Mannich Reaction Product of Quinolin-8-ol (Oxine) and its Antibacterial Activity

1997 ◽  
Vol 50 (8) ◽  
pp. 861 ◽  
Author(s):  
Shaheen Faizi ◽  
Bina Shaheen Siddiqui ◽  
Rubeena Saleem ◽  
Farzana Akhtar ◽  
Khursheed Ali Khan ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Single Crystal ◽  
Mannich Reaction ◽  
Gram Negative Bacteria ◽  
X Ray Diffraction ◽  
Gram Positive ◽  
Gram Negative ◽  
Antimicrobial Screening ◽  
X Ray

Quinolin-8-ol (1) on reaction with 2,6-dichloroaniline and m-nitrobenzaldehyde afforded 7-(α-hydroxy- m-nitrobenzyl)quinolin-8-ol (2), which is an unusual Mannich reaction product. The structure of (2) was determined by spectroscopic and single-crystal X-ray diffraction studies. Preliminary antimicrobial screening showed that (1) and (2) have activity against a large number of Gram-positive and Gram-negative bacteria.

Al2O3 Nanopowders, a Suitable Compound for Active Control of Biofouling

2015 ◽  
Vol 32 ◽  
pp. 71-80
Author(s):  
Mohsen Mehregan ◽  
Hossein Soltaninejad ◽  
Behnaz Toluei Nia ◽  
Hadi Zare-Zardini ◽  
Masoud Zare-Shehneh ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Antibacterial Activity ◽  
Blood Cells ◽  
Gram Negative Bacteria ◽  
Bacterial Strains ◽  
X Ray Diffraction ◽  
Gram Positive ◽  
Gram Negative ◽  
X Ray

The formation of biofilm (Biofouling) in different surface is the great concern in types of fields, especially in medical and health system as well as in membrane technology. The present study deals with the synthesis and characterization of Al2O3 nanopowders with antibacterial activity which can be a potentially utilized material for biocompatible implants. Nanostructure was synthesized based on sol-gel method and then, crystallite size, and microstructural and morphological characterization of nanostructure were determined by X-ray diffraction, electron-microscopic techniques - scanning electron microscopy (SEM) and transmission electron microscopy (TEM). According to X-ray diffraction, the value of particle size for Al2O3 nanopowders is 20.85 nm. In the following, the antibacterial activity of Al2O3 nanoparticles was assessed on three gram positive and three gram negative bacteria by radial diffusion assay and measurement of minimum inhibitory concentration (MIC). The toxicity of Al2O3 nanopowders on blood cells was also assessed. The results showed that this nanostructure has potent antibacterial activity against gram positive and gram negative bacteria. The synthesized Al2O3 nanopowders showed the antimicrobial activity against antibiotic resistant bacterium, Staphylococcus aureus. Significant antibacterial activity of this nanostructure was seen to have a greatest effect on Bacillus cereus with the MIC value of 9.2 μg/ml; while, among bacterial strains, Salmonellatyphimurium was investigated to be the most resistant one with the MIC of 35.6 μg/ml. Al2O3 nanopowders showed no toxicity on blood cells. according to acquired data in this study, Al2O3 nanopowders may be a good material for inhibition of biofilm formation.

scholarly journals CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF ZnO NANOPARTICLES SYNTHESIZED BY CO PRECIPITATION METHOD

2018 ◽  
Vol 10 (6) ◽  
pp. 224 ◽  
Author(s):  
Manyasree D. ◽  
Kiranmayi P. ◽  
Venkata R Kolli
Keyword(s):  
Antibacterial Activity ◽  
Zno Nanoparticles ◽  
Precipitation Method ◽  
Proteus Vulgaris ◽  
X Ray Diffraction ◽  
Gram Positive ◽  
Gram Negative ◽  
X Ray ◽  
Uv Visible ◽  
Co Precipitation

Objective: In the present study the antibacterial activity of zinc oxide (ZnO) nanoparticles was investigated against gram negative (Escherichia coli and Proteus vulgaris) and gram positive (Staphylococcus aureus and Streptococcus mutans) organisms.Methods: The synthesis of ZnO nanoparticles was carried out by co-precipitation method using zinc sulfate and sodium hydroxide as precursors. These nanoparticles were characterized by XRD (X-Ray Diffraction), FTIR (Fourier Transform Infrared Radiation), UV-Visible spectroscopy and SEM (Scanning Electron Microscope) with EDX (Energy Dispersive X-ray analysis). As well as antibacterial activity and minimum inhibitory concentration of the nanoparticles were carried out by agar well diffusion method and broth dilution method respectively against gram negative (Escherichia coli and Proteus vulgaris) and gram positive (Staphylococcus aureus and Streptococcus mutans) bacteria.Results: The average crystallite size of ZnO nanoparticles was found to be 35 nm by X-ray diffraction. The vibration bands at 450 and 603 cm-1 which were assigned for ZnO stretching vibration were observed in FTIR spectrum. The optical absorption band at 383 nm was obtained from UV-Visible spectrum. Spherical shape morphology was observed in SEM studies. The antibacterial assay clearly expressed that E. coli showed a maximum zone of inhibition (32±0.20 mm) followed by Proteus vulgaris (30±0.45 nm) at 50 mg/ml concentration of ZnO nanoparticles.Conclusion: Zinc oxide nanoparticles have exhibited good antibacterial activity with gram negative bacteria when compared to gram positive bacteria.

