Platelet Aggregability Measured by SFP Method in Cerebral Thrombosis and Haemorrhage

1975 ◽  
Author(s):  
I. Kobayashi ◽  
H. Yamazaki
Keyword(s):  
Essential Hypertension ◽  
Cerebral Hemorrhage ◽  
Time Course ◽  
Acute Stage ◽  
Cerebral Thrombosis ◽  
Recovery Stage ◽  
Platelet Aggregability ◽  
Significant Difference ◽  
The Difference ◽  
Death Cases

Platelet aggregability of 50 aged healthy people (64.0 ±9.4 yrs., Mean ±SD), 93 essential hypertension (65.6±8.5 yrs.), 166 recovery stage of cerebral thrombosis over 2 months from the onset (62.4 ± 11.8 yrs.) and 74 recovery stage of cerebral hemorrhage (57.4 ±10.0 yrs.) was measured using screen filtration pressure (SFP, Swank, 1961) method. SFP by 3 μM ADP of healthy, hypertension, recovery stage of cerebral hemorrhage and thrombosis were 148.7±53.5, 176.2± 74.4, 189.8±58.3 and 206.3±58.9 mmHg respectively. The differences of the SFP between the healthy and the diseased groups were statistically significant (P < 0.01-0.05). Meanwhile SFP of 9 cerebral thrombosis (66.8±9.5 yrs.) and 18 hemorrhage (66.4 ±10.6 yrs.) was measured during their time course of the diseases from the onset to 180 days. SFP in acute stage of thrombosis showed an increase and it decreased gradually during the time course. On the contrary SFP in acute stage of hemorrhage showed a decrease and it increased gradually. A statistically significant difference was observed between both the groups within 30 days from the onset (P < 0.01 ). SFP in acute stage of hemorrhage showed 95.2 ±17.7 in 9 survival and 1Ö4.0±Ö6.2 mmHg in 9 death cases within 10 days from the onset. The difference of the SFP between survival and death was statistically significant (P < 0.01).

Adhesive Platelet Count and Blood Coagulability in Myocardial Infarction and Cerebral Thrombosis

1970 ◽  
Vol 24 (03/04) ◽  
pp. 450-460 ◽  
Author(s):  
H Yamazaki ◽  
T Odakura ◽  
K Takeuchi ◽  
T Sano
Keyword(s):  
Myocardial Infarction ◽  
Platelet Count ◽  
Malignant Tumors ◽  
Total Cholesterol Level ◽  
Statistical Significance ◽  
Acute Stage ◽  
Cerebral Thrombosis ◽  
Prothrombin Activity ◽  
Recovery Stage ◽  
Blood Coagulability

SummaryIn 382 patients, aged 21 to 76 years, including 39 healthy volunteers, a platelet count by Olef’s method, an adhesive platelet count by Moolten-Vroman’s method, prothrombin activity due to one-stage prothrombin time and calcium clotting time were measured. In 39 cases of myocardial infarction and 40 cases of cerebral thrombosis, both in acute stage, a marked decrease in the adhesive platelet count and adhesive index and an increase of prothrombin activity were observed with statistical significance compared to the healthy group (P < 0.01). In the recovery stage of myocardial infarction, cerebral thrombosis and other diseases, except for malignant tumors, acute infectious diseases, diabetes mellitus and blood or liver diseases, the above observations were absent or reduced. In the case of thrombosis, a negative correlation was seen between the adhesive platelet count and prothrombin activity (r — —0.238, P < 0.01). There is no correlation between the changes in platelet adhesiveness or blood coagulability and total cholesterol level in serum.

Clinical Observation of Electro acupuncture Combined with Early Rehabilitation Training to Treat Hypertensive Cerebral Hemorrhage in Basal Ganglia

2021 ◽  
Author(s):  
Wei Wei ◽  
Tu Qin ◽  
Wang Yafen ◽  
Zeng Lang ◽  
Man Liao
Keyword(s):  
Cerebral Hemorrhage ◽  
Blood Stasis ◽  
Intervention Group ◽  
Clinical Treatment ◽  
Early Rehabilitation ◽  
Control Group ◽  
Rehabilitation Training ◽  
Significant Difference ◽  
The Difference ◽  
Hypertensive Intracerebral Hemorrhage

