scholarly journals Pseudocyst of the auricle : management options

2012 ◽  
Vol 01 (04) ◽  
pp. 181-185
Author(s):  
Atul M Bage ◽  
Nutan N Bage ◽  
Anand Karthikeyan D. ◽  
Keyword(s):  
Triamcinolone Acetonide ◽  
Treatment Option ◽  
Successful Treatment ◽  
Initial Treatment ◽  
Intralesional Injection ◽  
Serous Fluid ◽  
Management Options ◽  
High Propensity ◽  
Promising Treatment

Abstract Background & Aims : Pseudocyst of auricle otherwise called as auricular seroma is a cystic swelling filled with serous fluid. It occurs spontaneously or following surgery or trauma. Successful treatment of seromas remain a challenge because this disease has a high propensity for recurrence. The aim was to study the role of triamcinolone in reducing recurrence of pseudocyst of the auricle. Materials and methods : A total of 50 patients with pseudocyst of auricle were randomized into two groups. They were followed up to a year for recurrence. The technique of intra-lesional injection of triamcinolone acetonide after aspirating the fluid was followed in one group as against aspiration and tight bandaging in another group. Results : Out of seroma patients who underwent aspiration and bandaging, 90.91 % had recurrence as against only 25.64% recurrence in patients who underwent aspiration and Inj. Triamcinolone infiltration. Out of seroma patients who underwent aspiration and bandaging 54.55% had recurrence within 1 month of initial treatment and 27 .27% of them had a second recurrence within 3 months. Conclusion : Intralesional injection of triamcinolone is a promising treatment option for management of auricular seroma. It prevents the recurrence also.

scholarly journals Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-19

2020 ◽  
Vol 217 (9) ◽  
Author(s):  
Lars M. Koenig ◽  
Daniel F.R. Boehmer ◽  
Philipp Metzger ◽  
Max Schnurr ◽  
Stefan Endres ◽  
...  
Keyword(s):  
Immune Response ◽  
Severe Acute Respiratory Syndrome ◽  
Treatment Option ◽  
Neutrophil Recruitment ◽  
The Novel ◽  
Sars Coronavirus ◽  
Promising Treatment ◽  
Cxcr2 Antagonists ◽  
The Way

An exacerbated and unbalanced immune response may account for the severity of COVID-19, the disease caused by the novel severe acute respiratory syndrome (SARS) coronavirus 2, SARS-CoV-2. In this Viewpoint, we summarize recent evidence for the role of neutrophils in the pathogenesis of COVID-19 and propose CXCR2 inhibition as a promising treatment option to block neutrophil recruitment and activation.

scholarly journals Holmium laser ablation: a successful treatment option for an obstructing ureteric valve

2013 ◽  
Vol 4 (1) ◽  
pp. 15
Author(s):  
Muhammad Z. Aslam ◽  
B.D.R Gowda
Keyword(s):  
Laser Ablation ◽  
Treatment Option ◽  
Successful Treatment ◽  
Holmium Laser ◽  
Review Of The Literature

We present a case of an 80-year-old woman with intermittent flankpain, who was found to have a ureteric valve causing significanthydronephroureterosis. We discuss the role of holmium laser in successfullyablating the lesion, and present a review of the literature.

Psychological features of nursing in case of skin diseases in the department tumours of external localizations

2020 ◽  
pp. 19-23
Author(s):  
Lilia Shagvaleeva
Keyword(s):  
Patient Experience ◽  
Successful Treatment ◽  
Skin Diseases ◽  
Nursing Process ◽  
Oncological Patient ◽  
The Creation ◽  
Psychological Features

The article discloses the role of the medical sister of the oncological department in the creation of a positive psychological microclimate, which is the key to the successful treatment and rehabilitation of the oncological patient. Experience of organization of nursing process in the department of tumors of external localizations is presented.

