Glycaemic index and glycaemic load in relation to blood lipids – 6 years of follow-up in adult Danish men and women

AbstractBackgroundCross-sectional studies have suggested an association between glycaemic index (GI) or glycaemic load (GL) and serum lipids. However, no prospective studies have been performed.ObjectiveTo examine whether GI or GL was associated with subsequent changes in serum lipids.DesignProspective study with 6 years of follow-up. Overall dietary GI and GL of each participant were assessed from diet history interviews.SettingPopulation-based study.SubjectsThree hundred and thirty-five healthy men and women aged 35–65 years selected randomly from a larger sample of Danish adults.ResultsIn men GI was directly related to changes in total cholesterol (ΔTC), regression coefficient (β) = 0.0044 (95% confidence interval (CI): 0.0008–0.0081) and GL was positively related to changes in low-density lipoprotein cholesterol (ΔLDL),β= 0.1554 (95% CI: 0.0127–0.2982). Furthermore, the relationship between GL and ΔTC was modified by age, being particularly strong for the younger men (P= 0.02). In women the relationship between GI and ΔLDL was modified by age and was stronger for younger rather than older women (P= 0.01). A tendency for a similar interaction was seen for GI and ΔTC (P= 0.09). Associations between GL and ΔLDL and GL and ΔTC were inverse for women with body mass index ≥ 30 kg m−2(P= 0.03 and 0.04, respectively).ConclusionsThis is the first study to demonstrate that dietary GI and GL are related to 6-year changes in serum lipid levels. However, associations were weak and generally confined to subgroups.

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Subclinical Hypothyroidism and Indices for Metabolic Syndrome in Japanese Women: One-Year Follow-Up Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2013-1353 ◽

2013 ◽

Vol 98 (8) ◽

pp. 3280-3287 ◽

Cited By ~ 18

Author(s):

Yasuyo Nakajima ◽

Masanobu Yamada ◽

Masako Akuzawa ◽

Sumiyasu Ishii ◽

Yasuhiro Masamura ◽

...

Keyword(s):

Metabolic Syndrome ◽

Odds Ratio ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Serum Triglyceride ◽

Low Density ◽

Low Density Lipoprotein Cholesterol ◽

Free T4 ◽

The Relationship

Context: Subclinical hypothyroidism (SCH) and metabolic syndrome (MetS) increase with age; however, their relationship remains unclear. Objective: Our objective was to investigate the relationship between SCH and indices of metabolic syndrome and follow up subjects for 1 year. Design: Cross-sectional and longitudinal follow-up studies of cases were collected from Takasaki Hidaka Hospital between 2003 and 2007. Participants: Overall, 11 498 participants of health checkups were analyzed. The mean age was 48 ± 9 years. Main Outcome Measures: The relationship between SCH and indices of MetS were examined. Results: Serum free T4 levels were lower in women than men in most of the age groups, and the prevalence of SCH, 6.3% in women vs 3.4% in men, increased with age, reaching 14.6% in 70-year-old women. Multivariate logistic-regression analyses revealed that waist circumference and the serum triglyceride and low-density lipoprotein-cholesterol levels were significantly higher in subjects with SCH than without among women. Reflecting these findings, the adjusted odds ratio of MetS in patients with SCH was higher than in the euthyroid subjects in women with an odds ratio of 2.7 (95% confidence interval 1.1–5.6; P = .017) but not in men. Furthermore, progression from euthyroid into SCH resulted in a significant increase in the serum triglyceride levels but not low-density lipoprotein-cholesterol in women. Conclusion: Japanese women exhibited a high prevalence of SCH associated with low free T4 levels. There was a strong association between SCH and several indices of metabolic syndrome in women. SCH may affect serum triglyceride levels and be a risk factor for metabolic syndrome.

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Dietary phytochemical index associated with cardiovascular risk factor in patients with type 1 diabetes mellitus

10.21203/rs.3.rs-239129/v1 ◽

2021 ◽

Author(s):

Saeideh Delshad Aghdam ◽

Fereydoun Siassi ◽

Ensieh Nasli Esfahani ◽

Mostafa Qorbani ◽

Asadollah Rajab ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Lipoprotein Cholesterol ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Cross Sectional ◽

