scholarly journals Reverse cholestrol transport substantially influences the individual risk of coronary heart disease in hypercholesterolaemic patients

2001 ◽  
Vol 22 (6) ◽  
pp. 442-443
Author(s):  
R Poledne
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Individual Risk ◽  
The Individual

scholarly journals Relations between the residential fast-food environment and the individual risk of cardiovascular diseases in The Netherlands: A nationwide follow-up study

2018 ◽  
Vol 25 (13) ◽  
pp. 1397-1405 ◽  
Author(s):  
Maartje Poelman ◽  
Maciej Strak ◽  
Oliver Schmitz ◽  
Gerard Hoek ◽  
Derek Karssenberg ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Diseases ◽  
Food Environment ◽  
Fast Food ◽  
Individual Risk ◽  
Food Outlets ◽  
The Individual

Background The food environment has been hypothesized to influence cardiovascular diseases such as hypertension and coronary heart disease. This study determines the relation between fast-food outlet density (FFD) and the individual risk for cardiovascular disease, among a nationwide Dutch sample. Methods After linkage of three national registers, a cohort of 2,472,004 adults (≥35 years), free from cardiovascular disease at January 1st 2009 and living at the same address for ≥15 years was constructed. Participants were followed for one year to determine incidence of cardiovascular disease, including coronary heart disease, stroke and heart failure. Street network-based buffers of 500 m, 1000 m and 3000 m around residential addresses were calculated, while FFD was determined using a retail outlet database. Logistic regression analyses were conducted. Models were stratified by degree of urbanization and adjusted for age, sex, ethnicity, marital status, comorbidity, neighbourhood-level income and population density. Results In urban areas, fully adjusted models indicated that the incidence of cardiovascular disease and coronary heart disease was significantly higher within 500 m buffers with one or more fast-food outlets as compared with areas with no fast-food outlets. An elevated FFD within 1000 m was associated with an significantly increased incidence of cardiovascular disease and coronary heart disease. Evidence was less pronounced for 3000 m buffers, or for stroke and heart-failure incidence. Conclusions Elevated FFD in the urban residential environment (≤1000 m) was related to an increased incidence of cardiovascular heart disease and coronary heart disease. To better understand how FFD is associated with cardiovascular disease, future studies should account for a wider range of lifestyle and environmental confounders than was achieved in this study.

scholarly journals Building prediction models for coronary heart disease by synthesizing multiple longitudinal research findings

2005 ◽  
Vol 12 (5) ◽  
pp. 459-464 ◽  
Author(s):  
Guizhou Hu ◽  
Martin M. Root
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Prediction Model ◽  
Empirical Model ◽  
Complex Disease ◽  
Prediction Models ◽  
Longitudinal Research ◽  
Study Data ◽  
Individual Risk ◽  
Data Set

Background No methodology is currently available to allow the combining of individual risk factor information derived from different longitudinal studies for a chronic disease in a multivariate fashion. This paper introduces such a methodology, named Synthesis Analysis, which is essentially a multivariate meta-analytic technique. Design The construction and validation of statistical models using available data sets. Methods and results Two analyses are presented. (1) With the same data, Synthesis Analysis produced a similar prediction model to the conventional regression approach when using the same risk variables. Synthesis Analysis produced better prediction models when additional risk variables were added. (2) A four-variable empirical logistic model for death from coronary heart disease was developed with data from the Framingham Heart Study. A synthesized prediction model with five new variables added to this empirical model was developed using Synthesis Analysis and literature information. This model was then compared with the four-variable empirical model using the first National Health and Nutrition Examination Survey (NHANES I) Epidemiologic Follow-up Study data set. The synthesized model had significantly improved predictive power ( x2 = 43.8, P < 0.00001). Conclusions Synthesis Analysis provides a new means of developing complex disease predictive models from the medical literature.