In this study, we investigated the clinical efficacy and poor prognosis of patients with limb disorders after the operation of hypertensive cerebral hemorrhage, using the treatment of removing blood stasis and Shengxin acupuncture combined with early rehabilitation training using a randomized trial. A total of 100 patients with hypertensive intracerebral hemorrhage who underwent surgery in our hospital from May 2019 to May 2021 were selected and divided into control group were treated with early rehabilitation training, and the intervention group was treated with acupuncture for removing blood stasis and promoting new acupuncture based on the control group. We observed that there was no significant difference in the evaluation of limb function recovery between the two groups of patients (P>0.05). After the intervention, the modified Ashworth score, FMA score, and B1 index of the two groups were significantly different in the ADL scores and the scores of families and friends support were remarkably improved. The clinical treatment efficiency of the intervention group was 94.00%,significantly higher than that of the control groupof80.00%, and the difference was statistically significant (P<0.05). The study demonstrated that the rehabilitation training combined with removing blood stasis and Shengxin acupuncture is significantly better than rehabilitation training alone to improve postoperative limb dysfunction, daily life and quality of life and is a clinical treatment for hypertension.

scholarly journals Nao-Xue-ShuOral Liquid Protects and Improves Secondary Brain Insults of Hypertensive Cerebral Hemorrhage

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Hongning Jiang ◽  
Ying Qin ◽  
Te Liu ◽  
Liang Zhang ◽  
Mingzhe Wang ◽  
...  
Keyword(s):  
Treatment Group ◽  
Cerebral Hemorrhage ◽  
Clinical Medicine ◽  
Control Group ◽  
Clinical Effects ◽  
Favorable Prognosis ◽  
Significant Difference ◽  
Oral Liquid ◽  
The Difference ◽  
Brain Insults

Aim.To determine one traditional Chinese medicine (TCM)Nao-Xue-Shuoral liquid which protects and improves secondary brain insults (SBI) in hypertensive cerebral hemorrhage (HCH).Methods.158 patients with HCH were divided into routine clinical medicine plusNao-Xue-Shuoral liquid (n=78) as treatment group, and routine clinical medicine (n=80) only served as the control group. The incidence of SBI and the classification of a favorable prognosis and a bad prognosis using the Glasgow outcome scale (GOS) were assessed to evaluate the clinical effects. The changes of IL-6 and TNF-αlevels were determined to study the mechanism of the effects for the TCM.Results.The incidence of SBI at the end of week 2 was 8.97% in the treatment group and 23.75% in the control group, and the difference was significant (P<0.001). The incidence of a favorable prognosis was 48.72% in the treatment group and 32.72% in the control group, and the difference was significant (P<0.01) at the end of week 2. These findings indicate clear differences for IL-6 and TNF-αat the end of week 1 and week 2 compared with before treatment for the treatment group and a marked difference at the end of week 2 between the two groups. It also shows a significant difference between the end of week 2 and before treatment for IL-6 and TNF-αfor the control group, although the difference was much smaller than the treatment group.Conclusion. Nao-Xue-Shuoral liquid could protect against the occurrence of SBI and improve HCH and SBI patients. It may also decrease the damage and the mass effects of the hematoma by reducing IL-6 and TNF-αto obtain the effects, and thus it is a potentially suitable drug for HCH and SBI.

Decrease in Platelet Adenine Nucleotides Content In Patients With Dic, Thrombosis and After Operation

1979 ◽  
Author(s):  
H. Yamazaki ◽  
T. Motomiya ◽  
N. Miyagawa ◽  
C. Watanabe ◽  
Y. Yahara ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Time Course ◽  
Adenine Nucleotides ◽  
Firefly Luciferase ◽  
Acute Stage ◽  
Platelet Volume ◽  
Recovery Stage ◽  
Release Reaction ◽  
Postoperative State