scholarly journals CuO NANOPARTICLES: SYNTHESIS, CHARACTERIZATION AND THEIR BACTERICIDAL EFFICACY

2017 ◽  
Vol 9 (6) ◽  
pp. 71 ◽  
Author(s):  
Manyasree D ◽  
Kiran Mayi Peddi ◽  
Ravikumar R
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Copper Oxide ◽  
Cuo Nanoparticles ◽  
Proteus Vulgaris ◽  
X Ray Diffraction ◽  
Gram Positive ◽  
Gram Negative ◽  
X Ray ◽  
Ft Ir

Objective: In the present study copper oxide (CuO) nanoparticles were synthesized and characterized. The antibacterial activity of CuO nanoparticles was carried out against Escherichia coli, Proteus vulgaris, Staphylococcus aureus and Streptococcus mutans.Methods: The synthesis was carried out by coprecipitation method using copper sulfate and sodium hydroxide as precursors. The synthesized copper oxide nanoparticles were characterized by using X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FT-IR), UV-vis spectroscopy and scanning electron microscope (SEM) with Energy Dispersive X-ray Analysis (EDX) techniques. Besides, this study determines the antibacterial activity and minimum inhibitory concentration (MIC) of CuO nanoparticles against gram-positive (Staphylococcus aureus and Streptococcus mutans) and gram-negative (E. coli and Proteus vulgaris) bacteria.Results: The average crystallite size of CuO nanoparticles was found to be 19 nm by X-ray diffraction. FT-IR spectrum exhibited vibrational modes at 432 cm-1, 511 cm-1 and 611 cm-1were assigned for Cu-O stretching vibration. According to UV-Vis spectrum, two bands were observed at 402 nm and 422 nm. ED’s spectrum shows only elemental copper (Cu) and oxide (O) and no other elemental impurity was observed. The antimicrobial assay revealed that Proteus vulgaris showed a maximum zone of inhibition (37 mm) at 50 mg/ml concentration of CuO nanoparticles.Conclusion: In conclusion, copper oxide is a good antibacterial agent against both gram positive and gram-negative organisms.

scholarly journals SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF ALUMINIUM OXIDE NANOPARTICLES

2018 ◽  
Vol 10 (1) ◽  
pp. 32 ◽  
Author(s):  
Manyasree D. ◽  
Kiranmayi P. ◽  
Ravi Kumar R. V. S. S. N.
Keyword(s):  
Antibacterial Activity ◽  
Aluminium Oxide ◽  
Al2o3 Nanoparticles ◽  
X Ray Diffraction ◽  
Gram Positive ◽  
Gram Negative ◽  
X Ray ◽  
Ft Ir ◽  
Gram Negative Organisms ◽  
Aluminium Oxide Nanoparticles

Objective: In the present study, synthesized alumina (Al2O3) nanoparticles were characterized and their antibacterial activity against gram positive and gram negative organisms were studied.Methods: The synthesis was carried out by coprecipitation method using aluminium sulfate and NaOH as precursors. The synthesized aluminium oxide nanoparticles were characterized by using X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FT-IR) and scanning electron microscope (SEM) with Energy Dispersive X-ray Analysis (EDX) techniques. Besides, this study determines the antibacterial activity and minimum inhibitory concentration (MIC) of Al2O3 nanoparticles against gram-positive (Staphylococcus aureus and Streptococcus mutans) and gram-negative (E. coli and Proteus vulgaris) bacteria. Results: The average crystallite size of Al2O3 nanoparticles was found to be 35 nm by X-ray diffraction. FT-IR spectrum exhibited the peaks at 615 and 636 were assigned to the aluminium oxide stretching. The EDX measurements indicated the presence of Al along with O peaks. It indicates the purity of the sample. The antimicrobial assay revealed that E. coli showed a maximum zone of inhibition (39 mm) at 50 mg/ml concentration of Al2O3 nanoparticles.Conclusion: In conclusion, aluminium oxide is a good antibacterial agent against both gram positive and gram-negative organisms.

scholarly journals Four New Phloroglucinol-Terpene Adducts from the Leaves of Myrciaria cauliflora