Modifiable risk factors for coronary heart disease in women

1994 ◽  
Vol 3 (3) ◽  
pp. 177-184 ◽  
Author(s):  
MJ Hanson
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Disease Risk ◽  
Synergistic Effects ◽  
Modifiable Risk Factors ◽  
Additional Risk ◽  
Heart Disease Risk Factors ◽  
The Individual ◽  
Heart Disease Risk

Research in human coronary heart disease has been conducted primarily on males; however, investigators have begun to focus research efforts on female subjects as well. A literature review that identified studies on women and coronary heart disease was done to describe modifiable risk factors for coronary heart disease in women. Several modifiable risk factors such as smoking, hypertension, and disorders of lipid metabolism previously identified for men are also risk factors for women. However, the mechanisms by which some of these risk factors work in women are different from those in men. Moreover, women have additional risk factors related to menopause and, in some cases, the use of oral contraceptives. Significant initial information has been gained concerning women and coronary heart disease risk factors. However, gaps persist in information regarding the individual and synergistic effects of risk factors for CHD in women.

scholarly journals Triglyceride-containing lipoprotein sub-fractions and risk of coronary heart disease and stroke: A prospective analysis in 11,560 adults

2020 ◽  
Vol 27 (15) ◽  
pp. 1617-1626 ◽  
Author(s):  
Roshni Joshi ◽  
S Goya Wannamethee ◽  
Jorgen Engmann ◽  
Tom Gaunt ◽  
Deborah A Lawlor ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Odds Ratio ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Increased Risk ◽  
The Individual

Aims Elevated low-density lipoprotein cholesterol (LDL-C) is a risk factor for cardiovascular disease; however, there is uncertainty about the role of total triglycerides and the individual triglyceride-containing lipoprotein sub-fractions. We measured 14 triglyceride-containing lipoprotein sub-fractions using nuclear magnetic resonance and examined associations with coronary heart disease and stroke. Methods Triglyceride-containing sub-fraction measures were available in 11,560 participants from the three UK cohorts free of coronary heart disease and stroke at baseline. Multivariable logistic regression was used to estimate the association of each sub-fraction with coronary heart disease and stroke expressed as the odds ratio per standard deviation increment in the corresponding measure. Results The 14 triglyceride-containing sub-fractions were positively correlated with one another and with total triglycerides, and inversely correlated with high-density lipoprotein cholesterol (HDL-C). Thirteen sub-fractions were positively associated with coronary heart disease (odds ratio in the range 1.12 to 1.22), with the effect estimates for coronary heart disease being comparable in subgroup analysis of participants with and without type 2 diabetes, and were attenuated after adjustment for HDL-C and LDL-C. There was no evidence for a clear association of any triglyceride lipoprotein sub-fraction with stroke. Conclusions Triglyceride sub-fractions are associated with increased risk of coronary heart disease but not stroke, with attenuation of effects on adjustment for HDL-C and LDL-C.

Predicting individual risk of coronary heart disease (CHD) on an italian sample of patients with hypercholesterolemia

2000 ◽  
Vol 151 (1) ◽  
pp. 274
Author(s):  
L. Denti ◽  
A. Cecchetti ◽  
F. Merli ◽  
R. Benedetti ◽  
G. Pasolini ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Individual Risk ◽  
Italian Sample

Inflammation and atherosclerosis in rheumatoid arthritis

2005 ◽  
Vol 7 (7) ◽  
pp. 1-24 ◽  
Author(s):  
Robert J. Stevens ◽  
Karen M.J. Douglas ◽  
Athanasios N. Saratzis ◽  
George D. Kitas
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Individual Risk ◽  
Atherosclerotic Plaques ◽  
The Metabolic Syndrome ◽  
Inflammatory Processes ◽  
Individual Risk Factors

Rheumatoid arthritis (RA) associates with increased cardiovascular mortality. This appears to be predominantly due to ischaemic causes, such as myocardial infarction and congestive heart failure. The higher prevalence of cardiac ischaemia in RA is thought to be due to the accelerated development of atherosclerosis. There are two main reasons for this, which might be inter-related: the systemic inflammatory load, characteristic of RA; and the accumulation in RA of classical risk factors for coronary heart disease, which is reminiscent of the metabolic syndrome. We describe and discuss in the context of RA the involvement of local and systemic inflammatory processes in the development and rupture of atherosclerotic plaques, as well as the role of individual risk factors for coronary heart disease. We also present the challenges facing the clinical and scientific communities addressing this problem, which is receiving increasing attention.

Sign in / Sign up

Export Citation Format

Share Document