Increasing Body Mass Index Predicts Rapid Decline in Renal Function: A 5 Year Retrospective Study

2018 ◽  
Vol 50 (07) ◽  
pp. 556-561 ◽  
Author(s):  
Xiaojing Ma ◽  
Chengyin Zhang ◽  
Hong Su ◽  
Xiaojie Gong ◽  
Xianglei Kong
Keyword(s):  
Body Mass Index ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Retrospective Study ◽  
Kidney Disease ◽  
Body Mass ◽  
Adult Population ◽  
Rapid Decline ◽  
Logistic Regression Models ◽  
Baseline Bmi

AbstractWhile obesity is a recognized risk factor for chronic kidney disease, it remains unclear whether change in body mass index (ΔBMI ) is independently associated with decline in renal function (evaluated by the change in estimated glomerular filtration rate, ΔeGFR) over time. Accordingly, to help clarify this we conducted a retrospective study to measure the association of ΔBMI with decline in renal function in Chinese adult population. A total of 4007 adults (aged 45.3±13.7 years, 68.6% male) without chronic kidney disease at baseline were enrolled between 2008 and 2013. Logistic regression models were applied to explore the relationships between baseline BMI and ΔBMI, and rapid decline in renal function (defined as the lowest quartile of ΔeGFR ). During 5 years of follow-up, the ΔBMI and ΔeGFR were 0.47±1.6 (kg/m2) and –3.0±8.8 (ml/min/1.73 m2), respectively. After adjusted for potential confounders, ΔBMI (per 1 kg/m2 increase) was independently associated with the rapid decline in renal function [with a fully adjusted OR of 1.12 (95% CI, 1.05 to 1.20). By contrast, the baseline BMI was not associated with rapid decline in renal function [OR=1.05 (95% CI, 0.98 to 1.13)]. The results were robust among 2948 hypertension-free and diabetes-free participants, the adjusted ORs of ΔBMI and baseline BMI were 1.14 (95% CI, 1.05 to 1.23) and 1.0 (95% CI, 0.96 to 1.04) for rapid decline in renal function, respectively. The study revealed that increasing ΔBMI predicts rapid decline in renal function.

scholarly journals The Risk of Tuberculosis Infection in Non-dialysis Chronic Kidney Disease Patients

2021 ◽  
Vol 8 ◽  
Author(s):  
Chia-Hsiang Li ◽  
Hung-Jen Chen ◽  
Wei-Chun Chen ◽  
Chih-Yen Tu ◽  
Te-Chun Hsia ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Body Mass ◽  
Lower Risk ◽  
Tuberculosis Infection ◽  
University Hospital ◽  
Ckd Stage ◽  
Time Varying Covariates

Background: Patients with chronic kidney disease (CKD) receiving maintenance renal replacement therapy are at higher risk of tuberculosis (TB) infection. The risk of TB infection in CKD patients not receiving dialysis is unknown.Aim: We conduct this study to test the hypothesis that TB infection is negatively correlated to renal function.Design: Non-dialysis CKD stage 1–5 patients, admitted in China Medical University Hospital from January of 2003 to May of 2014, were enrolled in this study and were prospectively followed up to the diagnosis of TB, death, loss to follow-up, or December 2014. The risk factors of TB infection were analyzed using competing-risks regression analysis with time-varying covariates. The initiation of dialysis and patients' death were considered as competing events. Patients' estimated glomerular filtration rate (eGFR) and body mass index (BMI) were recorded at enrollment.Results: They were followed-up for a median duration of 1.4 years. Of the 7221 patients, TB infection was identified in 114 patients. Higher eGFR was associated with lower risk of TB infection (P < 0.01). The adjusted subdistribution hazard ratio (aSHR) was 0.82 [95% confidence interval (CI), 0.72 to 0.94] for every 5 ml/min/1.73 m2 increase in eGFR. In addition, higher BMI (p = 0.01) was associated with a lower risk of TB infection and the aSHR was 0.91 (95% CI, 0.85 to 0.98) for every 1 kg/m2 increase in BMI.Conclusion: Renal function and body mass index are independently associated with the risk of tuberculosis infection in patients with chronic kidney disease not receiving dialysis.

scholarly journals Is there any Gender Difference in the Association between Obesity, Chronic Kidney Disease and Anemia

2015 ◽  
Vol 13 (2) ◽  
pp. 79-83
Author(s):  
Krasimira Atanassova ◽  
Jelka Masin-Spasovska ◽  
Goce Spasovski ◽  
Emil Paskalev
Keyword(s):  
Body Mass Index ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Body Mass ◽  
Filtration Rate ◽  
Female Patients ◽  
Second Degree