2020 ◽  
Author(s):  
Ming Chen ◽  
Jia-Qing Cao ◽  
Wen-Jing Wang ◽  
Ni-Ping Li ◽  
Yan Wu ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Single Crystal ◽  
Spectroscopic Analysis ◽  
X Ray Diffraction ◽  
Gram Positive ◽  
Electronic Circular Dichroism ◽  
X Ray ◽  
Gram Positive Bacteria ◽  
Multiresistant Strains ◽  
Circular Dichroïsm

Abstract Myrcauones A–D (1–4), four new phloroglucinol–terpene adducts were isolated from the leaves of Myrciaria cauliflora. Their structures with absolute configurations were elucidated by combination of spectroscopic analysis, single crystal X-ray diffraction, and electronic circular dichroism (ECD) calculations. Compound 1 was a rearranged isobutylphloroglucinol–pinene adduct featuring an unusual 2,3,4,4a,10,11-hexahydro-1H-3,11a-methanodibenzo[b,f]oxepin backbone. Compound 4 showed moderate antibacterial activity against Gram-positive bacteria including multiresistant strains. Graphic Abstract

In-vitro Antioxidant and Antibacterial Activity of Methanolic Extract of Shorea robusta Gaertn. F. Resin

2016 ◽  
Vol 6 (4) ◽  
pp. 68
Author(s):  
Sushma Vashisht ◽  
Manish Pal Singh ◽  
Viney Chawla
Keyword(s):  
Antibacterial Activity ◽  
Methanolic Extract ◽  
Diffusion Method ◽  
Gram Negative Bacteria ◽  
Disc Diffusion ◽  
Gram Positive ◽  
Gram Negative ◽  
Shorea Robusta ◽  
Dose Dependent ◽  
Resin Extract

The methanolic extract of the resin of Shorea robusta was subjected to investigate its antioxidant and antibacterial properties its utility in free radical mediated diseases including diabetic, cardiovascular, cancer etc. The methanol extract of the resin was tested for antioxidant activity using scavenging activity of DPPH (1,1-diphenyl-2-picrylhydrazil) radical method, reducing power by FeCl3 and antibacterial activity against gram positive and gram negative bacteria using disc diffusion method. The phytochemical screening considered the presence of triterpenoids, tannins and flavoniods. Overall, the plant extract is a source of natural antioxidants which might be helpful in preventing the progress of various oxidative stress mediated diseases including aging. The half inhibition concentration (IC50) of resin extract of Shorea robusta and ascorbic acid were 35.60 µg/ml and 31.91 µg/ml respectively. The resin extract exhibit a significant dose dependent inhibition of DPPH activity. Antibacterial activity was observed against gram positive and gram negative bacteria in dose dependent manner.Key Words: Shorea robusta, antioxidant, antibacterial, Disc-diffusion, DPPH.

Antibacterial activity of magnesium oxide nanoparticles prepared by Calcination method

2019 ◽  
Vol 10 (03) ◽  
Author(s):  
Elaf Ayad Kadhem ◽  
Miaad Hamzah Zghair ◽  
Sarah , Hussam H. Tizkam, Shoeb Alahmad Salih Mahdi ◽  
Hussam H. Tizkam ◽  
Shoeb Alahmad
Keyword(s):  
Antibacterial Activity ◽  
Magnesium Oxide ◽  
Diffusion Method ◽  
Oxide Nanoparticles ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Magnesium Oxide Nanoparticles ◽  
Agar Disc

magnesium oxide nanoparticles (MgO NPs) were prepared by simple wet chemical method using different calcination temperatures. The prepared NPs were characterized by Electrostatic Discharge (ESD), Scanning Electron Microscope (SEM) and X-ray Diffraction (XRD). It demonstrates sharp intensive peak with the increase of crystallinty and increase of the size with varying morphologies with respect to increase of calcination temperature. Antibacterial studies were done on gram negative bacteria (E.coli) and gram positive bacteria (S.aureus) by agar disc diffusion method. The zones of inhibitions were found larger for gram positive bacteria than gram negative bacteria, this mean, antibacterial MgO NPs activity more active on gram positive bacteria than gram negative bacteria because of the structural differences. It was found that antibacterial activity of MgO NPs was found it has directly proportional with their concentration.

