An innovative green extraction process for the development of traditional herbal drugs or food supplements

A green extraction process using only water was proposed for the simultaneous extraction of alginate and bioactive compounds from Laminaria ochroleuca. Operation was carried out during non-isothermal heating up to maximal temperatures over the range of 70 °C to 100 °C. Once separated, the alginate and the crude extract were characterised and the biological activities and cytotoxicity of the extracts was studied, the latter in intestinal epithelial cells. Those alginates obtained at 90 °C exhibited the highest extraction yields and viscoelastic features of the corresponding hydrogels. The obtained results show that the extracts obtained by non-isothermal extraction were suitable to formulate nanoparticles, which showed the smallest size (≈250–350 nm) when the higher content of fucoidan extract was present. Given the evidenced properties, the extracts may find an application in the formulation of nanoparticulate carriers for drug delivery.

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Antidiabetic, Anticancer and Nephrolithiasis Used Wild Edible Food Supplements of Uttarakhand (Garhwal Himalaya)

10.20944/preprints202004.0340.v1 ◽

2020 ◽

Author(s):

Subhash Chandra ◽

Sarla Saklani ◽

Jen Tsung Chen

Keyword(s):

Natural Products ◽

Dietary Fibre ◽

Crude Protein ◽

Mineral Content ◽

Extraction Process ◽

Food Supplements ◽

Phytochemical Analysis ◽

Mineral Profile ◽

Aoac Method ◽

Scientific Report

The aim of this research was to develop new antidibetic, anticancer, nephrolithiasis and new food supplements with potential pharmacological activity from readily accessed natural products. In the present study, we investigated the nutritional, mineral profile and phytochemical analysis of the extracts of C. indicus, D. biflorus, G. soja, B. cerifera, O. frumentaceu, E. coracana, P. frutenscens, S. italica, C. viscosa and H. vulgare seeds or pulps. The extraction process involved fractionation with various solvents whereas the estimation of nutrients and minerals was done using AOAC method and ICPMS techniques. The levels of crude protein, carbohydrates, crude fiber, crude fat and ash contents in C. indicus seeds were found to 2.20%, 14.12%, 56.38%, 7.50%, 2.20% and 5.30%, respectively whereas 5.93%, 72.07%, 5.10%, 1.00% and 3.90%, respectively were measured in the seeds of H. vulgare. This is the first scientific report to explore the comprehensive nutrients, mineral content and phytochemical analysis on the C. indicus, D. biflorus, G. soja, B. cerifera, O. frumentaceu, E. coracana, P. frutenscens, S. italica, C. viscosa and H. vulgare seeds and pulps. Which were found as highly medicinal and nutritional due to the presence of dietary fibre, protein, vitamins, minerals and other needful nutrients.

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The usage of enzyme in ultrasound-assisted enzymatic extraction method and its effect on yield extract from Keji Beling (Strobilanthes crispus.) leaves

E3S Web of Conferences ◽

10.1051/e3sconf/20186703002 ◽

2018 ◽

Vol 67 ◽

pp. 03002

Author(s):

Angelina ◽

Mauhibah Yumna ◽

Abdullah ◽

Rita Arbianti ◽

Tania Surya Utami ◽

...

Keyword(s):

Extraction Method ◽

Maximum Yield ◽

Extraction Process ◽

Enzymatic Extraction ◽

Bioactive Substances ◽

Green Extraction ◽

Strobilanthes Crispus ◽

Ultrasound Assisted ◽

Effect On Yield ◽

Hydrolysis Of

Green extraction process is a method which is used to obtain various plant extracts with minimum impact on the environment. Green extraction will reduce energy consumption, allow use of alternative solvents and renewable natural products, and ensure a safe and high quality extract. Ultrasound-assisted enzymatic extraction (UAEE) is one of green extraction method. UAEE is a mild, efficient and environmental friendly extraction method and it has been adopted for extracting various kinds of compounds. The use of enzyme will catalyze hydrolysis of the cytoderm and glycoproteins, therefore enhancing the release of bioactive substances by disrupting plant cells. The optimum extraction conditions with a maximum yield extract of 48.63% are as follows: the concentration of ethanol is 50% and the amount of added enzyme is 70 mg/g. Crude extract from keji beling leaves is tested using Gas Chromatography and Mass Spectrometry (GC-MS) to identify components that have anti-hypercholesterolemic activity, which are hexadecanoic acid, octadecanoic acid and demethyl squalene.

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A green extraction design for enhancing flavonoid compounds from Ixora javanica flowers using a deep eutectic solvent

Royal Society Open Science ◽

10.1098/rsos.201116 ◽

2020 ◽

Vol 7 (10) ◽

pp. 201116

Author(s):

Nina Dewi Oktaviyanti ◽

Kartini Kartini ◽

Mochammad Arbi Hadiyat ◽

Ellen Rachmawati ◽

Andre Chandra Wijaya ◽

...

