rosa ◽

...

Keyword(s):

Systematic Review ◽

Surgical Treatment ◽

Conservative Treatment ◽

Femoroacetabular Impingement ◽

Methodological Quality ◽

Impingement Syndrome ◽

Level Of Evidence ◽

Femoroacetabular Impingement Syndrome ◽

Quality Evidence

Objective: To summarize the effects of surgical treatment compared to conservative treatment in femoroacetabular impingement syndrome in the short, medium, and long term. Study Design: Systematic review Methods: The following databases were searched on 14/09/2020: MEDLINE, EMBASE, CENTRAL, Web of Science, and PEDro. There were no date or language limits. The methodological quality assessment was performed using the PEDro scale and the quality of the evidence followed the GRADE recommendation. The outcomes pain, disability, and adverse effects were extracted. Results: Of 6264 initial studies, three met the full-text inclusion criteria. All studies were of good methodological quality. Follow up ranged from six months to two years, with 650 participants in total. The meta-analyses found no difference in disability between surgical versus conservative treatment, with a mean difference (MD) between groups of 3.91 points (95% CI –2.19 to 10.01) at six months, MD of 5.53 points (95% CI –3.11 to 14.16) at 12 months and 3.8 points (95% CI –6.0 to 13.6) at 24 months. The quality of the evidence (GRADE) varied from moderate to low across all comparisons. Conclusion: There is moderate-quality evidence that surgical treatment is not superior to conservative treatment for femoroacetabular impingement syndrome in the short term, and there is low-quality evidence that it is not superior in the medium term. Level of evidence: Therapy, level 1a. Registration number: PROSPERO CRD42019134118

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Effectiveness of an osteopathic treatment on the autonomic nervous system: a systematic review of the literature

European Journal of Medical Research ◽

10.1186/s40001-019-0394-5 ◽

2019 ◽

Vol 24 (1) ◽

Cited By ~ 2

Author(s):

Verena Rechberger ◽

Michael Biberschick ◽

Jan Porthun

Keyword(s):

Systematic Review ◽

Nervous System ◽

Autonomic Nervous System ◽

Methodological Quality ◽

Assessment Tools ◽

Controlled Trials ◽

Level Of Evidence ◽

Autonomic Nervous ◽

Osteopathic Treatment ◽

Significant Change

Abstract Objective The objective of this systematic review was to evaluate the effectiveness of an osteopathic treatment on the autonomic nervous system (ANS). For this purpose, published primary studies were analysed and critically evaluated. Method To generate this review, 15 electronic databases were systematically searched for studies. Randomized clinical controlled trials (RCT) and clinical controlled trials (CCT) are included in the review and evaluated with appropriate assessment tools (Downs and Black Checklist and the checklist from Kienle and Kiene). Results 23 published studies (10 RCT, 1 clinic multi-centre study, 1 CCT, 5 randomized cross-over studies, 5 randomized pilot studies and 1 single case study) are included in this review. The studies were evaluated with the assessment tools according to their quality. 3 studies are graded as high quality, 11 as moderate and 8 as low-quality studies. Conclusion The included published studies represent a good level of evidence. Due to a small number of subjects and no follow-ups, the methodological quality is rated as moderate. A significant change on the ANS was shown in studies including High-Velocity Low-Amplitude Techniques (HVLAT). No statement could be drawn in studies in which they used cranial osteopathic techniques due to the lack of methodological quality. A significant change on the ANS is shown in the treatment of the suboccipital region. In studies which evaluated the effectiveness of mobilization in the cervical and thoracic region, no statement could be displayed due to a low level of evidence. None of the findings in these studies have given statements if ANS activation takes place in the sympathetic or parasympathetic system.

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Methodological quality and synthesis of case series and case reports

BMJ evidence-based medicine ◽

10.1136/bmjebm-2017-110853 ◽

2018 ◽

Vol 23 (2) ◽

pp. 60-63 ◽

Cited By ~ 312

Author(s):

Mohammad Hassan Murad ◽

Shahnaz Sultan ◽

Samir Haffar ◽

Fateh Bazerbachi

Keyword(s):

Methodological Quality ◽

Medical Literature ◽

Case Reports ◽

Case Series ◽

Evidence Based ◽

Level Of Evidence ◽

Increased Risk ◽

Study Designs ◽

Inform Decision Making

Case reports and case series are uncontrolled study designs known for increased risk of bias but have profoundly influenced the medical literature and continue to advance our knowledge. In this guide, we present a framework for appraisal, synthesis and application of evidence derived from case reports and case series. We propose a tool to evaluate the methodological quality of case reports and case series based on the domains of selection, ascertainment, causality and reporting and provide signalling questions to aid evidence-based practitioners and systematic reviewers in their assessment. We suggest using evidence derived from case reports and case series to inform decision-making when no other higher level of evidence is available.

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The hemi-hamate autograft arthroplasty in proximal interphalangeal joint reconstruction: a systematic review

Journal of Hand Surgery (European Volume) ◽

10.1177/1753193414554356 ◽

2014 ◽

Vol 40 (1) ◽

pp. 24-32 ◽

Cited By ~ 25

Author(s):

F. S. Frueh ◽

M. Calcagni ◽

N. Lindenblatt

Keyword(s):

Systematic Review ◽

Proximal Interphalangeal Joint ◽

Interphalangeal Joint ◽

Fracture Dislocation ◽

Joint Involvement ◽

Level Of Evidence ◽

Systematic Analysis ◽

Joint Fracture ◽

Fracture Dislocations

Palmar lip injuries of the proximal interphalangeal joint with dorsal fracture-dislocation are difficult to treat and often require major reconstruction. A systematic review was performed and yielded 177 articles. Thirteen articles on hemi-hamate autograft were included in full-text analysis. Results of 71 cases were summarized. Mean follow-up was 36 months and mean proximal interphalangeal joint range of motion was 77°. Overall complication rate was around 35%. Up to 50% of the patients showed radiographic signs of osteoarthritis. However, few of those patients complained about pain or impaired finger motion. Based on this systematic analysis and review, hemi-hamate autograft can be considered reliable for the reconstruction of acute and chronic proximal interphalangeal joint fracture-dislocations with joint involvement >50%, but longer-term follow-up studies are required to evaluate its outcome, especially regarding the rate of osteoarthritis. Level of Evidence: II

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