Abstract Introduction. Nowadays, obesity has emerged as one of the most independent risk factors for chronic kidney disease (CKD) in both economically developed and undeveloped countries. The number of patients requiring dialysis as a consequence of obesity-related renal diseases, such as diabetes mellitus and hypertension, is increasing worldwide. Moreover, obesity has been shown to favorize the risk of cardiovascular diseases (CVD) with premature death due to CKD and/or end-stage renal disease (ESRD). The aim of the study was to investigate the association between obesity [e.g. body mass index (BMI)], kidney function [e.g. glomerular filtration rate (GFR)] and renal anemia in CKD patients. Methods. Retrospectively, data from the register of 315 pre-dialysis patients with different stages of CKD not on erythropoiesis stimulation agents (ESAs) during the period between 1 Jan 2013-30 June 2013 were used to assess the association between the degree of CKD impairment with the degree of obesity and anemia. The stage and/or progression of CKD was calculated by GFR, while the degree of obesity by the body mass index (BMI). CKD was defined as a glomerular filtration rate (GFR) <60 mL/min per 1.73 m2. Data analysis was performed by means of the simple Microsoft excel program. Results. Within the study population of 315 CKD patients, 123 were males with mean age of 63.4±1.33 years and 192 females of 57.3±1.2 years. The GFR reduced with the increased BMI in both genders, and majority of patients (n=243) were in CKD stage 3, with a mean GFR of 44.5 ml/min/1.73 m2. The BMI values in female patients with first and second degree of obesity negatively correlated with GFR (r=−0.46, p<0.05). Only female patients with second degree of obesity (BMI of 35-39.9 kg/m2) had a positive correlation between the decreased renal function and reduced Hb levels. Conclusions. Our study provided an unconditional evidence not only for the presence of an association between the degree of obesity (BMI) and the degree of renal function impairment (GFR), but also an association between the higher BMI and the higher degree of kidney anemia seen in women with second degree of obesity. Further larger scale trials and interventional studies are required to see the effect of body weight reduction on renal function and especially anemia.

scholarly journals Anthropometric measurements and markers of renal function in adults and older adults

2016 ◽  
Vol 29 (2) ◽  
pp. 199-209
Author(s):  
Victoria Araujo Ganzaroli AMADOR ◽  
Ana Tereza Vaz de Sousa FREITAS ◽  
Alessandra Vitorino NAGHETTINI ◽  
Edna Regina Silva PEREIRA ◽  
Maria do Rosário Gondim PEIXOTO
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Waist Circumference ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Body Mass ◽  
Filtration Rate

Objective: To determine whether anthropometric indicators are associated with markers of renal function in adults and older adults. Methods: This cross-sectional study included 279 adults and older adults attending eight primary healthcare units in eastern Goiânia, Góias. Sociodemographic, lifestyle, and clinical data were collected using a standard questionnaire. Body mass index was categorized as overweight (≥25 kg/m²) or non-overweight. Waist circumference was classified as normal or high; chronic kidney disease was defined as a glomerular filtration rate below 60 mL/minutes/1.73 m²; micro/macroalbuminuria was defined as an albumin/creatinine ratio above 30 mg/g. The association between anthropometric indicators and renal function markers was assessed by multiple linear regression analysis. Results: Chronic kidney disease was present in 8.9% and micro/macroalbuminuria in 34.8% of the sample. The prevalence of overweight was 57.0%. Waist circumference and body mass index were positively associated with glomerular filtration rate, characterized as glomerular hyperfiltration. Microalbuminuria was positively associated with body mass index in women. Conclusion: The prevalences of chronic kidney disease and overweight were high in the study population. Overweight was positively associated with glomerular filtration rate.

scholarly journals Evaluation of Nutritional Status of Chronic Kidney Disease Patients Undergoing Hemodialysis

Med Phoenix ◽  
2020 ◽  
Vol 5 (1) ◽  
pp. 19-25
Author(s):  
Sharmila Joshi ◽  
Samir Singh ◽  
Amrit Singh
Keyword(s):  
Body Mass Index ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Nutritional Status ◽  
Serum Albumin ◽  
Body Mass ◽  
Anthropometric Measurement ◽  
Arm Circumference ◽  
Low Serum

Background: Chronic kidney disease caused by deterioration of renal function is a growing problem in the world. In chronic kidney disease, renal function is decreased and waste can build to high level in blood. Malnutrition is common in chronic kidney disease patient who is related to poor food intake because of anorexia, restricted protein intake, nausea and vomiting. Objective: This study aims to assess the nutritional status of chronic kidney patients undergoing hemodialysis by anthropometric measurement and laboratory investigations. Materials and Methods: A cross-sectional study was conducted in Human Organ Transplant Center, Bhaktapur, Nepal over a period of 3 months (December, 2016 to February, 2017). Total of 53 patients (25 male and 28 female) undergoing hemodialysis were included in this study. Anthropometric measurements like body mass index, midupper arm circumference and laboratory investigation like serum albumin was used to evaluate the nutritional status of chronic kidney patients. The data were analyzed using SPSS version 16.0. Results: Mean age of study population was 43.07±16.1 years. Majority of study subjects belong to age group between 17-61 years (64.16%). On the basis of World Health Organization body mass index classification, 24.52% of patients had fallen in malnourished class whereas 64.15% of the patients had normal nutritional status. Similarly, on the basis of mid-upper arm circumference, 52% of the male patients and 75% of the female patients were malnourished. 54.72% of the patient’s calorie intake was below 1200 Kcal. 56.6% of the patients had low serum albumin indicating malnutrition. Conclusion: In conclusion, this study showed that malnutrition is a common problem in our patients with chronic kidney disease undergoing hemodialysis. Inadequate intake of energy and nutrients, low MUAC values, low BMI and low serum albumin concentration increases the degree of malnutrition.

Sign in / Sign up

Export Citation Format

Share Document