4.1 Strain-Promoted Azide–Alkyne Cycloaddition (SPAAC): Background, Substrate Preparation, and Reactivity

2022 ◽  
Author(s):  
T. Harris ◽  
I. V. Alabugin
Keyword(s):  
Substrate Preparation ◽  
Challenging Research ◽  
Research Questions ◽  
Synthetic Approaches ◽  
New Applications

AbstractThis chapter discusses the creative synthetic approaches to azides and cycloalkynes, provides the rationale for controlling SPAAC reactivity through tuning cycloalkyne and azide backbone modifications, and highlights research on nitrone cycloadditions with cycloalkynes. This synthetic and knowledge toolset will help in the design of better cycloalkynes and their partners to answer challenging research questions and aid the development of new applications.

On the Notion of Collective Intelligence

2010 ◽  
Vol 1 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Epaminondas Kapetanios
Keyword(s):  
Collective Intelligence ◽  
Point Of View ◽  
Social Web ◽  
Synergistic Interactions ◽  
Design And Implementation ◽  
Computing Paradigm ◽  
The Social ◽  
Challenging Research ◽  
Research Questions ◽  
Set Up

In this article, the author explores the notion of Collective Intelligence (CI) as an emerging computing paradigm. The article is meant to provide a historical and contextual view of CI through the lenses of as many related disciplines as possible (biology, sociology, natural and environmental sciences, physics) in conjunction with the computer science point of view. During this explorative journey, the article also aims at pinpointing the current strengths and weaknesses of CI-related computational and system engineering design and implementation methodologies of CI-based systems. A non-exhaustive list of case studies set up the stage for CI applications as well as challenging research questions. These can be particularly directed towards the Social Web, as a very prominent example of synergistic interactions of a group of people with diverse cultural and professional backgrounds and its potential to become a platform for the emergence of truly CI-based systems.

Water-swellable elastomers: synthesis, properties and applications

2018 ◽  
Vol 35 (1) ◽  
pp. 45-72 ◽  
Author(s):  
Lorenzo M. Polgar ◽  
Francesca Fallani ◽  
Juul Cuijpers ◽  
Patrizio Raffa ◽  
Antonius A. Broekhuis ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Hydrophobic Materials ◽  
Academic Researchers ◽  
Synthesis Properties ◽  
Swelling Characteristics ◽  
Patent Literature ◽  
Difficult Challenge ◽  
Water Swelling ◽  
Synthetic Approaches ◽  
New Applications

Abstract Water-swellable elastomers (WSE) constitute a class of rubbery materials that have been widely studied both in academia and industry during the last 25 years. Market pull is the major driver for the exploration of these materials. The need of WSE in several sealing applications has driven the attention of many academic researchers toward the possibility to provide a rubber with water-swelling characteristics. As commercial rubbers are hydrophobic materials, making them swell in water presents an interesting and difficult challenge. This paper reviews the scientific and patent literature on the fundamental aspects of WSE: the various synthetic approaches, the properties of the corresponding polymers (not only the swelling performance but also the mechanical behavior), and some of their applications. Particular attention is paid to the chemical structure/performance relationships of WSE. Finally, the authors speculate on a great future for WSE that can be rationally designed for improved and/or new applications.

Biomedical Informatics Publications: a Global Perspective

2012 ◽  
Vol 51 (01) ◽  
pp. 82-90 ◽  
Author(s):  
M. Garcia-Remesal ◽  
C. Bielza ◽  
J. Crespo ◽  
D. Perez-Rey ◽  
C. Kulikowski ◽  
...  
Keyword(s):  
Biomedical Informatics ◽  
Global Perspective ◽  
Genomic Research ◽  
Professional Groups ◽  
The Past ◽  
The World ◽  
Challenging Research ◽  
Research Questions ◽  
The Impact ◽  
Scientific Sense

SummaryBackground: In the past decade, Medical Informatics (MI) and Bioinformatics (BI) have converged towards a new discipline, called Biomedical Informatics (BMI) bridging informatics methods across the spectrum from genomic research to personalized medicine and global healthcare. This convergence still raises challenging research questions which are being addressed by researchers internationally, which in turn raises the question of how biomedical informatics publications reflect the contributions from around the world in documenting the research.Objectives: To analyse the worldwide participation of biomedical informatics researchers from professional groups and societies in the best-known scientific conferences in the field. The analysis is focused on their geographical affiliation, but also includes other features, such as the impact and recognition of the conferences.Methods: We manually collected data about authors of papers presented at three major MI conferences: Medinfo, MIE and the AMIA symposium. In addition, we collected data from a BI conference, ISMB, as a comparison. Finally, we analyzed the impact and recognition of these conferences within their scientific contexts.Results: Data indicate a predominance of local authors at the regional conferences (AMIA and MIE), whereas other conferences with a worldwide scope (Medinfo and ISMB) had broader participation. Our analysis shows that the influence of these conferences beyond the discipline remains somewhat limited.Conclusions: Our results suggest that for BMI to be recognized as a broad discipline, both in the geographical and scientific sense, it will need to extend the scope of collaborations and their interdisciplinary impacts worldwide.