The Relationship

Abstract Background Dietary phytochemical index (DPI) is useful and inexpensive method to identify the role of phytochemicals on cardiovascular disease (CVD) risk factors. This study aimed to assess the relationship between DPI and CVD risk factors in patients with type1 diabetes mellitus (T1DM). Methods A total of 261 participants aged 18–35 years with T1DM were enrolled in this cross-sectional study to assess the relationship between DPI and CVD risk factors. Anthropometric measurements, blood lipids, glucose, and antioxidant level were measured. Food intakes were determined using a food frequency questionnaire to calculate DPI. Logistic regression was used. Results The mean age of participants was 25 years. After adjustment for potential confounders, participants in the highest tertile of DPI had 88% lower chance of hyperglycemia (P for trend = 0.020), 81% lower chance of low high-density lipoprotein cholesterol (HDL-C) (P for trend = 0.030) and 98% lower chance of high low-density lipoprotein cholesterol to HDL-C ratio (P for tend = 0.040). There were no relationships between DPI and other CVD risk factors. Conclusions Although higher intake of phytochemical-rich foods had a beneficial effect on some risk factors of CVD, more studies more studies are warranted to corroborate the present findings.

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Social determinants of cardiac disease biomarkers: investigating a Swedish male cohort at ages 50 and 70

European Journal of Preventive Cardiology ◽

10.1177/1741826711405952 ◽

2011 ◽

Vol 19 (3) ◽

pp. 523-533 ◽

Cited By ~ 5

Author(s):

Amal Khanolkar ◽

Denny Vågerö ◽

Ilona Koupil

Keyword(s):

Cox Regression ◽

Low Density Lipoprotein ◽

Population Sample ◽

Density Lipoprotein ◽

Population Based ◽

Inverse Association ◽

Occupational Class ◽

Swedish Population ◽

Cvd Mortality

Background: Social status is associated with cardiovascular disease (CVD) prevalence and incidence. Aims: to investigate relationships between socioeconomic position (SEP) and common CVD biomarkers including adiponectin not previously investigated in a Swedish-population sample, and to assess if these associations changed with age. Design: Population-based longitudinal cohort study of men born 1920–24 with clinical measurements, blood samples, questionnaire data, and register-based information on SEP and cause of death. Methods: A total of 2322 men attended an investigation at age 50 of which 1221 attended a reinvestigation at age 70. Association between SEP and CVD biomarkers [cholesterol, low-density lipoprotein/high-density lipoprotein (LDL/HDL), apolipoprotein (Apo) ApoB/ApoA1, and adiponectin] were analysed by linear regression (adjusted for age, body mass index, and physical activity). SEP was measured as occupational class and educational level. CVD mortality over 36 years of follow-up was analysed by Cox regression. Results: At age 50, we found a significant inverse association of education with cholesterol level, LDL/HDL ratio and ApoB/ApoA1 ratio. Cholesterol was also associated with occupational class, statistically significant after adjustment for all covariates. At age 70, no significant associations were found between either measurement of SEP and any of the biomarkers studied. Highest educated men had decreased risk for CVD mortality during follow-up. Conclusions: Associations of SEP with cholesterol levels and LDL/HDL ratio that exist at age 50 are no longer apparent in the same group of men at age 70. We found no significant association between SEP and adiponectin levels at age 70.

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Hubungan antara Kadar Low Density Lipoprotein dengan Tekanan Darah Sistolik saat Puncak Exercise pada Personil Kepolisian Daerah Sulawesi Tenggara (The Relationship between Low Density Lipoprotein Levels and Systolic Blood Pressure during Peak Exercise of Police Personnel in Southeast Sulawesi)

MEDULA ◽

10.46496/medula.v7i2.11970 ◽

2020 ◽

Vol 7 (2) ◽

Author(s):

Dina Fitriana ◽

Hilma Yuniar ◽

Jamaluddin Jamaluddin

Keyword(s):

Blood Pressure ◽

Systolic Blood Pressure ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Peak Exercise ◽