Variation in the management of Kawasaki disease

2019 ◽  
Vol 105 (10) ◽  
pp. 1004-1006 ◽  
Author(s):  
Audrey Dionne ◽  
David Burgner ◽  
Sarah De Ferranti ◽  
Davinder Singh-Grewal ◽  
Jane Newburger ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Initial Treatment ◽  
Coronary Aneurysm ◽  
Medical Specialty ◽  
Primary Treatment ◽  
Management Options ◽  
Necrosis Factor Alpha ◽  
Coronary Aneurysms ◽  
Factor Alpha ◽  
Collaborative Efforts

Intravenous immunoglobulin (IVIG) reduces coronary aneurysms in patients with Kawasaki disease (KD), but additional management options remain challenging, with no generalisable evidence-based recommendations. We performed a survey of 724 physicians from 73 countries to assess variation in practice. IVIG was the preferred initial treatment by 659 (91%) of respondents. Criteria for adjunctive primary treatment varied considerably and definitions of IVIG resistance varied markedly by geographical continent, Human Development Index tiers and medical specialty. A second dose of IVIG was used most often for patients with coronary aneurysm non-responsive to initial treatment (572, 79%), but corticosteroids (379, 52%) and tumour necrosis factor alpha inhibitors (208, 29%) were also frequently used. Our findings highlight the need for international collaborative efforts to optimise management of patients with KD worldwide.

scholarly journals The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 675
Author(s):  
Saartje Uyttebroek ◽  
Jolien Onsea ◽  
Willem-Jan Metsemakers ◽  
Lieven Dupont ◽  
David Devolder ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Biofilm Formation ◽  
Potential Role ◽  
Phage Therapy ◽  
Well Being ◽  
Treatment Alternative ◽  
Surgical Interventions ◽  
Social And Emotional ◽  
Promising Treatment

Chronic rhinosinusitis is a common condition affecting 5–12% of the general population worldwide. In a limited number of cases, the disease is recalcitrant to medical and surgical interventions, causing a major impact on physical, social and emotional well-being and increasing pressure on healthcare systems. Biofilm formation and dysbiosis caused by Staphylococcus aureus and Pseudomonas aeruginosa play a role in the pathogenesis of recalcitrant chronic rhinosinusitis. In these cases, a promising treatment alternative is the application of bacteriophages, which are viruses that infect and lyse bacteria. In this review, we appraise the evidence for the use of bacteriophages in the treatment of recalcitrant chronic rhinosinusitis. Additionally, (dis)advantages of bacteriophages and considerations for implementation of phage therapy in otorhinolaryngology practice will be discussed.

scholarly journals Targeting macrophages in cancer immunotherapy

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Zhaojun Duan ◽  
Yunping Luo
Keyword(s):  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Therapeutic Strategies ◽  
Cellular Immunotherapy ◽  
Cancer Therapies ◽  
Tumor Vaccines ◽  
Development And Differentiation ◽  
Promising Treatment ◽  
Cancer Immunotherapies

AbstractImmunotherapy is regarded as the most promising treatment for cancers. Various cancer immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies, immune checkpoint inhibitors, and small-molecule inhibitors, have achieved certain successes. In this review, we summarize the role of macrophages in current immunotherapies and the advantages of targeting macrophages. To better understand and make better use of this type of cell, their development and differentiation characteristics, categories, typical markers, and functions were collated at the beginning of the review. Therapeutic strategies based on or combined with macrophages have the potential to improve the treatment efficacy of cancer therapies.

scholarly journals Therapeutic Alliance in Interpreter-Mediated Psychotherapy from the Perspective of Refugee Patients: Results of Qualitative Interviews

2021 ◽  
pp. 1-9
Author(s):  
Saskia Hanft-Robert ◽  
Nadine Janis Pohontsch ◽  
Cornelia Uhr ◽  
Alexander Redlich ◽  
Franka Metzner
Keyword(s):  
Content Analysis ◽  
Therapeutic Alliance ◽  
Successful Treatment ◽  
Qualitative Content Analysis ◽  
Qualitative Interviews ◽  
Therapeutic Treatment ◽  
Factors Influencing ◽  
Recommendations For Action ◽  
Patients Perspective

<b><i>Background:</i></b> The therapeutic alliance is considered to be one of the most important factors of psychotherapy and is a necessary requirement for a successful treatment in interpreter-mediated psychotherapy. <b><i>Patients and Methods:</i></b> Using interpreter-mediated guided interviews, 10 refugee patients who experienced interpreter-mediated psychotherapy were asked about factors influencing the development of a trusting therapeutic alliance in the triad. The analysis of the interviews followed the rules of content-structuring qualitative content analysis. <b><i>Results:</i></b> A total of 11 factors were identified which could be assigned to the interpreter, therapist, or patient. In the analysis, the central role of the interpreter in establishing a therapeutic alliance in the triad became particularly clear. <b><i>Conclusions:</i></b> Consideration of the factors that, from the patients’ perspective, influence the establishment and maintenance of a trusting alliance within the triad, as well as the recommendations for action derived from this for psychotherapists and interpreters can lead to an improvement in the therapeutic treatment of refugees.

