scholarly journals Corticobasal Degeneration Misdiagnosed As Musculoskeletal Disease: A Challenging Diagnosis of Higher-Level Gait Disease

2020 ◽  
Vol 11 (04) ◽  
pp. 640-642
Author(s):  
Halil Onder
Keyword(s):  
Corticobasal Degeneration ◽  
The Elderly ◽  
Gait Disorders ◽  
Physiological Changes ◽  
Gait Abnormality ◽  
Age Related ◽  
Musculoskeletal Problems ◽  
Neurological Exam ◽  
Long Time ◽  
High Level

AbstractGait disorders are common in the elderly as there are various causes of neurological and non-neurological conditions. On the other hand, most of the gait parameters do change with advancing age which is identified as age-related physiological changes in gait. At this point, the discrimination between age-related physiological changes and gait disorders may be strictly challenging. After identifying gait as an abnormal pattern, classification of it and making the responsible pathophysiology also require high-level expertise in this regard. Herein, we present a rare patient with corticobasal degeneration (CBD) who had admitted initially due to complaints of gait problems. Over a long time, the patient had received the misdiagnosis of gait abnormality due to musculoskeletal problems by multiple physicians. However, the detailed neurological exam showed a higher level gait disorder (HLGD). Further investigations at this point yielded the diagnosis of CBD.

scholarly journals Információs és kommunikációs technológiák alkalmazása dementiában szenvedők komplex ellátásában

2018 ◽  
Vol 159 (24) ◽  
pp. 965-973
Author(s):  
Péter Osváth ◽  
Attila Kovács ◽  
Adrienn Boda-Jörg ◽  
Tamás Tényi ◽  
Sándor Fekete ◽  
...  
Keyword(s):  
Information And Communication Technologies ◽  
New Technologies ◽  
The Elderly ◽  
Complex Model ◽  
Significant Advance ◽  
Healthcare Applications ◽  
People With Dementia ◽  
Age Related ◽  
Information And Communication ◽  
High Level

Abstract: Modern information and communication tools have increasingly become an indispensable part of our everyday life. Research data demonstrate that it can be used effectively to preserve and restore health, not just among young people but also among the elderly, as for nowadays the use of the internet is widespread among the elderly, but healthcare applications are less well-known. This supports the significance of our project since it is important to develop and introduce disease-specific healthcare applications. Our preliminary results also indicated that men are less open to these new technologies, so in their case, specific methods are needed to facilitate the use of electronic devices. The high level of internet activity and the interest in information and communication technologies provide a reliable basis for applying these new technologies to the elderly. Thus, based on our research, we can develop a complex model of care based on the bio-psycho-social principles, which can be a significant advance in the prevention and early detection of age-related mental disorders and in alleviating the physical and psychological burdens of people with dementia and their families. Orv Hetil. 2018; 159(24): 965–973.

scholarly journals Dizziness and prevention of falls in the elderly

2017 ◽  
Vol 3 (4) ◽  
Author(s):  
Augusto P. Casani ◽  
Elena Navari
Keyword(s):  
Older Adults ◽  
The Elderly ◽  
Western Society ◽  
Physiological Changes ◽  
Vestibular Disorders ◽  
Great Role ◽  
Risk Of Falling ◽  
Old Adults ◽  
Age Related ◽  
Treatable Condition

Disequilibrium is one of the most common complaints that older adults bring to their physician and falling is a frequent complication; because of the increasing number of elderly patients in western society the problem grows. The increasing susceptibility to falling can be consequence of age-related physiological changes and of a higher prevalence of comorbidities causing dizziness, vertigo and imbalance; these symptoms can worse the already poor balance of old adults increasing the risk of falling. Among the major reasons of vertigo and dizziness, central vertigo and orthostatic vertigo are very common; also vestibular disorders have a great role and are currently thought to account for 48% of dizziness reported by older adults. An early identification of the treatable condition underlying dizziness in elderly would surely ameliorate the outcome of these patients.

Special considerations for geriatric therapeutic drug monitoring.