scholarly journals Spanning the boundaries of qualitative grounded theory methods: breaking new grounds into the new online era

2020 ◽  
Vol 55 (4) ◽  
pp. 491-509
Author(s):  
Leandro Bonfim
Keyword(s):  
Grounded Theory ◽  
Design Methodology ◽  
Boundary Spanning ◽  
Online Data ◽  
Content Type ◽  
Challenging Research ◽  
Scant Attention ◽  
Catch Up ◽  
Research Questions

Purpose This study aims to present a guide for using grounded theory methods for exploring organizational phenomena of the new online era. Design/methodology/approach A reflexive account is adopted on how one can build upon the foundations of traditional offline grounded theory for conducting grounded theorizing with online-based data. Findings Guidelines for conducting grounded theory on online contexts are presented for crafting research questions, gathering online data and using consolidated methods for analyzing online data. This study shows future and present challenges posed by the new online era for grounded theorizing, as well as helpful lessons to be learned from traditional offline grounded theory to mitigate them. Research limitations/implications The implications are helpful for established qualitative organizational scholars that are yet to catch-up in the boundary spanning process of using the digital sources of data in grounded theory. They are equally helpful for newcomers on qualitative grounded theory by guiding them on where and how to start these challenging research endeavors of grounded theorizing in this new online era. Originality/value Scant attention has been given on applications of grounded theory in the new online era. The differences between online and offline settings have not been clearly defined to this date, and neither do guidelines exist for how qualitative grounded theorists can take advantage of online data to build theory about new organizational phenomena emerging in the online era.

scholarly journals A Survey of Field-based Testing Techniques

2021 ◽  
Vol 54 (5) ◽  
pp. 1-39
Author(s):  
Antonia Bertolino ◽  
Pietro Braione ◽  
Guglielmo De Angelis ◽  
Luca Gazzola ◽  
Fitsum Kifetew ◽  
...  
Keyword(s):  
Field Tests ◽  
Field Testing ◽  
Software Systems ◽  
Research Directions ◽  
Systematic Survey ◽  
Challenging Research ◽  
Testing Techniques ◽  
Research Questions ◽  
Testing Field

Field testing refers to testing techniques that operate in the field to reveal those faults that escape in-house testing. Field testing techniques are becoming increasingly popular with the growing complexity of contemporary software systems. In this article, we present the first systematic survey of field testing approaches over a body of 80 collected studies, and propose their categorization based on the environment and the system on which field testing is performed. We discuss four research questions addressing how software is tested in the field, what is tested in the field, which are the requirements , and how field tests are managed , and identify many challenging research directions.

1250-kilovolt scanning transmission electron microscope

1984 ◽  
Vol 42 ◽  
pp. 624-625
Author(s):  
T. Imura ◽  
S. Maruse ◽  
K. Mihama ◽  
M. Iseki ◽  
M. Hibino ◽  
...  
Keyword(s):  
High Voltage ◽  
Electron Probe ◽  
Scanning Transmission Electron Microscope ◽  
Pressure Vessels ◽  
Practical Applications ◽  
Voltage Generator ◽  
Transmission Electron ◽  
Scanning Transmission ◽  
New Applications ◽  
High Voltage Generator

Ultra high voltage STEM has many inherent technical advantages over CTEM. These advantages include better signal detectability and signal processing capability. It is hoped that it will explore some new applications which were previously not possible. Conventional STEM (including CTEM with STEM attachment), however, has been unable to provide these inherent advantages due to insufficient performance and engineering problems. Recently we have developed a new 1250 kV STEM and completed installation at Nagoya University in Japan. It has been designed to break through conventional engineering limitations and bring about theoretical advantage in practical applications.In the design of this instrument, we exercised maximum care in providing a stable electron probe. A high voltage generator and an accelerator are housed in two separate pressure vessels and they are connected with a high voltage resistor cable.(Fig. 1) This design minimized induction generated from the high voltage generator, which is a high frequency Cockcroft-Walton type, being transmitted to the electron probe.

Pyridyl disulfide-based thiol–disulfide exchange reaction: shaping the design of redox-responsive polymeric materials

2020 ◽  
Vol 11 (48) ◽  
pp. 7603-7624
Author(s):  
Ismail Altinbasak ◽  
Mehmet Arslan ◽  
Rana Sanyal ◽  
Amitav Sanyal
Keyword(s):  
Exchange Reaction ◽  
Functional Materials ◽  
Polymeric Materials ◽  
Disulfide Exchange ◽  
Redox Responsive ◽  
Synthetic Approaches

This review provides an overview of synthetic approaches utilized to incorporate the thiol-reactive pyridyl-disulfide motif into various polymeric materials, and briefly highlights its utilization to obtain functional materials.