scholarly journals The role of trans obturator tape as a surgical procedure for female stress urinary incontinence and its impact on quality of life in Jammu region

2019 ◽  
Vol 8 (12) ◽  
pp. 4975
Author(s):  
Sapna Puri ◽  
Manisha Kohli
Keyword(s):  
Quality Of Life ◽  
Stress Incontinence ◽  
Symptomatic Relief ◽  
Female Stress Urinary Incontinence ◽  
Medical Sciences ◽  
King’S Health Questionnaire ◽  
Promising Treatment ◽  
Pre Treatment

Background: Stress incontinence is one of the most common but debilitating health issue among women. It has a detrimental effect on overall health and quality of life of women. Trans obturator tape (TOT) has emerged as a promising treatment modality. The aim of present study was to assess the usefulness of TOT in terms of change in quality of life of stress incontinence patients.Methods: The study was performed at Department of Obstetrics and Gynecology, Acharya Shri Chandler of Medical Sciences (ASCOMS), Jammu. A total of 50 symptomatic women were enrolled in the study and underwent TOT procedure using outside-in technique. The quality of life of women was assessed at enrolment and 12 months after the procedure using King’s Health Questionnaire (KHQ). Change in QOL was assessed using paired ‘t’-test.Results: After 12 months follow-up, a total of 27 (54%) patients were entirely symptom free. As compared to pre-treatment QOL assessment on KHQ for general health/incontinence impact, quality of life and symptom scores a % decline of 73.2%, 79.8% and 78.4% was observed. For all the three parts, the change in scores was significant statistically. No other complications and side effects were reported.Conclusions: TOT is a useful procedure which provided symptomatic relief as well as QOL enhancement.

Diagnosis and successful treatment of an Austrian dog infected with Trypanosoma congolense forest type

2021 ◽  
Vol 49 (02) ◽  
pp. 142-147
Author(s):  
Michael Leschnik ◽  
Katja Silbermayr ◽  
Abigail Guija ◽  
Barbara Nell
Keyword(s):  
Clinical Improvement ◽  
Successful Treatment ◽  
Initial Treatment ◽  
Blood Smear ◽  
Forest Type ◽  
Trypanosoma Congolense ◽  
Lethal Outcome ◽  
Complete Eradication ◽  
Western Africa ◽  
Mongrel Dog

AbstractCanine African Trypanosomosis (CAT) is a rarely described disease with frequently lethal outcome. A 5-year-old female mongrel dog weighing 22 kg was presented in Austria due to unilateral uveitis, pancytopenia, and anorexia 4 months after return from a trip through Western Africa. Trypanosoma spp. flagellates were detected in a blood smear and identified as Trypanosoma congolense forest type by PCR. Initial treatment with imidocarb and miltefosine led to clinical improvement but only isometamidium chloride hydrochloride applied intramuscularly led to complete eradication of the pathogen from the dog’s blood 4 months later.

scholarly journals The Roles of DNA Demethylases in Triple-Negative Breast Cancer

2021 ◽  
Vol 14 (7) ◽  
pp. 628
Author(s):  
Shoghag Panjarian ◽  
Jean-Pierre J. Issa
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Tumor Suppressor Genes ◽  
Hormone Receptors ◽  
Triple Negative ◽  
Breast Cancers ◽  
Therapeutic Implications ◽  
High Propensity ◽  
Dna Methylation Profile

Triple-negative breast cancers (TNBCs) are very heterogenous, molecularly diverse, and are characterized by a high propensity to relapse or metastasize. Clinically, TNBC remains a diagnosis of exclusion by the lack of hormone receptors (Estrogen Receptor (ER) and Progesterone Receptor (PR)) as well as the absence of overexpression and/or amplification of HER2. DNA methylation plays an important role in breast cancer carcinogenesis and TNBCs have a distinct DNA methylation profile characterized by marked hypomethylation and lower gains of methylations compared to all other subtypes. DNA methylation is regulated by the balance of DNA methylases (DNMTs) and DNA demethylases (TETs). Here, we review the roles of TETs as context-dependent tumor-suppressor genes and/or oncogenes in solid tumors, and we discuss the current understandings of the oncogenic role of TET1 and its therapeutic implications in TNBCs.

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