1989 ◽  
Vol 35 (7) ◽  
pp. 1337-1341 ◽  
Author(s):  
T M Annesley
Keyword(s):  
Renal Excretion ◽  
Blood Perfusion ◽  
Hepatic Metabolism ◽  
The Elderly ◽  
Tubular Secretion ◽  
Gastric Ph ◽  
The Body ◽  
Therapeutic Drug ◽  
Physiological Changes ◽  
Age Related

Abstract Numerous physiological changes during the normal aging process can potentially affect how drugs are handled by the body. Gastrointestinal changes include increased gastric pH, decreased intestinal motility, and decreased blood perfusion. Age-related changes in body composition and protein concentrations in plasma contribute to alterations in the distribution of drugs. Hepatic metabolism of drugs may be affected, and renal excretion via glomerular filtration or tubular secretion is diminished. The importance of each of these physiological changes in the elderly, as well as the contribution of multi-drug therapy and other external factors, is discussed.

scholarly journals Mediterranean diet and cognitive decline

2004 ◽  
Vol 7 (7) ◽  
pp. 959-963 ◽  
Author(s):  
F Panza ◽  
V Solfrizzi ◽  
AM Colacicco ◽  
A D'Introno ◽  
C Capurso ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Mediterranean Diet ◽  
The Elderly ◽  
Monounsaturated Fatty Acids ◽  
High Energy ◽  
Therapeutic Interventions ◽  
Age Related ◽  
Essential Components ◽  
The Mediterranean ◽  
High Level

AbstractObjective:To investigate the possible role of diet in age-related cognitive decline (ARCD) and cognitive impairment of both degenerative (Alzheimer's disease, AD) and vascular (vascular dementia, VaD) origin.Design:Literature review.Results:In an elderly population of southern Italy with a typical Mediterranean diet, high energy intake of monounsaturated fatty acids (MUFA) appeared to be associated with a high level of protection against ARCD. In addition, dietary fat and energy in the elderly seem to be risk factors, while fish consumption and cereals are found to reduce the prevalence of AD in European and North American countries. Finally, the relative risk of dementia (AD and VaD) was lower in the subjects of a French cohort who drank three or four glasses of red wine each day compared with total abstainers.Conclusion:Essential components of the Mediterranean diet – MUFA, cereals and wine – seem to be protective against cognitive decline. As such, dietary antioxidants and supplements, specific macronutrients of the Mediterranean diet, oestrogens and anti-inflammatory drugs may act synergistically with other protective factors, opening up new therapeutic interventions for cognitive decline.

DIFFERENCES OF THE HEALTH- RELATED QUALITY OF LIFE OF THE SENIOR CITIZENS

2020 ◽  
Vol 18 (2) ◽  
pp. 183-193
Author(s):  
Aleksandra Błachnio
Keyword(s):  
Quality Of Life ◽  
Old Age ◽  
The Elderly ◽  
Health Related Quality ◽  
Age Related ◽  
Related Quality ◽  
Health Related ◽  
Polish Adaptation ◽  
High Level

The aim of the study was to examine the health-related quality of life (HRQoL) of the elderly in Poland. Researcher investigated if differences between gender groups were influenced by other variables such as period of ageing („young-old” vr „old-old”) and place of residence (big city, small town, village). The study sample comprised 2565 elderly who were at least 60 years of age. The average age for men was 72,76 and for women 72,39. The health-related quality of life was evaluated using the Polish adaptation WHOQOL-BREF questionnaire. Respondents rated both quality of life and general health well. Nevertheless the health-related quality of life domains’ rating decreases with age. Women are commonly less satisfied with the WHOQOL-BREF domains. Men living in little towns declared not only a high level of quality of life, but their estimates in the early and late old age are similar. The diversity of health-related quality of life needs further investigation along with a number of more subjective indicators of individual experiencing one’s old age (e.g. sense of one’s time of life or the awareness of age-related changes).

scholarly journals Review on Mechanisms, Importance of Homeostasis and Fluid Imbalances in the Elderly

2016 ◽  
Vol 4 (Special-Issue-November) ◽  
pp. 01-07 ◽  
Author(s):  
Aggie Bak ◽  
Amalia Tsiami
Keyword(s):  
The Elderly ◽  
Hormone Release ◽  
Physiological Changes ◽  
Hormonal Stimulation ◽  
Care For The Elderly ◽  
Age Related ◽  
Subsequent Response ◽  
Pressure Water ◽  
Essential Nutrient ◽  
Age Related Changes

Water is considered an essential nutrient, but very often is overlooked in favour of nutrition. Due to age related changes, older people are more vulnerable to both, dehydration and overhydration. This article describes the principles of water homeostasis and provides a description of common age-related physiological changes related to water balance. Fluid homeostasis largely depends on osmo- and baro-receptors that respectively react to changes in osmolality and blood pressure, water-regulating hormone release, the subsequent response of kidneys to the hormonal stimulation and activation of thirst. These mechanisms diminish with age and put elderly at risk of dehydration. All involved in a care for the elderly should be informed and become vigilant to prevent dehydration from occurring.