The Collaborative Network Approach: a model for advancing patient-centric research for Castleman disease and other rare diseases

2019 ◽  
Vol 3 (1) ◽  
pp. 97-105
Author(s):  
Mary Zuccato ◽  
Dustin Shilling ◽  
David C. Fajgenbaum
Keyword(s):  
Rare Diseases ◽  
Treatment Options ◽  
Castleman Disease ◽  
High Impact ◽  
Collaborative Network ◽  
Network Approach ◽  
Grant Applications ◽  
Research Questions ◽  
Novel Strategy ◽  
Patient Centric

Abstract There are ∼7000 rare diseases affecting 30 000 000 individuals in the U.S.A. 95% of these rare diseases do not have a single Food and Drug Administration-approved therapy. Relatively, limited progress has been made to develop new or repurpose existing therapies for these disorders, in part because traditional funding models are not as effective when applied to rare diseases. Due to the suboptimal research infrastructure and treatment options for Castleman disease, the Castleman Disease Collaborative Network (CDCN), founded in 2012, spearheaded a novel strategy for advancing biomedical research, the ‘Collaborative Network Approach’. At its heart, the Collaborative Network Approach leverages and integrates the entire community of stakeholders — patients, physicians and researchers — to identify and prioritize high-impact research questions. It then recruits the most qualified researchers to conduct these studies. In parallel, patients are empowered to fight back by supporting research through fundraising and providing their biospecimens and clinical data. This approach democratizes research, allowing the entire community to identify the most clinically relevant and pressing questions; any idea can be translated into a study rather than limiting research to the ideas proposed by researchers in grant applications. Preliminary results from the CDCN and other organizations that have followed its Collaborative Network Approach suggest that this model is generalizable across rare diseases.

Factors Influencing Cognate Performance for Young Multilingual Children's Vocabulary: A Research Synthesis

2020 ◽  
Vol 29 (4) ◽  
pp. 2170-2188
Author(s):  
Lindsey R. Squires ◽  
Sara J. Ohlfest ◽  
Kristen E. Santoro ◽  
Jennifer L. Roberts
Keyword(s):  
Test Validity ◽  
Reaction Times ◽  
Bilingual Children ◽  
Second Grade ◽  
High Quality Research ◽  
Word Level ◽  
Research Questions ◽  
Word Characteristics ◽  
Study Inclusion ◽  
Task Level

Purpose The purpose of this systematic review was to determine evidence of a cognate effect for young multilingual children (ages 3;0–8;11 [years;months], preschool to second grade) in terms of task-level and child-level factors that may influence cognate performance. Cognates are pairs of vocabulary words that share meaning with similar phonology and/or orthography in more than one language, such as rose – rosa (English–Spanish) or carrot – carotte (English–French). Despite the cognate advantage noted with older bilingual children and bilingual adults, there has been no systematic examination of the cognate research in young multilingual children. Method We conducted searches of multiple electronic databases and hand-searched article bibliographies for studies that examined young multilingual children's performance with cognates based on study inclusion criteria aligned to the research questions. Results The review yielded 16 articles. The majority of the studies (12/16, 75%) demonstrated a positive cognate effect for young multilingual children (measured in higher accuracy, faster reaction times, and doublet translation equivalents on cognates as compared to noncognates). However, not all bilingual children demonstrated a cognate effect. Both task-level factors (cognate definition, type of cognate task, word characteristics) and child-level factors (level of bilingualism, age) appear to influence young bilingual children's performance on cognates. Conclusions Contrary to early 1990s research, current researchers suggest that even young multilingual children may demonstrate sensitivity to cognate vocabulary words. Given the limits in study quality, more high-quality research is needed, particularly to address test validity in cognate assessments, to develop appropriate cognate definitions for children, and to refine word-level features. Only one study included a brief instruction prior to assessment, warranting cognate treatment studies as an area of future need. Supplemental Material https://doi.org/10.23641/asha.12753179

Nonconscious Activation of Achievement Goals

2009 ◽  
Vol 68 (4) ◽  
pp. 193-200 ◽  
Author(s):  
Stefan Engeser
Keyword(s):  
Achievement Goals ◽  
Priming Effect ◽  
Achievement Goal ◽  
Word Class ◽  
Achievement Motive ◽  
Goal Priming ◽  
Series Of Experiments ◽  
Research Questions

In a series of experiments, Bargh, Gollwitzer, Lee-Chai, Barndollar, and Trötschel (2001) documented that achievement goals can be activated outside of awareness and can then operate nonconsciously in order to guide self-regulated behavior effectively. In three experiments (N = 69, N = 71, N = 56), two potential moderators of the achievement goal priming effect were explored. All three experiments showed small but consistent effects of the nonconscious activation of the achievement goal, though word class did not moderate the priming effect. There was no support for the hypothesis that the explicit achievement motive moderates the priming effect. Implications are addressed in the light of other recent studies in this domain and further research questions are outlined.

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