Conditions which induce platelet release reaction in vivo are not yet obvious. To detect the conditions, platelet ATP and ADP content (firefly luciferase method) and plasma beta-thromboglobulin level were measured in 51 healthy young volunteers, 10 patients with typical DIC syndrome during time course of cancer, 27 patients in acute stage of thrombosis in cerebral, coronary and femoral arteries, 29 patients in recovery stage of thrombosis and 69 patients one day before, and one day, one week and one month after a laparotomy. Platelet count and volume were counted by a Coulter Counter and Channelyzer. Platelet aggregation induced by ADP, adrenaline and collagen was also measured. In the healthy, platelet mode volume was 4.21 ± 0.08 μ3 (mean ± SE). beta-TG was 29.9 ± 5.9 ng/ml, and ATP and ADP contents were 5.81 ± 0.17 and 3.19 ± 0.09 μmoles/1011 platelets and ATP/ADP was 1.82 ± 0.05. In DIC, acute stage of thrombosis and one week after laparotomy, platelet volume became to smaller and ADP content decreased significantly. Changes in beta-TG level were rather variable. Platelet aggregation increased in thrombosis and postoperative state, while it decreased in DIC. In DIC, decrease in ATP and ADP content was marked as compared with other groups. It suggests that ADP content In platelets may reflect release reaction in vivo. Following the release reaction, platelet aggregability may increase. However, platelets with large decrease in adenine nucleotides content may have hypofunction.

Influence of Nanoparticle-Loaded Edaravone on Postoperative Effects in Patients with Cerebral Hemorrhage

2021 ◽  
Vol 21 (2) ◽  
pp. 1202-1211
Author(s):  
Lianfeng Dang ◽  
Xin Dong ◽  
Jie Yang
Keyword(s):  
Minimally Invasive ◽  
Cerebral Hemorrhage ◽  
Combined Treatment ◽  
Neurological Function ◽  
The Body ◽  
Inflammatory Factors ◽  
Edema Volume ◽  
Significant Difference ◽  
The Difference ◽  
Recovery And Healing

In order to explore the influence of nanoparticle-loaded edaravone on postoperative effects in patients with cerebral hemorrhage, a total of 120 patients who were diagnosed as cerebral hemorrhage and underwent minimally invasive hematoma removal at the designated hospital by the study from December 2014 to December 2018 were selected as research objects and divided into three groups according to the random number table method: edaravone treatment (ET) group, nanoparticle-loaded edaravone treatment (NET) group, and combined treatment (CT) group with 40 patients in each group. Three groups of patients underwent routine treatments based on their conditions, including regulating blood sugar, regulating blood pressure, anti-infection, nutritional support, and managing complications, in which 25 mg edaravone injection and 100 ml saline were added for patients in NET and CT group on the basis of the routine treatment of patients in ET group. The results showed that, after 15 days of standard treatment, the 40 patients in NET group had significantly improved neurological function than that before the treatment; the secretion of inflammatory factors in peripheral serum increased on the 7th day of treatment and decreased on the 14th day of treatment; there was no statistically significant difference in edema volume before treatment and the edema volume in the NET group was (11.56±0.44) mL after treatment, which was significantly smaller than that in ET group of (14.63±1.15) mL and the difference between the three groups was statistically significant (P <0.05). Therefore, it is believed that nanoparticle-loaded edaravone has an important effect on the postoperative effect of patients with cerebral hemorrhage; it can significantly improve the neurological function of patients with cerebral hemorrhage after minimally invasive drainage, and obviously reduce the production and release of interleukin and tumor necrosis factor, which is beneficial to protect healthy brain tissue and other organs throughout the body, and is conducive to the recovery and healing of cerebral hemorrhage. The results of this study provide a reference for further research on the influence of nanoparticle-loaded edaravone on postoperative effects in patients with cerebral hemorrhage.

scholarly journals Clinical effect of minimally invasive aspiration and drainage of intracranial hematoma in the treatment of cerebral hemorrhage

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Chao Deng ◽  
Yuanling Ji ◽  
Wei Song ◽  
Jingfang Bi
Keyword(s):  
Minimally Invasive ◽  
Cerebral Hemorrhage ◽  
Clinical Effect ◽  
Statistical Significance ◽  
Control Group ◽  
Efficacy Rate ◽  
Observation Group ◽  
Intracranial Hematoma ◽  
Significant Difference ◽  
The Difference