Keyword(s):

Extraction Method ◽

Choline Chloride ◽

Deep Eutectic Solvent ◽

Extraction Process ◽

Raw Material ◽

Molar Ratio ◽

Flavonoid Compound ◽

Total Flavonoids ◽

Green Extraction ◽

Optimum Extraction

In this study, an environmentally friendly extraction method for flavonoid compound from Ixora javanica , as a new raw material candidate for herbal medicine and cosmetics, was developed. The objectives of the present work were to provide recommendations for the optimal extraction conditions and to investigate the effects of any extraction parameters on flavonoid yields from the I. javanica flower. The extraction process was performed using deep eutectic solvent (DES) (choline chloride and propylene glycol at molar ratio of 1 : 1) and the ultrasound-assisted extraction method. Both single-factor and response surface analyses using three-level and three-factor Box Behnken designs were conducted to obtain the optimum flavonoid concentrations. The results showed that the optimum extraction conditions for total flavonoids featured an extraction time of 40 min, 25% water content in DES and a solid-to-liquid ratio of 1 : 25 g ml −1 . An extract obtained under optimum extraction conditions showed higher total flavonoid yields than an ethanolic extract which was used for comparison. Scanning electron microscope images demonstrated that both of the solvents also showed different effects on the outer surface of the I. javanica flower during the extraction process. In summary, our work succeeded in determining the optimum conditions for total flavonoids in the I. javanica flower using a green extraction method.

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Herbal drugs and food supplements in menopause

European Journal of Integrative Medicine ◽

10.1016/j.eujim.2012.07.594 ◽

2012 ◽

Vol 4 ◽

pp. 51-52 ◽

Cited By ~ 1

Author(s):

Cancellieri Francesco ◽

Giacobbe Annamaria ◽

Becorpi Angelamaria

Keyword(s):

Food Supplements ◽

Herbal Drugs

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A Green Extraction Process to Recover Polyphenols from Byproducts of Hemp Oil Processing

Recycling ◽

10.3390/recycling3020015 ◽

2018 ◽

Vol 3 (2) ◽

pp. 15 ◽

Cited By ~ 5

Author(s):

Ioannis Mourtzinos ◽

Nikolaos Menexis ◽

Dimitrios Iakovidis ◽

Dimitris Makris ◽

Athanasia Goula

Keyword(s):

Extraction Process ◽

Green Extraction ◽

Oil Processing ◽

Hemp Oil

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Application of Green Extraction Techniques for Natural Additives Production

10.5772/intechopen.100320 ◽

2021 ◽

Author(s):

Anxo Carreira-Casais ◽

Catarina Lourenço-Lopes ◽

Paz Otero ◽

María Carpena ◽

Antia Gonzalez Pereira ◽

...

Keyword(s):

Raw Materials ◽

Extraction Process ◽

Extraction Methods ◽

World Market ◽

Extraction Techniques ◽

Chemical Additives ◽

Green Extraction ◽

Market Needs ◽

Natural Foods ◽

Natural Additives

During the last decades, consumers have increased the demand for healthier natural foods with lower presence of chemical additives. One reason of this choice is the controversy about chemical additives possible adverse effects. To fulfill market needs, different techniques have been developed to extract compounds from various raw materials to produce natural additives with different properties (preservatives, emulsifiers, or colorants) and bioactivities. In addition, the growing concern about the effects of climate change has led the development of more sustainable techniques to carry out the extraction. The use of new alternative nonconventional, emerging, or green extraction methodologies has gained considerable attention during the last decade. These novel techniques have been applied to minimize any negative changes in the nutritional, physicochemical or sensory properties of the natural source, while at the same time reducing the environmental impact of the process and gaining competitiveness of the world market. For this purpose, new green extraction methods have been proposed and optimized for the reduction of the consumption of raw materials, solvents, and energy. In this chapter, a revision of different types of green extraction techniques is compiled together with the main factor that can affect extraction-process feasibility and the main challenges and future trends for their development.

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ISOLATION AND INVESTIGATION OF PHYTOCHEMICALS AND PHARMACOLOGICAL SCREENING OF TAGETES ERECTA L. LEAVES EXTRACT

Asian Journal of Pharmaceutical Research and Development ◽

10.22270/ajprd.v6i4.360 ◽

2018 ◽

Vol 6 (4) ◽

pp. 39-44

Author(s):

Thorat Kranti Jayavant

Keyword(s):

Drug Development ◽

Development Process ◽

Cancer Cell Line ◽

Extraction Process ◽

Herbal Drugs ◽

Synthetic Drugs ◽

Muscular Pain ◽

Plant Constituents ◽

Tagetes Erecta L ◽

Pharmacological Screening

Extraction and isolation of plant constituents plays an important role as a therapeutic remedy. Isolation of active plant constituents helps in developing lead molecule in drug development process. Aim of present study is to extract, isolate plant constituents and spectral and pharmacological investigation. The major advantage of herbal drugs to synthetic drugs is that they produce more therapeutic effect and fewer side effects. Herbal drugs also have potential in drug development by generating a lead molecule which helps in designing of synthetic drugs. Tagetes species belonging to family Asteraceae, are most common in plant kingdom, which is used in different areas like cosmetic preparation, medicines as well as it is most commonly used as ornamentals. Flowers are mainly used for all these purposes by using extraction process. Tagetes species contains mainly lutien such as carotenoids or xanthophylls containing two cyclic end groups and basic C-40 isoprene unit. The leaves are reported to possess wound healing, antiulcer, muscular pain relief activities10. The basic criteria of present work are to isolate the active plant constituents from these plants and to avail about its anticancer activity on cancer cell line

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