Healthy Aging – Mikronährstoffe

2021 ◽  
Vol 19 (01) ◽  
pp. 15-21
Author(s):  
Uwe Gröber
Keyword(s):  
Vitamin B12 ◽  
Vitamin K ◽  
Healthy Aging ◽  
Vitamine D ◽  
Alzheimer Demenz

ZusammenfassungDie Vitamine D und K2 interagieren auf vielen Stoffwechselwegen, v. a. im Kalzium- und Knochenstoffwechsel und haben günstige Effekte für die Knochendichte. Vitamin-K-abhängige Proteine sind an der Blutgerinnung beteiligt und schützen Arterien vor arteriosklerotischer Mikrokalzifizierung. Ein Mangel an Vitamin B12 und/oder Folsäure resultiert in Hyperhomocysteinämie. Diese ist im fortgeschrittenen Alter mit einer Abnahme von kognitiver Leistungsfähigkeit und Hirngröße assoziiert und gilt als Risikofaktor für eine Alzheimer-Demenz. Coenzym Q10 (Ubiquinon) spielt eine essenzielle Rolle bei der zellulären Energieproduktion. Das Vitaminoid ist Zellregulator, Antioxidanz und beeinflusst die Aktivität zahlreicher Gene. So beugt es Zellläsionen sowie Inflammaging vor. Das Verhältnis der reduzierten Form Ubiquinol zu Ubiquinon im Blut ist ein Marker für oxidativen Stress. Eine unzureichende Versorgung führt zu Störungen u. a. im Herz-Kreislauf- und Immunsystem.

scholarly journals Kombinierte Vitamin-D- und Vitamin-K-Supplemente für Kinder und Jugendliche: Nutzen oder Risiko?

2020 ◽  
Author(s):  
Susanne Greber-Platzer ◽  
◽  
Nadja Haiden ◽  
Almuthe Christina Hauer ◽  
Roland Lanzersdorfer ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin K ◽  
Kinder Und Jugendliche ◽  
Randomisierte Kontrollierte Studien ◽  
Vitamine D ◽  
Kontrollierte Studien ◽  
Unerwünschte Nebenwirkungen

ZusammenfassungEine tägliche Vitamin-D-Supplementierung für Säuglinge bis zum zweiten erlebten Frühsommer zur Prävention der Rachitis und die Gabe von Vitamin K1 bei Neugeborenen zur Prävention von Vitamin-K-Mangel-Blutungen sind empfohlen.Seit einiger Zeit sind in Österreich Kombinationsprodukte der beiden fettlöslichen Vitamine D3 und K2 auf dem Markt erhältlich, die mit gesundheitsfördernden Effekten wie verbesserter Knochenmineralisation und Schutz vor vaskulärer Kalkeinlagerung beworben werden.Die Wirkung einer kombinierten Supplementierung von Vitamin D und Vitamin K2 bei Kindern ist aus physiologischer Sicht gesehen zwar potenziell sinnvoll, um Effekt, Risiken oder unerwünschte Nebenwirkungen zu evaluieren. Zuvor werden aber Dosisfindungs- und Sicherheitsstudien für die kombinierte Verabreichung benötigt. Insbesondere sind randomisierte kontrollierte Studien bei Risikokindern und Frühgeborenen notwendig. Solange diese Daten nicht vorliegen, erscheint die Gabe von Vitamin D in Kombination mit Vitamin K2 im Kindesalter nicht gerechtfertigt und kann daher auch nicht empfohlen werden.

scholarly journals Vitamin K Activity in Vitamin B12-Antibiotic Supplements

1955 ◽  
Vol 34 (1) ◽  
pp. 243-245 ◽  
Author(s):  
P. Griminger ◽  
W.D. Morrison ◽  
H.M. Scott
Keyword(s):  
Vitamin B12 ◽  
Vitamin K ◽  
K Activity

scholarly journals Các Vitamin cần thiết như thế nào đối với bệnh nhân đái tháo đường typ 2

2020 ◽  
pp. 16-22
Author(s):  
Trung Vinh Hoàng
Keyword(s):  
Vitamin D ◽  
Vitamin A ◽  
Vitamin B12 ◽  
Vitamin K ◽  
Vitamin B6 ◽  
Vitamin B1

Bài tổng quan sau đây nói về mối liên quan giữa đái tháo đường typ 2 (ĐTĐT2) với từng loại vitamin nói chung cũng như vitamin tổng hợp. Nồng độ các vitamin có tác dụng chống gốc tự do như vitamin A, C và E đều giảm ở BN ĐTĐ làm gia tăng các stress oxi hóa, góp phần gây bất thường chuyển hóa glucose. Mặt khác các protein mang retinol (vitamin A) còn có tác dụng điều biến tương tự như các adipokin. Mặc dù cơ chế gây giảm nồng độ các vitamin nhóm B như thiamin (vitamin B1), vitamin B6 và biotin là hoàn toàn chưa rõ song nếu bổ sung các loại đó lại có tác dụng cải thiện kiểm soát chuyển hóa ở BN ĐTĐ. Hấp thu acid folic và vitamin B12 sẽ bị giảm đi nếu sử dụng merformin kéo dài trong khi đó đây lại là thuốc lựa chọn hàng đầu để điều trị ĐTĐ chưa có biến chứng. Chính vì vậy nồng độ hai loại này bị thiếu hụt, rất cần bổ sung thường xuyên. Vitamin D đóng vai trò như là yếu tố nguy cơ (YTNC) gây biến chứng ở BN trong đó có biến chứng tim mạch. Cũng có ý kiến cho rằng vitamin K có liên quan đến chuyển hóa glucose song cần phải có thêm bằng chứng trong nghiên cứu. Việc sử dụng vitamin tổng hợp cho hiệu quả chưa rõ rệt. Tuy vậy hiện nay vẫn chưa có một chỉ định thống nhất nào về bồi phụ vitamin thiếu hụt ngoại trừ sử dụng acid folic và vitamin B12 nếu điều trị bằng metformin kéo dài.