P Value ◽

Low Density ◽

Cross Sectional ◽

Police Personnel ◽

The Relationship

Background: Systolic blood pressure during exercise is the blood pressure as measured by aneroid sphygmomanometer at the peak exercise (treadmill), namely when the subject has experienced fatigue or heart rate has reached > 85% of Maximum Heart Rate. Purpose:This research purpose is to determine the relationship between LDL level and systolic blood pressure at the exercise peak of police personnel in Southeast Sulawesi. Methods: This research used analytical-observasional study with cross sectional aproach. The independent variables used in this research are LDL level while the dependent variables was systolic blood pressure during the peak exercise. Research location is in Maxima Laboratory Kendari.The subjects of this study were 95 people based on the inclusion and exclusion criteria that selected by Purposive Sampling method. Data collection was gained by taking the secondary data and was processed by using statistical test data of Independent T-test with a significance p-value <0.05. Result: The result of bivariate analysis showed that there was a relationship between LDL level and systolic blood pressure at the exercise peak on the police personnel in Southeast Sulawesi with a p-value = 0,000 (<0.05). Conclusion: This study can be conlcuded that there was a relationship between LDL level and systolic blood pressure at the peak exercise of police personnel in Southeast Sulawesi.Keywords: low density lipoprotein, systolic blood pressure, peak exercise. ABSTRAKLatar belakang : Puncak tekanan darah sistolik pada saat exercise adalah tekanan darah sistolik yang diukur dengan menggunakan sfignomanometer air raksa pada saat puncak exercise, dimana subyek sudah mengalami kelelahan atau denyut jantung telah mencapai 85% dari denyut jantung maximal. Tujuan: Tujuan penelitian ini adalah untuk mengetahui hubungan antara kadar LDL plasma dengan tekanan darah sistolik pada puncak exercise pada personil Kepolisian Daerah Sulawesi Tenggara. Metode: penelitian ini merupakan penelitian analitik-observasional dengan metode cross sectional. variabel independen adalah kadar LDL plasma dan dependen variabel adalah tekanan darah sistol pada puncak exercise. penelitian dilakukan di Laboratorium Klinik Maxima Kendari. sebanyak 95 sampel penelitian yang memenuhi kriteria inklusi dan eksklusi diambil dengan metode purposive sampling. Data tekanan darah saat puncak exercise dan kadar LDL plasma diambil dari data sekunder rekam medik pasien. Data kemudian dianalisa dengan uji statistik Independent T-test dan bermakna bila nilai p <0,05. Hasil: Analisa statistik menunjukkan adanya hubungan antara kadar LDL plasma dengan tekanan darah sistolik pada puncak exercise pada personil POLDA Sulawesi Tenggara, dengan nilai p=0,000. Simpulan : Pada penelitian ini dapat disimpulkan bahwa terdapat hubungan antara kadar LDL plasma dengan tekanan darah sistolik pada puncak exercise pada personil POLDA Sulawesi Tenggara.Kata Kunci: low density lipoprotein, tekanan darah sistolik, puncak exercise

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Associations of Serum Lipids with Risk of Cognitive Impairment in Chinese Centenarians

10.21203/rs.3.rs-274807/v1 ◽

2021 ◽

Author(s):

Yujian Chen ◽

Ya Huang ◽

ChaoXue Ning ◽

Qiao Zhu ◽

Yao Yao ◽

...

Keyword(s):

Cognitive Impairment ◽

Cognitive Functions ◽

Serum Lipids ◽

Low Density Lipoprotein ◽

Multiple Logistic Regression Analysis ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Inverse Association ◽

Cross Sectional ◽

Low Hdl

Abstract Background Dyslipidaemia and cognitive impairment are common in old adults and risks of both of them increase with increasing age. However, the relationship between lipids and cognitive impairment in longevous people is still unclear. This study aimed to assess the association between serum lipids and cognitive impairment in Chinese centenarians. Methods In a cross-sectional study, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were biochemically measured in 924 centenarians and cognitive functions were evaluated. Multiple logistic regression analysis was used to examine the associations of lipids with cognitive impairment and the risks for cognitive impairment associated with quartile of serum lipid concentrations. Results The results demonstrated HDL-C was an independent beneficial factor for cognitive impairment after controlling for the potential covariates (Odds ratio, OR = 0.350, 95% Confidence interval, CI = 0.159–0.774; P = 0.009). An inverse association of HDL-C with cognitive impairment was found (P for trend = 0.001) and the association remained significant after adjusting for possible cofounders (P for trend = 0.012). The OR of cognitive impairment for the lowest versus highest quartiles of HDL-C was 1.96 (95%CI, 1.09–3.45). Conclusions The results indicated that low HDL-C is likely to be harmful for cognitive functions in centenarians. The cognitive function of longevous persons with low HDL-C concentrations deserves more attention.

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Dietary inflammatory index significantly affects lipids profile among adults: An updated systematic review and meta-analysis

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000688 ◽

2020 ◽

pp. 1-17

Author(s):

Mahdi Vajdi ◽

Mahdieh Abbasalizad Farhangi ◽

Mahsa Mahmoudi-Nezhad

Keyword(s):