The Biological Clock and Sleep in the Elderly

2006 ◽  
Vol 19 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Myriam Juda ◽  
Mirjam Münch ◽  
Anna Wirz-Justice ◽  
Martha Merrow ◽  
Till Roenneberg
Keyword(s):  
Circadian Rhythms ◽  
Biological Clock ◽  
The Elderly ◽  
Early Morning ◽  
Behavioral Changes ◽  
Older Age ◽  
Age Related ◽  
Theoretical Considerations ◽  
Sleep Difficulties ◽  
Circadian Biology

Abstract: Among many other changes, older age is characterized by advanced sleep-wake cycles, changes in the amplitude of various circadian rhythms, as well as reduced entrainment to zeitgebers. These features reveal themselves through early morning awakenings, sleep difficulties at night, and a re-emergence of daytime napping. This review summarizes the observations concerning the biological clock and sleep in the elderly and discusses the documented and theoretical considerations behind these age-related behavioral changes, especially with respect to circadian biology.

To the memory of the geobotanist. Leonid E. Rodin (to the 100th anniversary of his birthday)

2007 ◽  
pp. 106-107
Author(s):  
B. K. Gannibal
Keyword(s):  
End Of Life ◽  
100Th Anniversary ◽  
State University ◽  
Botanical Institute ◽  
Komarov Botanical Institute ◽  
The Future ◽  
Long Time ◽  
High Level

Leonid Efimovich Rodin (1907-1990) was a graduate of Leningrad state University. To him, the future is known geobotanica, happened to a course in Botanical geography is still at the N. A. Bush. His teachers were also A. P. Shennikov and A. A. Korchagin, who subsequently headed related Department of geobotany and Botanical geography of Leningrad state University. This was the first school scientist. And since the beginning of the 30s of XX century and until the end of life L. E. was an employee of the Department of geobotany of the Komarov Botanical Institute (RAS), where long time worked together with E. M. Lavrenko, V. B. Sochava, B. A. Tikhomirov, V. D. Alexandrova and many other high-level professionals, first continuing to learn and gain experience, then defining the direction of development of geobotany in the Institute and the country as a whole.

What Can We Learn from Sarcopenia with Curarisation in the Context of Cancer Surgery? A Review of the Literature

2019 ◽  
Vol 25 (28) ◽  
pp. 3005-3010
Author(s):  
Georges Samouri ◽  
Alexandre Stouffs ◽  
Lionel V. Essen ◽  
Olivier Simonet ◽  
Marc De Kock ◽  
...  
Keyword(s):  
Frail Elderly ◽  
Muscle Fibers ◽  
Motor Units ◽  
The Elderly ◽  
Hepatic Function ◽  
Volume Of Distribution ◽  
Neuromuscular Blocking ◽  
Cancer Surgery ◽  
Old People ◽  
Age Related

Introduction: The monitoring of the curarisation is a unique opportunity to investigate the function of the neuromuscular junction (NMJ) during cancer surgery, especially in frailty-induced and age-related sarcopenia. Method: We conducted a comprehensive literature review in PubMed, without any limit of time related to frailty, sarcopenia, age and response to neuromuscular blockers in the context of cancer surgery. Results: Several modifications appear with age: changes in cardiac output, a decrease in muscle mass and increase in body fat, the deterioration in renal and hepatic function, the plasma clearance and the volume of distribution in elderly are smaller. These changes can be exacerbated in cancer patients. We also find modifications of the NMJ: dysfunctional mitochondria, modifications in the innervation of muscle fibers and motor units, uncoupling of the excitation-contraction of muscle fibers, inflammation. : Neuromuscular blocking agents (NMBAs) compete with acetylcholine and prevent it from fixing itself on its receptor. Many publications reported guidelines for using NMBAs in the elderly, based on studies comparing old people with young people. : No one screened frailty before, and thus, no studies compared frail elderly and non-frail elderly undergoing cancer surgery. Conclusion: Despite many studies about curarisation in the specific populations, and many arguments for a potential interest for investigation, no studies investigated specifically the response to NMBAs in regard of the frailty-induced and age-related sarcopenia.

Language and Aging

2019 ◽  
pp. 294-316
Author(s):  
Jonathan E. Peelle
Keyword(s):  
Language Processing ◽  
Brain Function ◽  
Neural Systems ◽  
Language Abilities ◽  
Physiological Mechanisms ◽  
Cognitive Changes ◽  
Older Adulthood ◽  
Neural Organization ◽  
Age Related ◽  
High Level

Language processing in older adulthood is a model of balance between preservation and decline. Despite widespread changes to physiological mechanisms supporting perception and cognition, older adults’ language abilities are frequently well preserved. At the same time, the neural systems engaged to achieve this high level of success change, and individual differences in neural organization appear to differentiate between more and less successful performers. This chapter reviews anatomical and cognitive changes that occur in aging and popular frameworks for age-related changes in brain function, followed by an examination of how these principles play out in the context of language comprehension and production.

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