Objectives: To explore the clinical value of minimally invasive aspiration and drainage of intracranial hematoma in the treatment of cerebral hemorrhage. Methods: Seventy-eight patients with cerebral hemorrhage who were treated in the Taian City Central Hospital and the Second Affiliated Hospital of Shandong First Medical University between June 2018 and December 2019 were selected. The patients were randomly numbered and divided into two groups by drawing lots, 39 in each group. The control group was treated with the traditional internal medicine conservative therapy, and the observation group was treated with minimally invasive intracranial hematoma aspiration and drainage. The indexes of the two groups were compared. Results: The efficacy rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). The National Institutes of Health Stroke Scale (NIHSS) score of the observation group was lower than that of the control group after treatment, and the difference was statistically significant (P<0.05). After treatment, the good recovery rate of the observation group was higher compared to the control group, and the difference had statistical significance (P<0.05). The incidence of complications in the observation group was lower than that of the control group, with a statistically significant difference (P<0.05). Conclusion: In the treatment of cerebral hemorrhage, minimally invasive intracranial hematoma aspiration and drainage facilitates the recovery of patients, promotes the improvement of neurological function, and has a high safety profile and an ideal prognostic quality. doi: https://doi.org/10.12669/pjms.38.1.4618 How to cite this:Deng C, Ji Y, Song W, Bi J. Clinical effect of minimally invasive aspiration and drainage of intracranial hematoma in the treatment of cerebral hemorrhage. Pak J Med Sci. 2022;38(1):---------. doi: https://doi.org/10.12669/pjms.38.1.4618 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Differences in Metabolic-Energy Potential in U16 Football Players (Cadet Age) in Relation to Competition Level // Razlike u metaboličko-energetskim potencijalima fudbalera kadetskog uzrasta u odnosu na takmičarski nivo

2017 ◽  
Vol 12 (2) ◽  
Author(s):  
Slobodan Andrašić ◽  
Milan Cvetković ◽  
Zoran Milić
Keyword(s):  
Metabolic Energy ◽  
Football Players ◽  
Energy Potential ◽  
Recovery Stage ◽  
Football Team ◽  
Significant Difference ◽  
Competition Level ◽  
Survey Results ◽  
Three Stages ◽  
The Difference

In order to determine the difference in metabolic-energy potential in U16 football players (cadet age) at different levels of competition, a survey was conducted on a sample of sixty players aged 14 to 16. The sample of respondents is divided into the following subsamples: players of Serbian national football team (n=20), players from high-quality league of Vojvodina (n=21) and the players from the regional competition levels (n=19). The lactate blood level was determined by testing capillary blood from the finger during three stages of Cooper test: the concentration of lactate in the standstill stage was measured before the start of the test – before the load; the concentration of lactate during the load stage was measured one minute after completion of the test; and the concentration of lactate in the recovery stage was measured in the tenth minute of recovery. The survey results indicate a statistically significant difference between the said groups of players in relation to the analyzed metabolic-energy parameters of the players.

Time-course of attentional bias for culture-related cues in Mongolian-Chinese bilingual children

2018 ◽  
Vol 23 (6) ◽  
pp. 1483-1501
Author(s):  
Hongyu Yu ◽  
Nisha Yao ◽  
Jijia Zhang ◽  
Bing Gao
Keyword(s):  
Comparative Analysis ◽  
Attentional Bias ◽  
Repeated Measures ◽  
Time Course ◽  
Language Fluency ◽  
Dot Probe ◽  
Probe Task ◽  
Significant Difference ◽  
The Difference ◽  
Han Culture

Aims and objectives/purpose/research questions: Using a modified dot-probe task, the present research examined the time-course of attentional bias for culture-related cues in Mongolian-Chinese bilinguals. Design/methodology/approach: Using a mixed experimental design, children with different language fluency (fluent bilingual, limited bilingual and mandarin monolingual) were recruited ( N = 168; 51% boys; Mage = 9.88 years, SD = 0.38 years; 59% Mongolian) to complete a dot-probe task in which they were shown pairs of pictures representing Mongolian and Han culture for short (60 ms) and long (500 ms) exposure durations. The difference between fluent and limited bilinguals lies in their proficiency in Mongolian. Data and analysis: The attentional bias scores ( d) were entered into a 2 × 3 mixed design repeated-measures analysis of variance with language fluency (fluent bilingual versus limited bilingual versus monolingual) as a between-subjects variable and the time-course (60 versus 500 ms) as a within-subject variable. Findings/conclusions: In the task, compared with pictures representing Han culture, all students showed preferential attention to pictures conveying Mongolian culture across presentation durations. However, for 60 ms, fluent bilinguals showed a smaller attentional bias than did monolinguals, with no difference between limited bilinguals and monolinguals; there was no significant difference among the three groups at 500 ms. Originality: Relatively less research has been performed on comparative analysis between fluent and non-fluent bilinguals, and most of the culture-related content is measured by subjective methods. This study attempts to directly compare these two bilinguals’ attentional bias for culture-related cues using a dot-probe task. Significance/implications: The results of comparative analysis showed that fluent bilinguals were more familiar with Mongolian language and preserved their ethnic culture better, which may indicate a close relationship between language and culture.