Systematic Review ◽

Serum Lipids ◽

Meta Analysis ◽

Density Lipoprotein ◽

Case Control ◽

Lipoprotein Cholesterol ◽

Dietary Inflammatory Index ◽

Cross Sectional ◽

Inflammatory Index ◽

The Relationship

Abstract. Background: The available data on the relationship between dietary inflammatory index (DII®) and serum lipids are controversial. This systematic review and meta-analysis aimed to investigate the relationship between DII® and serum lipids, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) in general populations. Methods: PubMed, Web of Science, SCOPUS, and Cochrane electronic databases were systematically searched from inception to December 2019. Case-control, cohort or cross-sectional studies that evaluated the relationship between DII® and serum lipids were included. The random-effects model was applied to evaluate the pooled weighted mean difference (WMD) and 95% confidence intervals (CI). Results: In total, twenty-four cross-sectional and one case-control studies with a total sample size of 129,759 were included in the meta-analysis. The pooled results showed that the highest category of DII® was associated with 5.16 mg/dl increase in TC (Pooled WMD: 5.16; 95% CI: 0.58–9.73, p = 0.02) and 3.99 mg/dl increase in LDL-C (Pooled WMD: 3.99; 95% CI: 1.16–6.81, p = 0.006). However, no significant association between DII® scores, HDL-C and TG was found. In subgroup analysis, the geographical region, gender, and dietary assessment methods were potent sources of heterogeneity. Conclusion: This study showed that a higher level of DII® was associated with higher levels of TC and LDL-C in apparently healthy populations. Since the included studies had observational designs, therefore, no conclusion of causality was possible. More studies with interventional designs are required to elucidate the causality of the observed association between DII® and the risk of abnormal lipid profile.

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High serum adiponectin is associated with favorable lipoprotein subclass profile in 6.4-year follow-up

Acta Endocrinologica ◽

10.1530/eje-10-1065 ◽

2011 ◽

Vol 164 (4) ◽

pp. 549-552 ◽

Cited By ~ 11

Author(s):

Mauno Vanhala ◽

Linda S Kumpula ◽

Pasi Soininen ◽

Antti J Kangas ◽

Mika Ala-Korpela ◽

...

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Population Based ◽

High Serum ◽

Proton Nuclear Magnetic Resonance ◽

Serum Adiponectin ◽

Resonance Spectroscopy ◽

Lipoprotein Subclass ◽

Lipoprotein Particle

ObjectiveAdiponectin is linked to a favorable lipoprotein profile, but potential longitudinal associations are not known.DesignA population-based follow-up study of all inhabitants born in 1942, 1947, 1952, and 1957 (n=1294) in Pieksämäki, a town in Finland. Of the 690 subjects participating in both the check-ups, 228 subjects with diabetes or any medication for dyslipidemia, high blood pressure, or diabetes were excluded. The final study population consisted of 462 (182 men and 280 women) apparently healthy subjects.MethodsMain outcome measures were lipoprotein particle sizes and concentrations, apolipoprotein A-1 (APOA1) and APOB levels at baseline and follow-up across baseline adiponectin tertiles. Serum adiponectin concentrations were determined using an enzyme immunoassay, and lipoprotein subclasses using proton nuclear magnetic resonance spectroscopy.ResultsAt the second health check-up 6.4 years later, the very low-density lipoprotein particle concentration decreased across the baseline adiponectin tertiles in men from 1.04 (0.28) to 0.91 (0.29) nmol/l (P for linearity=0.011) and in women from 0.92 (0.32) to 0.80 (0.24) nmol/l (P=0.002). Correspondingly, the mean high-density lipoprotein particle size increased from 9.78 to 9.90 nm in men (P<0.006) and from 10.00 to 10.14 nm in women (P<0.001).ConclusionThe favorable links between adiponectin and lipoproteins are detectable 6.4 years later.

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Low-density lipoprotein cholesterol within the normal range and nonalcoholic fatty liver disease in the non-obese Chinese population: a secondary analysis based on a cross-sectional study

10.21203/rs.3.rs-22525/v1 ◽

2020 ◽

Author(s):

Zhigang (N/A) Xu ◽

Baohong Xu

Keyword(s):

Fatty Liver Disease ◽

Chinese Population ◽

Low Density Lipoprotein ◽

Secondary Analysis ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Sectional Study ◽

