Nickel-Catalyzed N-Arylation of Amides with (Hetero)aryl Electrophiles using a DBU/NaTFA Dual-Base System

Synlett ◽  
2020 ◽  
Author(s):  
Travis Lundrigan ◽  
Joseph P. Tassone ◽  
Mark Stradiotto
Keyword(s):  
Secondary Amide ◽  
Base System ◽  
Organic Amine ◽  
Aryl Chloride ◽  
System A ◽  
Pseudo Halides ◽  
Dual Base ◽  
Selection Of

The first nickel-catalyzed N-arylation of amides with (hetero)aryl (pseudo)halides employing an organic amine base is described. When using Ni(COD)2/CyPAd-DalPhos catalyst mixtures in combination with DBU/NaTFA as a dual-base system, a diversity of (hetero)aryl chloride, bromide, tosylate, and mesylate electrophiles were successfully cross-coupled with structurally varied primary amides, as well as a selection of secondary amide, lactam, and oxazolidone nucleophiles.

scholarly journals Sensitivity Based Selection of an Optimal Cable-Driven Parallel Robot Design for Rehabilitation Purposes

Robotics ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 7
Author(s):  
Ferdaws Ennaiem ◽  
Abdelbadiâ Chaker ◽  
Juan Sebastián Sandoval Arévalo ◽  
Med Amine Laribi ◽  
Sami Bennour ◽  
...  
Keyword(s):  
Pareto Front ◽  
Parallel Robot ◽  
Elastic Stiffness ◽  
Upper Limb Rehabilitation ◽  
Daily Life Activities ◽  
System A ◽  
The Monte Carlo Method ◽  
Genetic Algorithm Method ◽  
Limb Rehabilitation ◽  
Selection Of

This paper deals with the design of an optimal cable-driven parallel robot (CDPR) for upper limb rehabilitation. The robot’s prescribed workspace is identified with the help of an occupational therapist based on three selected daily life activities, which are tracked using a Qualisys motion capture system. A preliminary architecture of the robot is proposed based on the analysis of the tracked trajectories of all the activities. A multi-objective optimization process using the genetic algorithm method is then performed, where the cable tensions and the robot size are selected as the objective functions to be minimized. The cables tensions are bounded between two limits, where the lower limit ensures a positive tension in the cables at all times and the upper limit represents the maximum torque of the motor. A sensitivity analysis is then performed using the Monte Carlo method to yield the optimal design selected out of the non-dominated solutions, forming the obtained Pareto front. The robot with the highest robustness toward the disturbances is identified, and its dexterity and elastic stiffness are calculated to investigate its performance.

scholarly journals An Analytical Approach for the Selection of Technologies to be Integrated in a Plug&play Façade Unit: The RenoZEB Case Study

Proceedings ◽  
2021 ◽  
Vol 65 (1) ◽  
pp. 29
Author(s):  
Alessandro Pracucci ◽  
Sara Magnani ◽  
Laura Vandi ◽  
Oscar Casadei ◽  
Amaia Uriarte ◽  
...  
Keyword(s):  
Building Envelope ◽  
Design System ◽  
Decision Matrix ◽  
Design Guideline ◽  
Existing Building ◽  
Building Conditions ◽  
Zero Energy Building ◽  
System A ◽  
Selection Of

The nearly Zero Energy building (nZEB) renovation market is currently the key feature in the construction sector. RenoZEB aims to develop a systematic approach for retrofitting by assembling different technologies in a plug and play building envelope. This paper presents the methodology used to transform the RenoZEB concept in the design system. A multi-criteria decision matrix is used for the selection of the best façade technologies within the market while the analysis of the existing building conditions allows to develop a replicable approach for designing deep retrofitting intervention through a plug&play façade. The methodology appears to be a valuable support for the selection of technologies and allows to define a design guideline for the envelope.

Method Base System: A Tool for Decision Support

1983 ◽  
pp. 107-130 ◽  
Author(s):  
M. Bever ◽  
W. Gaube ◽  
P. C. Lockemann ◽  
H. C. Mayr
Keyword(s):  
Decision Support ◽  
Base System ◽  
System A ◽  
Method Base

scholarly journals CB1 Activity Drives the Selection of Navigational Strategies: A Behavioral and c-Fos Immunoreactivity Study

2020 ◽  
Vol 21 (3) ◽  
pp. 1072
Author(s):  
Daniela Laricchiuta ◽  
Francesca Balsamo ◽  
Carlo Fabrizio ◽  
Anna Panuccio ◽  
Andrea Termine ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Dorsal Striatum ◽  
Endocannabinoid System ◽  
Cognitive Map ◽  
Cb1 Receptors ◽  
Spatial Problem ◽  
System A ◽  
Hole Board ◽  
Selection Of

To promote efficient explorative behaviors, subjects adaptively select spatial navigational strategies based on landmarks or a cognitive map. The hippocampus works alone or in conjunction with the dorsal striatum, both representing the neuronal underpinnings of the navigational strategies organized on the basis of different systems of spatial coordinate integration. The high expression of cannabinoid type 1 (CB1) receptors in structures related to spatial learning—such as the hippocampus, dorsal striatum and amygdala—renders the endocannabinoid system a critical target to study the balance between landmark- and cognitive map-based navigational strategies. In the present study, mice treated with the CB1-inverse agonist/antagonist AM251 or vehicle were trained on a Circular Hole Board, a task that could be solved through either navigational strategy. At the end of the behavioral testing, c-Fos immunoreactivity was evaluated in specific nuclei of the hippocampus, dorsal striatum and amygdala. AM251 treatment impaired spatial learning and modified the pattern of the performed navigational strategies as well as the c-Fos immunoreactivity in the hippocampus, dorsal striatum and amygdala. The present findings shed light on the involvement of CB1 receptors as part of the selection system of the navigational strategies implemented to efficiently solve the spatial problem.