P3-126: Vitamin B12, holotranscobalamin and risk of cognitive decline: 10-year follow-up of the Oxford Healthy Aging Project

2006 ◽  
Vol 2 ◽  
pp. S410-S411
Author(s):  
Robert Clarke ◽  
Jacqueline Birks ◽  
Ebba Nexo ◽  
Kathleen Emmens ◽  
Joern Schneede ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Vitamin B12 ◽  
Healthy Aging

scholarly journals The Effects of Vitamin D3, Vitamin B12, and Vitamin K on the Differentiation of Porcine Adipose-Derived Stem Cells (ASC) into Osteoblasts

2020 ◽  
pp. 1-5
Author(s):  
Matthew B. Wheeler ◽  
Bane T.A. ◽  
Bertels J.C. ◽  
Matthew B. Wheeler ◽  
Polkoff K.M. ◽  
...  
Keyword(s):  
Stem Cells ◽  
Vitamin B12 ◽  
Vitamin K ◽  
Vitamin D3 ◽  
Positive Influence ◽  
Difficult Problem ◽  
Osteogenic Medium ◽  
Large Bone ◽  
Tremendous Challenge ◽  
Large Bone Defects

Large bone defects present a tremendous challenge to the treating surgeon. Tissue engineering using scaffolds of various sizes and shapes that contain stem cells and other osteoinductive molecules offer a potential solution to this difficult problem. The aim of this project was to evaluate if standard osteogenic medium infused with either vitamin D3, vitamin K, or vitamin B12 influences the differentiation of adiposederived stem cells (ASC) into osteoblasts. Only the 100 nM vitamin D3 treatment had a positive influence on ASC differentiation into osteoblasts. Moreover, we found higher levels (statistically significant) of osteocalcin production in all vitamin groups compared with the standard osteogenic medium.

scholarly journals Roles of vitamin K (phylloquinone and menaquinones) and related proteins (prothrombin, des-γ-carboxyprothrombin, and γ-glutamic acid) in healthy adults

2020 ◽  
Vol 4 (2) ◽  
pp. 075-084
Author(s):  
Yuichi Fukuzawa ◽  
Katsuhiro Gotoh ◽  
Soichiro Uehara
Keyword(s):  
Liver Cirrhosis ◽  
Vitamin K ◽  
Plasma Levels ◽  
Healthy Aging ◽  
Healthy Adults ◽  
Reverse Phase Hplc ◽  
Reverse Phase ◽  
The Status ◽  
Positive Correlations ◽  
Related Proteins

The aim of the study was to evaluate the plasma levels of vitamin K (VK), prothrombin, des-γ-carboxyprothrombin (DCP) by ELISA with two types of monoclonal antibodies (MU-3 and 19B7), and urinary γ-carboxyglutamic acid (γ-Gla) in healthy adults (45 males and 45 females) and 11 patients with liver cirrhosis. VK and γ-Gla were analyzed by reverse-phase HPLC, prothrombin was determined using a method with a synthetic chromogenic substrate, and DCPs were analyzed by immunoaffinity chromatography and reverse-phase HPLC, and measured by ELISA. We were able to detect phylloquinone K (PK) and menaquinones MK-4, -5, -6, -7, -8 and -9, and we isolated several DCPs from plasma. Age had significant positive correlations with levels of urinary γ-Gla, plasma MK-7 and total VK, and VKDPs (prothrombin and DCP using MU-3 antibody) in the healthy adults. Significant positive correlations were also found between urinary γ-Gla and plasma levels of PK, MK-4, MK-7, and total VK and VKDPs (prothrombin and DCP using MU-3 antibody) in the healthy adults. γ-Gla and total VK levels were significantly higher in healthy adults than in patients with liver cirrhosis, and VK components, prothrombin, DCPs, and the MU-3/19B7 ratio showed a tendency to be higher in the healthy adults. We conclude that the status of VK and related proteins may reflect the latent increase in des-γ-carboxylation in healthy aging.

Vitamin B12 Content of Liver and Serum in Malignant Neoplasia

1962 ◽  
Vol 42 (4) ◽  
pp. 414-418 ◽  
Author(s):  
Robert S. Nelson ◽  
Vasant M. Doctor
Keyword(s):  
Vitamin B12 ◽  
Malignant Neoplasia
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