Outcomes of surgical repair of Retinoschisis-associated retinal detachment compared to Rhegmatogenous retinal detachment

Background The aim of this study is to compare outcomes of primary retinal detachment (RD) repair in retinoschisis-associated RD (RSRD) and rhegmatogenous RD (RRD). Methods This is a retrospective observational cohort study. Charts of 2247 consecutive patients operated for RD repair at the Centre hospitalier universitaire de Québec – Université Laval between 2014 and 2018 were reviewed. Patients with RSRD and RRD were included to compare the visual and anatomical outcomes of both groups. Results There were 41 patients (1.8%) with RSRD and 1661 patients (74%) with RRD. RSRD patients had more primary repair failures (n = 9, 22%, vs. n = 166, 10%; p = 0.013). The primary anatomical success rates for pars plana vitrectomy with and without scleral buckle (PPV-SB vs. PPV) as primary repair method were similar in both RSRD patients (n = 11/14, 79% vs. n = 20/25, 80%; p = 0.92) and RRD patients (n = 751/827, 91% vs. n = 641/721, 89%; p = 0.21). At final follow-up, best corrected visual acuity (VA) in logarithm of the minimum angle of resolution (logMAR) was 0.30 [0.10, 0.88] and 0.18 [0.10, 0.40] (p = 0.03) in RSRD patients and RRD patients, respectively. Presence of retinoschisis was associated with worse final VA (β 0.082, p < 0.001). Other predictive variables included female sex, macula-off presentation, number of RD quadrants involved, longer symptoms duration, worse baseline VA, and primary repair failure. The greatest predictors were worse baseline VA, primary repair failure, and macula-off status at presentation. Presence of retinoschisis did not significantly increase risk of primary repair failure in multivariable analysis (OR 1.45, 95% CI: 0.50–4.17; p = 0.49). Symptoms duration was the greatest effect factor associated with for primary repair failure (OR 1.37, 95% CI: 1.12–1.69; p = 0.003). Conclusions RSRD is associated with more primary repair failure in univariate analysis, but not in multivariate analysis after adjusting for symptoms duration. It is however associated with worse final VA even after adjusting for primary repair failure. Both PPV and PPV-SB are valid repair methods for RSRD. However, RSRD remains a challenge to treat.

The Mediating Role of Boredom and Mind Wandering in the Relationship Between Evolutionary Fitness and Tendency to Substance Use Among University Students

Background: Substance abuse promotes a sense of self-perceived evolutionary ability by stimulating the cortico-mesolimbic in the brain. Although the relationship between substance use and evolutionary fitness has been demonstrated, the role of mediating variables that may contribute to the relationship between self-perceived evolutionary fitness and substance use is not clear yet. Objectives: The present study aimed to examine the relationship between self-perceived evolutionary fitness and the tendency to substance use and the mediating role of boredom and mind wandering in this relationship. Patients and Methods: This correlational study was performed using structural equation modeling (SEM). The statistical population comprised of all students at state-run universities of medical sciences in Tehran. A sample of 200 students from Iran University of Medical Sciences was selected via convenience sampling. Results: A significant negative correlation was found between evolutionary fitness and addiction potential (r = -0.75). The proposed model showed the direct effect factor of evolutionary fitness on addiction potential (β = -0.50, t = 7.90), boredom (β = -0.71, t = -14.12), and mind wandering (β = -0.46, t = -7.28). Moreover, the direct effect factor of boredom (β = 0.37, t = 5.94) and mind wandering (β = -0.02, t = -0.47) for addiction potential was established. Conclusions: Poor evolutionary fitness starts mind wandering about fitness-related issues. Eventually, this wandering leads to the unpleasant sense of boredom. Taking drugs artificially and temporarily increases evolutionary fitness and reduces one’s sense of boredom.

Recent Progress in the Understanding of the Effect of Sympathetic Nerves on Hair Follicle Growth

Clinical observation and experimental studies have long suggested that the perifollicular nerves have nutritional and regulatory effects on the growth, development, and physiological cycle of hair follicles (HFs), even though the concrete mechanism remains obscure. Recently, with the progress of immunohistochemistry and molecular biology techniques, more innovation has been made in the study of the follicular sympathetic nerves and its nerve-effect factor norepinephrine affecting hair follicle stem cells. This review highlights the progress in the regulation of the sympathetic nervous system toward the growth of HFs.