Low Density Lipoprotein Cholesterol ◽

Cross Sectional ◽

The Relationship

Abstract Background Evidence regarding the relationship between normal low-density lipoprotein cholesterol (LDL-c) levels and non-alcoholic fatty liver disease (NAFLD) was limited. Therefore, this dissertation seeks to investigate the relationship between LDL-c and NAFLD in the non-obese Chinese population after adjusting for other covariates. Methods The present study was a cross-sectional study. A total of 183903 non-obese participants were involved in a Wenzhou Medical Center of Wenzhou People’s Hospital from 2010 to 2014. The target independent variable and the dependent variable were LDL-c measured at baseline and NAFLD respectively. Covariates involved in this study included SEX, AGE, BMI, SBP, DBP, FPG, ALB, ALT, AST, BUN, Cr, TG, TC, HDL-c, UA. It was noted that the entire study was completed by Dan-Qin Sun et al., and uploaded the data to the DATADRYAD website. The author only used this data for secondary analysis. Results The average age of 183903 selected participants was 41.0 ± 14.1 years old,and about 49.6% of them was male. After adjusting potential confounders (SEX, AGE, BMI, FPG, ALB, GLB, ALT, AST, GGT, BUN, Cr, TG, TC, HDL-c, UA), non-linear relationship was detected between normal LDL-c levels and NAFLD, whose point was 1.51. The effect sizes and the confidence intervals on the left and right sides of inflection point were 0.87 (0.64, 1.18) and 1.79 (1.67, 1.92), respectively. Conclusion The relationship between normal LDL-c levels and NAFLD is non-linear. Normal LDL-c levels was positively correlated with NAFLD when LDL-c was more than 1.51.

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Associations of Serum Lipids With Risk of Cognitive Impairment in Chinese Centenarians

10.21203/rs.3.rs-145816/v1 ◽

2021 ◽

Author(s):

Yujian Chen ◽

Ya Huang ◽

ChaoXue Ning ◽

Qiao Zhu ◽

Yao Yao ◽

...

Keyword(s):

Cognitive Impairment ◽

Cognitive Functions ◽

Serum Lipids ◽

Low Density Lipoprotein ◽

Multiple Logistic Regression Analysis ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Inverse Association ◽

Cross Sectional ◽

Low Hdl

Abstract Background: Dyslipidaemia and cognitive impairment are common in old adults and risks of both of them increase with increasing age. However, the relationship between lipids and cognitive impairment in longevous people is still unclear. This study aimed to assess the association between serum lipids and cognitive impairment in Chinese centenarians.Methods: In a cross-sectional study , total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were biochemically measured in 924 centenarians and cognitive functions were evaluated. Multiple logistic regression analysis was used to examine the associations of lipids with cognitive impairment and the risks for cognitive impairment associated with quartile of serum lipid concentrations.Results: The results demonstrated HDL-C was an independent beneficial factor for cognitive impairment after controlling for the potential covariates (Odds ratio, OR=0.350, 95% Confidence interval, CI=0.159–0.774; P=0.009). An inverse association of HDL-C with cognitive impairment was found (P for trend=0.001) and the association remained significant after adjusting for possible cofounders (P for trend =0.012). The OR of cognitive impairment for the lowest versus highest quartiles of HDL-C was 1.96 (95%CI, 1.09–3.45).Conclusions: The results indicated that low HDL-C is likely to be harmful for cognitive functions in centenarians. The cognitive function of longevous persons with low HDL-C concentrations deserves more attention.

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Cluster headache is associated with an increased risk of depression: A nationwide population-based cohort study

Cephalalgia ◽

10.1177/0333102412469738 ◽

2012 ◽

Vol 33 (3) ◽

pp. 182-189 ◽

Cited By ~ 24

Author(s):

Jen-Feng Liang ◽

Yung-Tai Chen ◽

Jong-Ling Fuh ◽

Szu-Yuan Li ◽

Chia-Jen Liu ◽

...

Keyword(s):

Risk Factor ◽

Cluster Headache ◽

Population Based ◽

Small Sample ◽

Cross Sectional ◽

Increased Risk ◽

Taiwan National Health Insurance ◽

Small Sample Sizes ◽

The Relationship

Objective To investigate whether cluster headache (CH) was a risk factor for depression in a nationwide population-based follow-up study. Background There are few studies about the relationship between CH and depression, and prior research has been limited by cross-sectional studies or small sample sizes. Methods We identified 673 CH patients from the Taiwan National Health Insurance database between 2005 and 2009. The two comparison cohorts included age-, sex- and Charlson’s score-matched migraine patients ( n = 2692) and controls (patients free from migraine or CH, n = 2692). The cumulative incidence of depression was compared among these three cohorts until the end of 2009. We also calculated predictors of depression in the CH cohort. Results After the median 2.5-year follow-up duration, the CH cohort had a greater risk for developing depression compared to the control cohort (adjusted hazard ratio; aHR = 5.6, 95% CI 3.0–10.6, p < 0.001) but not the migraine cohort (aHR = 1.1, 95% CI 0.7–1.7, p = 0.77). Of the CH patients, the number of cluster bout periods per year was a risk factor for depression (aHR = 3.8, 95% CI 2.6–5.4, p < 0.001). Conclusion Our results showed that CH is associated with an increased risk for depression. The strength of this association is similar to that of migraine.

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