scholarly journals Rifampicin-Resistant Disseminated Tuberculosis in an Immunocompetent Adolescent Male Presenting with Retropharyngeal Abscess and Spinal Involvement

2021 ◽  
Author(s):  
Arghya Das ◽  
Vineeta Gupta ◽  
Shampa Anupurba
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Effective Treatment ◽  
Spinal Tuberculosis ◽  
Clinical Specimen ◽  
Retropharyngeal Abscess ◽  
Adolescent Male ◽  
Irreversible Damage ◽  
Disseminated Tuberculosis ◽  
Rare Manifestation ◽  
Microbiological Confirmation

AbstractRetropharyngeal abscess is a rare manifestation in spinal tuberculosis. Early clinical diagnosis followed by microbiological confirmation and effective treatment is crucial to avoid irreversible damage to the spine. Here, we report a case of disseminated tuberculosis in an immunocompetent adolescent male who presented with retropharyngeal abscess, multifocal involvement of the spine, and skin tuberculids. Xpert MTB/RIF assay in this patient facilitated early lifesaving treatment by detecting rifampicin-resistant Mycobacterium tuberculosis (MTB) in the clinical specimen.

Emergence of Heteroresistance Mycobacterium Tuberculosis in Saudi Arabia

2020 ◽  
Vol 20 (4) ◽  
pp. 491-494 ◽  
Author(s):  
Eltayib H. Ahmed Abakur ◽  
Tarig M.S. Alnour ◽  
Faisel Abuduhier ◽  
Fahad M.A. Albalawi ◽  
Khalid A.S. Alfifi
Keyword(s):  
Saudi Arabia ◽  
Mycobacterium Tuberculosis ◽  
Clinical Specimen ◽  
Rpob Gene ◽  
Rifampicin Resistance ◽  
Resistant Bacteria ◽  
Kingdom Of Saudi Arabia ◽  
Preliminary Stage ◽  
The North ◽  
Genotype Mtbdrplus

Purpose: Heteroresistant Mycobacterium tuberculosis (MTB) is defined as a group of drug-susceptible and resistant bacteria in a single clinical specimen from tuberculosis (TB) patients. Heteroresistance of MTB is considered a preliminary stage to full resistance. The present study aimed to determine the heteroresistance in Mycobacterium tuberculosis in Tabuk province, in the north of the Kingdom of Saudi Arabia. Method: GenoType MTBDRplus assay was used to determine mutations associated with isoniazid and rifampicin resistance. Results: A total number of 46 confirmed M. tuberculosis positive sputum samples were scanned for heteroresistance. The present study revealed 3 (6.5%) heteroresistant mutations to either rpoB gene alone, 2 (4.4%) to rpoB and 1 (2.2%) to inhA genes. Conclusion: The detection of heteroresistant mutations could guide the initiation of an appropriate regimen of treatment.

Tubercular Abscess of the Spleen in a Child: Conservative Management and Long-Term Follow-Up

2017 ◽  
Vol 13 (04) ◽  
pp. 316-318
Author(s):  
Vijai Williams ◽  
Sarvanan Chandrasekaran ◽  
Keerthivasan Seetharaman ◽  
Kushaljit Sodhi ◽  
Devi Dayal
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Splenic Abscess ◽  
Complete Healing ◽  
Rare Occurrence ◽  
Line Probe Assay ◽  
Rare Manifestation ◽  
Long Term Follow Up ◽  
Probe Assay

AbstractIsolated involvement of the spleen is a rare manifestation of childhood tuberculosis. The rare occurrence and presence of nonspecific clinical features often pose diagnostic challenges even in countries where tuberculosis is endemic. Splenectomy is often performed for establishing the diagnosis or achieving a cure in combination with antitubercular therapy (ATT). In this report, we describe a boy who presented with nonspecific symptoms and was detected to have a well-defined lesion in the spleen on ultrasonography. The diagnosis of tubercular splenic abscess was made after line probe assay for the detection of Mycobacterium tuberculosis and cytomorphology of the aspirated material. The tubercular abscess showed complete healing after 9 months of four-drug ATT.

scholarly journals Imaging of Central Nervous System Tuberculosis

2017 ◽  
Vol 2 (2) ◽  
pp. 84-90
Author(s):  
Anggraini Dwi Sensusiati
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mycobacterium Tuberculosis ◽  
Lymph Node ◽  
Ct Scan ◽  
Spinal Tuberculosis ◽  
Bacterial Disease ◽  
Pulmonary Tb ◽  
Intracranial Tuberculoma ◽  
Extra Pulmonary

Tuberculosis, or TB, is an infectious bacterial disease caused by Mycobacterium tuberculosis. TB can occur in pulmonary or extra pulmonary. Extra pulmonary TB occurs in locations other than the lung, such as larynx, lymph node, pleura, brain, kidneys and bones. CT Scan can detect intracranial tuberculoma, and MRI is the best method to detect the abnormality in spinal tuberculosis.