Sales Strategy considering Advertising in Advance-Selling and Spot-Selling Integration Mode for Fresh Product

In this paper, we look into the optimal sales strategy of e-commerce platform which sells fresh-product advertising in advance-selling period and spot-selling period, respectively, when advance-selling and spot-selling integration mode is applied. The study found that, with the increase of advertising investment, the marginal benefit of e-commerce platform is declining; whether advertising during the advance-selling period or the advertising during the spot-selling period, the e-commerce platform can improve its profit, but under the same advertising effect factor, the optimal advertising investment for the sale period is smaller, and the profit when advertising in the advance-selling period is greater. When advertising in different periods, the optimal advertising and price strategy depends on the maximum valuation of consumers about the product and the advertising effect factor.

Environmental Courts, Environment and Employment: Evidence from China

Whether environmental governance will cause unemployment has always been an aspect that the government needs to pay attention to in the process of making environmental policies, and is also a concern of residents. This paper analyzes the policy effect of environmental courts, which is a very important policy tool for the legalization of China’s environmental governance. While investigating whether environmental courts can effectively improve environmental quality, we also analyze its possible impact on employment and the specific mechanisms. The results show that: (1) After the establishment of environmental courts, the PM2.5 concentration has been significantly reduced. (2) While improving the environmental quality, environmental courts will produce a weak employment promotion effect. (3) Environmental courts affect the amount of employment through cost effect, factor substitution effect and innovation effect. This study provides empirical evidence for China and other developing countries to promote the legalization of environmental governance.

Flexural Strength Evaluation of Multi-Cell Composite T-Shaped Concrete-Filled Steel Tubular Beams

The multi-cell composite T-shaped concrete-filled steel tubular (MT-CFST) element is an innovative structural form. It has great potential for construction applications because of favorable advantages over traditional composite elements. The flexural strength of MT-CFST beams was investigated in this study to provide recommendations in line with existing design codes. First, formulations to evaluate the flexural strength of MT-CFST beams were derived based on the Unified Theory and plastic stress distribution method (PSDM). For the Unified Theory-based formula, a modified confinement effect factor that considers the shape of a cross-section was proposed. An experimental study on the flexural behavior of six MT-CFST beams as well as two hollow section counterparts was conducted. The influence of bending moment direction, concrete infill, wall thickness, and cross-section sizes were investigated. The accuracy of the proposed formulations was verified against the test results and numerical results from finite element modeling. The comparisons showed that the formula in line with the Unified Theory provided more accurate predictions with reasonable conservatism for the studied MT-CFST beams.

Analysis of the Aggregate Effect on the Compressive Strength of Concrete Using Dune Sand

In this study, the compressive strengths of concrete were investigated based on water content and aggregate volume fractions, comprising dune sand (DS), crushed sand (CS), and coarse aggregate (CA), for different ages. Experimental data were used to analyze the effects of the volume fraction changes of aggregates on the compressive strength. The compressive strength of concrete increases until the volumetric DS to fine aggregate (FA) ratio (DS/FA ratio) reaches 20%, after which it decreases. The relationship between changes in compressive strength and aggregate volume fractions was analyzed considering the effect factor of each aggregate on the compressive strength and at 2 conditions: (1) 0 < DS < CS < CA and (2) 0 < CA < CS < DS. For condition (1), when the effect factor of CA = 1, those of DS and CS were within 0.04–0.83 and 0.72–0.92, respectively, for all mixtures. For condition (2), when the effect factor of DS = 1, those of CS and CA were within 0.68–0.80 and 0.02–0.79, respectively.

An Examination of the Gust Effect Factor for Rigid High-Rise Buildings

In order to systematically investigate the gust effect factor for rigid buildings, the derivation of the gust effect factor in ASCE 7–16 is carefully reviewed and scale model pressure tests were carried out for rectangular-plan high-rise buildings with plan aspect ratios ranging from 0.11 to 9. The gust effect factor and the aerodynamic admittance function (AAF) for area-averaged pressure coefficients and base drag coefficients were obtained and discussed in detail. The results show that the AAF has direct influence on the value of the gust effect factor, depending on whether effects of non-contemporaneous gust actions or body-generated turbulence are playing a leading role. The ASCE 7–16 gust effect factor for rigid buildings underestimates the measured values for individual walls due to differences in the AAF, peak factors, and the employment of the 3 s moving average filter. However, the ASCE 7–16 gust factor for overall drag is estimated within 5% or better.

Strategies for enhancing the perylene diimide photocatalytic degradation activity: Method, Effect factor, and Mechanism

In the past few decades, countless organic and inorganic pollutants caused serious environmental problems all over the world. One way to remove or degrade pollutants in the environment is to...