scholarly journals Evidence of entropically driven C60 fullerene aggregation in aqueous solution

2014 ◽  
Vol 140 (10) ◽  
pp. 104909 ◽  
Author(s):  
Dmitry P. Voronin ◽  
Anatoly S. Buchelnikov ◽  
Viktor V. Kostjukov ◽  
Sergii V. Khrapatiy ◽  
Dariusz Wyrzykowski ◽  
...  
2019 ◽  
Vol 721 ◽  
pp. 22-26 ◽  
Author(s):  
Andrei Mosunov ◽  
Vladyslav Evstigneev ◽  
Anatoly Buchelnikov ◽  
Viktoria Salo ◽  
Yuriy Prylutskyy ◽  
...  

Langmuir ◽  
2014 ◽  
Vol 30 (14) ◽  
pp. 3967-3970 ◽  
Author(s):  
Yu. I. Prylutskyy ◽  
V. I. Petrenko ◽  
O. I. Ivankov ◽  
O. A. Kyzyma ◽  
L. A. Bulavin ◽  
...  

Carbon ◽  
2004 ◽  
Vol 42 (5-6) ◽  
pp. 1199-1201 ◽  
Author(s):  
P. Scharff ◽  
L. Carta-Abelmann ◽  
C. Siegmund ◽  
O.P. Matyshevska ◽  
S.V. Prylutska ◽  
...  

Author(s):  
A.A. Alekseev ◽  
◽  
N.A. Pudovkin ◽  
V.V. Salautin ◽  
◽  
...  

The active use of fullerene C60 in veterinary medicine has a positive effect on the functions of hepatocytes, promotes the restoration of metabolic processes in the gastrointestinal tract, improving metabolic and redox processes in the body, reducing inflammatory and fibrosing processes in the liver. The aim of the work was to change the protein-nitrogen metabolism in laboratory animals under the action of an aqueous solution of fullerene C60. For the research, 3 groups of white rats were formed. It was found that after the introduction of the studied compounds, we observed changes in the parameters of protein-nitrogen metabolism, which were expressed in an increase in the level of total protein, urea, ammonia and urea in the blood serum of white rats. However, there was a decrease in the concentration of glutamine. The change in the content of albumins in the blood serum by 8.6-10.1 % and globulins by 6-6.5 % was also found. The results obtained indicate a positive effect of C60 fullerene solutions on the animal body.


2013 ◽  
Vol 15 (23) ◽  
pp. 9351 ◽  
Author(s):  
Yuriy I. Prylutskyy ◽  
Anatoly S. Buchelnikov ◽  
Dmitry P. Voronin ◽  
Viktor V. Kostjukov ◽  
Uwe Ritter ◽  
...  

2019 ◽  
Vol 30 (6) ◽  
pp. 2327-2338
Author(s):  
Kamila Butowska ◽  
Witold Kozak ◽  
Magdalena Zdrowowicz ◽  
Samanta Makurat ◽  
Michał Rychłowski ◽  
...  

Abstract Conjugating an anticancer drug of high biological efficacy but large cytotoxicity with a “transporting” molecule of low toxicity constitutes a valuable approach to design safe drug delivery system. In the present study, doxorubicin (DOX) a drug of large cardiotoxicity was chemically conjugated to a C60-fullerene. The synthesized molecule, a fullerene-doxorubicin conjugate (Ful-DOX), was characterized using the 1H NMR and MALDI TOF mass spectrometry. The absorption and fluorescence spectra and dynamic light scattering of the conjugate were recorded in an aqueous solution, while the impact on viability of several cancer cell lines of the free DOX and the conjugate was compared using the SRB and WST-1 assays. A low antiproliferative activity of the conjugate as compared to the free DOX is a consequence of the presence of fullerene moiety in the former, which is also responsible for the conjugate aggregation in an aqueous solution. Unlike free DOX, these aggregates cannot pass through the nuclear membrane (as demonstrated by the confocal microscopy measurements), which makes them marginally cytotoxic.


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