Exploring the policy selection of the P2P VoD system: A simulation-based research

2014 ◽  
Vol 8 (3) ◽  
pp. 459-473 ◽  
Author(s):  
Ke Xu ◽  
Xin Liu ◽  
Zhen Ma ◽  
Yifeng Zhong ◽  
Wenlong Chen
Keyword(s):  
System A ◽  
Policy Selection ◽  
Simulation Based ◽  
Selection Of

scholarly journals First-Principles Design of Refractory High Entropy Alloy VMoNbTaW

Entropy ◽  
2018 ◽  
Vol 20 (12) ◽  
pp. 965 ◽  
Author(s):  
Shumin Zheng ◽  
Shaoqing Wang
Keyword(s):  
Elastic Properties ◽  
First Principles ◽  
High Entropy Alloy ◽  
Low Density ◽  
High Entropy ◽  
System A ◽  
Small Influence ◽  
High Concentrations ◽  
General Guidance ◽  
Selection Of

The elastic properties of seventy different compositions were calculated to optimize the composition of a V–Mo–Nb–Ta–W system. A new model called maximum entropy approach (MaxEnt) was adopted. The influence of each element was discussed. Molybdenum (Mo) and tungsten (W) are key elements for the maintenance of elastic properties. The V–Mo–Nb–Ta–W system has relatively high values of C44, bulk modulus (B), shear modulus (G), and Young’s modulus (E), with high concentrations of Mo + W. Element W is brittle and has high density. Thus, low-density Mo can substitute part of W. Vanadium (V) has low density and plays an important role in decreasing the brittleness of the V–Mo–Nb–Ta–W system. Niobium (Nb) and tantalum (Ta) have relatively small influence on elastic properties. Furthermore, the calculated results can be used as a general guidance for the selection of a V–Mo–Nb–Ta–W system.

scholarly journals Concentrating Solar Collectors for a Trigeneration System—A Comparative Study

2020 ◽  
Vol 10 (13) ◽  
pp. 4492
Author(s):  
Evangelos Bellos ◽  
Christos Tzivanidis
Keyword(s):  
Energy Efficiency ◽  
Organic Rankine Cycle ◽  
Rankine Cycle ◽  
Payback Period ◽  
Weather Data ◽  
Parabolic Trough ◽  
Efficient Technology ◽  
System A ◽  
Linear Fresnel Reflector ◽  
Selection Of

The objective of this study is the investigation of different solar concentrating collectors for application in a trigeneration system. Parabolic trough collectors, linear Fresnel reflectors and solar dishes are the examined solar concentrating technologies in this work. The trigeneration unit includes an organic Rankine cycle coupled with an absorption heat machine that operates with LiBr/water. The analysis is performed throughout the year by using the weather data of Athens in Greece. The results of this work indicate that the selection of parabolic trough collectors is the best choice because it leads to the maximum yearly system energy efficiency of 64.40% and to the minimum simple payback period of 6.25 years. The second technology is the solar dish with the energy efficiency of 62.41% and the simple payback period of 6.95 years, while the linear Fresnel reflector is the less efficient technology with the energy efficiency of 35.78% and with a simple payback period of 10.92 years. Lastly, it must be stated that the thermodynamic investigation of the system is performed with a created model in Engineering Equation Solver, while the dynamic analysis is performed with a code in the programming language FORTRAN.

A Working Model of a Fully Digital Academic High-Throughput Microscopy Facility

1998 ◽  
Vol 4 (S2) ◽  
pp. 72-73
Author(s):  
M. R. Dickson
Keyword(s):  
Microprobe Analysis ◽  
List Type ◽  
Experimental Science ◽  
Science And Engineering ◽  
Image Capture ◽  
The Past ◽  
System A ◽  
Analysis System ◽  
The University ◽  
Selection Of

The Electron Microscope Unit at the University has a good selection of microscopes: two tungsten SEMs, two FESEMs, a microprobe analysis system, a 125 kY TEM, a 200 kV TEM, an AFM, an FIB miller, a Zeiss Photomicroscope and a Leica Macroscope. We service around 300 clients’ projects a year in every field of experimental science and engineering, logging over 8,000 hrs of beam time annually.But funding constraints have always kept us short staffed and our laboratory has been working towards complete digital image capture for the past ten years to enhance our productivity. The perceived benefits of digitisation for us are:Photographic processing of negatives eliminated.Archiving of (bulky) photographic negatives eliminated.Need for special darkroom & graphics skills eliminatedResponsibility for archiving and indexing images devolved to individual usersResponsibility for image processing devolved to individual users.Rapid turnaround of images.Rapid sharing of results.

Palladium-Catalyzed Amidation and Amination of (Hetero)aryl Chlorides under Homogeneous Conditions Enabled by a Soluble DBU/NaTFA Dual-Base System

2019 ◽  
Vol 23 (8) ◽  
pp. 1529-1537 ◽  
Author(s):  
Gregory L. Beutner ◽  
John R. Coombs ◽  
Rebecca A. Green ◽  
Bahar Inankur ◽  
Dong Lin ◽  
...  
Keyword(s):  
Base System ◽  
Aryl Chlorides ◽  
Palladium Catalyzed ◽  
Dual Base
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