Advances in the validation of TRPM7 as a drug target using natural products – Update on waixenicin A

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
FD Horgen
Keyword(s):  
Natural Products ◽  
Drug Target

scholarly journals Characterizing the structure–activity relationships of natural products, tanshinones, reveals their mode of action in inhibiting spleen tyrosine kinase

RSC Advances ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 2453-2461
Author(s):  
Min-Che Tung ◽  
Keng-Chang Tsai ◽  
Kit-Man Fung ◽  
Ming-Jaw Don ◽  
Tien-Sheng Tseng
Keyword(s):  
Natural Products ◽  
Protein Kinase ◽  
Tyrosine Kinase ◽  
Mode Of Action ◽  
Drug Target ◽  
Receptor Protein ◽  
Inflammatory Disorder ◽  
Spleen Tyrosine Kinase ◽  
Structure Activity Relationships ◽  
Structure Activity

The cytosolic non-receptor protein kinase, spleen tyrosine kinase (SYK), is an attractive drug target in autoimmune, inflammatory disorder, and cancers indications.

scholarly journals A Drug-Target Network-Based Approach to Evaluate the Efficacy of Medicinal Plants for Type II Diabetes Mellitus

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Jiangyong Gu ◽  
Lirong Chen ◽  
Gu Yuan ◽  
Xiaojie Xu
Keyword(s):  
Diabetes Mellitus ◽  
Natural Products ◽  
Medicinal Plants ◽  
Medicinal Plant ◽  
Binding Affinity ◽  
Type Ii Diabetes ◽  
Drug Target ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Target Network

The use of plants as natural medicines in the treatment of type II diabetes mellitus (T2DM) has long been of special interest. In this work, we developed a docking score-weighted prediction model based on drug-target network to evaluate the efficacy of medicinal plants for T2DM. High throughput virtual screening from chemical library of natural products was adopted to calculate the binding affinity between natural products contained in medicinal plants and 33 T2DM-related proteins. The drug-target network was constructed according to the strength of the binding affinity if the molecular docking score satisfied the threshold. By linking the medicinal plant with T2DM through drug-target network, the model can predict the efficacy of natural products and medicinal plant for T2DM. Eighteen thousand nine hundred ninety-nine natural products and 1669 medicinal plants were predicted to be potentially bioactive.

Small Natural Molecules Targeting DNA G-Quadruplexes

2014 ◽  
Vol 955-959 ◽  
pp. 423-426
Author(s):  
Zi Jian Li ◽  
Yan Ping Ding ◽  
Su Lin Zhang ◽  
Yan Ling Wu ◽  
Wen Zhang
Keyword(s):  
Natural Products ◽  
Drug Target ◽  
Binding Mode ◽  
Current Understanding ◽  
Tumor Treatment ◽  
Potential Significance ◽  
New Drug ◽  
G4 Dna ◽  
G Quadruplex

DNA G-quadruplex (G4-DNA) has emerged as a new drug target for anti-tumor. The small compounds can induce the formation of G4-DNA and stabilize its structures, which is of potential significance for the tumor treatment. This paper focuses on our current understanding about the structure of G4-DNA, the binding mode between G4-DNA and small molecular ligands, and natural products targeting G4-DNA.

Target identification of natural products and bioactive compounds using affinity-based probes

2016 ◽  
Vol 33 (5) ◽  
pp. 612-620 ◽  
Author(s):  
Sijun Pan ◽  
Hailong Zhang ◽  
Chenyu Wang ◽  
Samantha C. L. Yao ◽  
Shao Q. Yao
Keyword(s):  
Natural Products ◽  
Bioactive Compounds ◽  
Drug Target ◽  
Target Identification ◽  
Direct Capture

Direct capture of drug–target complexesin situby using affinity-based probes allows target identification of natural products and bioactive compounds, even if the binding is reversible with moderate affinity.

scholarly journals Genetic Algorithm-Based Docking of Potent Inhibitors Against SARS-CoV-2 Main Protease: A Comparison Between Natural Products and Synthetic Drugs.

2020 ◽  
Author(s):  
Pragadeeshwara Rao R ◽  
Tinku Basu
Keyword(s):  
Genetic Algorithm ◽  
Natural Products ◽  
Severe Acute Respiratory Syndrome ◽  
Betulinic Acid ◽  
Drug Target ◽  
Vital Role ◽  
Intensive Research ◽  
Synthetic Drugs ◽  
Main Protease ◽  
Potential Inhibitors

<p>The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused coronavirus disease-2019 (COVID-19) pandemic. Despite the intensive research currently, there are no therapeutics and vaccines available. As the main protease (M<sup>Pro</sup>) plays a vital role in SARS-CoV-2, it is an attractive drug target. Herein we report, potential inhibitors form natural products and synthetic drugs against M<sup>Pro</sup>. In detail, we studied the interaction of inhibitors (Curcumin, Theaflavin, Deserpidine, Betulinic acid, Sinigrin, Emodin, Leptodactylone, Synthetic drugs, Lopinavir, Ritonavir, Indinavir, Amprenavir, Darunavir, Nelfinavir, Remdesivir, Saquinavir, Sivelestat, Galidesivir, and Favipiravir) with the catalytic site of M<sup>Pro</sup>. Lastly, ADME (Absorption, Distribution, Metabolism, and Excretion) properties of Natural products and synthetic drugs are explored. We identified eight potential inhibitors against M<sup>Pro</sup>. <b></b></p>

scholarly journals Establishment and Validation of a Drug-Target Microarray for SARS-CoV-2

2020 ◽  
Author(s):  
Peng Chen ◽  
Zehua Zeng ◽  
Hongwu Du
Keyword(s):  
Natural Products ◽  
Global Economy ◽  
Drug Target ◽  
Drug Targets ◽  
Protein Microarray ◽  
Herbal Medicines ◽  
Human Beings ◽  
Clinical Value ◽  
Therapy Targets ◽  
Target Screening

<p>COVID-19 has become one of the worst epidemic in the world, currently already more than four million people have been infected, which probably co-exist with human beings, and has a significant impact on the global economy and political order. In the process of fighting against the epidemic in China, the clinical value of a variety of herbal medicines has been recognized and written into the clinical application guide. However, their effective molecular mechanism and potential targets are still not clear. Pathology and pharmacology research will gradually attract attention in the post-epidemic outbreak term. Here, we constructed a COVID-19 protein microarray of potential therapy targets, which contains the main drug targets to the SARS-COV-2 virus and the anti-virus, anti-inflammatory cellar targets of the host. Series of quality controls test has been carried out, which showed that it could be applied for drug target screening of bio-active natural products. The establishment of this microarray will provide a useful tool for the study of the molecular pharmacology of natural products.</p>

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