Nanotheranostics: combining non-invasive imaging with tumor-targeted drug delivery to individualize (chemo-) therapeutic interventions

2012 ◽  
Vol 184 (S 01) ◽  
Author(s):  
T Lammers ◽  
G Storm ◽  
F Kiessling
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Therapeutic Interventions ◽  
Non Invasive ◽  
Targeted Drug

scholarly journals Challenges in IBD Research: Novel Technologies

2019 ◽  
Vol 25 (Supplement_2) ◽  
pp. S24-S30 ◽  
Author(s):  
Manish Dhyani ◽  
Nitin Joshi ◽  
Willem A Bemelman ◽  
Michael S Gee ◽  
Vijay Yajnik ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Treatment Response ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Septic Complications ◽  
Novel Technologies ◽  
Non Invasive ◽  
Targeted Drug ◽  
Active Inflammation ◽  
Targeted Drug Delivery Systems

This section is focused on prioritizing unmet clinical needs that will benefit from novel technologies applied to non-invasive detection and monitoring of active inflammation and assessment of treatment response, mucosal targeted drug delivery systems, and prevention of post-operative septic complications and treatment of fistulizing complications.

scholarly journals Polysaccharide-Based Nanoparticles for Colon-Targeted Drug Delivery Systems

2021 ◽  
Vol 2 (3) ◽  
pp. 626-647
Author(s):  
Yubia De Anda-Flores ◽  
Elizabeth Carvajal-Millan ◽  
Alma Campa-Mada ◽  
Jaime Lizardi-Mendoza ◽  
Agustin Rascon-Chu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Gi Tract ◽  
Colonic Delivery ◽  
Drug Degradation ◽  
Non Invasive ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

Polysaccharide biomaterials have gained significant importance in the manufacture of nanoparticles used in colon-targeted drug delivery systems. These systems are a form of non-invasive oral therapy used in the treatment of various diseases. To achieve successful colonic delivery, the chemical, enzymatic and mucoadhesive barriers within the gastrointestinal (GI) tract must be analyzed. This will allow for the nanomaterials to cross these barriers and reach the colon. This review provides information on the development of nanoparticles made from various polysaccharides, which can overcome multiple barriers along the GI tract and affect encapsulation efficiency, drug protection, and release mechanisms upon arrival in the colon. Also, there is information disclosed about the size of the nanoparticles that are usually involved in the mechanisms of diffusion through the barriers in the GI tract, which may influence early drug degradation and release in the digestive tract.

A Novelistic Approach for Delivering of API through a Transvermillion Route: An updated review

2021 ◽  
Vol 13 ◽  
Author(s):  
Bhavana Singh ◽  
N V Satheesh Madhav
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Anatomy And Physiology ◽  
Non Invasive ◽  
Targeted Drug ◽  
The Rich ◽  
Targeted Drug Delivery System ◽  
Do So

: Present review highlights the potential of vermillion border as an administration route for targeting drug delivery. Vermillion border could attract a broad observation of researchers as a convenient, non-invasive, reliable, and safe route to realize faster and better levels of drugs within the targeted site. It is thought to do so through the rich supply of blood vessels and nerve supply following the neural pathway which could bypass the varied physiological barriers and permit the direct transport of drug from the vermillion border to the target site. Herein, authors tried to highlight the prominent aspects and key findings relevant to drug delivery system for targeting drug delivery via transvermillion route of drug administration. Anatomy and physiology of lips, key benefits offered by lips drug delivery system, mechanism of drug absorption across lip skin. The intrinsic advantage of this system results in administration of required drug with its reduced dose and reducing its side effect. This innate advantage of targeted drug delivery system is under high deliberation of research and development in clinical and pharmaceutical fields as backbone of therapeutics and diagnostics too. The goal of a targeted drug delivery system is to extend, localize, target and have a protected drug interaction with the diseased tissue.

scholarly journals Fluorescence Imaging as a Tool in Preclinical Evaluation of Polymer-Based Nano-DDS Systems Intended for Cancer Treatment

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 471 ◽  
Author(s):  
Tomáš Etrych ◽  
Olga Janoušková ◽  
Petr Chytil
Keyword(s):  
Drug Delivery ◽  
Fluorescence Imaging ◽  
Targeted Drug Delivery ◽  
Near Infrared ◽  
Fluorescent Dyes ◽  
Imaging Modality ◽  
Imaging Techniques ◽  
Fluorescent Imaging ◽  
Non Invasive ◽  
Targeted Drug

Targeted drug delivery using nano-sized carrier systems with targeting functions to malignant and inflammatory tissue and tailored controlled drug release inside targeted tissues or cells has been and is still intensively studied. A detailed understanding of the correlation between the pharmacokinetic properties and structure of the nano-sized carrier is crucial for the successful transition of targeted drug delivery nanomedicines into clinical practice. In preclinical research in particular, fluorescence imaging has become one of the most commonly used powerful imaging tools. Increasing numbers of suitable fluorescent dyes that are excitable in the visible to near-infrared (NIR) wavelengths of the spectrum and the non-invasive nature of the method have significantly expanded the applicability of fluorescence imaging. This chapter summarizes non-invasive fluorescence-based imaging methods and discusses their potential advantages and limitations in the field of drug delivery, especially in anticancer therapy. This chapter focuses on fluorescent imaging from the cellular level up to the highly sophisticated three-dimensional imaging modality at a systemic level. Moreover, we describe the possibility for simultaneous treatment and imaging using fluorescence theranostics and the combination of different imaging techniques, e.g., fluorescence imaging with computed tomography.

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