Structure-Activity Relationship and Antimicrobial Evaluation of N-Phenylpyrazole Curcumin Derivatives

2020 ◽  
Vol 16 (4) ◽  
pp. 481-488
Author(s):  
Heli Sanghvi ◽  
Satyendra Mishra
Keyword(s):  
Antibacterial Activity ◽  
Gram Negative Bacteria ◽  
Pyrazole Derivatives ◽  
Gram Positive ◽  
Gram Negative ◽  
E Coli ◽  
Curcumin Derivatives ◽  
Structure Activity ◽  
Electron Donating Groups ◽  
Derivatives Of

Background: Curcumin, one of the most important pharmacologically significant natural products, has gained significant consideration among scientists for decades since its multipharmacological activities. 1, 3-Dicarbonyl moiety of curcumin was found to be accountable for the rapid degradation of curcumin molecule. The aim of present work is to replace 1, 3-dicarbonyl moiety of curcumin by pyrazole and phenylpyrazole derivatives with a view to improving its stability and to investigate the role of substitution in N-phenylpyrazole curcumin on its antibacterial activity against both Gram-positive as well as Gram-negative bacteria. Methods: Pyrazole derivatives of curcumin were prepared by heating curcumin with phenyhydrazine/ substituted phenyhydrazine derivatives in AcOH. The residue was purified by silica gel column chromatography. Structures of purified compounds were confirmed by 1H NMR and Mass spectroscopy. The synthesized compounds were evaluated for their antibacterial activity by the microdilution broth susceptibility test method against gram positive (S. aureus) and gram negative (E. coli). Results: Effects of substitution in N-phenylpyrazole curcumin derivatives against S. aureus and E. coli were studied. The most active N-(3-Nitrophenylpyrazole) curcumin (12) exhibits twenty-fold more potency against S. aureus (MIC: 10μg/mL)) and N-(2-Fluoroophenylpyrazole) curcumin (5) fivefold more potency against E. coli (MIC; 50 μg/mL) than N-phenylpyrazole curcumin (4). Whereas, a remarkable decline in anti-bacterial activity against S. aureus and E. coli was observed when electron donating groups were incorporated in N-phenylpyrazole curcumin (4). Comparative studies of synthesized compounds suggest the effects of electron withdrawing and electron donating groups on unsubstituted phenylpyrazole curcumin (4). Conclusion: The structure-activity relationship (SAR) results indicated that the electron withdrawing and electron donating at N-phenylpyrazole curcumin played key roles for their bacterial inhibitory effects. The results of the antibacterial evaluation showed that the synthesized pyrazole derivatives of curcumin displayed moderate to very high activity in S. aureus. In conclusion, the series of novel curcumin derivatives were designed, synthesized and tested for their antibacterial activities against S. aureus and E. coli. Among them, N-(3-Nitrophenylpyrazole curcumin; 12) was most active against S. aureus (Gram-positive) and N-(2-Fluoroophenylpyrazole) curcumin (5) against E. coli (Gram-negative) bacteria.

scholarly journals Rational Design of Ag/ZnO Hybrid Nanoparticles on Sericin/Agarose Composite Film for Enhanced Antimicrobial Applications

2020 ◽  
Vol 22 (1) ◽  
pp. 105
Author(s):  
Wanting Li ◽  
Zixuan Huang ◽  
Rui Cai ◽  
Wan Yang ◽  
Huawei He ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Antimicrobial Activity ◽  
Composite Film ◽  
Water Absorption ◽  
Rational Design ◽  
Hybrid Nanoparticles ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
X Ray

Silver-based hybrid nanomaterials are receiving increasing attention as potential alternatives for traditional antimicrobial agents. Here, we proposed a simple and eco-friendly strategy to efficiently assemble zinc oxide nanoparticles (ZnO) and silver nanoparticles (AgNPs) on sericin-agarose composite film to impart superior antimicrobial activity. Based on a layer-by-layer self-assembly strategy, AgNPs and ZnO were immobilized on sericin-agarose films using the adhesion property of polydopamine. Scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray powder diffraction spectroscopy were used to show the morphology of AgNPs and ZnO on the surface of the composite film and analyze the composition and structure of AgNPs and ZnO, respectively. Water contact angle, swelling ratio, and mechanical property were determined to characterize the hydrophilicity, water absorption ability, and mechanical properties of the composite films. In addition, the antibacterial activity of the composite film was evaluated against Gram-positive and Gram-negative bacteria. The results showed that the composite film not only has desirable hydrophilicity, high water absorption ability, and favorable mechanical properties but also exhibits excellent antimicrobial activity against both Gram-positive and Gram-negative bacteria. It has shown great potential as a novel antimicrobial biomaterial for wound dressing, artificial skin, and tissue engineering.

Light mediated, switchable, antibacterial activity of cerium dioxide nanoparticles on gram positive and gram negative bacteria

2020 ◽  
Author(s):  
Rekhachandran Prasanna Ramachandran ◽  
Archana Valliyamma ◽  
Nitha Nellithanathu Thomas ◽  
Mangalaraja Ramalinga Viswanathan ◽  
Boby Theophilofe Edwin ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Cerium Dioxide ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative
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