scholarly journals RAPID AND SPESIFIC DETECTION OF MYCOBACTERIUM TUBERCULOSIS USING POLYMERASE CHAIN REACTION

2019 ◽  
Vol 3 (2) ◽  
pp. 83
Author(s):  
Anita Kurniati ◽  
Desak Nyoman Surya Suameitra Dewi ◽  
Ni Nyoman Purwani
Keyword(s):  
Polymerase Chain Reaction ◽  
Mycobacterium Tuberculosis ◽  
Clinical Specimen ◽  
Laboratory Diagnosis ◽  
Nucleic Acid Amplification ◽  
Valuable Insight ◽  
Chain Reaction ◽  
Severe Condition ◽  
Middle Income ◽  
Polymerase Chain

Background: Tuberculosis (TB) is one of the major causes of health burden worldwide, especially in lower middle-income countries. TB is caused by Mycobacterium tuberculosis (MTB) and characterized by severe condition incuding coughing and fever. Purpose: To review the current methods for detection of TB using Polymerase Chain Reaction (PCR). Review: several studies have been done to give valuable insight into TB transmission, diagnosis, and treatment, however research  is constantly  needed  to decrease the incidence of eradicate TB. This infectious disease still give big health problem in all over the world by being second in causing high mortality rates after HIV/AIDS.  A specific, sensitive, rapid and cheap method for TB and other mycobacteria diagnosis in clinical specimen is a desperate needed in the laboratory diagnosis and hence management of tuberculosis. PCR as one of nucleic acid amplification assays have revolutionized MTB detection. Since it was first invented in fifteen years ago, it’s been through many developments. Conclusion: PCR  is one of the most specific and sensitive method currently available for TB diagnosis that can also detect in in all types of specimens obtained from TB patients.

Endometriosis of the sciatic nerve with cyclic sciatica

2014 ◽  
Vol 21 (3) ◽  
pp. 99-102 ◽  
Author(s):  
Ozdil Baskan ◽  
Ferda Ozdemir
Keyword(s):  
Magnetic Resonance Imaging ◽  
Sciatic Nerve ◽  
Soft Tissues ◽  
Uterine Cavity ◽  
Common Disease ◽  
Resonance Imaging ◽  
Irreversible Damage ◽  
Rare Manifestation ◽  
Magnetic Resonance Imaging Mri ◽  
Gynecological Disorder

Endometriosis is an important gynecological disorder which is characterized by proliferation of the functional endometrial tissue outside the uterine cavity, affects most commonly the ovaries and less frequently the gastrointestinal tract, chest, urinary tract, and soft tissues. Endometriosis invading the sciatic nerve is a rare manifestation of a common disease. The cyclic rhythm of pain, associated with the magnetic resonance imaging (MRI) signal of the lesion should suggest a diagnosis of endometriosis. Early diagnosis and treatment are important to prevent irreversible damage to the sciatic nerve.

Rapid recovery and identification of Mycobacterium tuberculosis within 48 hours of receipt of a clinical specimen — efficient use of rapid methods

2004 ◽  
Vol 26 (22) ◽  
pp. 176-178 ◽  
Author(s):  
David R. Miller ◽  
Sharon M. Deml ◽  
Arthur P. Guruswamy ◽  
Lynette K. Ostgaard ◽  
Peggy S. Schneider ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Clinical Specimen ◽  
Rapid Recovery ◽  
Rapid Methods

scholarly journals Pre-Multidrug-Resistant Mycobacterium tuberculosis Beijing Strain Associated with Disseminated Tuberculosis in a Pet Dog

2013 ◽  
Vol 52 (1) ◽  
pp. 354-356 ◽  
Author(s):  
A. Botelho ◽  
J. Perdigao ◽  
A. Canto ◽  
T. Albuquerque ◽  
N. Leal ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Multidrug Resistant ◽  
Beijing Strain ◽  
Disseminated Tuberculosis

scholarly journals Nitric oxide-inducible Fe-S cluster biogenesis enables Mycobacterium tuberculosis to persist in mice

2020 ◽  
Author(s):  
Kushi Anand ◽  
Ashutosh Tripathi ◽  
Kaustubh Shukla ◽  
Nitish Malhotra ◽  
Anilkumar Jamithireddy ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mycobacterium Tuberculosis ◽  
Transcriptional Repressor ◽  
Buffering Capacity ◽  
Dependent Manner ◽  
Activated Macrophages ◽  
Irreversible Damage ◽  
Host Environment ◽  
Host Tissues ◽  
Inducible Nitric Oxide

AbstractHost-inducible nitric oxide (NO) suppresses Mycobacterium tuberculosis (Mtb) without eradicating it. Mechanisms underlying the persistence of residual bacteria in a hostile host environment are not known. Since NO damages Fe-S clusters of essential enzymes, the mechanism used to repair Fe-S clusters could help Mtb persist in host tissues. Here, we show that Mtb utilizes the suf operon (Rv1460-Rv1466) for Fe-S cluster biogenesis to persist under NO stress. Further, transcriptional repressor SufR (Rv1460) senses NO through its 4Fe-4S cluster to directly regulate Suf-meditated Fe-S cluster biogenesis. We discovered that NO inflicted irreversible damage upon Fe-S clusters to exhaust respiratory reserves and redox buffering capacity of MtbΔsufR. Importantly, MtbΔsufR failed to recover from a NO-induced non-growing state and displayed persistence defect inside immune-activated macrophages and murine lungs in a NO-dependent manner. Data suggest that SufR is a sensor of NO that supports persistence by reprogramming Fe-S cluster metabolism and bioenergetics of Mtb.

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