Abstract 2039: Urinary 8-Hydroxy-2′-Deoxyguanosine Levels Decrease After Cardioversion in Atrial Fibrillation

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Takashi Uemura ◽  
Hiroshige Yamabe ◽  
Yasuhiro Nagayoshi ◽  
Yasuaki Tanaka ◽  
Kenji Morihisa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Atrial Fibrillation ◽  
Dna Damage ◽  
Time Course ◽  
Oxidative Dna Damage ◽  
Enzyme Linked Immunosorbent Assay ◽  
Potential Marker ◽  
Significant Difference ◽  
The Difference ◽  
Pharmacological Cardioversion

Background : Atrial fibrillation (AF) has been shown to be associated with increased oxidative stress mediated by reactive oxygen species (ROS). Previous studies have proposed that there is a link between oxidative stress and AF, and thus oxidative stress may contribute to the pathological consequences of AF such as thrombosis, inflammation, and atrial tissue remodeling. Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) which is a product of deoxyribonucleic acid (DNA) damage by ROS has become to be regarded as a putative biomarker of oxidative DNA damage. Also, biopyrrins which are oxdative metabolites of bilirubin (an important scavenger of ROS) are considered as the potential marker of oxdative stress. In the present study, we assessed serial changes in oxidative stress in patients with AF after cardioversion by measuring urinary 8-OHdG and urinary biopyrrin excretion. Methods and Results : The study subjects consisted of 15 patients with persistent or chronic AF, who underwent electrical or pharmacological cardioversion. We measured urinary 8-OHdG and biopyrrin levels obtained before cardioversion and 24 hours after cardioversion using enzyme-linked immunosorbent assay. There was no significant difference in the biopyrrin/creatinine levels before and 24 hours after cardioversion (3.2±2.6 vs. 3.3±2.4 mU/mg, P=NS). However, 8-OHdG/creatinine levels decreased significantly 24 hours after cardioversion (18.4±9.1 vs. 14.7±8.5 ng/mg, P=0.0012). There was no significant correlation between urinary 8-OHdG/creatinine and biopyrrin/creatinine levels. This discrepancy may be related to the difference in the time course between urinary 8-OHdG/creatinine and biopyrrin/creatinine levels. Thus, measurement of 8-OHdG/creatinine levels seemed to be a more useful marker which reflects the oxidative stress than biopyrrin/creatinine levels at the time 24 hours after cardioversion. Conclusions : These findings suggest that the restoration of sinus rhythm by cardioversion decreases oxidative DNA damage in AF patients, and urinary 8-OHdG may be useful for the estimation of oxidative stress in AF patients. The increase of oxidative stress may play an important role in the pathogenesis of AF, and persist AF and result in the perpetuation of AF.

Destruction of Actin Filaments by Osmium Tetroxide

1977 ◽  
Vol 35 ◽  
pp. 466-467
Author(s):  
P. Maupin-Szamier ◽  
T. D. Pollard
Keyword(s):  
Actin Filaments ◽  
Time Course ◽  
Osmium Tetroxide ◽  
Rabbit Muscle ◽  
Muscle Actin ◽  
Sodium Phosphate Buffer ◽  
Transmission Electron ◽  
The Difference ◽  
Rates Of Decay ◽  
Short Time

We have studied the destruction of rabbit muscle actin filaments by osmium tetroxide (OSO4) to develop methods which will preserve the structure of actin filaments during preparation for transmission electron microscopy.Negatively stained F-actin, which appears as smooth, gently curved filaments in control samples (Fig. 1a), acquire an angular, distorted profile and break into progressively shorter pieces after exposure to OSO4 (Fig. 1b,c). We followed the time course of the reaction with viscometry since it is a simple, quantitative method to assess filament integrity. The difference in rates of decay in viscosity of polymerized actin solutions after the addition of four concentrations of OSO4 is illustrated in Fig. 2. Viscometry indicated that the rate of actin filament destruction is also dependent upon temperature, buffer type, buffer concentration, and pH, and requires the continued presence of OSO4. The conditions most favorable to filament preservation are fixation in a low concentration of OSO4 for a short time at 0°C in 100mM sodium phosphate buffer, pH 6.0.

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